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61.发明授权Method and apparatus for detecting natural electrical coherence within the heart and for administering therapy based thereon 有权用于检测心脏内的自然电相干性并用于基于其进行治疗的方法和装置公开(公告)号：US06766195B1
公开(公告)日：2004-07-20
申请号：US09686630
申请日：2000-10-10
IPC分类号： A61N0118
CPC分类号： A61N1/3962 , A61N1/395
摘要： Techniques are provided for detecting natural electrical coherence within the heart and for administering or adjusting therapy based upon whether natural electrical coherence is detected. In one example, an implantable cardioverter defibrillator (ICD), upon detecting atrial fibrillation, delays administering an atrial defibrillation pulse until a period of natural electrical coherence is detected between the left and the right atria of the heart. The ICD may further delay the pulse until the ventricles of the heart are refractory so as to help prevent triggering ventricular fibrillation. The pulses are administered at a time selected based upon the period of electrical coherence to reduce the amount of electrical energy required within the pulse to reliably defibrillate the heart. Other types of therapy besides defibrillation therapy such as anti-tachycardia pacing pulses may also be timed based upon detection periods of natural electrical coherence. Method and apparatus embodiments are described.
摘要翻译： 提供了用于检测心脏内的自然电连贯性的技术，并且用于基于是否检测到自然电连贯来施用或调整治疗。 在一个实例中，在检测心房颤动时，植入式心律转复除颤器（ICD）延迟施用心房除颤脉冲，直到在心脏的左心房和右心房之间检测到自然电相干的时间段。 ICD可以进一步延迟脉冲，直到心脏的心室难以耐受，以便有助于防止触发心室颤动。 在基于电相干周期选择的时间施加脉冲以减少脉冲内所需的电能量以可靠地除颤心脏。 除了除颤疗法之外的其他类型的治疗，如抗心动过速起搏脉冲也可以基于自然电连续性的检测周期来计时。 描述了方法和设备实施例。
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62.发明授权System and method of automatically determining the onsets and ends of cardiac events and far-field signals 有权自动确定心脏事件和远场信号的开始和结束的系统和方法公开(公告)号：US06650931B1
公开(公告)日：2003-11-18
申请号：US09992740
申请日：2001-11-14
申请人： Kelly H. McClure , Gene A. Bornzin , Junyu Mai
发明人： Kelly H. McClure , Gene A. Bornzin , Junyu Mai
IPC分类号： A61B504
CPC分类号： A61B5/0452 , A61B5/7257
摘要： A system and method for determining the onset and termination of cardiac events, such as the R-wave, the T-wave and the far-field signals sensed in the atria associated with the R-wave (FFR) and T-wave (FFT). The onset is defined as the time of the first sampled point of the cardiac signal whose magnitude exceeds a pre-defined threshold for the particular event. Once the onset of an event is positively determined, the cardiac signal is sampled at given intervals. The change in magnitude of these sampled points is determined. The termination of the event is identified through an algorithm that compares the difference in magnitude of these sampled points.
摘要翻译： 用于确定心脏事件的发作和终止的系统和方法，例如与R波（FFR）和T波（FFT）相关联的心房中感测到的R波，T波和远场信号 ）。 起始被定义为心脏信号的第一采样点的时间，其幅度超过特定事件的预定阈值。 一旦确定了事件的开始，就以给定的间隔对心脏信号进行采样。 确定这些采样点的幅度变化。 通过比较这些采样点的幅度差异的算法来识别事件的终止。
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63.发明授权System and method for deriving hemodynamic signals from a cardiac wall motion sensor 失效用于从心脏壁运动传感器导出血液动力学信号的系统和方法
公开(公告)号：US6009349A
公开(公告)日：1999-12-28
申请号：US942237
申请日：1997-10-01
CPC分类号： A61N1/36542 , A61N1/3956
摘要： A processing system and method are provided for deriving an improved hemodynamic indicator from cardiac wall acceleration signals. The cardiac wall acceleration signals are provided by a cardiac wall motion sensor that responds to cardiac mechanical activity. The cardiac wall acceleration signals are integrated over time to derive cardiac wall velocity signals, which are further integrated over time to derive cardiac wall displacement signals. The cardiac wall displacement signals correlate to known hemodynamic indicators, and are shown to be strongly suggestive of hemodynamic performance. An implantable cardiac stimulating device which uses cardiac wall displacement signals to detect and discriminate cardiac arrhythmias is also provided.
摘要翻译： 提供了一种用于从心脏壁加速度信号导出改进的血液动力学指标的处理系统和方法。 心脏壁加速度信号由响应于心脏机械活动的心脏壁运动传感器提供。 随着时间的推移，心脏壁加速度信号被积分以导出心脏壁速度信号，其随时间进一步积分以导出心脏壁位移信号。 心脏壁位移信号与已知的血液动力学指标相关，并且显示出强烈地提示血流动力学性能。 还提供了使用心脏壁位移信号来检测和区分心律不齐的可植入心脏刺激装置。
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64.发明授权
公开(公告)号：US5549650A
公开(公告)日：1996-08-27
申请号：US259084
申请日：1994-06-13
CPC分类号： A61N1/36542 , A61N1/3682
摘要： A system and method for a pacemaker are provided, for using cardiac wall motion sensor signals to provide hemodynamically optimal pacing therapy to patient at rest, and for providing rate-responsive pacing therapy. The cardiac wall motion sensor signals are provided by an implantable lead that incorporates an accelerometer for measuring cardiac mechanical activity. The cardiac wall motion sensor signals are processed to derive cardiac wall velocity signals and cardiac wall displacement signals. The derived signals are further processed to derive physiologic parameters indicative of cardiac performance, including stroke volume, contractility, pre-ejection period, and ejection time. The physiological parameters, in turn, are used by the pacemaker to provide hemodynamically optimal pacing therapy at rest, and rate-responsive pacing therapy.
摘要翻译： 提供了一种用于起搏器的系统和方法，用于使用心脏壁运动传感器信号为静息患者提供血液动力学最佳起搏治疗，并提供速率响应性起搏治疗。 心脏壁运动传感器信号由可植入引线提供，其包含用于测量心脏机械活动的加速度计。 处理心脏壁运动传感器信号以导出心脏壁速度信号和心脏壁位移信号。 导出的信号被进一步处理以得出指示心脏性能的生理参数，包括脑卒中体积，收缩性，预喷射期和排出时间。 生理参数又由起搏器用于提供血液动力学优化的静息起搏治疗和速率响应性起搏治疗。
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公开(公告)号：US08874239B2
公开(公告)日：2014-10-28
申请号：US12267489
申请日：2008-11-07
申请人： Robert J. Greenberg , David Daomin Zhou , Jordan Matthew Neysmith , Kelly H. McClure , Jianing Wei , Neil Hamilton Talbot , James Singleton Little
发明人： Robert J. Greenberg , David Daomin Zhou , Jordan Matthew Neysmith , Kelly H. McClure , Jianing Wei , Neil Hamilton Talbot , James Singleton Little
CPC分类号： A61N1/0541 , A61N1/0472
摘要： A cochlear stimulation device comprising an electrode array designed to provide enhanced charge injection capacity necessary for neural stimulation. The electrode array comprises electrodes with high surface area or a fractal geometry and correspondingly high electrode capacitance and low electrical impedance. The resultant electrodes have a robust surface and sufficient mechanical strength to withstand physical stress vital for long term stability. The device further comprises wire traces having a multilayer structure which provides a reduced width for the conducting part of the electrode array. The cochlear prosthesis is attached by a grommet to the cochleostomy that is made from a single piece of biocompatible polymer. The device, designed to achieve optimum neural stimulation by appropriate electrode design, is a significant improvement over commercially available hand-built devices.
摘要翻译： 耳蜗刺激装置包括设计成提供神经刺激所需的增强的电荷注入能力的电极阵列。 电极阵列包括具有高表面积或分形几何形状的电极以及相当高的电极电容和低的电阻抗。 所得电极具有坚固的表面和足够的机械强度以抵抗对于长期稳定性至关重要的物理应力。 该装置还包括具有多层结构的导线迹线，其为电极阵列的导电部分提供减小的宽度。 耳蜗假体通过索环连接到由单一生物相容性聚合物制成的耳蜗切开术。 该设备旨在通过适当的电极设计实现最佳神经刺激，这是相对于市售的手工设备的显着改进。
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公开(公告)号：US08428739B2
公开(公告)日：2013-04-23
申请号：US12548275
申请日：2009-08-26
申请人： Ashish Ahuja , Avraham Caspi , Jessy Dorn , Robert J. Greenberg , Kelly H. McClure , Matthew J. McMahon , Devyani Nanduri
发明人： Ashish Ahuja , Avraham Caspi , Jessy Dorn , Robert J. Greenberg , Kelly H. McClure , Matthew J. McMahon , Devyani Nanduri
IPC分类号： A61N1/18
CPC分类号： A61N1/36046 , A61N1/37247
摘要： This system gives the experimenter great flexibility to present spatio-temporal stimulation patterns to a subject. A video configuration file (VCF) editor allows the experimenter to determine the electrical stimulation parameters for each electrode. A Pattern Stimulation software program allows direct stimulation of chosen patterns of electrodes, scaled by the subject's VCF, through a Graphical User Interface. The subject then responds by drawing the outline of the phosphene he or she perceives on a touchscreen. The Pattern Stimulation program saves all of the trial parameters and the parameters of an ellipse fit to their drawing, as well as a raw data file containing the input to the touchscreen is saved. After the experiment, offline image analysis can be performed to obtain a detailed quantitative description of the subject's percepts. Image descriptors can assigned to the touchscreen data; these image descriptors can be used to make formalized comparisons between various experimental conditions. Various types of image descriptors can be used, including simple ellipse fitting, projections of the 2-D drawings onto one-dimensional axes, calculations of Hu moments, PCA, and ICA.
摘要翻译： 该系统给予实验者极大的灵活性，以向受试者呈现时空刺激模式。 视频配置文件（VCF）编辑器允许实验者确定每个电极的电刺激参数。 图案刺激软件程序允许通过图形用户界面直接刺激由对象的VCF缩放的所选择的电极图案。 然后，该主题通过绘制他或她在触摸屏上感知的磷光体的轮廓来进行响应。 模式刺激程序将所有试验参数和椭圆参数保存到其图形中，并保存包含触摸屏输入的原始数据文件。 实验后，可以进行离线图像分析，以获得对主体感知的详细定量描述。 图像描述符可以分配给触摸屏数据; 这些图像描述符可用于在各种实验条件之间进行正式比较。 可以使用各种图像描述符，包括简单的椭圆拟合，将二维图纸投影到一维轴上，计算Hu矩，PCA和ICA。
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67.发明授权Systems and methods for communicating with or providing power to an implantable stimulator 有权用于与植入式刺激器通信或提供电力的系统和方法公开(公告)号：US08386048B2
公开(公告)日：2013-02-26
申请号：US11034190
申请日：2005-01-11
IPC分类号： A61N1/378
CPC分类号： A61N1/3787 , A61N1/36007 , A61N1/3605 , A61N1/37205 , A61N1/37211 , A61N1/37229 , A61N1/3727 , A61N1/37276 , A61N1/375 , H04B5/0037 , H04B5/0081 , H04L27/02 , H04L27/10
摘要： An exemplary system for communicating with or providing power to an implantable stimulator includes a coil configured to emit a magnetic field for driving a corresponding circuit in the implantable stimulator and a coil driver circuit configured to drive the coil with a tuning frequency. The coil driver circuit actively adjusts the tuning frequency such that the coil operates at a frequency substantially equal to a resonant frequency. An exemplary method of communicating with or providing power to an implantable stimulator includes driving a coil with a tuning frequency and actively adjusting the tuning frequency such that the coil operates at a frequency substantially equal to a resonant frequency. The coil emits a magnetic field used to drive a corresponding circuit in the implantable stimulator.
摘要翻译： 用于与可植入刺激器通信或向其提供动力的示例性系统包括配置成发射用于驱动可植入刺激器中相应电路的磁场的线圈和配置成以调谐频率驱动线圈的线圈驱动器电路。 线圈驱动器电路主动调节调谐频率，使得线圈以基本上等于谐振频率的频率工作。 与可植入刺激器通信或向其提供功率的示例性方法包括以调谐频率驱动线圈并主动调节调谐频率，使得线圈以基本上等于谐振频率的频率工作。 线圈发出用于驱动可植入刺激器中相应电路的磁场。
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公开(公告)号：US08374698B2
公开(公告)日：2013-02-12
申请号：US11893939
申请日：2007-08-18
申请人： Jerry Ok , Robert J. Greenberg , Neil Hamilton Talbot , James Singleton Little , Rongqing Dai , Jordan Matthew Neysmith , Kelly H. McClure
发明人： Jerry Ok , Robert J. Greenberg , Neil Hamilton Talbot , James Singleton Little , Rongqing Dai , Jordan Matthew Neysmith , Kelly H. McClure
IPC分类号： A61N1/375
CPC分类号： A61N1/36046 , A61F15/001 , A61N1/0529 , A61N1/0543 , A61N1/36125 , A61N1/375 , H01L23/055 , H01L23/06 , H01L23/08 , H01L23/10 , H01L24/16 , H01L24/48 , H01L25/18 , H01L2224/16225 , H01L2224/45144 , H01L2224/48091 , H01L2224/48106 , H01L2224/48225 , H01L2924/00011 , H01L2924/00014 , H01L2924/00 , H01L2224/0401
摘要： The present invention is an improved hermetic package for implantation in the human body. The implantable device includes an electrically non-conductive substrate with electrically conductive vias. A flip-chip circuit is attached to the substrate using conductive bumps and electrically connected to a first subset of the vias. The flip-chip circuit can contain one or more stacks or a folded stack. A wire-bonded circuit is also attached to the substrate and electrically connected to a second subset of the vias. A cover is bonded to the substrate. The cover, substrate, and vias form an improved hermetic package for implantation.
摘要翻译： 本发明是用于植入人体的改进的密封包装。 可植入装置包括具有导电通孔的非导电基底。 使用导电凸块将倒装芯片电路连接到基板，并电连接到通孔的第一子集。 倒装芯片电路可以包含一个或多个堆叠或折叠堆叠。 引线键合电路也附接到基板并电连接到通孔的第二子集。 盖子粘合到基底上。 盖，衬底和通孔形成改进的用于植入的密封包装。
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69.发明授权公开(公告)号：US08301248B1
公开(公告)日：2012-10-30
申请号：US12163803
申请日：2008-06-27
IPC分类号： A61N1/36
CPC分类号： A61N1/3627 , A61N1/3684
摘要： A patient's ejection fraction is maximized through simultaneous sensing and stimulating across multiple electrodes. In one exemplary embodiment, a catheter or lead having multiple electrodes connected to a pulse generator is used. The pulse generator provides individual current control of the stimulus applied to each electrode, and further includes the ability to sense intrinsic and evoked depolarization through multiple electrodes. In another exemplary embodiment, a multiplicity of individual implantable microstimulators, each having its own current source and/or sensor and electrodes, cooperate in concert to provide multi-site stimulation and sensing.
摘要翻译： 患者的射血分数通过同时感测和刺激跨多个电极而最大化。 在一个示例性实施例中，使用具有连接到脉冲发生器的多个电极的导管或引线。 脉冲发生器提供对施加到每个电极的刺激的单独电流控制，并且还包括通过多个电极感测固有和诱发去极化的能力。 在另一个示例性实施例中，多个单独的可植入微型激励器（各自具有其自身的电流源和/或传感器和电极）协同协作以提供多位点刺激和感测。
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公开(公告)号：US20100249878A1
公开(公告)日：2010-09-30
申请号：US12748179
申请日：2010-03-26
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/37247
摘要： The present invention is an improved fitting and training system for a visual prosthesis. A patient, using the visual prosthesis observes a display and indicates location, movement, shape or other properties of the display image to provide for improved fitting and training. In one embodiment, the patient uses a touch screen monitory which displays an image. The patient touches the monitor at the location where the patient perceives the image. The system then corrects the image to the location indicated by the patient. In another embodiment a patient observes an image moving across the touch screen monitor and indicates by moving their hand across the monitor which direction the believe the image is moving. The system can then rotate the image to match the image perceived by the patient.
摘要翻译： 本发明是用于视觉假体的改进的装配和训练系统。 使用视觉假体的患者观察显示器并且指示显示图像的位置，运动，形状或其他属性以提供改进的装配和训练。 在一个实施例中，患者使用显示图像的触摸屏监视器。 患者在患者感知图像的位置触摸显示器。 然后系统将图像校正到患者指示的位置。 在另一个实施例中，患者观察图像移动穿过触摸屏监视器并通过移动他们的手穿过监视器指示图像相对于移动的方向来指示。 然后，系统可以旋转图像以匹配患者感觉到的图像。
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