公开(公告)号：US6013473A

公开(公告)日：2000-01-11

申请号：US813574

申请日：1997-03-07

申请人： Ying-Fei Wei

发明人： Ying-Fei Wei

IPC分类号： G01N33/53 ,  A61K38/00 ,  A61K48/00 ,  A61P35/00 ,  C07H21/02 ,  C07H21/04 ,  C07K14/47 ,  C07K16/30 ,  C12N9/22 ,  C12N9/24 ,  C12N15/00 ,  C12N15/09 ,  C12P21/02 ,  C12P21/08 ,  C12R1/19 ,  C12R1/91 ,  C12P21/06 ,  C12N1/20

CPC分类号： C07K14/47 ,  C12N9/22 ,  C12N9/2471 ,  C12Y302/01023 ,  A61K38/00

摘要： A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

摘要翻译： 公开了编码这种多肽的人类mutY多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来预防和/或治疗与该基因突变有关的疾病的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

公开(公告)号：US5858705A

公开(公告)日：1999-01-12

申请号：US464402

申请日：1995-06-05

申请人： Ying-Fei Wei ,  Guo-Liang Yu ,  William A. Haseltine

发明人： Ying-Fei Wei ,  Guo-Liang Yu ,  William A. Haseltine

IPC分类号： A61K48/00 ,  C12N9/00 ,  C12N15/52 ,  C12N15/63

CPC分类号： C12N9/93 ,  A61K48/00 ,  C12N2799/026

摘要： A human DNA Ligase III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques are disclosed. Also disclosed are methods for utilizing such polypeptide via gene therapy for the treatment of disorders associated with a defect in DNA Ligase III. Antagonists against such polypeptides and their use as a therapeutic to destroy unwanted cells are also disclosed. Diagnostic assays to detect mutant DNA Ligase III genes are also disclosed.

摘要翻译： 公开了人DNA连接酶III多肽和编码这种多肽的DNA（RNA）以及通过重组技术产生这种多肽的方法。 还公开了通过基因治疗将这种多肽应用于治疗与DNA连接酶III缺陷相关的病症的方法。 还公开了抗这些多肽的拮抗剂及其作为破坏不想要的细胞的治疗剂的用途。 还公开了用于检测突变DNA连接酶III基因的诊断测定。

公开(公告)号：US5747312A

公开(公告)日：1998-05-05

申请号：US783266

申请日：1997-01-15

申请人： Ying-Fei Wei ,  Granger G. Sutton, III

发明人： Ying-Fei Wei ,  Granger G. Sutton, III

IPC分类号： A61K38/00 ,  A61K48/00 ,  C07K14/47 ,  C12N9/22 ,  C12N15/12 ,  C12N9/00 ,  C12P21/06 ,  C12P19/56 ,  C07H17/00

CPC分类号： C07K14/4702 ,  C07K14/47 ,  C12N9/22 ,  A61K38/00 ,  A61K48/00

摘要： A human hABH polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of mutations and the treatment of diseases which result from damaged DNA, for example, cancer. Antagonists against such polypeptides and their use as a therapeutic to augment chemotherapy of cancer cells are also disclosed.

摘要翻译： 公开了编码这种多肽的人hABH多肽和DNA（RNA）以及通过重组技术产生这种多肽的方法。 还公开了利用这种多肽来治疗由受损的DNA例如癌症引起的疾病的突变和治疗的方法。 还公开了抗这些多肽的拮抗剂及其作为增强癌细胞化疗的治疗剂的用途。

公开(公告)号：US07927803B2

公开(公告)日：2011-04-19

申请号：US12204655

申请日：2008-09-04

申请人： Ying-Fei Wei

发明人： Ying-Fei Wei

IPC分类号： C12Q1/68

CPC分类号： C07K14/47 ,  A61K38/00 ,  C12N9/22 ,  C12N9/2471 ,  C12Y302/01023

摘要： A human mutY polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for preventing and/or treating diseases associated with a mutation in this gene. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.

摘要翻译： 公开了编码这种多肽的人类mutY多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽来预防和/或治疗与该基因突变有关的疾病的方法。 还公开了用于鉴定编码本发明多肽的核酸序列中的突变并用于检测用于检测疾病例如癌症的本发明多肽的改变水平的诊断测定法。

公开(公告)号：US20100130417A1

公开(公告)日：2010-05-27

申请号：US12495569

申请日：2009-06-30

申请人： Ying-Fei Wei ,  Paul S. Meissner ,  Jian Ni

发明人： Ying-Fei Wei ,  Paul S. Meissner ,  Jian Ni

IPC分类号： A61K38/16 ,  C07H21/02 ,  C12N15/74 ,  C12N1/21 ,  C12P21/02 ,  C07K14/00 ,  C07K16/00 ,  A61K31/7088 ,  G01N33/53 ,  A61P31/04

CPC分类号： A61K38/1841 ,  A61K48/00 ,  C07K14/495 ,  Y10T436/143333

摘要： The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating wound healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders, and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptides and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

摘要翻译： 本发明公开了转化生长因子αHII多肽和编码这种多肽的多核苷酸。 还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法，其包括刺激伤口愈合，治疗神经障碍，治疗眼部疾病，治疗肾脏和肝脏疾病，以及刺激胚胎发生和血管发生。 还公开了抗这些多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。

公开(公告)号：US20070048256A1

公开(公告)日：2007-03-01

申请号：US11537681

申请日：2006-10-02

申请人： Ying-Fei Wei ,  Brent Kreider ,  Craig Rosen

发明人： Ying-Fei Wei ,  Brent Kreider ,  Craig Rosen

IPC分类号： A61K38/19 ,  C07K14/52 ,  C07K16/24 ,  C07H21/04 ,  C12P21/02

CPC分类号： C07K14/523

摘要： The present invention concerns a member of the human chemokine CC protein family. In particular, isolated nucleic acid molecules are provided encoding the chemokine β-15 protein. Chemokine β-15 polypeptides are also provided. The invention further concerns diagnostic methods for detecting thymus disorders and therapeutic methods for modulating bone marrow cell proliferation and differentiation.

摘要翻译： 本发明涉及人趋化因子CC蛋白家族的成员。 特别地，提供编码趋化因子β-15蛋白的分离的核酸分子。 还提供趋化因子β-15多肽。 本发明还涉及用于检测胸腺疾病的诊断方法和用于调节骨髓细胞增殖和分化的治疗方法。

公开(公告)号：US20050255100A1

公开(公告)日：2005-11-17

申请号：US11182946

申请日：2005-07-18

申请人： Ying-Fei Wei ,  Jian Ni ,  Reiner Gentz ,  Steven Ruben

发明人： Ying-Fei Wei ,  Jian Ni ,  Reiner Gentz ,  Steven Ruben

IPC分类号： A61K31/522 ,  A61K31/66 ,  A61K38/00 ,  A61K38/13 ,  A61K38/17 ,  A61K38/19 ,  A61K38/20 ,  A61K38/21 ,  A61K39/395 ,  A61K45/06 ,  A61K48/00 ,  C07K14/705 ,  C07K16/28

CPC分类号： A61K31/522 ,  A61K31/66 ,  A61K39/395 ,  A61K45/06 ,  A61K48/00 ,  A61K2039/505 ,  C07K14/70578 ,  C07K16/2878 ,  C07K2319/00 ,  C07K2319/30 ,  C12N2799/026 ,  A61K2300/00

摘要： The present invention relates to a novel human gene encoding a polypeptide which is a member of the TNF receptor family, and has now been found to bind TRAIL. More specifically, an isolated nucleic acid molecule is provided encoding a human polypeptide named tumor necrosis factor receptor-5, sometimes referred to as “TNFR-5” or “TR5,” and now referred to hereinafter as “TRAIL receptor without intracellular domain” or “TRID.” TRID polypeptides are also provided, as are vectors, host cells, and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists or antagonists of TRAIL polypeptide activity. Also provided are diagnostic and therapeutic methods utilizing such compositions.

摘要翻译： 本发明涉及编码作为TNF受体家族成员的多肽的新型人基因，现已发现其结合TRAIL。 更具体地，提供编码称为肿瘤坏死因子受体-5（有时称为“TNFR-5”或“TR5”）的人多肽的分离的核酸分子，以下在下文中称为“没有细胞内结构域的TRAIL受体”或 “TRID”。 还提供了TRID多肽，载体，宿主细胞以及用于制备它们的重组方法也是如此。 本发明还涉及用于鉴定TRAIL多肽活性的激动剂或拮抗剂的筛选方法。 还提供了利用这种组合物的诊断和治疗方法。

公开(公告)号：US06410506B1

公开(公告)日：2002-06-25

申请号：US08930564

申请日：1998-01-30

申请人： Ying-Fei Wei ,  Paul S. Meissner ,  Jian Ni

发明人： Ying-Fei Wei ,  Paul S. Meissner ,  Jian Ni

IPC分类号： C12N1512

CPC分类号： A61K38/1841 ,  A61K48/00 ,  C07K14/495 ,  Y10T436/143333

摘要： The present invention discloses transforming growth factor alpha HII polypeptides and polynucleotides encoding such polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques and therapeutic uses of the polypeptides which include stimulating would healing, treating neurological disorders, treating ocular disorders, treating kidney and liver disorders, and stimulating embryogenesis and angiogenesis. Also disclosed are antagonists against such polypeptides and their use as a therapeutic to treat neoplasia. Also disclosed are diagnostic assays for detecting altered levels of the polypeptide of the present invention and mutations in the nucleic acid sequences which encode the polypeptides of the present invention.

摘要翻译： 本发明公开了转化生长因子αHII多肽和编码这种多肽的多核苷酸。 还提供了通过重组技术和多肽的治疗用途产生此类多肽的方法，其包括刺激愈合，治疗神经障碍，治疗眼部疾病，治疗肾脏和肝脏疾病，以及刺激胚胎发生和血管发生。 还公开了抗这些多肽的拮抗剂及其作为治疗瘤形成的治疗剂的用途。 还公开了用于检测本发明多肽的改变水平的诊断测定和编码本发明多肽的核酸序列中的突变。

公开(公告)号：US06284504B1

公开(公告)日：2001-09-04

申请号：US09054775

申请日：1998-04-03

申请人： Ying-Fei Wei ,  Guo-Liang Yu ,  William A. Haseltine

发明人： Ying-Fei Wei ,  Guo-Liang Yu ,  William A. Haseltine

IPC分类号： C12N900

CPC分类号： C12N9/93 ,  A61K48/00 ,  C12N2799/026

摘要： A human DNA Ligase III polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide via gene therapy for the treatment of disorders associated with a defect in DNA Ligase III. Antagonists against such polypeptides and their use as a therapeutic to destroy unwanted cells are also disclosed. Diagnostic assays to detect mutant DNA Ligase III genes are also disclosed.

摘要翻译： 公开了人类DNA连接酶III多肽和编码这种多肽的DNA（RNA）和通过重组技术产生这种多肽的方法。 还公开了通过基因治疗将这种多肽应用于治疗与DNA连接酶III缺陷相关的病症的方法。 还公开了抗这些多肽的拮抗剂及其作为破坏不想要的细胞的治疗剂的用途。 还公开了用于检测突变DNA连接酶III基因的诊断测定。

公开(公告)号：US6103871A

公开(公告)日：2000-08-15

申请号：US916989

申请日：1997-08-21

申请人： Ying-Fei Wei ,  Ewen F. Kirkness

发明人： Ying-Fei Wei ,  Ewen F. Kirkness

IPC分类号： A61K38/00 ,  C12N9/16 ,  C07H21/02 ,  C07K1/00 ,  C12Q1/68

CPC分类号： C12N9/16 ,  A61K38/00 ,  Y10S530/809

摘要： A human hMutT2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for hydrolyzing and eliminating oxidized guanine nucleotides from the nucleotide pool to ensure correct DNA synthesis. Diagnostic assays are also disclosed which detect the presence of a mutated form of hMutT2 and over-expression of the hMutT2 protein.

摘要翻译： 公开了编码这种多肽的人hMutT2多肽和DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种多肽从核苷酸库水解和消除氧化的鸟嘌呤核苷酸以确保正确的DNA合成的方法。 还公开了诊断测定法，其检测突变形式的hMutT2的存在和hMutT2蛋白的过表达。