公开(公告)号：US4903124A

公开(公告)日：1990-02-20

申请号：US673244

申请日：1989-03-16

申请人： Nobuhiro Hoshi ,  Hisashi Ishikawa ,  Yoshiki Ishii ,  Toshihiro Yagisawa ,  Akio Fujii

发明人： Nobuhiro Hoshi ,  Hisashi Ishikawa ,  Yoshiki Ishii ,  Toshihiro Yagisawa ,  Akio Fujii

IPC分类号： G06T9/00 ,  H04N7/24 ,  H04N7/26 ,  H04N7/28

CPC分类号： G06T9/008 ,  H04N19/94 ,  H04N19/98 ,  H04N7/24 ,  H04N19/30

摘要： Disclosed is an image information signal transmission apparatus wherein an image information signal in which one frame is constituted by a plurality of sample data is input, the input image information signal is divided into a plurality of blocks each consisting of a predetermined number of sample data, at least two types of reference value data associated with a dynamic range of sample data of each block is formed in units of blocks, the sample data of each block is coded by using the reference value data to form a plurality of first coded data in units of blocks, the plurality of first coded data formed in units of blocks are vector-quantized to form second coded data in units of blocks, and transmission data is formed by using as a transmission unit the reference data formed in units of blocks and the second coded data formed in units of blocks. The image information signal can be transmitted in a small information volume without degrading the image information signal.

摘要翻译： 公开了一种图像信息信号传输装置，其中输入一个帧由多个采样数据构成的图像信息信号，输入图像信息信号被分成多个块，每个块由预定数量的采样数据组成， 与块的采样数据的动态范围相关联的至少两种参考值数据以块为单位形成，通过使用参考值数据对每个块的采样数据进行编码，以形成多个第一编码数据 以块为单位形成的多个第一编码数据被矢量量化，以块为单位形成第二编码数据，并且通过以块为单位使用形成为块的参考数据作为发送单位来形成发送数据，并且第二 以块为单位形成的编码数据。 图像信息信号可以以小的信息量发送，而不降低图像信息信号。

公开(公告)号：US4824955A

公开(公告)日：1989-04-25

申请号：US928551

申请日：1986-11-10

申请人： Hisao Ekimoto ,  Masanobu Suzuki ,  Takao Izawa ,  Katsutoshi Takahashi ,  Tokuji Nakatani ,  Akio Fujii

发明人： Hisao Ekimoto ,  Masanobu Suzuki ,  Takao Izawa ,  Katsutoshi Takahashi ,  Tokuji Nakatani ,  Akio Fujii

IPC分类号： C07D207/20 ,  C07D213/06 ,  C07D213/22 ,  C07D213/61 ,  C07D213/64 ,  C07D213/68 ,  C07D213/73 ,  C07D213/74 ,  C07D213/79 ,  C07D213/80 ,  C07D213/84 ,  C07D213/85 ,  C07D213/89 ,  C07D215/06 ,  C07D215/18 ,  C07D215/22 ,  C07D215/233 ,  C07D215/24 ,  C07D217/02 ,  C07D233/68 ,  C07D235/06 ,  C07D235/08 ,  C07D471/04 ,  C07D473/08 ,  C07D473/10 ,  C07D473/12 ,  C07D521/00 ,  C07F9/11 ,  C07D401/04 ,  C07D213/65

CPC分类号： C07D213/06 ,  C07D207/20 ,  C07D213/22 ,  C07D213/61 ,  C07D213/64 ,  C07D213/68 ,  C07D213/73 ,  C07D213/74 ,  C07D213/79 ,  C07D213/80 ,  C07D213/84 ,  C07D213/85 ,  C07D213/89 ,  C07D215/06 ,  C07D215/18 ,  C07D215/233 ,  C07D215/24 ,  C07D217/02 ,  C07D231/12 ,  C07D233/56 ,  C07D233/68 ,  C07D235/06 ,  C07D235/08 ,  C07D249/08 ,  C07D471/04 ,  C07D473/08 ,  C07D473/10 ,  C07D473/12 ,  C07F9/11

摘要： This invention relates to the novel selenium compounds which are useful as an antineoplastic agent. The compounds are represented by the general formula (I):Se(O).sub.a (R).sub.b (X).sub.c (A).sub.n (Y).sub.m (I)wherein R, X, A and Y represent the groups specified below, a represents a number of 0 or 1, b represents a number of 0, 1 or 2, and (1) when a is 0 and b is also 0, c is 4, n is 1 or 2 and m is 0, (2) when a is 1 and b is 0, c is 2, n is 1 or 2 and m is 0 or 1, and (3) when b is 1 or 2, c, n and m are all 0;(i) when b is 2, R represents (1) a C.sub.4-10 alkoxy group substituted with a halogen atom, (2) a lower alkoxyl group substituted with a halogen atom and a phenyl group, or (3) a cycloalkyloxy group substituted with a halogen atom, and (ii) when b is 1, R represents a group represented by the formula ##STR1## (wherein R.sub.0 is a C.sub.2-6 alkyl group); X represents a halogen atom;A represents a compound represented by the formula ##STR2## (wherein R.sub.1 and R.sub.2 may be the same or different and represent a hydrogen atom, a hydroxyl group, a lower alkyl group, a halogen atom, a phenyl group, a cyano group, a lower alkoxycarbonly group, a phenoxycarbonyl group, an amino group (to which a lower alkyl, lower alkylaminocarbonyl, lower halogenoalkylaminocarbonyl or lower alkoxycarbonyl group may be bonded), a benzoyl group, a loweralkoxyl group, a carbamyl group or an allyloxycarbonyl group; R.sub.7 represents a hydrogen atom, a lower alkyl group or a group represented by the formula ##STR3## (wherein R.sub.9 represents an amino group or a lowr alkoxyl group); Y represents H.sub.2 O.

摘要翻译： 本发明涉及可用作抗肿瘤剂的新型硒化合物。 这些化合物由通式（I）表示：Se（O）a（R）b（X）c（A）n（Y）m（I）其中R，X，A和Y表示下面规定的基团， a表示0或1的数，b表示0,1或2的数，以及（1）当a为0且b为0时，c为4，n为1或2，m为0，（2） ）当a为1且b为0时，c为2，n为1或2，m为0或1，（3）当b为1或2时，c，n和m均为0; （i）当b为2时，R表示（1）被卤素原子取代的C 4-10烷氧基，（2）被卤素原子和苯基取代的低级烷氧基，或（3）环烷氧基取代 和（ii）当b为1时，R表示由式“IMAGE”表示的基团（其中R 0为C 2-6烷基）; X表示卤原子; A表示由式“IMAGE”表示的化合物（其中R 1和R 2可以相同或不同，表示氢原子，羟基，低级烷基，卤原子，苯基，氰基， 苯氧基羰基，氨基（可以键合有低级烷基，低级烷基氨基羰基，低级卤代烷基氨基羰基或低级烷氧基羰基），苯甲酰基，低级烷氧基，氨基甲酰基或烯丙氧基羰基; R7表示 氢原子，低级烷基或下式表示的基团（其中R9表示氨基或低级烷氧基）; Y表示H 2 O。

公开(公告)号：US4761836A

公开(公告)日：1988-08-09

申请号：US947930

申请日：1986-12-30

申请人： Osamu Tsutsui ,  Hirohiko Yasuda ,  Hidehiko Kuwahara ,  Hirofumi Takeuchi ,  Keiji Hayashi ,  Mitsuhiro Higuchi ,  Akio Fujii

发明人： Osamu Tsutsui ,  Hirohiko Yasuda ,  Hidehiko Kuwahara ,  Hirofumi Takeuchi ,  Keiji Hayashi ,  Mitsuhiro Higuchi ,  Akio Fujii

IPC分类号： E03D9/08 ,  F16K11/074 ,  G05D23/13 ,  A47K3/20

CPC分类号： E03D9/08 ,  F16K11/0746 ,  G05D23/1393

摘要： A washing device for parts of human body being such as anus or private part of female is disclosed. Such washing device is substantially characterized in that the heated-water supply source and the cold-water supply source which are connected with a heated-and-cold-water mixing valve respectively are both installed outside of a toilet chamber or a bathroom and a mixed-water ejecting nozzle is connected to a downstream end of a mixed-water supply passage which has an upper end thereof connected to an outlet opening of the heated-and-cold-water mixing valve. Due to such construction, the washing deivce can extremely improve the heating efficiency so as to enable the considerable energy saving and can unnecessitate the installation of the heat exchangers in the washing device so as to make full use of a narrow space of a toilet chamber or a bathroom.

摘要翻译： 公开了一种用于人体部分的洗涤装置，例如肛门或女性的私人部分。 这种洗涤装置的特征在于，分别与加热和冷水混合阀连接的加热水供应源和冷水供应源都安装在厕所室或浴室的外部，并且混合 水喷射喷嘴连接到混合水供应通道的下游端，混合水供应通道的上端连接到加热和冷水混合阀的出口。 由于这样的结构，洗涤活动可以极大地提高加热效率，从而能够节省大量能量，并且不需要在洗涤装置中安装热交换器，以充分利用厕所室的狭窄空间或 一个卫生间。

公开(公告)号：US4326054A

公开(公告)日：1982-04-20

申请号：US167439

申请日：1980-07-09

申请人： Hamao Umezawa ,  Tomohisa Takita ,  Akio Fujii ,  Yasuhiko Muraoka ,  Mamoru Kunishima

发明人： Hamao Umezawa ,  Tomohisa Takita ,  Akio Fujii ,  Yasuhiko Muraoka ,  Mamoru Kunishima

IPC分类号： C12P17/00 ,  A61K31/70 ,  A61K31/7028 ,  A61P31/04 ,  A61P35/00 ,  C07H15/26 ,  C07K9/00 ,  C12P19/44 ,  C12P19/60 ,  C12R1/465 ,  C07H11/02 ,  C07H13/12

CPC分类号： C12R1/465 ,  C07H15/26 ,  C07K9/003 ,  C12P19/60 ,  Y10S930/19 ,  Y10S930/27

摘要： Novel antibiotics cleomycins represented by the formula ##STR1## wherein R is a terminal amino residue of the cleomycin. These compounds are useful as a chemotherapeutic agent for treating cancer and bacterial infections.

摘要翻译： 由式表示的新型抗生素cleomycins，其中R是克霉霉素的末端氨基残基。 这些化合物可用作治疗癌症和细菌感染的化学治疗剂。

公开(公告)号：USRE30413E

公开(公告)日：1980-10-07

申请号：US41995

申请日：1979-05-24

申请人： Hamao Umezawa ,  Yasushi Takahashi ,  Tadashi Shirai ,  Akio Fujii

发明人： Hamao Umezawa ,  Yasushi Takahashi ,  Tadashi Shirai ,  Akio Fujii

IPC分类号： C07K9/00

CPC分类号： C07K9/003 ,  Y10S435/866 ,  Y10S435/886 ,  Y10S435/911 ,  Y10S435/929

摘要： A process for preparing bleomycinic acid having a melting point of 228.degree.-230.degree. C. (decomposition) and an analysis of C: 40.80%, H: 5.29%, N: 16.45%, O: 24.78%, S: 4.53%, Cl: 3.37%, and Cu: 4.78% which is characterized by being soluble in water, difficultly soluble in methanol, acetic acid and dimethylsulfoxide, and insoluble in ethanol, ethyl acetate, acetone and ether, and which tests positive to Pauly and Ehrlich reactions but tests negative to ninhydrin, Sakaguchi, Dragendorf, Tollens, ferric chloride, Fehling and Molish reactions, and which has a maximum ultraviolet absorption spectrum at 246 m.mu. and 292 m.mu. and which has an infrared absorption spectrum bands at 3350, 1720, 1670, 1640, 1580, 1460, 1365, 1050, 770 (cm.sup.-1), and which can be hydrolyzed to yield 2'-(2-aminoethyl)-2,4'-bithiazole-4-carboxylic acid, L-threonine, 4-amino-3-hydroxy-2-methyl-.eta.-valeric acid, .beta.-hydroxy-histidine, .beta.-amino-.beta.-(4-amino-6-carboxy-5-methylpyrimidine-2-yl)-propionic acid, L-.beta.-amino-alanine, L-gulose and 3-O-carbamoyl-D-mannose, which comprises hydrolyzing bleomycin in the presence of a mycelium mass or enzyme.

公开(公告)号：US3984390A

公开(公告)日：1976-10-05

申请号：US337575

申请日：1973-03-02

申请人： Hamao Umezawa ,  Akio Fujii ,  Tomohisa Takita ,  Nobuyoshi Shimada

发明人： Hamao Umezawa ,  Akio Fujii ,  Tomohisa Takita ,  Nobuyoshi Shimada

IPC分类号： C12P21/00 ,  A61K35/74 ,  A61K38/00 ,  C07D277/56 ,  C07H15/26 ,  C07K9/00 ,  C12P1/06 ,  C12P19/58 ,  C12R1/465 ,  C07C103/52

CPC分类号： C07K9/003 ,  Y10S435/886 ,  Y10S930/19

摘要： By adding a specific amine in culturing under aerobic conditions actinomycetales capable of producing phleomycin group antibiotics, which have been inoculated into a nutrient medium to produce antitumor phleomycin group antibiotics, it is possible to obtain specific phleomycin group antibiotics having a side chain structure corresponding to said amine. The phleomycin group antibiotics thus produced are collected from the culture medium in a conventional way.

摘要翻译： 通过在需氧条件下培养特定的胺，其能够产生已经接种到营养培养基中以产生抗腐霉素腐霉素组抗生素的福来霉素组抗生素的放线菌素，可以获得具有对应于所述抗生素的侧链结构的特定的腐草霉素组抗生素 胺。 以常规方式从培养基中收集由此产生的腐草霉素组抗生素。

公开(公告)号：US08837899B2

公开(公告)日：2014-09-16

申请号：US12547113

申请日：2009-08-25

申请人： Akio Fujii

发明人： Akio Fujii

IPC分类号： H04N5/931 ,  H04N5/932 ,  H04N5/935 ,  H04N5/77 ,  H04N9/80 ,  G11B27/00 ,  H04N5/228 ,  H04N5/235 ,  G03B7/00

CPC分类号： G11B27/005

摘要： An image recording playback apparatus which, when recording moving image data, performs image capture at high-speed read time Dt, records all the captured images, and records a playback rate Ft (Vt), the read time Dt and image valid time St, with the image data, on a recording medium. Then upon playback of moving image data, the image recording playback apparatus plays back the recorded image data within the image valid time St in accordance with the playback rate. The image recording playback apparatus having this configuration can perform playback intended by a user. Further, when sharpness is to be changed, a playback image with different sharpness can be obtained by changing the image valid time St upon playback.

摘要翻译： 一种图像记录播放装置，当记录运动图像数据在高速读取时间Dt进行图像捕获时，记录所有拍摄图像，并记录播放速率Ft（Vt），读取时间Dt和图像有效时间St， 与图像数据一起在记录介质上。 然后，在播放运动图像数据时，图像记录重放装置根据回放速率在图像有效时间St内重放记录图像数据。 具有这种配置的图像记录播放设备可以执行用户想要的播放。 此外，当要改变锐度时，通过在重放时改变图像有效时间St可以获得具有不同清晰度的重放图像。

公开(公告)号：US08587683B2

公开(公告)日：2013-11-19

申请号：US13598004

申请日：2012-08-29

申请人： Akio Fujii

发明人： Akio Fujii

IPC分类号： H04N5/225 ,  H04N5/228 ,  H04N5/76

CPC分类号： H04N1/333 ,  H04N1/212 ,  H04N5/23245 ,  H04N5/772 ,  H04N5/781 ,  H04N5/85 ,  H04N5/907 ,  H04N9/7921 ,  H04N9/8042 ,  H04N9/8047 ,  H04N19/115 ,  H04N19/124 ,  H04N19/152 ,  H04N19/154 ,  H04N19/60 ,  H04N19/61 ,  H04N2201/212 ,  H04N2201/33357

摘要： An imaging apparatus includes a signal processing unit that generates moving image data and still image data using image data output from an imaging unit, a moving image coding unit that encodes the moving image data, a still image coding unit that encodes the still image data, a recording unit that records the coded moving and still image data on a recording medium, a setting unit that sets a data rate of the coded moving image data, and a control unit that controls the moving and still image coding units. The control unit controls the moving image coding unit based on the set data rate to adjust the data rate of the moving image data and the still image coding unit based on the set data rate and a recording data rate of the recording medium to adjust an amount of the still image data.

摘要翻译： 一种成像装置，包括：信号处理单元，其使用从成像单元输出的图像数据生成运动图像数据和静止图像数据;运动图像编码单元，对运动图像数据进行编码;静止图像编码单元，对静止图像数据进行编码; 记录单元，其将编码的移动和静止图像数据记录在记录介质上，设置单元，其设置编码的运动图像数据的数据速率;以及控制单元，其控制移动和静止图像编码单元。 控制单元基于设定的数据速率来控制运动图像编码单元，以基于设定的数据速率和记录介质的记录数据速率来调整运动图像数据和静止图像编码单元的数据速率，以调整量 的静止图像数据。

公开(公告)号：US08383833B2

公开(公告)日：2013-02-26

申请号：US12993661

申请日：2009-06-02

申请人： Shohei Yamamoto ,  Akio Fujii ,  Masaru Mitsuda

发明人： Shohei Yamamoto ,  Akio Fujii ,  Masaru Mitsuda

IPC分类号： C07D295/03

CPC分类号： C07B51/00 ,  C07B53/00 ,  C07C227/18 ,  C07C229/08 ,  C07C229/28 ,  C07C2601/02 ,  C07D207/12 ,  C07D211/60 ,  C07D295/18 ,  C07D403/12 ,  C07D495/04

摘要： The present application relates to a method for producing an optically active α-amino acid derivative, comprising steps of reacting an α-haloester derivative represented by the general formula (1): of which alcohol part of the ester group is an optically active alcohol derivative, with an amine compound; then deprotecting the obtained compound; further carrying out an ester exchange reaction. According to the present invention method, it is possible to easily produce an optically active α-amino acid ester derivative which is useful as an intermediate for drugs with high selectivity.

摘要翻译： 本申请涉及一种光学活性α-氨基酸衍生物的制造方法，包括使由通式（1）表示的α-卤代酯衍生物：酯基的醇部分为光学活性醇衍生物 ，与胺化合物; 然后使所得化合物脱保护; 进一步进行酯交换反应。 根据本发明的方法，可以容易地制备可用作高选择性药物的中间体的光学活性α-氨基酸酯衍生物。

公开(公告)号：US08252919B2

公开(公告)日：2012-08-28

申请号：US12919295

申请日：2009-02-26

申请人： Hirofumi Maeda ,  Akio Fujii ,  Masaru Mitsuda

发明人： Hirofumi Maeda ,  Akio Fujii ,  Masaru Mitsuda

IPC分类号： C07H23/00 ,  C07H19/00 ,  C07H19/167 ,  C07H19/173

CPC分类号： C07H19/067 ,  C07H19/167

摘要： The present invention relates to a method for producing a 2′-hydroxy-protected nucleoside derivative by reacting a ribonucleoside with an acylating or a carbamoylating reagent in the presence of a metal complex consisting of a copper compound and an optically active ligand. By the method according to the present invention, a 2′-hydroxy-protected ribonucleoside derivative, which is an important intermediate for producing an oligonucleoside, can be easily produced with good regioselectivity from a nucleoside derivative of which 2′,3′-hydroxy groups are not protected.

摘要翻译： 本发明涉及通过在由铜化合物和光学活性配体组成的金属络合物的存在下使核糖核苷与酰化剂或氨基甲酰化试剂反应来制备2'-羟基保护的核苷衍生物的方法。 通过本发明的方法，可以容易地制备作为制备寡核苷酸的重要中间体的2'-羟基保护的核糖核苷衍生物，其从2'，3'-羟基的核苷衍生物具有良好的区域选择性 没有保护。