摘要:
The pyrimido[1,2-a]indoles according to the invention are prepared by reacting appropriately substituted phenylacetic acid derivatives with phenylglycinols. The pyrimido[1,2-a]indoles can be used as active compounds in medicaments, in particular in medicaments with antiatherosclerotic activity.
摘要:
An electromagnetic actuator for operating an engine valve of an internal-combustion engine includes two electromagnets; an armature movably disposed in the space between the electromagnets for reciprocation in response to electromagnetic forces generated by the electromagnets; resetting springs operatively coupled to the armature for opposing armature motions effected by the electromagnetic forces; a push rod affixed to the armature for moving therewith as a unit; and a guide for guiding the push rod. The guide includes a guide cylinder and a push-rod piston carried by an end of the push rod. The push-rod piston is slidably received in the guide cylinder. A setting piston is slidably received in the guide cylinder and defines, with the push-rod piston, an intermediate chamber forming part of the cylinder. The setting piston has an end adapted to be operatively coupled to the engine valve. A fluid supply introduces hydraulic fluid into the intermediate chamber. Further, a fluid-control valve is provided which has an open state in which the intermediate chamber communicates with the fluid supply and a closed state in which hydraulic fluid is locked in the intermediate chamber for rigidly transmitting motions of the push-rod piston to the setting piston.
摘要:
A process for the preparation of halogen-free, reactive polyisobutene having a content of terminal double bonds of more than 50 mol % and an average molecular weight M.sub.n of from 500 to 5000 dalton by the cationic polymerization of isobutene or isobutene-containing hydrocarbon mixtures in the liquid phase, wherein the polymerization is carried out at a temperature of from -30.degree. to +40.degree. C. over a heterogeneous polymerization catalyst containing at least one element acting as promoter and selected from Group IB, Group IIB, Group IIIB, Group IVB, Group VB, Group VIIB, or Group VIIIB of the Periodic Table or from Group IIA, Group IIIA, Group IVA, Group VA, or Group VIA of the Periodic Table or a number of said elements in each case in the form of an oxygen-containing compound and zirconium in the form of an oxygen-containing compound, said polymerization catalyst containing no industrially effective amounts of halogens.
摘要:
The heterocyclically substituted phenylglycinolamides are obtained by reaction of heterocyclically substituted phenylacetic acids with appropriate phenylglycinols. The heterocyclically substituted phenylglycinolamides are suitable as active compounds in medicaments, in particular in antiatherosclerotically active medicaments.
摘要:
The phenylcyclohexylcarboxamides, some of which are known, are suitable as active compounds in medicaments, in particular in medicaments for the treatment of restenosis.
摘要:
In a process for preparing amines of the formula I ##STR1## where R.sup.1,R.sup.2,R.sup.3,R.sup.4,R.sup.5,R.sup.6 are hydrogen, C.sub.1 -C.sub.20 -alkyl, C.sub.2 -C.sub.20 -alkenyl, C.sub.2 -C.sub.20 -alkynyl, C.sub.3 -C.sub.20 -cycloalkyl, C.sub.4 -C.sub.20 -alkyl-cycloalkyl, C.sub.4 -C.sub.20 -cycloalkyl-alkyl, aryl, C.sub.7 -C.sub.20 -alkylaryl or C.sub.7 -C.sub.20 -aralkyl, R.sup.1 and R.sup.2 together form a saturated or unsaturated, divalent C.sub.3 -C.sub.9 -alkylene chain and R.sup.3 and R.sup.5 are C.sub.21 -C.sub.200 -alkyl, C.sub.21 -C.sub.200 -alkenyl or together form a divalent C.sub.2 -C.sub.12 -alkylene chain, by reating olefins of the formula II ##STR2## where R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are as defined above, with ammonia or primary or secondary amines of the formula III ##STR3## where R.sup.1 and R.sup.2 are as defined above, at from 200.degree. to 350.degree. C. and a pressure of from 100 to 300 bar in the presence of a heterogeneous catalyst, the heterogeneous catalysts being mesoporous oxides having a high surface area.
摘要:
Hydroxylamines are prepared from ammonia or the corresponding amines, hydrogen and oxygen by a process in which the starting materials are reacted under heterogeneous catalysis using an oxidation catalyst based on a titanium or vanadium silicalite having a zeolite structure and containing from 0.01 to 20% by weight of one or more platinum metals selected from the group consisting of ruthenium, rhodium, palladium, osmium, iridium and platinum, the platinum metals each being present in at least two different bond energy states.
摘要:
The invention relates to phenylacetic acid derivatives which are substituted by a five-membered nitrogen heterocycle bonded via an N atom. They are prepared by reaction of phenylacetic acid derivatives substituted with leaving groups with the appropriate nitrogen heterocycles and can be used as active substances in medicaments for the treatment of high blood pressure and atherosclerosis.
摘要:
A crystalline solid comprising a boro-, alumino-, gallo-, titano-, vanado- or zincosilicate or a mixture thereof having the RUB-13 structure, which has a monoclinic space group and exhibits an X-ray diffraction pattern in which at least the following reflections (hkl) occur at the stated diffraction angles:______________________________________ h k l Intensity I/I.sub.o d-spacings (d.sub.hkl) ______________________________________ 0 2 0 very strong 10.26 0 1 1 very strong 9.79 -1 3 1 weak 4.98 0 4 1 medium 4.53 -2 0 1 medium 4.52 -1 1 2 medium 4.46 ______________________________________ and their uses.
摘要:
Substituted antithrombotic substituted cycloalkano[b]dihydroindole- and -indole-sulphonamides for treatment of thromboses, thromboembolisms, ischaemias, asthma and allergies, of the formula ##STR1## in which R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are hydrogen or other radicals,X is aryl, alkyl or CF.sub.3,m and Z each is 1,2,3 or 4,n is 0,1 or 2,A is a bond or --NH--, andY is OH, alkoxy, aryloxy, amino or sulphonylamine,with the proviso, that in all cases, two of the substituents R.sup.1 -R.sup.4 are other than hydrogen in the event that m represents the number 2 and Y represents the hydroxyl group, or a salt thereof.