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61.发明申请Benzimidazole Derivatives and Their Use for Modulating the GABA-Alpha Receptor Complex 失效苯并咪唑衍生物及其用于调节GABA-α受体复合物的用途公开(公告)号：US20090048321A1
公开(公告)日：2009-02-19
申请号：US12085769
申请日：2006-12-04
IPC分类号： A61K31/4184 , C07D235/06 , A61P25/28 , A61P25/18 , A61P25/22
CPC分类号： C07D235/06
摘要： This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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公开(公告)号：US20050009816A1
公开(公告)日：2005-01-13
申请号：US10496859
申请日：2003-01-06
申请人： Alex Gouliaev , Frank Slok , Lene Teuber , Joachim Demnitz
发明人： Alex Gouliaev , Frank Slok , Lene Teuber , Joachim Demnitz
IPC分类号： C07D295/18 , A61K31/10 , A61K31/165 , A61K31/18 , A61K31/196 , A61K31/216 , A61K31/255 , A61K31/27 , A61K31/277 , A61K31/40 , A61K31/4164 , A61K31/4196 , A61K31/421 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4439 , A61K31/4453 , A61K31/454 , A61K31/519 , A61K31/522 , A61K31/573 , A61K31/662 , A61K31/665 , A61K31/675 , A61K31/7048 , A61K38/00 , A61K45/00 , A61P1/00 , A61P3/00 , A61P9/00 , A61P11/00 , A61P13/00 , A61P25/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07C233/11 , C07C255/35 , C07C255/36 , C07C255/37 , C07C255/40 , C07C255/41 , C07C271/12 , C07C313/06 , C07C317/10 , C07C317/12 , C07C317/14 , C07C323/52 , C07C323/60 , C07C327/42 , C07C333/04 , C07D213/30 , C07D213/32 , C07D213/70 , C07D213/71 , C07D213/89 , C07D233/54 , C07D233/84 , C07D263/32 , C07D277/20 , C07D277/24 , C07D277/26 , C07D277/32 , C07D277/36 , C07D277/52 , C07D295/108 , C07D295/20 , C07D295/26 , C07D401/12 , C07D417/12 , C07F9/38 , C07F9/40 , C07F9/58 , C07F9/6539 , C07F9/6574 , A61K31/54 , A61K31/497 , A61K31/445
CPC分类号： C07D213/30 , C07C233/11 , C07C255/35 , C07C255/36 , C07C255/37 , C07C255/40 , C07C255/41 , C07C271/12 , C07C313/06 , C07C317/10 , C07C317/12 , C07C317/14 , C07C323/52 , C07C333/04 , C07C2601/08 , C07C2601/14 , C07D213/32 , C07D213/70 , C07D213/89 , C07D233/64 , C07D233/84 , C07D263/32 , C07D277/24 , C07D277/26 , C07D277/32 , C07D277/36 , C07D295/108 , C07D295/20 , C07D295/26 , C07D401/12 , C07D417/12 , C07F9/4056 , C07F9/58 , C07F9/6539 , C07F9/65742
摘要： This invention relates to novel compounds useful as potassium channel modulators. More specifically the invention provides chemical compounds useful as modulators of SKCa and/or IKCa channels.
摘要翻译： 本发明涉及可用作钾通道调节剂的新化合物。 更具体地，本发明提供了可用作SKCa和/或IKCa通道调节剂的化合物。
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63.发明授权Benzimidazole compounds and their use as modulators of the GABA.sub.A receptor complex 失效苯并咪唑化合物及其用作GABA A受体复合物的调节剂
公开(公告)号：US5922725A
公开(公告)日：1999-07-13
申请号：US945123
申请日：1997-12-23
申请人： Lene Teuber , Frank Watjen , Yoshimasa Fukuda , Osamu Ushiroda , Toshiro Sasaki
发明人： Lene Teuber , Frank Watjen , Yoshimasa Fukuda , Osamu Ushiroda , Toshiro Sasaki
IPC分类号： C07D401/14 , A61K31/00 , A61K31/415 , A61K31/4164 , A61K31/4184 , A61K31/425 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4439 , A61K31/501 , A61K31/505 , A61K31/506 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/22 , A61P25/28 , A61P43/00 , C07D235/06 , C07D401/10 , C07D403/10 , C07D403/14 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/14 , C07D417/10 , C07D417/14 , C07D521/00
CPC分类号： C07D235/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/10 , C07D403/10 , C07D405/10 , C07D405/14 , C07D409/10 , C07D413/14 , C07D417/10 , C07D417/14
摘要： The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R.sup.3 is ##STR2## wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH;R.sup.11 is phenyl, benzimidazolyl, or monocyclic heteroaryl, all of which may be substituted one or more times with substituents selected from alkyl, alkoxy, halogen, CF.sub.3, amino, nitro, cyano, acylamino, acyl, phenyl and monocyclic heteroaryl;one of R.sup.6 and R.sup.7 is hydrogen and the other is --CR'.dbd.NOR", wherein R' and R" each independently are hydrogen, alkyl, alkenyl, alkynyl or phenyl.The compounds are useful for the treartment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
摘要翻译： PCT No.PCT / EP96 / 01649 Sec。 371 1997年12月23日第 102（e）1997年12月23日PCT PCT 1996年4月19日PCT公布。 WO96 / 33191 PCT出版物 日本特开1996年10月24日本专利申请公开了具有下式的化合物或其药学上可接受的盐或其氧化物，其中R 3为其中A，B和D各自为CH，或A，B和D中的一个为N， 其他都是CH; R 11是苯基，苯并咪唑基或单环杂芳基，它们都可以被选自烷基，烷氧基，卤素，CF 3，氨基，硝基，氰基，酰氨基，酰基，苯基和单环杂芳基的取代基取代一次或多次。 R6和R7之一是氢，另一个是-CR'= NOR“，其中R'和R”各自独立地是氢，烷基，烯基，炔基或苯基。 该化合物可用于各种中枢神经系统疾病如癫痫和其它惊厥性疾病，焦虑症，睡眠障碍和记忆障碍。
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公开(公告)号：US5554632A
公开(公告)日：1996-09-10
申请号：US352585
申请日：1994-12-09
申请人： Lene Teuber , Oskar Axelsson , Frank Watjen
发明人： Lene Teuber , Oskar Axelsson , Frank Watjen
IPC分类号： A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61K31/47 , A61K31/55 , A61K31/5517 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/20 , A61P25/22 , A61P25/28 , C07D235/02 , C07D235/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D413/10 , C07D413/14 , C07D471/04 , C07D471/06 , C07D487/06 , C07D513/04 , C07D521/00
CPC分类号： C07D235/02 , C07D231/12 , C07D233/56 , C07D235/06 , C07D249/08 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/10 , C07D405/14 , C07D413/10 , C07D413/14 , C07D471/04 , C07D471/06 , C07D487/06 , C07D513/04
摘要： The present patent application discloses compounds having the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R.sup.3, R.sup.4, R.sup.6 and R.sup.7 each have the meanings set forth in the specification.The compounds are useful for the treatment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
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65.发明授权Benzimidazole derivatives and their use for modulating the GABAA receptor complex 失效苯并咪唑衍生物及其用于调节GABA A受体复合物的用途公开(公告)号：US07851490B2
公开(公告)日：2010-12-14
申请号：US11887780
申请日：2006-04-07
IPC分类号： A61K31/44 , C07D401/02
CPC分类号： C07D403/10 , C07D401/10 , C07D417/10
摘要： This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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66.发明申请IMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA ALPHA RECEPTOR COMPLEX 失效咪唑衍生物及其用于调节GABA ALPHA受体复合物的用途公开(公告)号：US20090209597A1
公开(公告)日：2009-08-20
申请号：US12089883
申请日：2006-10-12
申请人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Ostergaard Nielsen
发明人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Ostergaard Nielsen
IPC分类号： A61K31/4439 , C07D233/90 , A61K31/4164 , C07D401/12 , A61P25/00
CPC分类号： C07D233/90 , C07D401/10 , C07D401/12 , C07D403/12
摘要： This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新颖的咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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67.发明申请Benzimidazole derivatives and their use for modulating the gaba-alpha receptor complex 审中-公开苯并咪唑衍生物及其用于调节gaba-α受体复合物的用途公开(公告)号：US20090062304A1
公开(公告)日：2009-03-05
申请号：US11918681
申请日：2006-04-18
IPC分类号： C07D403/10 , A61K31/496 , A61P25/00 , A61P25/18 , A61P25/30 , A61P25/28 , A61P25/06
CPC分类号： C07D235/06
摘要： This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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68.发明申请Benzimidazole Derivatives and Their Use for Modulating the GABA Alpha Receptor Complex 失效苯并咪唑衍生物及其用于调节GABAα受体复合物的用途公开(公告)号：US20090036493A1
公开(公告)日：2009-02-05
申请号：US11887780
申请日：2006-04-07
IPC分类号： A61K31/4439 , C07D403/02 , C07D277/20 , C07D401/02 , A61P25/18 , A61P25/24 , A61P25/28 , A61K31/4184 , A61K31/427
CPC分类号： C07D403/10 , C07D401/10 , C07D417/10
摘要： This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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69.发明申请BENZIMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABAA RECEPTOR COMPLEX 有权苯并咪唑衍生物及其用于调节GABA A受体复合物的用途公开(公告)号：US20090036476A1
公开(公告)日：2009-02-05
申请号：US12279511
申请日：2007-03-22
IPC分类号： A61K31/506 , C07D235/06 , C07D403/10 , C07D401/10 , A61P3/10 , A61P25/28 , A61K31/4439 , A61K31/4184
CPC分类号： C07D235/06 , C07D401/10 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/10 , C07D405/14 , C07D413/04
摘要： This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗对调节GABA A受体复合物有反应的中枢神经系统疾病和病症，特别是用于对抗焦虑和相关疾病。
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70.发明申请Benzimidazole derivatives and their use for modulating the gabaalpha receptor complex 失效苯并咪唑衍生物及其用于调节gabaalpha受体复合物的用途公开(公告)号：US20090030018A1
公开(公告)日：2009-01-29
申请号：US11918679
申请日：2006-04-18
IPC分类号： C07D235/12 , A61K31/4184 , A61K31/4439 , C07D401/12 , C07D403/12 , C07D417/12 , A61K31/506 , A61K31/4196 , A61K31/427 , A61P25/00 , A61P25/28 , A61P25/18 , A61P25/24
CPC分类号： C07D235/06 , C07D401/12 , C07D417/12
摘要： This invention relates to novel benzimidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新的苯并咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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