摘要:
Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR7, —NH—SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl; R4 is aryl or Het; n is 3, 4, 5, or 6; R5 is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het; R6 is C1-6alkoxy, or dimethylamino; R7 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R8 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl optionally substituted with one, two or three substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.
摘要:
A navigation system includes a display for displaying at least a part of a digital map. The navigation system includes a navigation database which stores any text and/or symbol(s) associated with a signpost independently from a background of the signpost. The text and/or symbol(s) and the background may be retrieved from the navigation database and displayed as a signpost image in the displayed part of the digital map.
摘要:
A navigation system includes a display for displaying at least a part of a digital map. A landmark detected within the digital map is displayed as a three-dimensional graphical object or a two-dimensional graphical object depending on a location of the landmark.
摘要:
A navigation system may display a map element represented by a spline including a plurality of vertices. Label coordinate values derived from coordinate values of the plurality of vertices may be retrieved from a database. A label assigned to the map element may be displayed based on the stored label coordinate values. The assigned label may be adapted to the geometric form of at least a portion of the map element.
摘要:
Inhibitors of HCV replication of formula (I) and the N-oxides, salts, and stereoisomers, wherein each dashed line represents an optional double bond; X is N, CH and where X bears a double bond it is C; R1 is —OR7, —NH—SO2R8; R2 is hydrogen, and where X is C or CH, R2 may also be C1-6alkyl; R3 is hydrogen, C1-6alkyl, C1-6alkoxyC1-6alkyl, C3-7cycloalkyl; R4 is aryl or Het; n is 3, 4, 5, or 6; R5 is halo, C1-6alkyl, hydroxy, C1-6alkoxy, phenyl, or Het; R6 is C1-6alkoxy, or dimethylamino; R7 is hydrogen; aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; R8 is aryl; Het; C3-7cycloalkyl optionally substituted with C1-6alkyl; or C1-6alkyl optionally substituted with C3-7cycloalkyl, aryl or with Het; aryl is phenyl optionally substituted with one, two or three substituents; Het is a 5 or 6 membered saturated, partially unsaturated or completely unsaturated heterocyclic ring containing 1 to 4 heteroatoms selected from nitrogen, oxygen and sulfur, and being optionally substituted with one, two or three substituents; pharmaceutical compositions containing compounds (I) and processes for preparing compounds (I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavir are also provided.
摘要:
A method for pumping remote optically-pumped fiber amplifiers (ROPAs) in fiber-optic telecommunication systems is disclosed which uses cascaded Raman amplification to increase the maximum amount of pump power that can be delivered to the ROPA. According to the prior art, high power at the ROPA pump wavelength, λp, is launched directly into the fiber and the maximum launch power is limited by the onset of pump depletion by Raman noise and oscillations due to the high Raman gain at ˜(λp+100) nm. In preferred embodiments of the present invention, a ‘primary’ pump source of wavelength shorter than λp is launched into the delivery fiber along with two or more significantly lower-power ‘seed’ sources, among which is included one at λp. The wavelength and power of the seed source(s) are chosen such that, when combined with the high-power primary source, a series, n, where n≧2, of Raman conversions within the fiber ultimately leads to the development of high power at λp. In another embodiment, one or more of the seed sources at wavelengths shorter than λp are replaced by reflecting means to return, into the fiber, backward-travelling amplified spontaneous Raman scattered light resulting from high power in the fiber at a wavelength one Raman shift below the particular seed wavelength. In either case, the high power at λp is developed over a distributed length of the fiber, reaching its maximum some distance into the fiber and exceeding the maximum power possible at that point with the prior art.
摘要:
Software code sections can include at least one calling procedure (110) and a called procedure (140). The called procedure can include an interpreted code body (144). Execution of the interpreted code body can require the use of an associated interpreter. The software code sections can also include prologue (142) associated with the called procedure. The prologue can be invoked by the at least one calling procedure and can responsively actuate the interpreted code body causing programmatic actions defined within the interpreted code body to execute. Execution of the prologue does not require use of an interpreter. In one embodiment, the interpreted code body of the called procedure can execute upon a platform having an application binary interface (115). The prologue can actuate the interpreted code body according to specifications of the application binary interface.
摘要:
A work surface, e.g. an integrated circuit, is treated with a plasma jet. The work surface is shielded from an ambient medium by a shielding gas jet directed to create a shielded zone around the work surface, or which is blown over the work surface so it intersects the plasma jet on the work surface.
摘要:
Plasma treatment apparatus includes means to generate a plasma jet at atmospheric pressure, and means to control both the cross-sectional size of the jet and the relative speed of movement between the jet and a body being treated.