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    Use of 14-3-3 proteins and a method for determining the same in the fluids or tissues of organisms
    61.
    发明申请
    Use of 14-3-3 proteins and a method for determining the same in the fluids or tissues of organisms 审中-公开

    公开(公告)号：US20050009094A1

    公开(公告)日：2005-01-13

    申请号：US10479925

    申请日：2002-06-04

    Applicant: Werner Mueller ,  Heinz Schroeder

    Inventor： Werner Mueller ,  Heinz Schroeder

    IPC: G01N33/68 ,  G01N33/53

    CPC classification number: G01N33/6896 ,  G01N2800/2828

    Abstract: The object of the present invention is to provide a method for the detection and/or quantification of the 14-3-3 proteins or their isoforms for early stage diagnosis of TSE-diseases, which method allows to perform the diagnosis in the living organism. It is furthermore an object, to detect a contamination of the sample by the parallel determination of a second antigen. This object according to the invention is solved by making use of the biochemical characteristics of the members of the 14-3-3 protein family, which bind to specific amino acid motifs like X(n)-XSXXSXXSX-X(n) or to the motif RSXpSXP (SEQ ID NO: 12) within peptides or proteins. For determining one or more isoforms or the entirety of the 14-3-3 protein(s) and for specific binding, one uses modified solid phases like e.g. microtiter plates, which are coated with a synthetic or natural peptide containing a binding motif for 14-3-3 proteins, e.g. a chemically synthesised peptide having the motif CAALPKINRSApSEPSLHR (SEQ ID NO: 1). After the addition of the extracts or bodily fluids to be investigated the detection and quantification of the generated peptide-14-3-3 protein complexes is accomplished by means of labeled antibodies. The use of the 14-3-3 protein family and/or of individual isoforms of the 14-3-3 proteins according to the invention can be employed as an effect monitor or biomonitor in aquatic invertebrates after environmental effects like the presence of polychlorinated biphenyls (PCBs), (xeno)estrogens etc. Moreover, the method can be used for early diagnosis of TSE-diseases like e.g. Creutzfeldt-Jakob disease (CJD) and its novel form (variant) in young persons (vCJD) and Bovine Spongiform Encephalopathy (BSE) or comparable diseases. Thus a diagnostic marker (surrogate marker) is available, which can be used in the living organism as a screening marker, confirmation marker or single marker.

    Machine tool with horizontal spindles
    63.
    发明授权
    Machine tool with horizontal spindles 失效
    卧式主轴机床

    公开(公告)号：US6066078A

    公开(公告)日：2000-05-23

    申请号：US336725

    申请日：1999-06-21

    Applicant: Rolf Koelblin ,  Reinhard Schneider ,  Werner Mueller ,  Horst Fein

    Inventor： Rolf Koelblin ,  Reinhard Schneider ,  Werner Mueller ,  Horst Fein

    IPC: B23C1/04 ,  B23B39/02 ,  B23Q3/157 ,  B23Q39/02

    CPC classification number: B23Q39/024 ,  B23Q3/15706 ,  B23Q2039/002 ,  Y10T483/15 ,  Y10T483/1736 ,  Y10T483/1793 ,  Y10T483/1795 ,  Y10T483/1891

    Abstract: The machine tool comprises two headstocks (16,17), arranged on a support (10), which are movable independently of each other along their height and their longitudinal direction. A respective one (17) of the headstocks is active in the treatment of a workpiece attached on a workpiece carrier (20), while the other headstock (16) can be moved behind a tool magazine (24) for receiving a tool therefrom. While the one headstock is still working on the workpiece, the other headstock with the next tool can already be accelerated to the required working rotational speed and be advanced to the tool. Thus, the time required for exchange of tools is extremely shortened.

    Abstract translation: 该机床包括布置在支撑件（10）上的两个主轴箱（16,17），它们可沿其高度和纵向方向彼此独立地移动。 主轴箱中相应的一个（17）主动用于处理附着在工件载体（20）上的工件，而另一个主轴箱（16）可以移动到用于从其接收工具的工具仓（24）后面。 当一个主轴箱仍然在工件上工作时，另一个具有下一个工具的主轴箱可以被加速到所需的工作转速并提前到工具。 因此，交换工具所需的时间大大缩短。

    Method and apparatus for calibrating a travel path and/or an angular position of a holding device in a means for manufacturing electrical assemblies as well as a calibration substrate
    64.
    发明授权
    Method and apparatus for calibrating a travel path and/or an angular position of a holding device in a means for manufacturing electrical assemblies as well as a calibration substrate 失效
    用于校准用于制造电组件的装置中的保持装置的行进路径和/或角位置的方法和装置以及校准基板

    公开(公告)号：US06055049A

    公开(公告)日：2000-04-25

    申请号：US179830

    申请日：1998-10-28

    Applicant: Werner Mueller

    Inventor： Werner Mueller

    IPC: G01B11/00 ,  G01B11/26 ,  H05K13/04 ,  H05K13/08 ,  G01J1/10

    CPC classification number: H05K13/08

    Abstract: Prior art methods calibrate the travel path and/or the angular position of holding devices in equipment for manufacturing electrical assemblies by optical measurements of the position of simulations of electrical components that are equipped on a calibration substrate. Markings on the simulations and local reference marks on the calibration substrate serve this purpose. Printed circuit board cameras that are utilized as optical sensors exhibit a pronounced camera distortion that makes the calibration more difficult. As a result of the method, the apparatus as well as the calibration substrate, a sensor correction factor is determined in that the position of two correction marks that are applied on the calibration substrate at a predetermined nominal spacing and a predetermined position relative to one another are measured with the printed circuit board camera. The result of the measurement is compared to the nominal spacing.

    Abstract translation: 现有技术的方法通过对装配在校准基板上的电气部件的模拟的位置的光学测量来校准用于制造电组件的设备中的保持装置的行进路径和/或角位置。 校准基板上的模拟和局部参考标记上的标记用于此目的。 用作光学传感器的印刷电路板相机表现出明显的相机失真，使得校准更加困难。 作为该方法的结果，设备以及校准基板，传感器校正因子被确定为以预定的标称间隔和相对于彼此的预定位置施加在校准基板上的两个校正标记的位置 用印刷电路板照相机测量。 将测量结果与标称间距进行比较。

    Process for regenerating bone and cartilage
    65.
    发明授权
    Process for regenerating bone and cartilage 失效
    骨和软骨再生的过程

    公开(公告)号：US5837235A

    公开(公告)日：1998-11-17

    申请号：US602833

    申请日：1996-05-09

    Applicant: Werner Mueller ,  Thomas Thaler

    Inventor： Werner Mueller ,  Thomas Thaler

    IPC: A61L27/36 ,  A61L27/38 ,  C12N5/06 ,  C12N5/08 ,  C12N11/02 ,  C12N11/08

    CPC classification number: A61L27/3852 ,  A61L27/3847

    Abstract: Bone and cartilage are regenerated in a patient by a process of removing fatty tissue such as omentum tissue from a patient, comminuting the tissue to form small tissue particles, suspending the particles in a liquid to form a suspension, depositing the suspension on a solid carrier to prepare a solid implanting material, implanting the implanting material in a patient in an environment favoring bone or cartilage formation, and regenerating bone or cartilage in the patient. The carrier can be demineralized bone, collagen, mineral material or synthetic polymer material in pulverulent, textile, porous particle or monolith form. A cell adhesion agent may be applied to the carrier or added to the suspension, and a growth factor may be deposited on the carrier. Comminuting is performed by digesting with an enzyme and/by mechanically comminuting. Liquid used to form the suspension may contain a gel precursor which is gelled after the suspension is deposited to the carrier. Preferably, the implanting material is implanted within about 1 hour of removing the fatty tissue from the patient.

    Abstract translation: PCT No.PCT / CH95 / 00158 Sec。 371日期：1996年5月9日 102（e）日期1996年5月9日PCT提交1995年7月6日PCT公布。 公开号WO96 / 01641 日期1996年1月25日骨和软骨在患者体内通过从患者去除脂肪组织如网膜组织的过程再生，粉碎组织以形成小的组织颗粒，将颗粒悬浮在液体中以形成悬浮液， 悬浮在固体载体上以制备固体植入材料，将植入材料植入患者体内有利于骨或软骨形成的环境中，以及在患者体内再生骨或软骨。 载体可以是粉末状，纺织品，多孔颗粒或整体形式的软化骨，胶原蛋白，矿物材料或合成聚合物材料。 可以将细胞粘附剂施用于载体或加入到悬浮液中，并且可以在载体上沉积生长因子。 通过用酶消化和/通过机械粉碎来进行灭菌。 用于形成悬浮液的液体可以含有在悬浮液沉积到载体上之后凝胶化的凝胶前体。 优选地，在从患者去除脂肪组织的约1小时内植入植入材料。

    SECURITY LABEL FOR IDENTIFYING PRODUCTS
    69.
    发明申请
    SECURITY LABEL FOR IDENTIFYING PRODUCTS 审中-公开
    用于识别产品的安全标签

    公开(公告)号：US20120279101A1

    公开(公告)日：2012-11-08

    申请号：US13510559

    申请日：2010-07-27

    Applicant: Thorsten Pretsch ,  Werner Mueller

    Inventor： Thorsten Pretsch ,  Werner Mueller

    IPC: G09F3/02 ,  B29C59/02

    CPC classification number: B42D25/425 ,  B42D25/29 ,  B42D25/324 ,  B42D25/45 ,  B42D2033/30 ,  B42D2035/34 ,  G06K19/041 ,  G07D7/003 ,  G07D7/14 ,  G09F3/0291 ,  G09F3/0292

    Abstract: The invention relates to a security label for identifying products comprising a layer comprising a shape memory polymer, wherein a surface profile comprising information for identifying the product is embossed in the layer and wherein the layer has a smooth surface in a first state and the layer has the embossed surface profile in a second state, wherein the security label is adapted such that the layer can be changed from the first or second state to the second or first state upon reading out the security label and to a connection means for connecting the layer to the product.

    Abstract translation: 本发明涉及一种用于识别包括包含形状记忆聚合物的层的产品的安全标签，其中包括用于识别产品的信息的表面轮廓被压印在该层中，并且其中该层具有处于第一状态的平滑表面，并且该层具有 在第二状态下的压花表面轮廓，其中所述安全标签适于使得所述层可以在读出所述安全标签时从所述第一状态或所述第二状态改变到所述第二状态或第一状态;以及连接装置，用于将所述层连接到 该产品。

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