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公开(公告)号：US20150031884A1
公开(公告)日：2015-01-29
申请号：US14368233
申请日：2011-12-15
IPC分类号： C07D403/14 , C07D401/14
CPC分类号： C07D403/14 , C07D401/14 , C07D413/14 , C07D417/14
摘要： The present invention relates to anti-HCV compounds, compositions comprising the same and methods of using the same to treat HCV infection.
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公开(公告)号：US20140364616A1
公开(公告)日：2014-12-11
申请号：US14367988
申请日：2011-12-15
IPC分类号： C07D409/14 , C07D401/14 , C07D403/14
CPC分类号： C07D409/14 , C07D401/14 , C07D403/14
摘要： The present invention relates to anti-HCV compounds, compositions comprising the same and methods of using the same to treat HCV infection.
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公开(公告)号：US20130330348A1
公开(公告)日：2013-12-12
申请号：US13817721
申请日：2011-08-19
申请人： Susan E. Lacy , Jeffrey A. Barbon , Meha Chhaya , Emma Fung , Charles W. Hutchins , Diane M. Lang , Eve H. Barlow , Mary Leddy , Ravi Chari
发明人： Susan E. Lacy , Jeffrey A. Barbon , Meha Chhaya , Emma Fung , Charles W. Hutchins , Diane M. Lang , Eve H. Barlow , Mary Leddy , Ravi Chari
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K39/3955 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/50 , C07K2317/51 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/569 , C07K2317/60 , C07K2317/622 , C07K2317/624 , C07K2317/626 , C07K2317/64 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/566
摘要： The present disclosure encompasses NGF binding proteins, specifically to antibodies that are chimeric, CDR grafted and canonized antibodies, and methods of making and uses thereof. The antibodies, or antibody portions, of the disclosure are useful for detecting NGF and for inhibiting NGF activity, e.g., in a mammal subject suffering from a disorder in which NGF activity is detrimental.
摘要翻译： 本公开内容涵盖NGF结合蛋白，特别是嵌合抗体，CDR移植和标准化抗体的抗体，及其制备和使用方法。 本公开的抗体或抗体部分可用于检测NGF和抑制NGF活性，例如在患有NGF活性有害的病症的哺乳动物受试者中。
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64.发明授权Substituted oxindole derivatives and their use as vasopressin and/or oxytocin receptor ligands 有权取代的羟吲哚衍生物及其作为加压素和/或催产素受体配体的用途公开(公告)号：US08431567B2
公开(公告)日：2013-04-30
申请号：US12438696
申请日：2007-08-24
申请人： Herve Geneste , Thorsten Oost , Astrid Netz , Charles W. Hutchins , Wolfgang Wernet , Wilfred Lubisch , Liliane Unger , Wilfried Hornberger
发明人： Herve Geneste , Thorsten Oost , Astrid Netz , Charles W. Hutchins , Wolfgang Wernet , Wilfred Lubisch , Liliane Unger , Wilfried Hornberger
IPC分类号： A61K31/551 , A61K31/496 , A61K31/4439 , C07D243/08 , C07D401/14 , C07D401/02
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to novel oxindole derivatives of general formula (I), in which the substituents R1, R2, A, B and Y are as defined in claim 1, medicinal products containing them and use thereof for the prophylaxis and/or treatment of vasopressin-dependent and/or oxytocin-dependent diseases.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物，其中取代基R1，R2，A，B和Y如权利要求1所定义，含有它们的药物及其用于预防和/或治疗 血管升压素依赖性和/或催产素依赖性疾病。
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公开(公告)号：US08283363B2
公开(公告)日：2012-10-09
申请号：US12940339
申请日：2010-11-05
申请人： Helmut Mack , Andreas Kling , Katja Jantos , Achim Moeller , Wilfried Hornberger , Charles W. Hutchins
发明人： Helmut Mack , Andreas Kling , Katja Jantos , Achim Moeller , Wilfried Hornberger , Charles W. Hutchins
IPC分类号： A61P35/00 , A61P25/00 , A61P29/00 , A61P31/00 , A61P9/00 , A61P27/02 , A61K31/425 , A61K31/451 , A61K31/4015 , A61K31/4439 , A61K31/4164 , C07D211/40 , C07D207/12 , C07D401/02 , C07D233/02 , C07D275/03
CPC分类号： C07D207/22 , C07D207/26 , C07D207/28 , C07D211/76 , C07D211/78 , C07D213/81 , C07D233/32 , C07D233/34 , C07D239/10 , C07D275/03 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention relates to novel carboxamide compounds and their use for the manufacture of a medicament. The carboxamide compounds are inhibitors of calpain (calcium dependant cysteine proteases). The invention therefore also relates to the use of these carboxamide compounds for treating a disorder associated with an elevated calpain activity.The carboxamide compounds are compounds of the general formula I in which R1, R2, R3a, R3b, R4, Q, Y, A and X have the meanings mentioned in the claims and the description, the tautomers thereof and the pharmaceutically suitable salts thereof. In particular, the compounds have the general formula Ia and Ib in which R1, r, R2b, R3a, R3b, R4, Y and X have the meanings mentioned in the claims, including the tautomers thereof and the pharmaceutically suitable salts thereof. Of these compounds those are preferred wherein Y is a moiety CH2—CH2, CH2—CH2—CH2, N(Ry#)—CH2, N(Ry#)—CH2—CH2 or CH═CH—CH═, each optionally having 1 or 2 H-atoms replaced with identical or different radicals Ry, wherein Ry and Ry# have the meanings mentioned in the claims.
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公开(公告)号：US20100317568A1
公开(公告)日：2010-12-16
申请号：US12813301
申请日：2010-06-10
申请人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Todd N. Soltwedel , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Michael J. Lavin , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi
发明人： David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Todd N. Soltwedel , Dachun Liu , John K. Pratt , Todd W. Rockway , Clarence J. Maring , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Michael D. Tufano , David A. Betebenner , Michael J. Lavin , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi
IPC分类号： A61K38/05 , C07D403/14 , A61P31/14 , C07D401/14 , A61K31/4178 , A61K31/4184 , C07D413/14 , C07D417/14 , A61K31/428 , A61K31/496 , A61K31/5377 , A61K31/55 , C07F9/6506 , A61K31/675 , C07D491/113 , A61K31/438 , C07D279/12 , A61K31/541
CPC分类号： C07F9/65583 , C07C33/26 , C07C201/06 , C07C205/19 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D471/04 , C07D491/113 , C07K5/06
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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公开(公告)号：US20100168138A1
公开(公告)日：2010-07-01
申请号：US12644427
申请日：2009-12-22
申请人： David A. DeGoey , Pamela L. Donner , Warren M. Kati , Charles W. Hutchins , Mark A. Matulenko , Tammie K. Jinkerson , Ryan G. Keddy
发明人： David A. DeGoey , Pamela L. Donner , Warren M. Kati , Charles W. Hutchins , Mark A. Matulenko , Tammie K. Jinkerson , Ryan G. Keddy
IPC分类号： A61K31/519 , C07D471/04 , C07D487/04 , A61P31/12
CPC分类号： C07D471/04
摘要： Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
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68.发明申请SUBSTITUTED OXINDOLE DERIVATIVES AND THEIR USE AS VASOPRESSIN AND/OR OXYTOCIN RECEPTOR LIGANDS 有权取代的氧化衍生物及其作为血管收缩素和/或氧化受体配体使用公开(公告)号：US20090318406A1
公开(公告)日：2009-12-24
申请号：US12438696
申请日：2007-08-24
申请人： Herve Geneste , Thorsten Oost , Astrid Netz , Charles W. Hutchins , Wolfgang Wernet , Wolfgang Lubisch , Liliane Unger , Wilfried Hornberger
发明人： Herve Geneste , Thorsten Oost , Astrid Netz , Charles W. Hutchins , Wolfgang Wernet , Wolfgang Lubisch , Liliane Unger , Wilfried Hornberger
IPC分类号： A61K31/404 , C07D401/14 , C07D401/02 , A61K31/496 , A61K31/4439 , A61K31/551 , A61K31/407 , A61P3/00 , A61P25/00
CPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D487/04 , C07D487/08
摘要： The present invention relates to novel oxindole derivatives of general formula (I), in which the substituents R1, R2, A, B and Y are as defined in claim 1, medicinal products containing them and use thereof for the prophylaxis and/or treatment of vasopressin-dependent and/or oxytocin-dependent diseases.
摘要翻译： 本发明涉及通式（I）的新型羟基吲哚衍生物，其中取代基R1，R2，A，B和Y如权利要求1所定义，含有它们的药物及其用于预防和/或治疗 血管升压素依赖性和/或催产素依赖性疾病。
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公开(公告)号：US5767144A
公开(公告)日：1998-06-16
申请号：US442575
申请日：1995-05-30
申请人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen
发明人： Martin Winn , Steven A. Boyd , Charles W. Hutchins , Hwan-Soo Jae , Andrew S. Tasker , Thomas W. von Geldern , Jeffrey A. Kester , Bryan K. Sorensen
IPC分类号： C07D207/16 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/572 , C07F9/59 , A61K31/40 , C07D207/08
CPC分类号： C07D401/04 , C07D207/16 , C07D403/04 , C07D405/04 , C07D405/14 , C07F9/5722 , C07F9/592
摘要： A compound of the formula (I): ##STR1## or a pharmaceutically acceptable salt thereof is disclosed, as well as processes for and intermediates in the preparation thereof, and a method of antagonizing endothelin.
摘要翻译： 公开了式（I）的化合物：其中（I）或其药学上可接受的盐，以及其制备方法和中间体，以及拮抗内皮素的方法。
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