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公开(公告)号:US08840861B2
公开(公告)日:2014-09-23
申请号:US13578820
申请日:2011-01-14
申请人: Rolf Wagner , Manuel Matussek
发明人: Rolf Wagner , Manuel Matussek
IPC分类号: C01B21/068 , C23C24/08 , C04B41/00 , C30B28/04 , C04B41/87 , C04B41/50 , C30B15/10 , C23C8/24
CPC分类号: C04B41/5066 , C04B41/009 , C04B41/87 , C23C8/24 , C23C24/082 , C30B15/10 , C30B28/04 , C04B41/4519 , C04B41/4539 , C04B41/4558 , C04B35/565 , C04B35/522 , C04B35/83
摘要: A method for producing a workpiece comprising a layer of an additive-free silicon nitride includes providing a base body of the workpiece. A layer of a slip comprising a silicon powder is applied to an inside of the base body so as to obtain a coated base body. The coated base body is subjected to a reactive firing under nitrogen so as to convert the silicon powder to the additive-free silicon nitride.
摘要翻译: 包括无添加剂的氮化硅层的工件的制造方法包括提供工件的基体。 将包含硅粉末的滑动层施加到基体的内侧,以获得涂覆的基体。 将涂覆的基体在氮气下进行反应性烧制,以将硅粉末转化为无添加剂的氮化硅。
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公开(公告)号:US08741914B2
公开(公告)日:2014-06-03
申请号:US13260206
申请日:2010-03-25
申请人: Todd W. Rockway , David A. Betebenner , David A. DeGoey , Charles A. Flentge , Douglas K. Hutchinson , Warren M. Kati , Allan C. Krueger , Dachun Liu , Kenton L. Longenecker , John K. Pratt , Kent D. Stewart , Rolf Wagner , Clarence J. Maring
发明人: Todd W. Rockway , David A. Betebenner , David A. DeGoey , Charles A. Flentge , Douglas K. Hutchinson , Warren M. Kati , Allan C. Krueger , Dachun Liu , Kenton L. Longenecker , John K. Pratt , Kent D. Stewart , Rolf Wagner , Clarence J. Maring
IPC分类号: C07D401/04 , C07D403/04 , A61K31/513
CPC分类号: C07D401/04 , C07D403/04 , C07D407/04 , C07D409/14
摘要: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
摘要翻译: 本发明涉及:(a)特别是抑制HCV的化合物及其盐; (b)可用于制备这些化合物和盐的中间体; (c)包含这些化合物和盐的组合物; (d)制备这种中间体,化合物,盐和组合物的方法; (e)使用这些化合物,盐和组合物的方法; 和(f)包含这些化合物,盐和组合物的试剂盒。
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公开(公告)号:US20120315208A1
公开(公告)日:2012-12-13
申请号:US13578820
申请日:2011-01-14
申请人: Rolf Wagner , Manuel Matussek
发明人: Rolf Wagner , Manuel Matussek
IPC分类号: C01B21/068 , B05D7/22
CPC分类号: C04B41/5066 , C04B41/009 , C04B41/87 , C23C8/24 , C23C24/082 , C30B15/10 , C30B28/04 , C04B41/4519 , C04B41/4539 , C04B41/4558 , C04B35/565 , C04B35/522 , C04B35/83
摘要: A method for producing a workpiece comprising a layer of an additive-free silicon nitride includes providing a base body of the workpiece. A layer of a slip comprising a silicon powder is applied to an inside of the base body so as to obtain a coated base body. The coated base body is subjected to a reactive firing under nitrogen so as to convert the silicon powder to the additive-free silicon nitride.
摘要翻译: 包括无添加剂的氮化硅层的工件的制造方法包括提供工件的基体。 将包含硅粉末的滑动层施加到基体的内侧,以获得涂覆的基体。 将涂覆的基体在氮气下进行反应性烧制,以将硅粉末转化为无添加剂的氮化硅。
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公开(公告)号:US08178548B2
公开(公告)日:2012-05-15
申请号:US12212315
申请日:2008-09-17
申请人: Pamela L. Donner , John T. Randolph , Allan C. Krueger , David A. Betebenner , Douglas K. Hutchinson , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , John K. Pratt , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , John E. Hengeveld , Rodger F. Henry , Xiaochun Lou , Geoff G. Z. Zhang
发明人: Pamela L. Donner , John T. Randolph , Allan C. Krueger , David A. Betebenner , Douglas K. Hutchinson , Dachun Liu , Yaya Liu , Kenton L. Longenecker , Clarence J. Maring , John K. Pratt , Todd W. Rockway , Kent D. Stewart , Rolf Wagner , Shuang Chen , Yi Gao , John E. Hengeveld , Rodger F. Henry , Xiaochun Lou , Geoff G. Z. Zhang
IPC分类号: A61K31/505 , C07D239/02 , C07D401/00
CPC分类号: C07D239/22 , A61K31/513 , C07D239/54 , C07D239/553 , C07D401/10 , C07D403/10 , C07D405/10 , C07D409/10 , C07D413/10
摘要: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
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公开(公告)号:US20120100104A1
公开(公告)日:2012-04-26
申请号:US13260206
申请日:2010-03-25
申请人: Todd W. Rockway , David A. Betebenner , David A. DeGoey , Charles A. Flentge , Douglas K. Hutchinson , Warren M. Kati , Allan C. Krueger , Dachun Liu , Kenton L. Longenecker , John K. Pratt , Kent D. Stewart , Rolf Wagner , Clarence J. Maring
发明人: Todd W. Rockway , David A. Betebenner , David A. DeGoey , Charles A. Flentge , Douglas K. Hutchinson , Warren M. Kati , Allan C. Krueger , Dachun Liu , Kenton L. Longenecker , John K. Pratt , Kent D. Stewart , Rolf Wagner , Clarence J. Maring
IPC分类号: A61K31/506 , C07D403/10 , C07D409/14 , A61P31/14 , A61K31/7056 , A61K38/21 , C12N7/06 , C07D401/10 , A61K31/517
CPC分类号: C07D401/04 , C07D403/04 , C07D407/04 , C07D409/14
摘要: This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.
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公开(公告)号:US08163769B2
公开(公告)日:2012-04-24
申请号:US10387318
申请日:2003-03-12
申请人: David Anderson , Bruce Beutel , Todd D. Bosse , Richard Clark , Curt Cooper , Peter Dandliker , Caroline David , Yu-Gui Gu , Todd Matthew Hansen , Mira Hinman , Douglas Kalvin , Daniel P. Larson , Linda Lynch , Zhenkun Ma , Christopher Motter , Fabio Palazzo , Teresa Rosenberg , Tamara Rehm , William Sanders , Michael Tufano , Rolf Wagner , Moshe Weitzberg , Hong Yong , Tianyuan Zhang
发明人: David Anderson , Bruce Beutel , Todd D. Bosse , Richard Clark , Curt Cooper , Peter Dandliker , Caroline David , Yu-Gui Gu , Todd Matthew Hansen , Mira Hinman , Douglas Kalvin , Daniel P. Larson , Linda Lynch , Zhenkun Ma , Christopher Motter , Fabio Palazzo , Teresa Rosenberg , Tamara Rehm , William Sanders , Michael Tufano , Rolf Wagner , Moshe Weitzberg , Hong Yong , Tianyuan Zhang
IPC分类号: A61K31/04 , C07D215/38
CPC分类号: C07D471/04
摘要: Antibacterials having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods of prophylaxis and treatment of bacterial infections using the compounds are disclosed.
摘要翻译: 公开了具有式(I)的抗菌剂及其前体药物的盐,前药和盐,用于制备本方法中使用的化合物和中间体的方法,含该化合物的组合物,以及使用该化合物预防和治疗细菌感染的方法。
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公开(公告)号:US20120037065A1
公开(公告)日:2012-02-16
申请号:US13258458
申请日:2010-02-11
申请人: Rolf Wagner , Florian Arzberger
发明人: Rolf Wagner , Florian Arzberger
CPC分类号: C30B11/002 , C30B29/06 , C30B35/002 , Y10T117/1032
摘要: A crucible for producing a silicon suitable for producing a semiconductor includes a plurality of components and at least one unclosed joint gap.
摘要翻译: 用于制造适于制造半导体的硅的坩埚包括多个部件和至少一个未闭合的接头间隙。
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公开(公告)号:US20110207699A1
公开(公告)日:2011-08-25
申请号:US12964027
申请日:2010-12-09
申请人: David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Todd N. Soltwedel , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Clarence J. Maring , Michael D. Tufano , David A. Betebenner , Todd W. Rockway , Dachun Liu , John K. Pratt , Michael J. Lavin , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
发明人: David A. DeGoey , Warren M. Kati , Charles W. Hutchins , Pamela L. Donner , Allan C. Krueger , John T. Randolph , Christopher E. Motter , Lissa T. Nelson , Sachin V. Patel , Mark A. Matulenko , Ryan G. Keddy , Tammie K. Jinkerson , Todd N. Soltwedel , Douglas K. Hutchinson , Charles A. Flentge , Rolf Wagner , Clarence J. Maring , Michael D. Tufano , David A. Betebenner , Todd W. Rockway , Dachun Liu , John K. Pratt , Michael J. Lavin , Kathy Sarris , Kevin R. Woller , Seble H. Wagaw , Jean C. Califano , Wenke Li , Daniel D. Caspi , Mary E. Bellizzi , William A. Carroll
IPC分类号: A61K31/695 , C07D401/14 , A61K31/454 , C07F5/02 , A61K31/69 , C07D401/10 , C07D403/14 , A61K31/4178 , A61K31/496 , A61K31/506 , C07D413/14 , A61K31/5377 , A61K31/397 , C07F7/10 , A61P31/18
CPC分类号: C07F9/65583 , C07C33/26 , C07C201/06 , C07C205/19 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/14 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D453/00 , C07D471/04 , C07D491/113 , C07K5/06
摘要: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) are described. This invention also relates to processes of making such compounds, compositions comprising such compounds, and methods of using such compounds to treat HCV infection.
摘要翻译: 描述了有效抑制丙型肝炎病毒(“HCV”)复制的化合物。 本发明还涉及制备这种化合物的方法,包含这些化合物的组合物,以及使用这些化合物治疗HCV感染的方法。
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公开(公告)号:US07951800B2
公开(公告)日:2011-05-31
申请号:US12613607
申请日:2009-11-06
IPC分类号: C07D498/02 , C07D417/04 , A61K31/549
CPC分类号: C07D495/04
摘要: The present invention provides HCV polymerase inhibiting compounds having the formula (I): where R1 is cyclobutyl-N(Ra)—, n is 1, 2, 3 or 4, and at least one R5 is RaSO2N(Rj)alkyl-. In a non-limiting example, a compound of the present invention is N-[(3-{1-[(cyclobutyl)amino]-4-hydroxy-2-oxo-1,2-dihydro-quinolin-3-yl}-1,1-dioxo-1,4-dihydro-1λ6-thieno[2,3-e][1,2,4]thiadiazin-7-yl)methyl]methanesulfonamide. The present invention also features compositions comprising the compounds of the present invention or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, and methods of using the same to treat or prevent HCV infection.
摘要翻译: 本发明提供了具有式(I)的HCV聚合酶抑制化合物:其中R1是环丁基-N(Ra) - ,n是1,2,3或4,并且至少一个R5是RaSO2N(Rj)烷基 - 。 在非限制性实例中,本发明的化合物是N - [(3- {1 - [(环丁基)氨基] -4-羟基-2-氧代-1,2-二氢 - 喹啉-3-基} -1,1-二氧代-1,4-二氢-1λ6-噻吩并[2,3-e] [1,2,4]噻二嗪-7-基)甲基]甲磺酰胺。 本发明还特征在于包含本发明化合物或其药学上可接受的盐,立体异构体或互变异构体的组合物及其用于治疗或预防HCV感染的方法。
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公开(公告)号:US07737159B2
公开(公告)日:2010-06-15
申请号:US11675160
申请日:2007-02-15
申请人: David D. Anderson , Bruce A. Beutel , Curt S. Cooper , Yu-Gui Gu , Mira M. Hinman , Douglas M. Kalvin , Robert F. Keyes , Xenia B. Searle , Rolf Wagner
发明人: David D. Anderson , Bruce A. Beutel , Curt S. Cooper , Yu-Gui Gu , Mira M. Hinman , Douglas M. Kalvin , Robert F. Keyes , Xenia B. Searle , Rolf Wagner
IPC分类号: A61K31/44 , C07D515/02
CPC分类号: C07D513/04 , C07D207/12 , C07D207/16 , C07D239/48 , C07D277/36 , C07D471/04
摘要: Bacterial protein synthesis-inhibiting compounds having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates in the processes, compositions containing the compounds, and methods of using the compounds are disclosed.
摘要翻译: 公开了具有式(I)的具有式(I)的细菌蛋白质合成抑制化合物及其前体药物的前体药物,其制备方法,含该化合物的组合物,使用该化合物的方法。
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