公开(公告)号：US11819532B2

公开(公告)日：2023-11-21

申请号：US16389292

申请日：2019-04-19

申请人： Hoffmann-La Roche Inc.

发明人： Konrad Bleicher ,  Daniella Cheang ,  Patrick Di Giorgio ,  Patrizio Mattei ,  Petra Schmitz ,  Theodor Stoll

IPC分类号： A61K38/12 ,  A61P31/04

CPC分类号： A61K38/12 ,  A61P31/04

摘要： The present invention provides compounds of formula (I)






wherein X1, X2, R1 to R6 and A are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by bacteria.

公开(公告)号：US20230365702A1

公开(公告)日：2023-11-16

申请号：US18132486

申请日：2023-04-10

申请人： HOFFMANN-LA ROCHE INC.

发明人： Harald Duerr ,  Sebastian Fenn ,  Ulrich Goepfert ,  Sabine Imhof-Jung ,  Christian Klein ,  Laurent Lariviere ,  Michael Molhoj ,  Joerg Thomas Regula ,  Petra Rueger ,  Wolfgang Schaefer

IPC分类号： C07K16/28 ,  C07K16/18 ,  C07K16/46 ,  A61P25/28

CPC分类号： C07K16/2881 ,  C07K16/18 ,  C07K16/468 ,  A61P25/28 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/55 ,  C07K2317/64 ,  A61K2039/505

摘要： Herein are provided bispecific anti-human A-beta/human transferrin receptor antibodies and methods of using the same.

公开(公告)号：US11814375B2

公开(公告)日：2023-11-14

申请号：US17017200

申请日：2020-09-10

申请人： Hoffmann-La Roche Inc.

发明人： Joerg Benz ,  Luca Gobbi ,  Uwe Grether ,  Katrin Groebke Zbinden ,  Benoit Hornsperger ,  Carsten Kroll ,  Bernd Kuhn ,  Rainer E. Martin ,  Fionn O'Hara ,  Bernd Puellmann ,  Hans Richter ,  Martin Ritter

IPC分类号： C07D413/12 ,  A61K9/20 ,  C07D265/28 ,  A61K9/48

CPC分类号： C07D413/12 ,  A61K9/2009 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  C07D265/28

摘要： The invention provides new heterocyclic compounds having the general formula (I)




wherein A, B, L1, X, m, n, and R1 to R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

公开(公告)号：US20230346641A1

公开(公告)日：2023-11-02

申请号：US18041635

申请日：2021-08-20

申请人： HOFFMANN-LA ROCHE INC.

发明人： Daniel KULLMANN ,  Carmen LEMA MARTINEZ ,  Gregoire SCHWACH ,  Joerg LUEMKEMANN ,  Thomas ZUMSTEIN ,  Pascal Markus HOFER ,  Jonas LUZIO

IPC分类号： A61J1/14 ,  F26B5/06 ,  A61K9/19

CPC分类号： A61J1/1468 ,  F26B5/06 ,  A61K9/19

摘要： A lyophilisate retainer for lyophilizing a substrate is disclosed that includes a three dimensional scaffold body having pores. The pores of the scaffold body are configured to receive and hold the substrate. The scaffold body is made of a scaffold material providing heat transfer properties in lyophilisation to induce heat transfer to the substrate held in the pores of the scaffold body.

公开(公告)号：US20230340134A1

公开(公告)日：2023-10-26

申请号：US18335789

申请日：2023-06-15

申请人： CHUGAI SEIYAKU KABUSHIKI KAISHA ,  HOFFMANN-LA ROCHE INC.

发明人： Toshiyuki MORICHIKA ,  Daisuke KAMEOKA ,  Yoshimi IMAEDA ,  Terutoshi MAEDA ,  Oliver Boris STAUCH

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K47/18 ,  A61K47/26 ,  C07K1/14 ,  A61K47/20

CPC分类号： C07K16/2866 ,  A61K39/39591 ,  A61K47/183 ,  A61K47/26 ,  C07K1/14 ,  A61K39/3955 ,  A61K47/20 ,  A61K9/0019

摘要： The problem to be solved is to provide a humanized anti-IL-6 receptor antibody MRA-containing formulation which is suitable for subcutaneous administration, wherein dimerization or deamidation is prevented during long-term storage. The present application is directed to a stable antibody-containing liquid formulation characterized by containing arginine and histidine buffer. A method of inhibiting deamidation or dimerization of such an antibody in a concentrated liquid formulation includes histidine buffer in the liquid formulation.

公开(公告)号：US20230331796A1

公开(公告)日：2023-10-19

申请号：US17850922

申请日：2022-06-27

申请人： Hoffmann-La Roche Inc.

发明人： Alexander KNAUPP ,  Laurent LARIVIERE ,  Petra RUEGER ,  Tilman SCHLOTHAUER ,  Stefan SEEBER

IPC分类号： C07K14/47 ,  B01D15/38 ,  C07K1/22 ,  C07K16/18

CPC分类号： C07K14/472 ,  B01D15/3809 ,  C07K1/22 ,  C07K16/18 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/00

摘要： Herein is reported a fusion polypeptide according to formula I (TAG-X1-C1qA-X2-C1qB-X3-C1qC-X4), comprising a fragment of SEQ ID NO: 01 (C1qA), a fragment of SEQ ID NO: 03 (C1qB), a fragment of SEQ ID NO: 05 (C1qC) and optionally a tag (TAG).

公开(公告)号：US20230331715A1

公开(公告)日：2023-10-19

申请号：US18319860

申请日：2023-05-18

申请人： Hoffmann-La Roche Inc.

发明人： Xianfeng LIN ,  Jianping WANG ,  Hongying YUN ,  Xiufang ZHENG

IPC分类号： C07D417/12 ,  C07D277/64 ,  C07D513/04 ,  C07F9/6541 ,  A61P31/20

CPC分类号： C07D417/12 ,  A61P31/20 ,  C07D277/64 ,  C07D513/04 ,  C07F9/6541

摘要： The present invention provides novel compounds having the general formula:





wherein R1 to R3 are as described herein, compositions including the compounds and methods of using the compounds.

公开(公告)号：US11788205B2

公开(公告)日：2023-10-17

申请号：US16906931

申请日：2020-06-19

申请人： Hoffmann-La Roche Inc.

发明人： Christian Klein ,  Ekkehard Moessner ,  Lydia Jasmin Hanisch ,  Wei Xu ,  Camille Loise Sophie Delon ,  Diana Darowski ,  Christian Jost ,  Vesna Pulko

IPC分类号： C40B30/04 ,  C40B30/06 ,  C07K16/28 ,  C12N15/10 ,  C12N15/86 ,  G01N33/50 ,  G01N33/574

CPC分类号： C40B30/06 ,  C07K16/2809 ,  C12N15/1037 ,  C12N15/1086 ,  C12N15/86 ,  G01N33/505 ,  G01N33/57492 ,  C07K2317/31 ,  C12N2740/15043

摘要： The present invention generally relates to specificity assays using cell cultures, in particular to chimeric antigen receptor (CAR) expressing reporter T (CAR-T cell) assays to test antigen binding moieties in different formats. Furthermore, the present invention relates to the use of CAR-T cells, transfected/transduced with an engineered chimeric antigen receptor (CAR) comprising a target antigen binding moiety capable of specific binding to a target antigen, e.g., tumor associated antigens.

公开(公告)号：US11787873B2

公开(公告)日：2023-10-17

申请号：US16744697

申请日：2020-01-16

申请人： Hoffmann-La Roche Inc.

发明人： Rebecca Croasdale-Wood ,  Lydia Jasmin Hanisch ,  Guy Georges ,  Thomas Hofer ,  Ralf Hosse ,  Christian Klein ,  Ekkehard Moessner ,  Samuel Moser ,  Wolfgang Schaefer ,  Juergen Michael Schanzer ,  Werner Scheuer ,  Claudio Sustmann ,  Pablo Umana

IPC分类号： C07K16/32 ,  A61K31/713 ,  C12N5/10 ,  C12N15/63 ,  A61K39/00

CPC分类号： C07K16/32 ,  A61K31/713 ,  C12N5/10 ,  C12N15/63 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/66 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention relates to bispecific HER2 antibodies, novel HER2 antibody variants, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.

公开(公告)号：US11787868B2

公开(公告)日：2023-10-17

申请号：US17130477

申请日：2020-12-22

申请人： HOFFMANN-LA ROCHE INC.

发明人： Harald Duerr ,  Sebastian Fenn ,  Ulrich Goepfert ,  Sabine Imhof-Jung ,  Christian Klein ,  Laurent Lariviere ,  Michael Molhoj ,  Joerg Thomas Regula ,  Petra Rueger ,  Wolfgang Schaefer

IPC分类号： C07K16/28 ,  C07K16/18 ,  C07K16/46 ,  A61P25/28 ,  A61K39/00

CPC分类号： C07K16/2881 ,  A61P25/28 ,  C07K16/18 ,  C07K16/468 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/64

摘要： Herein are provided bispecific anti-human A-betalhuman transferrin receptor antibodies and methods of using the same.