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    Carvable dental restorative compositions
    62.
    发明授权
    Carvable dental restorative compositions 失效
    可用牙修复组合物

    公开(公告)号：US4221698A

    公开(公告)日：1980-09-09

    申请号：US906926

    申请日：1978-05-18

    申请人： Henry L. Lee, Jr. ,  Jan A. Orlowski

    发明人： Henry L. Lee, Jr. ,  Jan A. Orlowski

    IPC分类号： A61K6/083 ,  C08K3/34 ,  C08K3/36 ,  C08K3/40

    CPC分类号： A61K6/083 ,  Y10S528/92

    摘要： Dental restorative compositions comprise self-curing systems of monomer containing two or more polymerizable ethylenically unsaturated groups of different respective reactivities, and thus of different curing rates, and other materials such as fillers, inhibitors, curing agents, and the like. The polymerizable groups may be selected from the group consisting of two or more vinyl, allyl, acryl, methacryl, and styryl groups.

    摘要翻译： 牙科修复组合物包含含有两种或更多种不同的反应活性，因此具有不同固化速率的可聚合烯属不饱和基团以及其它材料如填料，抑制剂，固化剂等的单体的自固化体系。 可聚合基团可以选自两个或更多个乙烯基，烯丙基，丙烯酰基，甲基丙烯酰基和苯乙烯基。

    Water extended hydrophilic molding compositions
    64.
    发明授权
    Water extended hydrophilic molding compositions 失效
    水延长亲水性成型组合物

    公开(公告)号：US4088500A

    公开(公告)日：1978-05-09

    申请号：US386984

    申请日：1973-08-09

    申请人： Charles W. Fairbanks ,  John F. Kistner

    发明人： Charles W. Fairbanks ,  John F. Kistner

    IPC分类号： A61K6/087 ,  C08G65/28 ,  C08G65/333 ,  C08L71/02 ,  C09K3/00

    CPC分类号： C08G65/33348 ,  A61K6/087 ,  C08G65/33396 ,  C08L71/02 ,  Y10S528/92

    摘要： Molding compositions useful for molding water-extended hydrophilic articles are provided which are tough, soft and form-stable and comprise, generally, an amide-endcapped hydrophilic alkylene oxide polymer, a crosslinking agent, water, and a filler. The composition is cured by means of an acid catalyst. The compositions are useful in the preparation of denture liners which exhibit excellent adhesion to denture plates and provide structural stability, toughness and softness.

    摘要翻译： 提供了用于模塑具有延伸性的亲水制品的成型组合物，其是坚韧的，柔软的和形态稳定的，并且通常包含酰胺封端的亲水性烯化氧聚合物，交联剂，水和填料。 该组合物通过酸催化剂固化。 该组合物可用于制备义齿衬里，其对义齿板具有优异的粘附性并提供结构稳定性，韧性和柔软性。

    Adhesive cement
    68.
    发明授权
    Adhesive cement 失效
    胶水泥

    公开(公告)号：US3839065A

    公开(公告)日：1974-10-01

    申请号：US71966268

    申请日：1968-04-08

    申请人： JOHNSON & JOHNSON

    发明人： OVERHULTS W ,  MC CREA POTTS R

    IPC分类号： C08K9/04 ,  A61C5/00 ,  A61K6/00 ,  A61K6/083 ,  C03C27/04 ,  C04B20/12 ,  C04B26/06 ,  C09C1/30 ,  C09C1/40 ,  C09C3/00 ,  C09J4/00 ,  C09J4/04 ,  C09C1/28

    CPC分类号： C04B20/12 ,  A61C5/00 ,  A61K6/0088 ,  C01P2004/61 ,  C01P2004/80 ,  C03C27/048 ,  C04B26/06 ,  C09C1/309 ,  C09C1/407 ,  C09C3/006 ,  C09J4/00 ,  Y10S528/92 ,  C08F222/00 ,  A61K6/0023 ,  C08L35/04 ,  C08L43/04

    摘要： where any of R, R1 or R2 may be a methyl or a ethyl group. When the filler is so treated, the effectiveness of the amine activator is found to remain constant indefinitely. Alumina, when used together with monomeric Alpha -cyanoacrylate in preparing adhesive cement compositions, appears to act substantially differently from other fillers. Thus, not only does it show substantially more effect on the amine activator, when not pretreated, but cements prepared utilizing the alumina possess substantially greater adhesive strength than cements made from other finely divided fillers utilizing the same monomeric Alpha -cyanoacrylate binder. Also cured cements so prepared have substantially greater compressive strength where finely divided alumina is the filler as compared, for example, with cements utilizing finely divided quartz. A further unexpected property possessed by the adhesive cements, utilizing alumina, is their tenacious adherence (to tooth structure) over long periods after application, permitting their use for the treatment of teeth in the prevention of caries by sealing pits, cracks, fissures, and the like, and their use in preparing dental restorations. The usefulness of these cements in dental applications is an important part of the present invention. Methyl- Alpha -cyanoacrylate hAs heretofore been proposed for the treatment of pits, cracks and fissures, the same being used in a mixture of one part methyl- Alpha -cyanoacrylate to which one part of a composition comprising equal parts of silicic acid, finished silicate, silica gel, and cold curing methyl methacrylate polymer has been added. Such a composition and method of use is described in an article by Dr. Buonocore (The Journal of American Dentistry Association, July 1967, Vol. 75, pgs. 121-128). Methyl- Alpha -cyanoacrylate, however, has the disadvantage that polymers formed therefrom tend to hydrolyze and deteriorate in the presence of moisture. Also, methyl- Alpha cyanoacrylate is somewhat irritating to living tissue, as are the deterioration products of polymers formed of the same. The monomeric alkyl Alpha -cyanoacrylates of alkyl groups above methyl are found to be substantially less irritating to living tissue than the methyl- Alpha -cyanoacrylate. Also, when polymerized they form polymers which are substantially more resistant to deterioration in the presence of moisture than are the polymers resulting from the polymerization of methyl- Alpha cyanoacrylate. However, when attempts are made to use monomeric alkyl Alpha -cyanoacrylate monomers of larger alkyl groups in place of the methyl- Alpha -cyanoacrylate in the system described in the Buonocore article, difficulty is encountered in obtaining polymerization. Thus, for example, when isobutyl Alpha cyanoacrylate is used in place of the methyl- Alpha cyanoacrylate in the system described in the Buonocore article, polymerization cannot be obtained in less than about an hour. This is too long for dental application. However, through the practice of the present invention, particularly where utilizing alumina as the filler, not only can cements be prepared which have the necessary tooth adherence and strength for effective treatment, but the same are prepared from monomers free of the problems inherent in the methyl- Alpha -cyanoacrylate. In preparing the adhesive cements the pretreated filler containing the amine activator is blended with the monomeric Alpha -cyanoacrylate binder in amounts of about one part binder to one to four parts filler. The admixed amine activated filler and binder form a fluid paste which is then applied to the surfaces to be bonded. The time of setting after mixing of the filler and monomeric binder solution is controlled by the amount of amine activator on the binder. With most amine activators shortly after admixing the monomeric Alpha -cyanoacrylate with the pretreated filler, the composition so formed tends to slowly increase in viscosity until the same has finally set into a hard cementitious mass. With the amine activators N,N-dimethyl-paratoluidine and N,N-dimethylaniline, the mix of pretreated filler and monomeric Alpha cyanoacrylate maintain its initial fluidity until just prior to its setting time at which a rapid set occurs into a hard cementitious mass. The adhesive cements, on mixing the amine activated filler and monomeric Alpha -cyanoacrylate, have a relatively thin fluid consistency and will wet most surfaces to which they are applied, adhering strongly to these surfaces on polymerization of the monomeric Alpha -cyanoacrylate binder. Although the adhesive cements are not tacky in the normal sense, it is found that on setting they have adhered strongly to the surfaces to which they have been applied. As previously indicated, the setting time can be varied from a fraction of a minute to as long as is desired by proper treatment of the filler. As a filler, any finely divided solid may be utilized that is substantially inert with respect to the monomeric Alpha cyanoacrylate binders. Thus, one may use inorganic fillers such as fused silica, quartz, aluminum oxide, and the like, or organic fillers such as finely divided polyethylene or other organic polymer which is insoluble in monomeric esters of Alpha cyanoacrylic acid and inert Thereto. The particle size of the
    WHERE R may be any of the terminal groups consisting of an alkyl group one to 16 carbons, a cyclohexyl group and a phenyl group. Such polymerizable monomer adhesives are described, for example, in U.S. Pat. No. 2,794,788. Although the methyl- Alpha cyanoacrylate has been used as an all-purpose adhesive, bonding to most surfaces and curing in a relatively short time under normal atmospheric conditions, this is not necessarily true with respect to the other monomeric Alpha -cyanoacrylates. Thus, for example, the monomeric alkyl Alpha -cyanoacrylates with alkyl groups of ethyl and higher are generally unsatisfactory because of the long curiNg time and relatively poor adherence to some surfaces. This is illustrated, for example, by monomeric isobutyl Alpha -cyanoacrylate which adheres relatively poorly to many surfaces such as stainless steel, glass, and rubber. It has now been discovered that cement compositions can be prepared utilizing the monomeric Alpha -cyanoacrylates, which cements possess substantially better adherence on curing to surfaces then shown by the monomeric Alpha -cyanoacrylates employed in making the same. These adhesive cement compositions are prepared by admixing the monomeric Alpha -cyanoacrylate with a finely divided, activated, solid filler in amounts of about one to four parts by weight finely divided, activated filler for each part by weight of the monomeric Alpha -cyanoacrylate used. As previously indicated, the cement compositions so formed will adhere to a wide variety of surfaces substantially more tenaciously than the monomeric Alpha -cyanoacrylate used in their preparation and will also adhere to moist or wet surfaces, where the wetness is due to water. The activator used is an amine catalyst. The activator cannot be added to a mix of monomeric Alpha -cyanoacrylate and the filler as the cyanoacrylate polymerizes too rapidly when the amine activator is added to the cyanoacrylate-filler mix. Accordingly, the amine activator must first be added to the finely divided filler and the filler so treated then blended with the binder solution which comprises the monomeric Alpha -cyanoacrylate. With fillers such as quartz and alumina, the effectiveness of the amine catalyst, after treatment of the filler, is dissipated relatively rapidly. As a result, the amine treated filler, unless blended with the monomeric Alpha -cyanoacrylate shortly after preparation, will give varying and inconsistent setting times for the cement so obtained, with essentially no activation occurring after extended periods of storage. This is particularly true where alumina is used as the filler. When alumina is used as the filler the effectiveness of the amine activator is decreased even after standing for 1 hour, the sme becoming substantially ineffective after standing for 24 hours. With other fillers such, for example, as finely divided polyethylene, this loss of activity on the part of the amine activator does not occur. It has been further discovered that this loss of activity on the part of the amine activator can be prevented, and stable activated fillers obtained, if the filler, prior to treatment with the amine activator, is first treated with a non-catalytic trialkoxysilyl compound having a terminal group represented by the formula


    WHERE ANY ONE OF R, R1, and R2 may be -CH3 or -CH2CH3. The adhesive cements are particularly useful under moist or wet conditions because of their resistance to deterioration under such conditions and their ability to adhere to moist or wet surfaces. It is possible to apply the cements to surfaces while under water and bond the same together. Alumina is the preferred filler, appearing to possess unique properties. Alumina, as compared to other fillers, gives cements having both better adhesion and strength. Cements, particularly those utilizing finely divided alumina as the filling together with the monomeric alkyl Alpha cyanoacrylate, show good adherence to tooth structure and are useful for the treatment of teeth both for filling pits, cracks, fissures and the like in the prevention of caries and in preparing dental restorations. The present invention is drawn to cement compositions which, on curing, adhere tenaciously to surfaces to which they have been applied. The cement compositions adhere not only to dry surfaces but also to surfaces which have been wetted with water and, in fact, may be applied to such surfaces under water for bonding objects together. It has heretofore been proposed to use as adhesives the monomeric esters of alpha cyanoacrylic acid having the general formula:

    Adhesive cements, which on curing will adhere to dry as well as wet surfaces, are prepared by mixing a monomeric ester of Alpha -cyanoacrylic acid with a finely divided filler containing an amine activator. The preferred activators are the tertiary amines N,N-dimethyl-p-toluidine and N,N-dimethylaniline as time delayed but rapid setting is obtained through their use. With fillers such as finely divided quartz and alumina the effectiveness of the activator is substantially reduced on standing. To obtain a stable activated filler the filler is treated with a noncatalytic trialkoxysilyl compound prior to treatment with the amine activator. The non-catalytic trialkoxysilyl compound has a terminal group represented by the formula

    摘要翻译： 通过将α-氰基丙烯酸的单体酯与含有胺活化剂的细碎填料混合来制备固化时粘附于干燥和湿润表面的粘合剂粘合剂。 优选的活化剂是叔胺N，N-二甲基对甲苯胺和N，N-二甲基苯胺，因为它们的使用是快速固化的。 使用诸如精细分散的石英和氧化铝的填料，活化剂的有效性在静置时显着降低。 为了获得稳定的活性填料，在用胺活化剂处理之前，用非催化三烷氧基甲硅烷基化合物处理填料。 非催化性三烷氧基甲硅烷基化合物具有式R 1，R 2和R 2可以是-CH 3或-CH 2 CH 3的式。