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    Glycidol functionalized anion exchange stationary phases
    66.
    发明授权
    Glycidol functionalized anion exchange stationary phases 有权
    Glycidol官能化阴离子交换固定相

    公开(公告)号：US09486799B2

    公开(公告)日：2016-11-08

    申请号：US13610495

    申请日：2012-09-11

    Applicant: Christopher A. Pohl

    Inventor： Christopher A. Pohl

    IPC: B01J41/08 ,  B01J20/32 ,  B01J41/20 ,  B01D15/36 ,  B01J20/288

    CPC classification number: B01J41/20 ,  B01D15/363 ,  B01J20/288 ,  B01J20/3251 ,  B01J20/3289 ,  B01J41/09

    Abstract: Treatment of anion exchange materials containing hydroxyl containing moieties in the beta position relative to the quaternary center in the hydroxide form with glycidol substantially alters the selectivity of the anion exchange material. Furthermore, sequential treatments of first a hydroxide containing solution to put the anion exchange material in the hydroxide form followed by treatment with glycidol in an alternating sequence progressively changes selectivity in a predictable manner allowing facile manipulation of selectivity. Unique to the selectivities achievable with this chemistry is the ability to reverse the elution order of sulfate and carbonate. With all other known systems, carbonate elutes ahead of sulfate and sometimes compromises the ability to quantitate sulfate. With glycidol treatment, carbonate can be moved after sulfate which eliminates interference issues for samples containing significantly more carbonate than sulfate. This modification is useful for columns operated with a hydroxide or carbonate eluent system.

    Abstract translation: 含有羟基的阴离子交换材料相对于具有缩水甘油的氢氧化物形式的季中心的β位置的处理基本上改变了阴离子交换材料的选择性。 此外，首先连续处理含氢氧化物溶液以将阴离子交换材料置于氢氧化物形式，然后以交替的顺序用缩水甘油处理，以可预测的方式逐渐改变选择性，从而容易地操纵选择性。 通过该化学可以实现的选择性独特的是反转硫酸盐和碳酸盐的洗脱顺序的能力。 使用所有其他已知的系统，碳酸盐在硫酸盐之前洗脱，有时会损害硫酸盐的定量能力。 通过缩水甘油处理，碳酸盐可以在硫酸盐之后移动，消除了含有比硫酸盐显着更多的碳酸盐的样品的干扰问题。 该修饰对于用氢氧化物或碳酸盐洗脱液系统操作的柱是有用的。

    Preparation of cobaltocenium-containing monomers and their polymers
    67.
    发明授权
    Preparation of cobaltocenium-containing monomers and their polymers 有权
    制备含有乙烯基酮的单体及其聚合物

    公开(公告)号：US08592539B2

    公开(公告)日：2013-11-26

    申请号：US13209759

    申请日：2011-08-15

    Applicant: Chuanbing Tang ,  Lixia Ren

    Inventor： Chuanbing Tang ,  Lixia Ren

    IPC: C08F30/04 ,  C07F17/02 ,  C08F297/00 ,  B01J41/08 ,  H01M4/60

    CPC classification number: C07F17/02 ,  C08F230/04

    Abstract: Methods of forming a cobaltocenium-containing polymer are provided through polymerizing a plurality of cobaltocenium-containing monomers via controlled radical polymerization or controlled ring-opening polymerization. Each cobaltocenium-containing monomer comprises a cobaltocenium moiety covalently connected to a polymerizable group. Cobaltocenium-containing monomers are also provided that include a cobaltocenium moiety covalently connected to a polymerizable group. Cobaltocenium-containing polymers are also generally provided, such as the polymers formed according to any of the methods or from any of the monomers discussed herein. Methods are also generally provided for exchanging an anion associated with a cobaltocenium side group of a cobaltocenium-containing polymer with a new anion.

    Abstract translation: 通过经由受控的自由基聚合或受控的开环聚合使多种含有含钴的单体聚合来提供形成含有共轭二烯的聚合物的方法。 每个含有共轭二烯的单体包括与可聚合基团共价连接的共轭连接部分。 还提供了含有钴酸盐的单体，其包括与可聚合基团共价连接的共元醇部分。 还通常提供含钴基聚合物，例如根据任何方法或本文所讨论的任何单体形成的聚合物。 通常还提供了用于与含有新型阴离子的含有共轭二烯的聚合物的邻苯二酚侧基相关的阴离子交换的方法。

    NUCLEIC ACID PURIFICATION METHOD
    70.
    发明申请
    NUCLEIC ACID PURIFICATION METHOD 有权
    核酸纯化方法

    公开(公告)号：US20120245337A1

    公开(公告)日：2012-09-27

    申请号：US13141885

    申请日：2009-12-23

    Applicant: Roland Fabis ,  Jan Petzel ,  Sabine Scheltinga

    Inventor： Roland Fabis ,  Jan Petzel ,  Sabine Scheltinga

    IPC: C07H1/06 ,  B01J41/08

    CPC classification number: C12N15/101

    Abstract: The present intimation relates to a method for purifying nucleic acids from a sample containing nucleic acids, the method comprising at least the following steps: a. bringing the sample containing nucleic acids into contact with a nucleic acid binding phase comprising protonatable groups, wherein the protonatable groups have a pKa value of 9 to 12; b. binding the nucleic acids to the nucleic acid phase at a pH (binding pH) that is at least one pH unit less than the pKa value of at least one of the protonatable groups; c. eluting the nucleic acids at a pH greater than the binding pH but at least one pH unit less than the pKa value of at least one of the protonatable groups. Also disclosed are corresponding kits and nucleic acid binding phases that can be used for purifying nucleic acids.

    Abstract translation: 本发明涉及从含有核酸的样品中纯化核酸的方法，所述方法至少包括以下步骤：a。 使含有核酸的样品与包含可质子基团的核酸结合相接触，其中可质子化基团的pKa值为9至12; b。 在至少一个pH值单位小于至少一个可质子化基团的pKa值的pH（结合pH）下将核酸结合到核酸相上; C。 在大于结合pH的pH下洗脱核酸，但是至少一个pH单位小于至少一个可质子化基团的pKa值。 还公开了可用于纯化核酸的相应试剂盒和核酸结合相。

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