公开(公告)号：US10899691B2

公开(公告)日：2021-01-26

申请号：US16575587

申请日：2019-09-19

申请人： NEONC Technologies, Inc.

发明人： Thomas Chen ,  Daniel Levin ,  Satish Puppalli

IPC分类号： C07C29/92 ,  C07C67/14 ,  C07C201/12 ,  A61K31/045 ,  C07C29/78 ,  C07C29/88 ,  C07C201/16 ,  A61K31/4188 ,  A61K45/06 ,  A61N5/10 ,  C07C29/86

摘要： The present invention provides a process for purifying a monoterpene or sesquiterpene having a purity greater than about 98.5% (w/w). The process comprises the steps of derivatizing the monoterpene (or sesquiterpene) to produce a monoterpene (or sesquiterpene) derivative, separating the monoterpene (or sesquiterpene) derivative, and releasing the monoterpene (or sesquiterpene) from the derivative. Also encompassed by the scope of the present invention is a pharmaceutical composition comprising a monoterpene (or sesquiterpene) having a purity greater than about 98.5% (w/w). The purified monoterpene can be used to treat a disease such as cancer. The present monoterpene (or sesquiterpene) may be administered alone, or may be co-administered with radiation or other therapeutic agents, such as chemotherapeutic agents.

公开(公告)号：US10463987B2

公开(公告)日：2019-11-05

申请号：US16342269

申请日：2017-10-13

申请人： IFP Energies Nouvelles ,  Compagnie Generale des Etablissements Michelin

发明人： Celine Hognon ,  Sophie Drozdz ,  Marc Jacquin ,  Damien Leinekugel Le Cocq ,  Frederic Augier

IPC分类号： C07C29/00 ,  C07C45/80 ,  B01D11/00 ,  B01D11/04 ,  C07C29/88

摘要： The invention relates to a process for purifying an aqueous solution comprising ethanol, acetaldehyde and diethylacetal comprising: a step A) of countercurrent liquid-liquid extraction comprising an extraction section supplied at the top by said aqueous solution as a mixture with at least one fraction of the water/ethanol/acetaldehyde raffinate resulting from the back extraction step B), and at the bottom by an extraction solvent, and producing an extract at the top and a purified feedstock at the bottom; —a step B) of countercurrent liquid-liquid back extraction comprising a back extraction section supplied at the top by an acidic aqueous solution, the pH of which is between 0.5 and 5, and at the bottom by the extract resulting from step A), and producing an extract at the top and a water/ethanol/acetaldehyde raffinate at the bottom.

公开(公告)号：US20190233356A1

公开(公告)日：2019-08-01

申请号：US16380023

申请日：2019-04-10

申请人： Cameron Solutions, Inc.

发明人： Brian E. Messenger

IPC分类号： C07C29/88 ,  C07C29/76 ,  B01D3/00 ,  C07C29/78 ,  C07C29/50 ,  C10L3/10

CPC分类号： C07C29/88 ,  B01D3/009 ,  C07C29/50 ,  C07C29/76 ,  C07C29/78 ,  C10L3/107 ,  C10L2290/12 ,  C10L2290/54 ,  C07C31/202

摘要： A system and method for removing organic carboxylates from a mono ethylene glycol (“MEG”) stream includes a reaction vessel; means for cooling and diluting the MEG stream being routed to the reaction vessel; means for acidifying the cooled and diluted MEG stream during its residence time within the reaction vessel; and means for removing an acetic-rich overhead stream from the reaction vessel. The acidification of the cooled and diluted MEG stream occurs under a vacuum. The reaction vessel may be located downstream of a calcium removal vessel and receive a filtered bottom stream from that vessel, or it may be a single reaction vessel that cycles between a calcium removal mode and an acetate removal mode, with the pressure of the single vessel being greater during the calcium removal mode than during the acetate removal mode.

公开(公告)号：US10005708B2

公开(公告)日：2018-06-26

申请号：US15044752

申请日：2016-02-16

申请人： Cameron Solutions, Inc.

发明人： Brian E. Messenger

IPC分类号： C07C29/88 ,  B01D3/00 ,  C07C29/50 ,  C10L3/10 ,  C07C29/76 ,  C07C29/78

CPC分类号： C07C29/88 ,  B01D3/009 ,  C07C29/50 ,  C07C29/76 ,  C07C29/78 ,  C10L3/107 ,  C10L2290/12 ,  C10L2290/54 ,  C07C31/202

摘要： A system and method for removing organic carboxylates from a mono ethylene glycol (“MEG”) stream includes a reaction vessel; means for cooling and diluting the MEG stream being routed to the reaction vessel; means for acidifying the cooled and diluted MEG stream during its residence time within the reaction vessel; and means for removing an acetic-rich overhead stream from the reaction vessel. The acidification of the cooled and diluted MEG stream occurs under a vacuum. The reaction vessel may be located downstream of a calcium removal vessel and receive a filtered bottom stream from that vessel, or it may be a single reaction vessel that cycles between a calcium removal mode and an acetate removal mode, with the pressure of the single vessel being greater during the calcium removal mode than during the acetate removal mode.

公开(公告)号：US09926248B2

公开(公告)日：2018-03-27

申请号：US14902247

申请日：2014-06-25

申请人： BASF SE

发明人： Joaquim Henrique Teles ,  Joachim Simon ,  Martine Dehn ,  Manuel Danz ,  Richard Dehn

IPC分类号： C07C29/16 ,  C07C29/88 ,  C07C29/09

CPC分类号： C07C29/16 ,  C07C29/095 ,  C07C29/88 ,  C07C31/125

摘要： The invention relates to a method for producing 2,3,5-trimethyl benzoquinone or a compound containing 2,3,5-trimethyl benzoquinone, the method comprising the following steps: Oxidation of 2,3,6-trimethylphenol with oxygen or an oxygen-containing gas in a two- or multi-phase reaction medium in the presence of a catalyst or catalyst system containing at least one copper (II)-halide to a mixture containing 2,3,5-trimethyl benzoquinone, characterized in that the reaction medium contains water and at least one secondary aliphatic acyclic alcohol having 6 or more, preferably 7 or more, carbon atoms.

公开(公告)号：US09630894B2

公开(公告)日：2017-04-25

申请号：US14426009

申请日：2013-09-05

申请人： DYNASEP INC. ,  PHASEX CORPORATION

发明人： Hans Schonemann ,  Brian Waibel ,  Val Krukonis

IPC分类号： C07C29/86 ,  C07C29/80 ,  C07C7/10 ,  C07D307/48 ,  C07D307/36 ,  C07C45/48 ,  C07C27/34 ,  C07C29/88

CPC分类号： C07C7/10 ,  C07C27/34 ,  C07C29/80 ,  C07C29/86 ,  C07C29/88 ,  C07C45/48 ,  C07D307/36 ,  C07D307/48 ,  C07C31/08 ,  C07C31/12 ,  C07C49/08 ,  C07C31/125 ,  C07C33/025 ,  C07C31/207

摘要： The present invention relates to the energy efficient and selective extraction of dilute concentrations of biomolecules, e.g., small organic compounds, e.g., one or more C2-C6 alcohols, one or more C3-C5 carboxylic acids, one or more C8-18 fatty alcohols, one or more C1-C18 dicarboxylic acids, one or more furfurals, one or more furans, one or more butanediols, one or more butadienes, and mixtures thereof, from an aqueous solution using liquid phase dimethyl ether (DME).

公开(公告)号：US09533930B2

公开(公告)日：2017-01-03

申请号：US14613877

申请日：2015-02-04

申请人： ARCHER DANIELS MIDLAND COMPANY

发明人： Kevin J. Adlaf ,  Paul D. Bloom ,  William Chris Hoffman ,  Chicheng Ma ,  John G. Soper ,  Brad Zenthoefer

IPC分类号： C07C29/80 ,  C07B63/00 ,  C07C29/88 ,  C07C31/20 ,  B01D3/14 ,  C07C29/76 ,  B01D3/34 ,  B01D15/36 ,  C07C29/60

CPC分类号： C07C29/80 ,  B01D3/143 ,  B01D3/34 ,  B01D15/362 ,  C07B63/00 ,  C07C29/60 ,  C07C29/76 ,  C07C29/88 ,  C07C31/20 ,  C07C31/202 ,  C07C31/205

摘要： In the process of distilling a polyol product mixture including one or both of a biobased propylene glycol and a biobased ethylene glycol from the reaction of hydrogen with a biobased feed, it has been discovered that undesirable epoxides can form, and the present invention provides means for guarding against their formation, for removing epoxides which do form by particular methods of distilling, and for removing the epoxides from a finished, otherwise commercially acceptable biobased glycol product.

摘要翻译： 在从氢与生物基进料的反应中蒸馏包含生物基丙二醇和生物基乙二醇中的一种或两种的多元醇产物混合物的过程中，已经发现可以形成不期望的环氧化物，并且本发明提供了用于 防止其形成，用于去除通过特定蒸馏方法形成的环氧化物，以及从成品的商业上可接受的生物基二醇产物中除去环氧化物。

公开(公告)号：US09199900B2

公开(公告)日：2015-12-01

申请号：US13866119

申请日：2013-04-19

申请人： Symrise AG

发明人： Jürgen Siewert ,  Burghard Wilkening

IPC分类号： C07C29/56 ,  C07C33/02 ,  C07C29/88 ,  C07C33/14

CPC分类号： C07C29/56 ,  C07C29/88 ,  C07C33/14 ,  C07C33/02

摘要： A method for converting farnesol to nerolidol in the presence of alpha-bisabolol including providing or preparing a mixture of alpha-bisabolol, farnesol, and one or more catalysts for selective isomerization of farnesol to nerolidol in the presence of alpha-bisabolol, and converting at least a portion of the farnesol to nerolidol.

摘要翻译： 一种在α-红没药醇存在下将法呢醇转化为橙花叔醇的方法，包括提供或制备α-红没药醇，法呢醇和一种或多种催化剂的混合物，用于在α-红嘌呤的存在下将法呢醇选择性异构化为橙花叔醇， 法尼醇至橙花叔醇的至少一部分。

公开(公告)号：US09133086B2

公开(公告)日：2015-09-15

申请号：US14176789

申请日：2014-02-10

申请人： Cameron Solutions, Inc.

发明人： Bryan A. Bussell ,  Simon Crawley-Boevey ,  Ankur D. Jariwala

IPC分类号： C07C29/76 ,  C07C29/88 ,  B01D63/00 ,  B01J14/00

CPC分类号： C07C29/76 ,  B01D9/0059 ,  B01D61/145 ,  B01D61/16 ,  B01D63/16 ,  B01D65/02 ,  B01D2311/04 ,  B01D2311/08 ,  B01D2311/12 ,  B01D2311/22 ,  B01D2311/2642 ,  B01D2315/02 ,  B01D2315/04 ,  B01D2315/10 ,  B01D2321/02 ,  B01D2321/04 ,  B01D2321/10 ,  B01D2321/2058 ,  B01J14/00 ,  B01J19/24 ,  B01J2219/24 ,  C07C29/88 ,  C07C31/202 ,  C10L3/107 ,  C10L2290/547 ,  C10L2290/548

摘要： A system and process for removing divalent ions from a MEG feed stream is presented. The system includes a chemical treatment tank where chemicals are mixed with the feed stream to form insoluble carbonate and hydroxide salts. The system also includes a membrane-type solid-liquid separation unit that receives the feed stream from the chemical treatment tank and separates it into a filtrate containing MEG and a retentate containing the insoluble salts. The system may also include washing the retentate to remove additional MEG, which is then recycled to a MEG regeneration or reclamation process. The system may also include a dryer that receives waste slurry from the solid-liquid separation unit and dries it to form a solid waste, thereby facilitating its handling, storage, and disposal.

摘要翻译： 提出了从MEG进料流中除去二价离子的系统和方法。 该系统包括化学处理槽，其中化学品与进料流混合以形成不溶性碳酸盐和氢氧化物盐。 该系统还包括膜式固液分离单元，其接收来自化学处理槽的进料流并将其分离成含有MEG的滤液和含有不溶性盐的渗余物。 该系统还可以包括洗涤滞留物以除去附加的MEG，然后将其再循环到MEG再生或回收过程中。 该系统还可以包括干燥器，其接收来自固液分离单元的废料浆并将其干燥以形成固体废物，从而便于其处理，储存和处理。

公开(公告)号：US09000233B2

公开(公告)日：2015-04-07

申请号：US13456583

申请日：2012-04-26

申请人： David Lee ,  Adam Orosco ,  Claudio Ribeiro ,  R. Jay Warner ,  Robert Alan Deck ,  Emily Duff ,  Victor J. Johnston

发明人： David Lee ,  Adam Orosco ,  Claudio Ribeiro ,  R. Jay Warner ,  Robert Alan Deck ,  Emily Duff ,  Victor J. Johnston

IPC分类号： C07C29/149 ,  C07C29/88 ,  C07C29/80 ,  C07C67/08 ,  C07C67/54

CPC分类号： C07C29/88 ,  C07C29/149 ,  C07C29/80 ,  C07C67/08 ,  C07C67/54 ,  C07C31/08 ,  C07C69/14

摘要： A process for recovering ethanol obtained from the hydrogenation of acetic acid. The crude ethanol product is separated in a column to produce a distillate stream comprising acetaldehyde and ethyl acetate and a residue stream comprising ethanol, acetic acid and water. Acetal byproduct can be reduced or removed through configurations of hydrolysis secondary reactors. The ethanol product is recovered from the residue stream.

摘要翻译： 一种从乙酸氢化中回收乙醇的方法。 将粗乙醇产物在柱中分离以产生包含乙醛和乙酸乙酯的馏出物流和包含乙醇，乙酸和水的残余物流。 可以通过水解次级反应器的构型减少或除去乙缩醛副产物。 从残余物流中回收乙醇产物。