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公开(公告)号：US20240079224A1
公开(公告)日：2024-03-07
申请号：US18203356
申请日：2023-05-30
申请人： SHIMADZU CORPORATION
CPC分类号： H01J49/063 , H01J49/005 , H01J49/4215
摘要： An ion transport optical system includes N rod electrodes forming an N-pole arrangement externally tangent to a circle of diameter A1 at an ion-entrance end, where N is an even number not smaller than six. Four electrodes form a quadrupole arrangement externally tangent to a circle of diameter A2 at an ion-exit end, where A2
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公开(公告)号：US20240079223A1
公开(公告)日：2024-03-07
申请号：US18468380
申请日：2023-09-15
CPC分类号： H01J49/0495 , G01N30/7206 , G01N30/7233 , H01J49/0009 , H01J49/165
摘要： Exemplary embodiments may deploy a valve that introduces a sample of a calibrant coaxially with flow exiting a source of a mobile phase flow, such as a liquid chromatography (LC) column, on a path to an ion source for the mass spectrometer (MS). The valve may be positioned remotely on a branch that has a junction with the path leading form the source of the mobile phase flow to the ion source. Alternatively, the valve may be positioned in line on the flow path from the source of the mobile phase flow to the ion source of the MS. A novel five port valve design may be employed. With this valve design, a first position of the valve allows a sample loop for the calibrant to be filled. In a second position, the calibrant is added coaxially to the flow from the source of the mobile phase to the MS. In a third position of the valve, diversion of or infusion to a post-source flow is enabled.
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63.发明授权公开(公告)号：US11923184B2
公开(公告)日：2024-03-05
申请号：US17644073
申请日：2021-12-13
申请人： Plasmion GmbH
发明人： Jan-Christoph Wolf
CPC分类号： H01J49/105 , H01J27/02 , H01J37/08 , H01J37/32348 , H01J49/0031
摘要： The present invention discloses an ionization apparatus 10 for ionizing an analyte S, comprising an inlet E, an outlet A, a first electrode 1, a second electrode 2 and a dielectric element 3. The first electrode 1, the second electrode 2 and the dielectric element 3 are arranged relative to one another such that, by applying an electric voltage between the first electrode 1 and the second electrode 2, a dielectric barrier discharge is establishable in a discharge area 5 in the ionization apparatus 10. The first and second electrodes 1, 2 are arranged such that they are displaceable or movable relative to each other.
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公开(公告)号：US11915919B2
公开(公告)日：2024-02-27
申请号：US17600353
申请日：2019-05-27
申请人： SHIMADZU CORPORATION
发明人： Tomoya Kudo
CPC分类号： H01J49/045 , G01N30/7266 , H01J49/0009
摘要： A first spray unit (201) sprays a first sample into a first space (20) while charging the first sample. A second spray unit (202) sprays a second sample into the first space (20) or a second space (21) communicating with the first space (20) while charging the second sample. A determination unit (62) determines whether or not the second sample is sprayed from the second spray unit (202). A gas supply unit (74) supplies gas into the first space (20). A control unit (63) controls supply of the gas from the gas supply unit (74). In a case where the determination unit (62) determines that the second sample is sprayed from the second spray unit (202), the control unit (63) starts the supply of the gas from the gas supply unit (74) into the first space (20).
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公开(公告)号：US20240038524A1
公开(公告)日：2024-02-01
申请号：US18213974
申请日：2023-06-26
申请人： HITACHI, LTD.
发明人： Masuyuki SUGIYAMA , Shun KUMANO , Akihiro NOJIMA
CPC分类号： H01J49/4225 , H01J49/065 , H01J49/429 , H01J49/0031
摘要： The present disclosure proposes a mass spectrometer including a linear ion trap section and an analyzer that analyzes the ions ejected from the linear ion trap section having a multipole rod electrode including a plurality of segments arranged in a direction of a center axis of the linear ion trap section. A first radio frequency voltage in opposite phase is applied to adjacent rod electrodes. An electrostatic voltage having the same amplitude and a second radio frequency voltage are applied to the segments having the same position in the direction of the center axis. The electrostatic voltage is applied to the segments such that the electrostatic voltage decreases from an inlet to an outlet of the linear ion trap section. The second radio frequency voltage is applied to the segments such that the second radio frequency voltage increases from the inlet to the outlet of the linear ion trap section.
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公开(公告)号：US20240038518A1
公开(公告)日：2024-02-01
申请号：US18258359
申请日：2021-12-22
CPC分类号： H01J49/0454 , H01J49/0031
摘要： A method of ejecting a plurality of samples from a well plate includes receiving a first sample intensity prediction associated with a first sample in a first well of the well plate. A second sample intensity prediction associated with a second sample in a second well is also received. The second sample intensity prediction is less than the first sample intensity prediction. An ejection time delay value for a subsequent analysis of the first sample and the second sample is determined, based at least in part on the second sample intensity prediction. Thereafter, the first sample is acoustically ejected from the first well, and the second sample is acoustically ejected from the second well.
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67.发明授权公开(公告)号：US11885811B2
公开(公告)日：2024-01-30
申请号：US17981839
申请日：2022-11-07
发明人： Yuetian Yan , Shunhai Wang
CPC分类号： G01N33/6848 , G01N30/72 , H01J49/0036
摘要： The present invention provides rapid, sensitive high-throughput methods and systems for characterizing peptides or proteins using hydrophobic interaction chromatography-coupled native mass spectrometry to improve manufacturing process of biopharmaceutical products, such as identifying impurities during antibody purification, monitoring post-translational modification variants during production, or characterizing drug-to-antibody ratio of antibody-drug conjugates. The separation profiles of the peptides or proteins are generated and compared to identify or qualify the peptides or proteins.
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68.发明公开公开(公告)号：US20240027397A1
公开(公告)日：2024-01-25
申请号：US18021759
申请日：2021-07-30
发明人： John Daniel DeBord , Liulin Deng , Zongyuan Chen
IPC分类号： G01N27/623 , H01J49/00
CPC分类号： G01N27/623 , H01J49/004
摘要： A system for capturing full resolution ion mobility data includes an ion mobility separation device that receives ions, guides a portion thereof, and separates the guided ions based on mobility. An ion detector receives the ions, detects ions having a predefined mass-to-charge ratio during a time period, and generates a responsive signal(s). A data acquisition system receives the signal(s) from the detector and generates a time dependent ion signal representing intensity of the signal(s) at different arrival time periods during the time period. A system for performing multi-analyte targeted data acquisition includes an ion mobility separation device that receives a stream of ions, guides a portion of the ions, and separates the ions based on mobility. An ion detector receives the ions and switches from detecting a first mass-to-charge ratio during a first arrival time to detecting a second mass-to-charge ratio during a second arrival time of a first scan.
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公开(公告)号：US11881388B2
公开(公告)日：2024-01-23
申请号：US17427206
申请日：2020-01-28
发明人： James W Hager
CPC分类号： H01J49/4215 , H01J49/0031 , H01J49/24 , H01J49/36
摘要： Methods and systems for FTMS-based analysis having an improved duty cycle relative to conventional FTMS techniques are provided herein. In various aspects, the methods and systems described herein operate on a continuous ion beam, thereby eliminating the relatively long duration trapping and cooling steps associated with Penning traps or orbitraps of conventional FTMS systems, as well as provide increased resolving power by sequentially interrogating the continuous ion beam under different radially-confining field conditions.
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公开(公告)号：US11879900B2
公开(公告)日：2024-01-23
申请号：US17745551
申请日：2022-05-16
发明人： Karin O. Thomassian
IPC分类号： G01N33/94 , H01J49/00 , A61K31/785
CPC分类号： G01N33/94 , A61K31/785 , G01N33/9493 , H01J49/0036 , G01N2560/00
摘要： Methods are described for determining the amount of metabolites of leflunomide in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying teriflunomide in a sample.
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