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公开(公告)号：US20130217618A1
公开(公告)日：2013-08-22
申请号：US13865437
申请日：2013-04-18
发明人： Orlando Borras Hidalgo , Roxana Caridad Portieles Alvarez , Merardo Pujol Ferrer , Gil Alberto Enriquez Obregon , Ernesto Manuel Gonzalez Ramos , Camilo Ayra Pardo , Carlos Guillermo Borroto Nordelo
IPC分类号： A01N37/18
CPC分类号： A01N37/18 , C07K14/415 , C12N15/8279 , C12N15/8282
摘要： The present invention reveals a nucleic acid sequence from Nicotiana megalosiphon encoding for an anti-pathogenic protein. The invention comprises the use of this nucleic acid molecule in transgenic plants of agricultural interest to confer resistance to pathogens. The invention also includes a bioproduct that comprises this anti-pathogenic protein to control plant pathogen agents.
摘要翻译： 本发明揭示了编码抗病原性蛋白质的烟草巨乳的核酸序列。 本发明包括在农业感兴趣的转基因植物中使用该核酸分子来赋予对病原体的抗性。 本发明还包括一种生物产物，其包含该抗病原性蛋白质以控制植物病原体。
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公开(公告)号：US08420311B2
公开(公告)日：2013-04-16
申请号：US12298808
申请日：2007-04-26
申请人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martin Dunn , Monica Sarria Nunez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sanchez Puente , Vladimir Armando Besada Perez , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramon Padron Palomares , Luis Javier Gonzalez Lopez
发明人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martin Dunn , Monica Sarria Nunez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sanchez Puente , Vladimir Armando Besada Perez , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramon Padron Palomares , Luis Javier Gonzalez Lopez
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70596 , C07K14/8107 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
摘要翻译： 本发明涉及一种基于干扰病毒包膜蛋白与细胞受体的直接相互作用或其通过载体蛋白与所述细胞受体的间接相互作用而阻断登革热病毒感染细胞的方法，以及相关的 用途; 其中所述细胞受体是α-2巨球蛋白受体，也称为低密度受体相关蛋白或CD91，所述载体蛋白是人α-2巨球蛋白。
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73.发明授权公开(公告)号：US08367620B2
公开(公告)日：2013-02-05
申请号：US12281085
申请日：2007-02-28
申请人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
发明人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过在硅分子模拟中获得的肽化学化合物，其具有使得它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养补充剂或人或动物使用的其它制剂中的用途。
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公开(公告)号：US20120308661A1
公开(公告)日：2012-12-06
申请号：US13578211
申请日：2011-02-10
申请人： Raimundo Ubieta Gómez , Ana Aguilera Barreto , Eduardo Martínez Díaz , Rolando Paez Meireles , Antonio Sereno Guerra
发明人： Raimundo Ubieta Gómez , Ana Aguilera Barreto , Eduardo Martínez Díaz , Rolando Paez Meireles , Antonio Sereno Guerra
CPC分类号： A61K38/1808 , A61K9/48 , A61K9/50 , A61K9/5026 , A61K9/5078 , A61K47/02 , A61K47/183 , A61K47/38
摘要： The present invention comprises a pellet of epidermal growth factor and methionine or K2S2O7, a capsule which comprises these pellets, processes for theirs preparations and it use for the treatment of ulcerative colitis.
摘要翻译： 本发明包括表皮生长因子和甲硫氨酸颗粒或K 2 S 2 O 7，其包含这些颗粒的胶囊，其制备方法及其用于治疗溃疡性结肠炎。
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公开(公告)号：US08268306B2
公开(公告)日：2012-09-18
申请号：US12857194
申请日：2010-08-16
申请人： Jesus Mena Campos , Eulogio Pimentel Vazquez , Armando Tomas Hernadez Garcia , Liuven Veloz Gonzalez , Marieta Marin Bruzos , Oscar Compte Alberto , Marilin Domingo Puente , Licette Leon Barreras , Merardo Pujol Ferrero , Juan Diego Mencho Ponce , Carlos Borroto Nordelo
发明人： Jesus Mena Campos , Eulogio Pimentel Vazquez , Armando Tomas Hernadez Garcia , Liuven Veloz Gonzalez , Marieta Marin Bruzos , Oscar Compte Alberto , Marilin Domingo Puente , Licette Leon Barreras , Merardo Pujol Ferrero , Juan Diego Mencho Ponce , Carlos Borroto Nordelo
CPC分类号： A01N63/00 , A01N63/02 , A01N2300/00
摘要： This invention relates to pesticide and antiparasitic compositions for the control of pests, diseases and parasites attacking plants and animals. The compositions include, at least one chitinolytic agent or a chitinolytic activity-inducing agent, and sulfide or a sulfide-producing agent from microorganisms or chemical compounds, wherein the chitinolytic agent or the chitinolytic activity-inducing agent and sulfur or a sulfur-producing agent obtaining from microorganisms or chemical compounds are concurrently applied at a range significantly lower than any of the above-mentioned compounds, when they are individually to attain effective control.
摘要翻译： 本发明涉及用于防治害虫，疾病和寄生虫攻击植物和动物的农药和抗寄生虫剂组合物。 所述组合物包括至少一种chitinotictic试剂或chitinolytic活性诱导剂，以及来自微生物或化学化合物的硫化物或硫化物生成剂，其中所述chitinolytic试剂或所述chitinolytic活性诱导剂和硫或硫产生剂 当微生物或化合物单独获得有效控制时，从微生物或化合物获得的同时应用于显着低于任何上述化合物的范围。
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公开(公告)号：US20090274718A1
公开(公告)日：2009-11-05
申请号：US12483607
申请日：2009-06-12
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
IPC分类号： A61K39/07 , C07K14/245 , A61K38/16
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
摘要翻译： 本发明涉及获得编码蛋白质的蛋白质的嵌合链，其能够在受体中诱导抗登革病毒感染的血清型特异性和保护性体液免疫应答，从而消除血清型非特异性病毒免疫增强的作用 导致这种病理描述的出血和临床并发症。 核酸的这些嵌合链由来自脑膜炎奈瑟氏球菌与脱氢酶活性的突变蛋白质的基因的片段的特异性组合和编入来自登革病毒的包膜（E）蛋白的区域的片段组成，当插入时 表达载体，产生具有特定性质的嵌合蛋白。 所得到的本发明的嵌合分子适用于获得用于人类的疫苗制剂和高血清型特异性的诊断方法的制药工业。
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公开(公告)号：US20090176703A1
公开(公告)日：2009-07-09
申请号：US12094339
申请日：2006-11-20
申请人： Juana Maria Lugo Gonzalez , Mario Pablo Estrada Garcia , Alina Rodriguez Mallon , Yamila Carpio Gonzalez , Antonio Morales Rojas , Osmany Rodrigo Gonzalez De Sosa , Reynold Morales Fernandez , Fidel Francisco Herrera Miyares
发明人： Juana Maria Lugo Gonzalez , Mario Pablo Estrada Garcia , Alina Rodriguez Mallon , Yamila Carpio Gonzalez , Antonio Morales Rojas , Osmany Rodrigo Gonzalez De Sosa , Reynold Morales Fernandez , Fidel Francisco Herrera Miyares
CPC分类号： A61K38/17 , A01K61/80 , A23K20/147 , A23K50/80 , C07K14/57563 , Y02A40/845
摘要： The present invention is related to the use of variants of the Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) to stimulate the growth and to improve the immunological system of aquatic organisms. The variants of the peptide were provided by immersion, injection or as a food additive.
摘要翻译： 本发明涉及使用垂体腺苷酸环化酶活化多肽（PACAP）的变体来刺激生长并改善水生生物的免疫系统。 通过浸渍，注射或作为食品添加剂提供肽的变体。
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公开(公告)号：US07279164B2
公开(公告)日：2007-10-09
申请号：US10484114
申请日：2002-07-12
申请人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
发明人： Lisset Hermida Cruz , Rayner Rodriguez Diaz , Laura Lazo Vazquez , Aida Zulueta Morales , Carlos Lopez Abarrategui , Iris Valdes Prado , Ricardo de la C. Silva Rodriguez , Glay Chinea Santiago , Gerardo Enrique Guillen Nieto , Maria Guadalupe Guzman Tirado , Beatriz de la Caridad Sierra Vazquez , Raul Rafael Espinosa Perez
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N9/0006 , C12N2770/24122 , Y02A50/386
摘要： The present invention is related to the obtaining of chimeric chains coding for proteins capable of inducing, in the recipient, a serotype-specific and protective humoral immune response against the infection by the Dengue virus, thus eliminating the effects of the serotype-nonespecific viral immunoenhancement that causes hemorrhagies and clinical complications described for this kind of pathology. These chimeric chains of nucleic acids are composed by the specific combination of fragments belonging to the gene of a mutated protein from Neisseria meningitidis with dehydrogenase activity and fragments that codify for a region of the envelope (E) protein from the Dengue virus which, when inserted to an expression vector, give rise to chimeric proteins with particular properties. The resultant chimeric molecules from this invention are applicable to the pharmaceutical industry for the obtaining of vaccine preparations and diagnostic means of high serotype-specificity to be used in humans.
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公开(公告)号：US20070160575A1
公开(公告)日：2007-07-12
申请号：US11656301
申请日：2007-01-22
申请人： Iraldo Rivero , Yeny Ruiz , Elizabeth Garces , Giselle Roll , Pedro Saura
发明人： Iraldo Rivero , Yeny Ruiz , Elizabeth Garces , Giselle Roll , Pedro Saura
CPC分类号： C07K14/55 , A61K38/00 , C07K14/7156 , C07K2319/00
摘要： A recombinant chimeric antagonist formed by a 60 amino acid fragment of the N-terminal region of human interleukin 2 (IL-2) fused to the N-terminal of the extracellular region of the alpha subunit of the gamma IFN (IFN γ) receptor. In vitro this protein has a T cell growth stimulating activity, it inhibits the growth stimulating activity of IL-2 in T cells, it inhibits the induction of HLA-DR by IFN γ and it inhibits the antiproliferative activity of γ IFN. This invention can be applied in the field of medicine for the treatment of several pathologies such as autoimmune diseases, graft rejections, chronic inflammations, sepsis, ischemia and reperfusion syndrome and atherosclerosis.
摘要翻译： 由IL-2受体的α亚基的胞外区的N末端融合的人白细胞介素2（IL-2）的N末端区域的60个氨基酸片段形成的重组嵌合拮抗剂。 体外该蛋白具有T细胞生长刺激活性，它抑制T细胞中IL-2的生长刺激活性，其通过IFNγ抑制HLA-DR的诱导，并且其抑制γIFN的抗增殖活性。 本发明可应用于医学领域，用于治疗诸如自身免疫疾病，移植排斥，慢性炎症，败血症，缺血再灌注综合征和动脉粥样硬化等几种病症。
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