公开(公告)号：US20140005760A1

公开(公告)日：2014-01-02

申请号：US13747161

申请日：2013-01-22

申请人： Zeltiq Aesthetics, Inc.

发明人： Mitchell E. Levinson ,  Donald Johnson ,  Jessica Preciado ,  Edward A. Ebbers ,  Daniel Bucks

IPC分类号： A61F7/00

CPC分类号： A61F7/00 ,  A61B90/04 ,  A61F7/10 ,  A61F2007/0001 ,  A61F2007/0075 ,  A61F2007/029

摘要： A cryoprotectant for use with a treatment device for improved removal of heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cryoprotectant is a non-freezing liquid, gel, or paste for allowing pre-cooling of the treatment device below 0° C. while preventing the formation of ice thereon. The cryoprotectant may also prevent freezing of the treatment device to the skin or ice from forming from moisture seeping out from the skin. The cryoprotectant may further be hygroscopic, thermally conductive, and biocompatible.

摘要翻译： 提供了一种用于治疗装置的冷冻保护剂，用于从具有皮肤的受试者的皮下富含脂质的细胞中改善对热的去除。 冷冻保护剂是一种非冻结液体，凝胶或糊剂，用于允许将处理装置预冷却至低于0℃，同时防止其上形成冰​​。 冷冻保护剂还可以防止治疗装置冻结到皮肤或冰层，从而从皮肤渗出的湿气中形成。 冷冻保护剂可以进一步具有吸湿性，导热性和生物相容性。

公开(公告)号：US08435230B2

公开(公告)日：2013-05-07

申请号：US12337544

申请日：2008-12-17

申请人： John W. Allison

发明人： John W. Allison

IPC分类号： A61M1/00

摘要： Systems for removing heat from a subject's subcutaneous lipid-rich regions, such as tissue, organs, cells, and so forth, are described herein. In various embodiments, the system includes a treatment device and a controller for controlling a treatment process. The controller is configured to detect and compensate for an interruption in the treatment process.

公开(公告)号：US20130079684A1

公开(公告)日：2013-03-28

申请号：US13616633

申请日：2012-09-14

申请人： Jesse N. Rosen ,  Mitchell E. Levinson

发明人： Jesse N. Rosen ,  Mitchell E. Levinson

IPC分类号： A61H7/00

CPC分类号： A61H7/001 ,  A61F7/10 ,  A61F2007/0056 ,  A61F2007/0075 ,  A61F2007/0228 ,  A61F2007/029 ,  A61H7/00 ,  A61H7/008 ,  A61H9/00 ,  A61H9/0007 ,  A61H9/005 ,  A61H9/0057 ,  A61H23/0254 ,  A61H23/0263 ,  A61H2201/165 ,  A61H2201/5082 ,  A61H2230/50

摘要： A treatment device for removing heat from subcutaneous lipid-rich cells of a subject having an actuator that provides mechanical energy to the tissue. The mechanical energy provided may include a vibratory component that can range between low and ultra-high frequencies, and such energy may include various combinations of two or more frequencies tailored to produce the desired effect on the subcutaneous tissue. Disruption of adipose tissue cooled by an external treatment device may be enhanced by applying mechanical energy to cooled tissue. Furthermore, such mechanical energy may impart a vibratory effect, a massage effect, a pulsatile effect, or combinations thereof on the tissue.

摘要翻译： 一种治疗装置，用于从具有向组织提供机械能的致动器的受试者的皮下富含脂质的细胞中除去热量。 提供的机械能可以包括可以在低频和超高频之间范围内的振动分量，并且这种能量可以包括被定制以产生对皮下组织所需效果的两个或多个频率的各种组合。 可以通过向冷却的组织施加机械能来增强由外部处理装置冷却的脂肪组织的破坏。 此外，这样的机械能可以在组织上施加振动效果，按摩效果，脉动效应或其组合。

公开(公告)号：US20130066309A1

公开(公告)日：2013-03-14

申请号：US13471826

申请日：2012-05-15

申请人： Mitchell E. Levinson

发明人： Mitchell E. Levinson

IPC分类号： A61B18/02 ,  A61B18/04

CPC分类号： A61H1/008 ,  A61B18/14 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00047 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61F7/007 ,  A61F7/02 ,  A61F7/10 ,  A61F2007/0001 ,  A61F2007/0054 ,  A61F2007/0075 ,  A61F2007/029

摘要： Methods are provided herein for affecting a region of a subject's body, comprising exposing the region to a cooling element under conditions effective to cool subcutaneous adipose tissue in said region; and increasing the blood flow rate to the cooled tissue by exposing the tissue to an energy source. Methods are also provided for treating subcutaneous adipose tissue in a region of a subject's body, comprising exposing said region to a cooling element under conditions effective to cool said tissue; and exposing the tissue to an energy source to increase the blood flow rate to the cooled tissue, thereby stimulating reperfusion in, and/or causing an ischemia-reperfusion injury to, the cooled tissue.

公开(公告)号：US08337539B2

公开(公告)日：2012-12-25

申请号：US12942852

申请日：2010-11-09

申请人： Joseph Ting ,  Samuel W. Tolkoff ,  Timothy Robinson ,  Richard Wisdom

发明人： Joseph Ting ,  Samuel W. Tolkoff ,  Timothy Robinson ,  Richard Wisdom

IPC分类号： A61F7/00

CPC分类号： A61F7/00 ,  A61F7/007 ,  A61F7/10 ,  A61F2007/0056 ,  A61F2007/0075 ,  A61F2007/0076 ,  A61F2007/0086 ,  A61F2007/0087 ,  A61F2007/029

摘要： A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cooling device includes a support having a first portion and a second portion. A first cooling element having a first heat exchanging surface is located at the first portion of the support. A second cooling element having a second heat exchanging surface is located at the second portion of the support. At least one of the first and second cooling elements is movable along the support and is configured to rotate for adjusting an angle between the first and second heat exchanging surfaces.

摘要翻译： 提供了一种用于从具有皮肤的受试者的皮下富含脂质细胞中除去热量的冷却装置。 冷却装置包括具有第一部分和第二部分的支撑件。 具有第一热交换表面的第一冷却元件位于支撑件的第一部分。 具有第二热交换表面的第二冷却元件位于支撑件的第二部分。 第一和第二冷却元件中的至少一个可沿着支撑件移动，并且构造成旋转以调节第一和第二热交换表面之间的角度。

公开(公告)号：US08192474B2

公开(公告)日：2012-06-05

申请号：US11558046

申请日：2006-11-09

申请人： Mitchell Levinson

发明人： Mitchell Levinson

IPC分类号： A61F7/00

CPC分类号： A61H1/008 ,  A61B18/14 ,  A61B2018/00011 ,  A61B2018/00023 ,  A61B2018/00047 ,  A61B2018/00452 ,  A61B2018/00476 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61F7/007 ,  A61F7/02 ,  A61F7/10 ,  A61F2007/0001 ,  A61F2007/0054 ,  A61F2007/0075 ,  A61F2007/029

摘要： Methods are provided herein for affecting a region of a subject's body, comprising exposing the region to a cooling element under conditions effective to cool subcutaneous adipose tissue in said region; and increasing the blood flow rate to the cooled tissue by exposing the tissue to an energy source. Methods are also provided for treating subcutaneous adipose tissue in a region of a subject's body, comprising exposing said region to a cooling element under conditions effective to cool said tissue; and exposing the tissue to an energy source to increase the blood flow rate to the cooled tissue, thereby stimulating reperfusion in, and/or causing an ischemia-reperfusion injury to, the cooled tissue.

摘要翻译： 本文提供了影响受试者身体区域的方法，包括在有效地冷却所述区域中的皮下脂肪组织的条件下将该区域暴露于冷却元件; 以及通过将组织暴露于能量来增加到冷却的组织的血液流速。 还提供了用于治疗受试者身体区域中的皮下脂肪组织的方法，包括在有效冷却所述组织的条件下将所述区域暴露于冷却元件; 并将组织暴露于能量源以增加到冷却的组织的血液流速，从而刺激冷却的组织的再灌注和/或引起缺血再灌注损伤。

公开(公告)号：US20240358613A1

公开(公告)日：2024-10-31

申请号：US18595026

申请日：2024-03-04

申请人： Zeltiq Aesthetics, Inc.

发明人： Joel N. Jimenez Lozano ,  Leonard C. DeBenedictis ,  Like Zeng ,  George Frangineas, JR.

IPC分类号： A61K8/60 ,  A61B18/00 ,  A61B18/02 ,  A61B90/00 ,  A61F7/00 ,  A61K8/36 ,  A61K8/42 ,  A61K8/86 ,  A61N1/30 ,  A61N1/32 ,  A61N7/00 ,  C07H3/04

CPC分类号： A61K8/602 ,  A61B18/0206 ,  A61F7/007 ,  A61K8/361 ,  A61K8/42 ,  A61K8/86 ,  A61N1/30 ,  A61N1/327 ,  C07H3/04 ,  A61B2018/00291 ,  A61B2018/00464 ,  A61B2018/0237 ,  A61B2018/0262 ,  A61B2090/0463 ,  A61F2007/0052 ,  A61F2007/0056 ,  A61F2007/0076 ,  A61F2007/0087 ,  A61F2007/0093 ,  A61F2007/0094 ,  A61K2800/244 ,  A61N2007/0034

摘要： A method in accordance with a particular embodiment of the present invention includes increasing a concentration of a modified or unmodified saccharide within a subject's skin, applying an applicator to the subject's skin, and cooling the subject's skin via a heat-transfer surface of the applicator. The saccharide within the subject's skin can enhance a resistance of at least some cells within the subject's skin to damage associated with the cooling. A corresponding system includes the applicator, the saccharide, and an energy-delivery device. The energy-delivery device can be configured to apply ultrasound, optical, thermal, or another type of energy to the subject's skin to drive the saccharide into the subject's skin. The system can also include a penetration enhancer configured to enhance penetration of the saccharide into the subject's skin. The penetration enhancer can be applied with the saccharide or separately.

公开(公告)号：US12070411B2

公开(公告)日：2024-08-27

申请号：US16595466

申请日：2019-10-08

申请人： Zeltiq Aesthetics, Inc.

发明人： Mitchell E. Levinson ,  Donald Johnson ,  Jessica Preciado ,  Edward A. Ebbers ,  Daniel Bucks

IPC分类号： A61F7/00 ,  A61B18/00 ,  A61B18/02 ,  A61B18/12 ,  A61B18/20 ,  A61F7/02 ,  A61F7/10 ,  A61B90/00

CPC分类号： A61F7/00 ,  A61B18/02 ,  A61B18/12 ,  A61B18/203 ,  A61F7/10 ,  A61B2018/00047 ,  A61B2018/00101 ,  A61B2018/00107 ,  A61B2018/00464 ,  A61B2018/00642 ,  A61B2018/00714 ,  A61B2018/00744 ,  A61B2018/00791 ,  A61B2018/0231 ,  A61B90/04 ,  A61F2007/0001 ,  A61F2007/0075 ,  A61F2007/0219 ,  A61F2007/0246 ,  A61F2007/029

摘要： A cryoprotectant for use with a treatment device for improved removal of heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cryoprotectant is a non-freezing liquid, gel, or paste for allowing pre-cooling of the treatment device below 0° C. while preventing the formation of ice thereon. The cryoprotectant may also prevent freezing of the treatment device to the skin or ice from forming from moisture seeping out from the skin. The cryoprotectant may further be hygroscopic, thermally conductive, and biocompatible.

公开(公告)号：US12048851B2

公开(公告)日：2024-07-30

申请号：US17100725

申请日：2020-11-20

申请人： ZELTIQ Aesthetics, Inc.

发明人： George Frangineas, Jr. ,  Theodorus Johannes Virginia Caberg

IPC分类号： A61N2/00 ,  A61N2/02

CPC分类号： A61N2/004 ,  A61N2/02

摘要： A method for strengthening, toning, and firming muscle tissues, the method includes receiving parameters for operating a magnetic muscle stimulation device. The parameters include: a first waveform frequency; one or more pulse durations; a second waveform frequency that is non-zero; causing, a first alternating current having one or more first pulses to flow for a first length of time through a coil according to the first waveform frequency; causing, a second alternating current having one or more second pulses to flow through the coil for a second length of time according to the second waveform frequency lower than the first waveform frequency. The method includes repeating the causing of the first and second alternating currents for a plurality of iterations to provide a continuously pulsed time-varying magnetic field that alternates between the first and the second waveform frequencies to generate a treatment session.

公开(公告)号：USD1028258S1

公开(公告)日：2024-05-21

申请号：US29714053

申请日：2019-11-20

申请人： Zeltiq Aesthetics, Inc.

设计人： Jarred William Harris Evans ,  Benjamin Joseph Nolan

摘要： FIG. 1 is a front, top perspective view of an embodiment of an applicator for an electromagnetic muscle stimulator therapeutic device;
FIG. 2 is a front side view of the applicator of FIG. 1;
FIG. 3 is a back side view of the applicator of FIG. 1;
FIG. 4 is a left side view of the applicator of FIG. 1, the right side view thereof being a mirror image;
FIG. 5 is a top plan view of the applicator of FIG. 1; and,
FIG. 6 is a bottom plan view of the applicator of FIG. 1.
The broken lines shown in the figures depict portions of the applicator for a therapeutic device and form no part of the claimed design.