公开(公告)号：US08203388B2

公开(公告)日：2012-06-19

申请号：US12161790

申请日：2007-01-15

申请人： Ganesh Kathiresan ,  Kritsapon Leelavattananon

发明人： Ganesh Kathiresan ,  Kritsapon Leelavattananon

IPC分类号： H03F1/22

CPC分类号： H03F3/189 ,  G06F1/3203 ,  G06F1/3287 ,  H03F3/45188 ,  H03F2200/294 ,  H03F2200/372 ,  H03F2200/489 ,  H03F2200/492 ,  H03F2203/45386 ,  H03K23/544 ,  Y02D10/171

摘要： An amplifier having multiple gain modes comprises a plurality of cascoded input transistors connected to an input and arranged in parallel, a degeneration stage connected to the input transistors and having a variable impedance, and switching means for switching between different modes of the amplifier by switching off one or more of the input transistors and varying the impedance of the degeneration stage.

摘要翻译： 具有多个增益模式的放大器包括连接到输入并并联布置的多个级联输入晶体管，连接到输入晶体管并具有可变阻抗的退化级，以及用于通过关断来切换放大器的不同模式的开关装置 一个或多个输入晶体管并改变退化阶段的阻抗。

公开(公告)号：US08188908B2

公开(公告)日：2012-05-29

申请号：US12840587

申请日：2010-07-21

申请人： Jeremy A. Landt

发明人： Jeremy A. Landt

IPC分类号： G01S13/08

CPC分类号： G01S3/02

摘要： Distance to a modulated backscatter tag is measured with a RFID reader that measures changes in phase with frequency of modulated backscattered RF signals. Measured distances are linked to a specific tag. The effects of other sources of reflected and interfering signals are mitigated. The techniques eliminate the need for high RF bandwidth used in time-of-flight methods, and may be used with linear, limiting or other types of amplifiers in the reader receiver. Unambiguous distance to a tag may be found using the derivative of phase with RF frequency of the modulated signal backscattered by a tag. The distance to a tag can be measured with an accuracy on the order of a centimeter. The techniques utilize the characteristics of cooperative backscatter tags (transponders, labels, etc.). New readers implement the techniques which may use unmodified tags.

摘要翻译： 使用RFID读取器测量到调制反向散射标签的距离，RFID读取器测量调制后向散射RF信号的频率的相位变化。 测量距离与特定标签相关联。 反映和干扰信号的其他来源的影响得到缓解。 该技术消除了在飞行时间方法中使用的高RF带宽的需要，并且可以与读取器接收器中的线性，限制或其他类型的放大器一起使用。 可以使用由标签反向散射的调制信号的RF频率的相位导数来找到与标签的明确距离。 与标签的距离可以以一厘米的数量级的精度进行测量。 该技术利用了协作反向散射标签（转发器，标签等）的特性。 新读者实现可能使用未修改标签的技术。

公开(公告)号：US08184274B2

公开(公告)日：2012-05-22

申请号：US12503348

申请日：2009-07-15

申请人： Hans Joachim Bruins

发明人： Hans Joachim Bruins

IPC分类号： G01N21/00

CPC分类号： G01N5/00 ,  G01N9/02 ,  G01N15/00 ,  G01N21/85 ,  G01N2015/0019 ,  G01N2015/0096 ,  G01N2021/8592

摘要： A measuring instrument (100) for measuring the properties of a sample (10) with a multitude of particles (11), including a spectroscopy device (20) to measure spectroscopic properties of the sample, and a weighing device (30) to measure the mass of the sample. Also described is a method for measuring the properties of a sample (10) with a multitude of particles (11).

摘要翻译： 一种测量仪器（100），用于测量具有多个颗粒（11）的样品（10）的性质，包括用于测量样品的光谱性质的光谱仪（20）和用于测量样品 质量的样品。 还描述了用多个颗粒（11）测量样品（10）的性质的方法。

公开(公告)号：US08183048B2

公开(公告)日：2012-05-22

申请号：US12668330

申请日：2008-07-25

申请人： Parkson Lee-Gau Chong ,  Michelle Olsher ,  Su-In Yoon

发明人： Parkson Lee-Gau Chong ,  Michelle Olsher ,  Su-In Yoon

IPC分类号： G01N33/92

CPC分类号： G01N33/487 ,  Y10S436/904 ,  Y10T436/104165 ,  Y10T436/142222

摘要： A method of screening an antioxidant for potency and/or toxicity in vitro, the method includes contacting the antioxidant with a model system containing a sterol superlattice formation capable of generating a detectable signal, wherein the detectable signal changes in a parameter representative of an integrity of the sterol superlattice formation; and detecting and/or measuring disruption of the sterol superlattice formation, wherein the disruption is caused by the insertion of the antioxidant into membranes and thereby screening the antioxidant for potency and/or toxicity.

摘要翻译： 一种在体外筛选抗氧化剂以获得效力和/或毒性的方法，所述方法包括使抗氧化剂与含有可产生可检测信号的固醇超晶格形成的模型系统接触，其中可检测信号在代表完整性的参数中变化 固醇超晶格形成; 以及检测和/或测量所述固醇超晶格形成的破坏，其中所述破坏是由抗氧化剂插入膜中引起的，从而筛选抗氧化剂的效力和/或毒性。

公开(公告)号：US08175208B2

公开(公告)日：2012-05-08

申请号：US12161155

申请日：2007-01-19

申请人： Mark Dawkins

发明人： Mark Dawkins

IPC分类号： H03D3/24

CPC分类号： H04H40/18 ,  H04B1/30 ,  H04L25/063 ,  H04L25/085

摘要： A method of reducing d.c. offset comprises comparing the a first variable signal with a second variable signal, producing a control signal in dependence upon the comparison, providing the control signal to a charge pump for generation of a feedback signal, and varying the first signal and/or the second signal in dependence upon the feedback signal thereby reducing any difference between the d.c. level of the first signal and the d.c. level of the second signal.

摘要翻译： 减少直径的方法 偏移包括将第一可变信号与第二可变信号进行比较，根据比较产生控制信号，将控制信号提供给电荷泵以产生反馈信号，以及改变第一信号和/或第二信号 根据反馈信号，从而减小dc之间的任何差异 第一个信号和直流电平。 第二信号的电平。

公开(公告)号：US08143213B2

公开(公告)日：2012-03-27

申请号：US12439939

申请日：2007-09-17

申请人： Alexander Tsygankov ,  Evgeniya Smirnova

发明人： Alexander Tsygankov ,  Evgeniya Smirnova

IPC分类号： A61P31/14 ,  A61P31/18 ,  C12N7/00 ,  A61K48/00

CPC分类号： C07K14/4702 ,  A61K38/00 ,  A61K48/00 ,  C12N2740/16011

摘要： A method of inhibiting a retrovirus production, the method includes administering a retrovirus inhibitor selected from at least one of a TULA protein, a fragment of TULA containing a UBA domain, a UBA domain of TULA, a peptide mimicking TULA, a peptide mimicking a fragment of TULA containing a UBA domain, a peptide mimicking a UBA domain of TULA, a polynucleotide encoding TULA, a polynucleotide encoding a fragment of TULA containing a UBA domain, a polynucleotide encoding a UBA domain of TULA, a polynucleotide encoding a peptide mimicking TULA, a polynucleotide encoding a peptide mimicking a fragment of TULA containing a UBA domain, a polynucleotide encoding a peptide mimicking the UBA domain of TULA, fragments thereof, muteins thereof, variants and splice variants thereof, and combinations thereof to a cell or a tissue infected by a retrovirus.

摘要翻译： 一种抑制逆转录病毒产生的方法，所述方法包括施用逆转录病毒抑制剂，其选自TULA蛋白，含有UBA结构域的TULA片段，TULA的UBA结构域，模拟TULA的肽，模拟片段的肽， 含有UBA结构域的TULA，模拟TULA的UBA结构域的肽，编码TULA的多核苷酸，编码含有UBA结构域的TULA片段的多核苷酸，编码TULA的UBA结构域的多核苷酸，编码TULA的肽的多核苷酸， 编码模仿含有UBA结构域的TULA片段的肽，编码模拟TULA的UBA结构域的肽的多核苷酸，其片段，其突变蛋白，其变体和剪接变体及其组合的多核苷酸，其组合被感染的细胞或组织 逆转录病毒。

公开(公告)号：US08129679B2

公开(公告)日：2012-03-06

申请号：US12823375

申请日：2010-06-25

申请人： Paul Mooney

发明人： Paul Mooney

IPC分类号： H01J37/22

CPC分类号： H01J37/05 ,  H01J37/244 ,  H01J37/26 ,  H01J2237/05 ,  H01J2237/2441 ,  H01J2237/24455 ,  H01J2237/24485 ,  H01J2237/26 ,  H01J2237/2802

摘要： Methods are disclosed for operating a device having a high energy particle detector wherein the particles create first incoming traversal events, outgoing backscatter events, higher-order in and out events and incoming events caused by particles which backscatter out of the device, hit nearby mechanical structures and are scattered back into the device. Exemplary method steps include discriminating incoming traversal events from outgoing backscatter events, higher-order in and out events and incoming events by limiting dose rate to a level at ensures that separate events do not overlap and discriminating events from background and from other events based on total energy in each event; discriminating backscatter events from incoming traversal events based on electron path shape; or determining that a first event and a second event are coincident with each other and separating incoming form backscatter events based on electron path shape and energy level.

摘要翻译： 公开了用于操作具有高能量粒子检测器的装置的方法，其中颗粒产生第一进入的穿越事件，出射的后向散射事件，高阶进入和离开事件以及由反向散射出装置的颗粒引起的进入事件，撞击附近的机械结构 并分散回设备。 示例性方法步骤包括通过将剂量率限制到一个水平来区分进入的遍历事件与输出的后向散射事件，高阶进入和离开事件以及进入的事件，以确保单独的事件不会与基于总计的背景和来自其他事件的事件重叠和区分事件 每个事件的能量; 基于电子路径形状鉴别反向散射事件与进入的穿越事件; 或者确定第一事件和第二事件彼此重合，并基于电子路径形状和能级分离入射形式的反向散射事件。

公开(公告)号：US08087322B1

公开(公告)日：2012-01-03

申请号：US12112395

申请日：2008-04-30

申请人： Eric D. Morris

发明人： Eric D. Morris

IPC分类号： F16H57/02

CPC分类号： E05B15/02 ,  E05B15/0013 ,  E05B15/0053 ,  E05F7/00 ,  E05Y2201/10 ,  Y10T74/2186

摘要： A mechanism for a window is provided including a mechanism case, a spindle inserted into the case, a screw mounting plate for mounting the mechanism to a surface by a pair of screws, the screw mounting plate having an aperture through which the spindle in the case freely passes, a cover plate having an aperture through which the spindle freely passes and sized to substantially cover the mechanism and screw mounting plate, and a retaining ring for fixed engagement with the aperture of the screw mounting plate. The retaining ring has an internal aperture through which the spindle passes and provides for the spindle to freely rotate within the internal aperture. The retaining ring is incapable of passing through the aperture in the cover plate. The retaining ring secures the cover plate to the screw mounting plate and the screw mounting plate secures the mechanism case to the surface.

摘要翻译： 提供了一种用于窗户的机构，其包括机构壳体，插入壳体中的心轴，用于通过一对螺钉将机构安装到表面的螺钉安装板，所述螺钉安装板具有孔，壳体中的心轴穿过该孔 自由通过具有孔的盖板，主轴自由地穿过该孔，并且其尺寸基本上覆盖机构和螺钉安装板，以及用于与螺钉安装板的孔固定接合的保持环。 保持环具有内孔，主轴通过该孔，并使主轴在内孔内自由旋转。 保持环不能穿过盖板中的孔。 保持环将盖板固定到螺钉安装板上，螺钉安装板将机构壳体固定在表面上。

公开(公告)号：US08086298B2

公开(公告)日：2011-12-27

申请号：US12335061

申请日：2008-12-15

申请人： Willet F. Whitmore, III ,  Craig J. Cermak

发明人： Willet F. Whitmore, III ,  Craig J. Cermak

IPC分类号： A61B5/05 ,  A61B19/00

CPC分类号： A61B5/06 ,  A61B5/062 ,  A61B5/064 ,  A61B5/065 ,  A61B5/066 ,  A61B8/0833 ,  A61B8/0841 ,  A61B8/12 ,  A61B8/4254 ,  A61B17/3403 ,  A61B34/20 ,  A61B34/70 ,  A61B46/10 ,  A61B90/11 ,  A61B90/37 ,  A61B2017/00725 ,  A61B2017/3405 ,  A61B2017/3407 ,  A61B2017/3413 ,  A61B2034/2051 ,  A61B2090/3975 ,  A61B2090/3983 ,  G06T7/0012

摘要： An EMT system for use in ultrasound and other imaging modality guided medical procedures. The system includes a tool set of various components to which EM sensors can be releasably secured. Thus, the sensors can be reused, notwithstanding the disposal of other components of the tool set. Various components of the tool set include keying elements to facilitate their registration to the anatomy of the patient undergoing the procedure via the EM sensors.

摘要翻译： 用于超声和其他成像模式的EMT系统指导医疗程序。 该系统包括可以可释放地固定EM传感器的各种部件的工具组。 因此，尽管处理了工具组的其他部件，传感器也可以重新使用。 工具组的各种部件包括键入元件，以便于它们通过EM传感器对经历该过程的患者的解剖结构进行配准。

公开(公告)号：US08084606B2

公开(公告)日：2011-12-27

申请号：US11722266

申请日：2007-06-15

申请人： Dodda Mohan Rao ,  Bitra Satyanarayana Rao

发明人： Dodda Mohan Rao ,  Bitra Satyanarayana Rao

IPC分类号： C07D241/04 ,  C07D295/00

CPC分类号： C07D295/073

摘要： The present invention relates to a novel and commercially viable process for substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine intermediate, 1-[(4-chlorophenyl)phenylmethyl]piperazine, thereby producing substantially optically pure levorotatory and dextrorotatory enantiomers of cetirizine and their pharmaceutical acceptable acid addition salts thereof in high purity and in high yield using novel intermediates.

摘要翻译： 本发明涉及一种用于西替立嗪中间体，1 - [（4-氯苯基）苯基甲基]哌嗪的基本上光学纯的左旋和右旋对映异构体的新型和商业上可行的方法，从而产生西替利嗪及其药学上可接受的基本上光学纯的左旋和右旋对映异构体 使用新型中间体，其高纯度和高产率的其酸加成盐。