公开(公告)号：US11291942B2

公开(公告)日：2022-04-05

申请号：US15753349

申请日：2016-08-23

Applicant: Cytiva Sweden AB

Inventor： Eric Faldt ,  Thomas Falkman ,  Patric Fricking ,  Patrick Jonsson ,  Tomas Agren

IPC: B01D5/00 ,  F25B9/04 ,  B01D46/42 ,  B01D53/00 ,  B01D53/26 ,  F25B39/04 ,  F25B39/00 ,  C12M1/00 ,  C12M3/00 ,  C12M1/02

Abstract: The invention discloses a condenser for a bioreactor exhaust, comprising: an inlet (1) adapted to be fluidically connected to a bioreactor exhaust port (2), a cooling chamber (3; 103) fluidically connected to the inlet and via a filter device (4) to an outlet (5), a cooling conduit (6; 106) in contact with the cooling chamber, a heating conduit (7) in contact with the filter device and a vortex tube (8) arranged to convey a cold gas stream through the cooling conduit and to convey a hot gas stream through the heating conduit.

公开(公告)号：US11291929B2

公开(公告)日：2022-04-05

申请号：US16481655

申请日：2018-01-30

Applicant: Cytiva Sweden AB

Inventor： Johan Avallin ,  Klaus Gebauer

IPC: B01D15/20 ,  G01N30/56 ,  A61L2/08

Abstract: A method and a system and a container system for transferring separation resin from at least one first container (3; 3; 3a, 3b; 3a′, 3b′, 3c′, 3d′) to a second container (5; 5′), wherein said first container is a deformable, single-use separation resin storage container, said method comprising the steps of:—preparing (S1) the at least one first container by providing a deformable, single-use container comprising an outlet port (4′) with a predefined volume of separation resin in a storage solution;—fluidizing (S3) the separation resin in the at least one first container to provide a resin slurry, said fluidizing being performed by mechanical interaction to the first container from an outside of the first container to provide a deformation of said first container;—fluidically connecting (S5) the outlet port (4′) of the at least one first container to an inlet port (103) of the second container;—transferring (S7) separation resin from the at least one first container to the second container by generating a pressure difference between an interior of the second container and an interior of the first container where the pressure is lower in the second container.

公开(公告)号：US11280722B2

公开(公告)日：2022-03-22

申请号：US17056543

申请日：2019-05-29

Applicant: Cytiva Sweden AB

Inventor： Hanno Ehring ,  Mats Lundkvist ,  David Carl Martin Bergman ,  Andreas Marcstrom

IPC: G01N21/00 ,  G01N21/05 ,  G01N21/03 ,  G01N21/85

Abstract: Disclosed is an optical flow cell (300′) comprising: a housing (910) forming; an enclosed and elongated fluid channel (920) arranged along a first axis (923); a first light guide (961) and a second light guide (962) generally concentrically arranged along a second axis (970) and on opposite side walls of the fluid channel, said first and second light guides having ends (961c,962c) removed in situ to provide a sensing gap (d).

公开(公告)号：US11255852B2

公开(公告)日：2022-02-22

申请号：US15519238

申请日：2015-10-26

Applicant: CYTIVA SWEDEN AB

Inventor： Olof Karlsson ,  Henrik Berling

IPC: G01N33/50 ,  G01N33/543 ,  G01N33/53 ,  G01N33/483 ,  G01N21/552 ,  G01N21/64 ,  B01L3/00 ,  B01F13/00

Abstract: In one embodiment, the present invention relates to a method for establishing a solvent correction curve as well as using the curve for obtaining a corrected sensorgram or corrected report points from a sensorgram of an analyte. In another embodiment, the present invention provides an analytical system for studying molecular interactions, which comprises computer processing means including program code means for performing the steps of the methods. Also provided is a computer program product comprising program code means stored on a computer readable medium or carried on an electrical or optical signal for performing the steps of the methods.

公开(公告)号：US20220025313A1

公开(公告)日：2022-01-27

申请号：US17296711

申请日：2019-12-10

Applicant: Cytiva Sweden AB

Inventor： Bjorn Olovsson ,  Andreas Lundin ,  Klaus Gebauer ,  Tim Francois ,  Kerstin Erickson

IPC: C12M1/00

Abstract: A flow distribution device for bioprocess systems, comprising: ⋅—a flow distribution manifold (12; 112; 212; 312) comprising: ⋅o at least four fluid connection tubes (14), wherein each fluid connection tube (14) comprises a first end (18) for fluid connection and an opposite second end (20) ⋅o a central common compartment (30; 130; 230; 330) to which the second ends (20) of each of the fluid connection tubes (14) are connected, whereby the first ends (18) of each of the fluid connection tubes (14) can be in fluid communication with the central common compartment (30; 130; 230; 330) ⋅—at least three pinching members (41) which are provided in connection with one fluid connection tube (14) of the flow distribution manifold (12; 112; 212; 312) each, wherein each of said pinching members (41) can be controlled into at least a first and a second position, wherein in the first position for each of the pinching members (41) the pinching member pinches one of the fluid connection tubes (14) such that fluid flow is prevented between the first end (18) and the second end (20) of this fluid connection tube (14)

公开(公告)号：US11224827B2

公开(公告)日：2022-01-18

申请号：US16348581

申请日：2017-11-10

Applicant: Cytiva Sweden AB

Inventor： Mats Lundkvist ,  Daniel Salomonsson

IPC: B01D15/22 ,  B32B1/08 ,  B32B3/06 ,  B32B7/12 ,  B32B27/08 ,  B32B27/30 ,  B32B27/32 ,  B32B37/12 ,  B32B37/18 ,  G01N30/60 ,  G01N30/02

Abstract: Disclosed is a chromatography column cylinder (200) formed from a polymer composite comprising an outer layer (220) and inner layer (210) intended to be in direct contact with the intended contents of the cylinder in a volume (202), wherein the outer layer supports the inner layer, for example when there is negative pressure in the volume (202). In one embodiment, one of said layers is molded directly onto a surface of the other layer such that there is no gap between the two layers. Disclosed also is a method for forming a chromatography column cylinder.

公开(公告)号：US20220001300A1

公开(公告)日：2022-01-06

申请号：US17280425

申请日：2019-10-09

Applicant: Cytiva Sweden AB

Inventor： Nils Stafstrom

IPC: B01D15/24 ,  G01N30/80

Abstract: A method for fraction collection and a fraction collection system (100) comprising: —a dispensing device (23) including an outlet (24) configured for dispensing fractions of a liquid received from a connected system; —plural receptacles (25) configured for receiving one or more of said fractions, wherein the receptacles (25) and the dispensing device (23) are movable in relation to each other into a number of different positions such that the dispensing device (23) is capable of dispensing a respective fraction of said liquid into one or more of the receptacles (25); —a waste collection device (27), which is arranged in the fraction collection system (100) such that it is movable into at least a first and a second position wherein, in said first position, an inlet (29) of the waste collection device (27) is positioned below the outlet (24) of the dispensing device (23) such that liquid being dispensed from the outlet (24) of the dispensing device (23) is received in the waste collection device (27) and wherein, in the second position, the inlet (29) of the waste collection device (27) is not positioned below the outlet (24) of the dispensing device (23) such that fractions being dispensed from the dispensing device (23) can be received in one or more of the receptacles (25).

公开(公告)号：US11179725B2

公开(公告)日：2021-11-23

申请号：US16315905

申请日：2017-07-06

Applicant: CYTIVA SWEDEN AB

Inventor： Hakan Erik Roos ,  Stefan Sjolander ,  Per Kjellin ,  Bharath Subrahmanya

IPC: B01L3/00 ,  G01N35/10 ,  B65D51/00 ,  A61J1/14

Abstract: A self-adhesive layered septum is disclosed. In one example, the septum includes a first outer layer including a thermoplastic elastomer such as a styrenic block copolymer, containing styrene ethylene butylene styrene (TPE-SEBS) capable of closing at least partially an aperture formed when a needle is inserted through the layer; an adhesive second layer for adhering the septum to a mouth area of a well or container to which the septum is attachable; and a thermoplastic third layer between the first and second layers, thermobonded to the first layer and providing better adherence for the adhesive layer. The first layer includes a recess and a vent, which reduce pressure differentials in use, but together with the third layer minimize evaporation through the septum.

公开(公告)号：US20210313033A1

公开(公告)日：2021-10-07

申请号：US17265780

申请日：2019-09-30

Applicant: Cytiva Sweden AB

Inventor： Klaus Gebauer ,  Hanish Lakhani ,  Swapnil Puranik ,  Nishu Garg ,  Hemalatha J

IPC: G16H20/10 ,  G05B13/02 ,  G16H70/40

Abstract: A monitoring system comprises a manufacture system with capability to manufacture a plurality of biopharmaceutical products, at least one image capture device arranged to capture a scene comprising the manufacture system, and a processing element connected to said at least one image capture device and arranged to process images captured by said at least one image capture device to track operator interactions and/or a result of operator interactions within the scene. The processing element is further is arranged to compare a predefined workflow process scheme relating to the selected biopharmaceutical product to at least a part of the tracked operator interactions with the manufacture system and/or to at least a part of the result of the tracked operator interactions with the manufacture system, and determine whether at least one pre-set criterion set by the workflow process scheme is fulfilled based on the comparison.

公开(公告)号：US20210261900A1

公开(公告)日：2021-08-26

申请号：US17268486

申请日：2019-08-20

Applicant: Cytiva Sweden AB

Inventor： Anoop Bhargav ,  Praveen Paul ,  Prashanth Hosabettu Mohan ,  Ajay Gore ,  Pradeep Kumar ,  Victor Jose ,  Sahebagouda Alagur ,  Melissa Marie Semple ,  Mark David Roberts

IPC: C12M1/26 ,  C12M1/00 ,  C12M1/34 ,  B01D65/02 ,  B01D61/20 ,  B01D61/10

Abstract: A method includes inducing a first quantity of a feed fluid (28) to flow along a first direction (72) from a bioreactor (12) to a tangential flow filter (16) to separate the first quantity of the feed fluid (28) into a permeate fluid (42) and a retentate fluid (48). Further, the control unit (66) is operated to control at least one feed flow control device (24, 26) to inhibit the flow of first quantity of the feed fluid (28). Furthermore, the control unit (66) is operated to control the at least one feed flow control device (24, 26) to direct at least one of further flow of a second quantity of the feed fluid (28) from the bioreactor (12), a portion of the permeate fluid (42), and a portion of a nutrient fluid, along a second direction (74) opposite to the first direction (72) via the tangential flow filter (16).