公开(公告)号：US11925692B2

公开(公告)日：2024-03-12

申请号：US17596496

申请日：2020-06-12

申请人： Ecole Normale Supérieure Paris-Saclay ,  Centre National de la Recherche Scientifique

发明人： Claude Nogues ,  Malcolm Buckle ,  Stéphanie Vial

IPC分类号： A61K9/00 ,  A61K9/50 ,  A61K31/711 ,  A61K47/60 ,  A61K47/69 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00

CPC分类号： A61K47/6923 ,  A61K9/5031 ,  A61K31/711 ,  A61K47/60 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y40/00

摘要： The present invention pertains to the field of pre-functionalized nanoparticles (NPs). It relates more particularly to NPs pre-functionalized using a self-assembled monolayer (SAM) and also to NPs functionalized using biomolecules such that the NPs are stable in solution. These NPs may be used in numerous applications, especially as a diagnostic tool, for depleting a molecule of interest in a solution, and therapeutic tool.

公开(公告)号：US20240075435A1

公开(公告)日：2024-03-07

申请号：US18462100

申请日：2023-09-06

申请人： QFLUIDICS ,  Université de Strasbourg ,  Centre national de la recherche scientifique

发明人： Vincent Pascal MARICHEZ ,  Thomas HERMANS ,  Caroline Julie THEBAULT ,  Lucas Jean Daniel GIACCHETTI

IPC分类号： B01F25/31 ,  B01F25/314 ,  B01F33/451

CPC分类号： B01F25/311 ,  B01F25/314 ,  B01F33/451

摘要： Disclosed is a mixing device including a chamber defining a circulation zone, the circulation zone including at least one base liquid and a mixing fluid, the mixing fluid being less paramagnetic than the base liquid, the mixing fluid including and/or consisting of at least one first fluid, the mixing device including at least one magnetic element which generates a magnetic field in the circulation zone so that the mixing fluid flows into the base liquid, the chamber including at least one first injection point of the first fluid into the circulation zone, the first injection point opening into the base liquid.

公开(公告)号：US20240071450A1

公开(公告)日：2024-02-29

申请号：US18257161

申请日：2021-12-16

申请人： Commissariat à l'énergie atomique et aux énergies alternatives ,  THALES ,  Centre national de la recherche scientifique ,  UNIVERSITE GRENOBLE ALPES

发明人： Jean-Philippe ATTANE ,  Laurent VILA ,  Manuel BIBES

IPC分类号： G11C11/16 ,  G11C19/08 ,  H10B61/00 ,  H10N50/80 ,  H10N52/00

CPC分类号： G11C11/161 ,  G11C11/1673 ,  G11C19/0808 ,  H10B61/00 ,  H10N50/80 ,  H10N52/00

摘要： A device for modifying at least the direction of magnetization of a magnetic layer, the modifying device including a ferroelectric layer having a ferroelectric polarization, arranged on or under the magnetic layer so as to define a stack including at least the magnetic layer and the ferroelectric layer, a generator apt to inject an electric current into the stack along a direction parallel to the plane of the layers of the stack, and a modification unit apt to modify the ferroelectric polarization of the ferroelectric layer, for modifying, with the generator, the direction of magnetization of the magnetic layer.

公开(公告)号：US20240058258A1

公开(公告)日：2024-02-22

申请号：US17755183

申请日：2020-10-23

申请人： Universite Paris-Saclay ,  Centre National de la Recherche Scientifique

发明人： Raphaël Haumont ,  Olesya Stukanova

IPC分类号： A61K8/9717 ,  A61K8/9794 ,  A61Q19/00 ,  B65D65/46 ,  A61K8/02 ,  A45D44/00 ,  C08J5/18

CPC分类号： A61K8/9717 ,  A61K8/9794 ,  A61Q19/007 ,  B65D65/466 ,  A61K8/0212 ,  A45D44/002 ,  C08J5/18 ,  A61K2800/882 ,  A61K2800/524 ,  C08J2305/00 ,  C08J2303/04

摘要： A stretch film for use in the cosmetic or agri-food packaging sectors comprises konjac and carrageenan in a mass ratio of between 20/80 and 60/40. A stretch film according to the present disclosure has advantageous properties for use as a biodegradable stretch cling film and cosmetic mask.

公开(公告)号：US11905253B2

公开(公告)日：2024-02-20

申请号：US17049680

申请日：2019-04-19

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  UNIVERSITE DE RENNES 1 ,  CENTRE HOSPITALIER UNIVERSITAIRE DE BORDEAUX ,  INSTITUT BERGONIE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE DE BORDEAUX

发明人： Pierre Vacher ,  Patrick Legembre ,  Mickael Jean ,  Patrick Blanco ,  Pierre Van De Weghe

IPC分类号： C07D233/64 ,  A61P37/00 ,  A61K45/06

CPC分类号： C07D233/64 ,  A61K45/06 ,  A61P37/00

摘要： The present invention relates the field of reducing CD95-mediated cell motility in a subject, in particular for their use in the reduction of CD-95 mediated cancer cell motility, the reduction of CD95-mediated lymphocyte motility and/or B cell maturation, or the treatment of B-cell tumors, in a subject. The inventors identified a novel family of compounds having the ability to disrupt CD95/PLCγ1 interaction and to neutralize the CD95-mediated calcium signaling pathway and cell migration in human peripheral blood lymphocytes (PBLs) and Th17 cells. Thus, the present invention relates to compounds of formula (A) as defined in the present text, to a pharmaceutical composition comprising said compounds in a pharmaceutically acceptable medium and to the use of these compounds and compositions as medicament, in particular for their use in the reduction or treatment of the above-mentioned pathologies, and in particular in the treatment of cancers and autoimmune inflammatory disease such as systemic lupus erythematosus, inflammatory condition and Th17-mediated disease.

公开(公告)号：US11904268B2

公开(公告)日：2024-02-20

申请号：US18067120

申请日：2022-12-16

申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS—

发明人： Thu-Hoa Tran-Thi ,  Ana Borta ,  Mickael Gineys ,  Marie-Pierre Som ,  Frédéric Hammel

IPC分类号： B01D53/02 ,  B01J20/20 ,  B01J20/10 ,  B01J20/22 ,  B01J20/28

CPC分类号： B01D53/02 ,  B01J20/20 ,  B01D2253/106 ,  B01D2253/306 ,  B01D2253/308 ,  B01D2258/06 ,  B01J20/103 ,  B01J20/22 ,  B01J20/28057

摘要： A method for preparing a nanoporous silica sol-gel matrix containing at least one amine reactant selected from hydroxylamine, methylhydroxylamine, tertbutylhydroxylamine, methoxyamine, tetraethylenepentamine, dicarboxylic acid dihydrazides, particularly adipic acid dihydrazide, and the salts thereof, said method including the following steps: a) synthesising a gel from tetramethoxysilane or from a mixture of tetramethoxysilane and another organosilicon precursor selected from among phenyltrimethoxysilane, phenyltriethoxysilane, a fluoroalkyltrimethoxysilane, a fluoroalkyltriethoxysilane, a chloroalkylmethoxysilane, a chloroalkylethoxysilane, an alkyltrimethoxysilane, an alkyltriethoxysilane, an aminopropyltriethoxysilane and the mixtures thereof, the synthesis being performed in an aqueous medium at a temperature ranging from 10 to 70° C. in the presence of at least one amine reactant selected from among hydroxylamine, methylhydroxylamine, tertbutylhydroxylamine, methoxyamine, dicarboxylic acid dihydrazides, particularly adipic acid dihydrazide, and the salts thereof; b) drying the gel obtained during step a) so as to obtain a sol-gel matrix containing at least one amine reactant.

公开(公告)号：US11903720B2

公开(公告)日：2024-02-20

申请号：US16741549

申请日：2020-01-13

申请人： DIGNITY HEALTH ,  LE CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Stephen L. Macknik ,  Susana Martinez-Conde ,  Zoi Kapoula ,  Jorge Otero-Millan

IPC分类号： A61B5/00 ,  A61B3/00 ,  A61B3/113

CPC分类号： A61B5/4088 ,  A61B3/0025 ,  A61B3/0091 ,  A61B3/113 ,  A61B5/4842 ,  A61B5/4848

摘要： A system and method of detecting eye movements of a subject for the diagnosis of neurological disorders. The method includes tracking eye movements of the subject, identifying microsaccades from the tracked eye movements, and characterizing microsaccade dynamics of the identified microsaccades to determine one or more parameters, such as microsaccade direction, microsaccade velocity, microsaccade magnitude, microsaccadic peak velocity-magnitude relationship, microsaccade duration, and intersaccadic intervals. The method also includes comparing the one or more determined parameters with a corresponding control parameter, assessing the comparison to determine differences between the one or more determined parameters and the corresponding control parameters, and generating a report including the diagnosis of neurological disorder based on the assessment.

公开(公告)号：US11903382B2

公开(公告)日：2024-02-20

申请号：US18095943

申请日：2023-01-11

申请人： UNIVERSITE DE TECHNOLOGIE DE COMPIEGNE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  SORBONNE UNIVERSITE ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS

发明人： Cécile Legallais ,  Patrick Paullier ,  Olivier Scatton ,  Eric Savier

IPC分类号： G09B23/30 ,  A01N1/02

CPC分类号： A01N1/0247

摘要： Disclosed is a device for the perfusion of an organ, including: a container of fluid, containing an organ bathed in the perfusion fluid; a first path including an inlet, an outlet and a pump; and a second path including an inlet, an outlet and a pump. The “arterial” outlet of the first path has a diameter smaller than a diameter of the “portal” outlet of the second path. The device additionally includes, between the pump and the outlet of the first path and/or between the pump and the outlet of the second path, an oxygenation unit arranged to oxygenate the fluid emerging from the “arterial” outlet of the first path more than the fluid emerging from the “portal” outlet of the second path. The device can include a communication path between the first path and the second path in order to oxygenate the second path. Use in liver transplantation.

公开(公告)号：US20240049745A1

公开(公告)日：2024-02-15

申请号：US18493456

申请日：2023-10-24

申请人： AVRIL ,  UNIVERSITE DE LORRAINE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE

发明人： Claire DEFAIX ,  Romain KAPEL ,  Olivier GALET

IPC分类号： A23J1/14 ,  C07K1/34

CPC分类号： A23J1/142 ,  A23J1/148 ,  C07K1/34 ,  C07K14/76

摘要： A process for producing a protein isolate from an oilseed meal, and the isolate thus obtained, said isolate comprising proteins and an amount of 4 wt % or less of phytic acid, said amount of phytic acid being by weight of proteins in said isolate. The process may comprise the following steps: a) providing an oilseed meal; b) mixing the oilseed meal with a first aqueous solvent to form a slurry at a pH ranging from 6 to 7.8, said slurry having a solid phase; c) separating said solid phase from said slurry, d) mixing said separated solid phase with a second aqueous solvent at a pH ranging from 1 to 3.5, preferably from 2 to 3, to form a mixture said mixture having a liquid phase; e) separating said liquid phase from said mixture formed in step d); f) f1) mixing the separated liquid phase to a phytase at a temperature and a pH suitable for phytase activity to obtain a mixture having a liquid phase and a solid phase; and/or f2) mixing the separated liquid to a salt, to obtain a resulting liquid composition having a molar concentration of said salt ranging from 0.05 M to 0.5 M, at a temperature ranging from 40° C. to 70° C., to obtain a mixture having a liquid phase and a solid phase; g) precipitating a solid phase from the liquid of step f) for example by a cooling down step of the mixture to a temperature of 30° C. or less; h) separating said solid precipitate from the liquid of step g) said liquid comprising a water-rich liquid phase and an oil-rich liquid phase; i) separating said water-rich liquid phase from said oil-rich liquid phase, j) subjecting said water-rich liquid phase obtained in step i) to one or several membrane filtration(s) to obtain a protein isolate; and k) optionally, drying said protein isolate to obtain a dry protein isolate.

公开(公告)号：US20240047601A1

公开(公告)日：2024-02-08

申请号：US18259017

申请日：2021-12-22

申请人： UNIVERSITE D’AIX MARSEILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE TOURS ,  INSA CENTRE VAL DE LOIRE

发明人： Gaël GAUTIER ,  Wilfried VERVISCH ,  Damien VALENTE

IPC分类号： H01L31/115 ,  H01L31/18 ,  H01L31/0352

CPC分类号： H01L31/115 ,  H01L31/1804 ,  H01L31/0352 ,  H01L31/028

摘要： A device for measuring a particle beam, includes front and rear faces, a first central portion including a device for forming a space charge region through which a particle beam to be measured passes, charge carriers of a first and second type being generated by the beam when the latter passes through the space charge region, a second peripheral portion including a device for collecting at least one type of charge carrier from the first or second type of charge carriers generated in the space charge region, the central portion having a maximum thickness less than or equal to that of the peripheral portion, the peripheral portion surrounding the central portion such that a particle beam can pass through the central portion without passing through the peripheral portion. The device includes, in a region of the central portion leading to the rear face, a layer of a porous material.