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71.发明授权公开(公告)号：US08283445B2
公开(公告)日：2012-10-09
申请号：US11983235
申请日：2007-11-08
Applicant: Thomas David Reed
Inventor： Thomas David Reed
CPC classification number: C07K14/001 , C07K14/47 , C07K2319/21 , C07K2319/43 , C07K2319/60 , C12N15/62 , C12N15/85
Abstract: The invention relates to kinase inhibitor ligands and polyligands. In particular, the invention relates to ligands and polyligands that modulate ERK activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
Abstract translation: 本发明涉及激酶抑制剂配体和聚合配体。 特别地，本发明涉及调节ERK活性的配体和聚合配体。 配体和聚合物配体被用作研究工具或治疗剂。 本发明包括配体和聚合配体与细胞定位信号，表位标签和/或报告子的连接。 本发明还包括编码配体和聚合配体的多核苷酸。
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公开(公告)号：US20110224872A1
公开(公告)日：2011-09-15
申请号：US12720701
申请日：2010-03-10
Applicant: David Reed
Inventor： David Reed
IPC: G06F19/00
CPC classification number: B66F11/04 , B60W10/20 , B62D6/002 , B66F9/07568
Abstract: A vehicle controlled via a joystick has a turn request mode and a return to center request. While the operator is requesting a turn, steered wheels are turned at a predetermined rate, steering angle continuing to change while the turn request is being applied. When the operator ceases requesting a turn, the return to center mode is invoked: a direction of a virtual wheel of the vehicle is determined and such direction is maintained. A vehicle angular velocity is computed based on vehicle velocity and a virtual steering angle, which is the angle between the direction the virtual wheel is pointing and the longitudinal axis of the vehicle. To maintain the direction of the virtual wheel during a return to center, the virtual wheel is turned at an angular velocity equal in magnitude to the angular velocity of the vehicle and in a direction to return to center.
Abstract translation: 通过操纵杆控制的车辆具有转向请求模式和返回中心请求。 当操作者请求转弯时，转向轮以预定速率转动，转向角在施加转弯请求时继续改变。 当操作者停止请求转弯时，调用返回中心模式：确定车辆的虚拟车轮的方向，并维持该方向。 基于车辆速度和虚拟转向角计算车辆角速度，虚拟转向角是虚拟车轮指向的方向与车辆的纵向轴线之间的角度。 为了在返回到中心期间保持虚拟轮的方向，虚拟轮以与车辆的角速度等于大小的角速度并且在返回到中心的方向上转动。
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73.发明申请公开(公告)号：US20110218159A1
公开(公告)日：2011-09-08
申请号：US13037490
申请日：2011-03-01
Applicant: Philip Manton Brown , Joel Philip Freiman , David Reed Powell
Inventor： Philip Manton Brown , Joel Philip Freiman , David Reed Powell
IPC: A61K31/7028 , C07H15/14 , A61P3/00 , A61P9/00
CPC classification number: A61K31/7028 , A61K31/155 , A61K31/351 , A61K31/4985 , A61K45/06 , A61K2300/00
Abstract: Methods of improving the cardiovascular and/or metabolic health of patients, particularly those suffering from type 2 diabetes, are disclosed, as well as compounds and pharmaceutical compositions useful therein.
Abstract translation: 公开了改善患者，特别是患有2型糖尿病的患者的心血管和/或代谢健康的方法，以及其中有用的化合物和药物组合物。
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74.发明申请MASTER TOOLS WITH SELECTIVELY ORIENTABLE REGIONS FOR MANUFACTURE OF PATTERNED SHEETING 审中-公开具有选择性区域的主要工具用于制作图案公开(公告)号：US20110216412A1
公开(公告)日：2011-09-08
申请号：US13040250
申请日：2011-03-03
Applicant: David Reed , John Nelson
Inventor： David Reed , John Nelson
CPC classification number: B29D11/00605 , G02B5/124
Abstract: In one embodiment of the invention, a master tool is disclosed including a top plate, a plurality of buttons, and a releasable locking mechanism. The top plate has an array of openings and a top side with a background patterned surface. The plurality of buttons are in the array of openings and configured to be repositioned to selectively orient their orientable patterned surface into a different orientation with respect to the background patterned surface. The releasable locking mechanism releasably locks the position of the plurality of buttons within the array of openings to hold the selected orientation of each orientable patterned surface with respect to the background patterned surface to provide a top surface pattern. The top surface pattern of the master tooling may be transferred to form a surface pattern into retro-reflective sheeting during its manufacture.
Abstract translation: 在本发明的一个实施例中，公开了一种主工具，其包括顶板，多个按钮和可释放的锁定机构。 顶板具有开口阵列和具有背景图案表面的顶侧。 多个按钮处于开口阵列中并且被配置为重新定位以选择性地将其可取向的图案化表面定向成相对于背景图案化表面的不同取向。 可释放的锁定机构将多个按钮的位置可释放地锁定在开口阵列内，以相对于背景图案化表面保持每个可定向图案化表面的选定取向以提供顶部表面图案。 主工具的顶表面图案可以在其制造期间被转移以形成逆反射片材。
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公开(公告)号：US20110216411A1
公开(公告)日：2011-09-08
申请号：US13040044
申请日：2011-03-03
Applicant: David Reed , John Nelson
Inventor： David Reed , John Nelson
IPC: G02B5/124
CPC classification number: B29D11/00605 , G02B5/124
Abstract: In one embodiment of the invention, retro-reflective sheeting is disclosed. The retro-reflective sheeting comprises a flexible optical material film or substrate having a geometric optical surface opposite a base surface. The geometric optical surface includes a background pattern region of corner cubes arranged at a first orientation with respect to an edge of the retro-reflective sheeting; and an array of circular corner cube regions periodically interrupting the background pattern region of corner cubes. Each of the circular corner cube regions has a second orientation with respect to the edge of the retro-reflective sheeting. The array of the plurality of circular corner cube regions reflects incident light differently than the background pattern region of corner cubes.
Abstract translation: 在本发明的一个实施例中，公开了逆反射片。 逆反射片包括具有与基面相对的几何光学表面的柔性光学材料膜或基底。 所述几何光学表面包括相对于所述逆反射片的边缘以第一取向布置的拐角立方体的背景图案区域; 以及周向性地中断角立方体的背景图案区域的圆形角立方体区域的阵列。 每个圆形拐角立方体区域相对于逆反射片材的边缘具有第二取向。 多个圆角棱镜区域的阵列反射与角立方体的背景图案区域不同的入射光。
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Patent Agency Ranking
公开(公告)号：US20110195504A1
公开(公告)日：2011-08-11
申请号：US12973624
申请日：2010-12-20
Applicant: Thomas David REED
Inventor： Thomas David REED
CPC classification number: C07K14/47
Abstract: The invention relates to polarized cell tubulo-vesicular structure localization signals. The localization signals are utilized as research tools or are linked to polypeptides of interest or therapeutic molecules. Disclosed are methods of making and using polypeptides and modified polypeptides as signals to localize therapeutics, experimental compounds, peptides, proteins and/or other macromolecules to the tubulo-vesicular structures of polarized cells. The polypeptides of the invention optionally include linkage to reporters, epitopes and/or other experimental or therapeutic molecules. The invention also encompasses polynucleotides encoding the localization signals and vectors comprising these polynucleotides.
Abstract translation: 本发明涉及极化细胞肾小管结构定位信号。 本地化信号被用作研究工具或与感兴趣的多肽或治疗分子连接。 公开了制备和使用多肽和修饰的多肽作为将治疗剂，实验化合物，肽，蛋白质和/或其他大分子定位于极化细胞的肾小管结构的信号的方法。 本发明的多肽任选地包括与记者，表位和/或其他实验或治疗分子的连接。 本发明还包括编码定位信号的多核苷酸和包含这些多核苷酸的载体。
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公开(公告)号：US07806559B2
公开(公告)日：2010-10-05
申请号：US11585005
申请日：2006-10-23
Applicant: Benjamin David Reed
Inventor： Benjamin David Reed
IPC: F21S4/00
CPC classification number: F21S4/10 , Y10S362/806
Abstract: Disclosed is a decorative light string, being formable to provide varying shapes, to hold position when wrapped around or placed upon structures to be decorated, and to facilitate storage without tangling of one or more light strings.
Abstract translation: 公开了一种装饰灯串，其可形成为提供不同的形状，以在缠绕或放置在待装饰的结构上时保持位置，并且便于存储而不会缠绕一个或多个光线。
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公开(公告)号：US07705122B2
公开(公告)日：2010-04-27
申请号：US11947880
申请日：2007-11-30
Applicant: Thomas David Reed , Amy H. Atzel
Inventor： Thomas David Reed , Amy H. Atzel
IPC: C07K1/00
CPC classification number: A61K38/16 , A61K48/00 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/4703 , C07K2319/02 , C07K2319/41 , C12N1/20 , C12N15/10 , C12N15/62
Abstract: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate mTOR activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
Abstract translation: 本发明涉及激酶配体和聚合配体。 特别地，本发明涉及调节mTOR活性的配体，均聚配体和杂多糖配体。 配体和聚合物配体被用作研究工具或治疗剂。 本发明包括配体和聚合配体与细胞定位信号，表位标签和/或报告子的连接。 本发明还包括编码配体和聚合配体的多核苷酸。
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公开(公告)号：US20090116198A1
公开(公告)日：2009-05-07
申请号：US11982630
申请日：2007-11-02
Applicant: Stephen Arthur McKeown , Gary Geno Stefani , David Reed Benedict , Andrew Karl Crane
Inventor： Stephen Arthur McKeown , Gary Geno Stefani , David Reed Benedict , Andrew Karl Crane
IPC: H05K7/20
CPC classification number: H01L23/42 , H01L23/4275 , H01L2023/4056 , H01L2924/0002 , Y10T29/4935 , H01L2924/00
Abstract: The present invention relates generally to heat removal from circuit board components and, more specifically, to improved thermal management for circuit board components mounted on electrical wiring boards. The structure comprises a heat sink; and an auxiliary heat sink positioned in thermal contact with the heat sink and a circuit board component on a wiring board, the auxiliary heat sink having a plurality of slots located in a central portion of the auxiliary heat sink, wherein the auxiliary heat sink is both mechanically compliant and thermally conductive with both the heat sink and the circuit board component.
Abstract translation: 本发明一般涉及从电路板部件的散热，更具体地说，涉及改进安装在电气布线板上的电路板组件的热管理。 该结构包括散热器; 以及与所述散热器热接触地配置的辅助散热器和布线板上的电路板部件，所述辅助散热器具有位于所述辅助散热器的中心部分中的多个狭槽，其中所述辅助散热器都是 与散热器和电路板部件兼容地机械地兼容并导热。
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公开(公告)号：US20080220475A1
公开(公告)日：2008-09-11
申请号：US11947880
申请日：2007-11-30
Applicant: Thomas David Reed , Amy H. Atzel
Inventor： Thomas David Reed , Amy H. Atzel
CPC classification number: A61K38/16 , A61K48/00 , C07K14/00 , C07K14/47 , C07K14/4702 , C07K14/4703 , C07K2319/02 , C07K2319/41 , C12N1/20 , C12N15/10 , C12N15/62
Abstract: The invention relates to kinase ligands and polyligands. In particular, the invention relates to ligands, homopolyligands, and heteropolyligands that modulate mTOR activity. The ligands and polyligands are utilized as research tools or as therapeutics. The invention includes linkage of the ligands and polyligands to a cellular localization signal, epitope tag and/or a reporter. The invention also includes polynucleotides encoding the ligands and polyligands.
Abstract translation: 本发明涉及激酶配体和聚合配体。 特别地，本发明涉及调节mTOR活性的配体，均聚配体和杂多糖配体。 配体和聚合物配体被用作研究工具或治疗剂。 本发明包括配体和聚合配体与细胞定位信号，表位标签和/或报告子的连接。 本发明还包括编码配体和聚合配体的多核苷酸。
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