公开(公告)号：US11690577B2

公开(公告)日：2023-07-04

申请号：US16884593

申请日：2020-05-27

Applicant: DexCom, Inc.

Inventor： Hari Hampapuram ,  Anna Leigh Davis ,  Naresh C. Bhavaraju ,  Apurv Ullas Kamath ,  Claudio Cobelli ,  Giovanni Sparacino ,  Andrea Facchinetti ,  Chiara Zecchin

IPC: A61B5/00 ,  A61B5/145

CPC classification number: A61B5/746 ,  A61B5/0004 ,  A61B5/0022 ,  A61B5/0031 ,  A61B5/14503 ,  A61B5/14532 ,  A61B5/4848 ,  A61B5/4866 ,  A61B5/7221 ,  A61B5/7275 ,  A61B5/002

Abstract: Systems and methods for providing sensitive and specific alarms indicative of glycemic condition are provided herein. In an embodiment, a method of processing sensor data by a continuous analyte sensor includes: evaluating sensor data using a first function to determine whether a real time glucose value meets a first threshold; evaluating sensor data using a second function to determine whether a predicted glucose value meets a second threshold; activating a hypoglycemic indicator if either the first threshold is met or if the second threshold is predicted to be met; and providing an output based on the activated hypoglycemic indicator.

公开(公告)号：US20230190151A1

公开(公告)日：2023-06-22

申请号：US18067427

申请日：2022-12-16

Applicant: Dexcom, Inc.

Inventor： James S. Amidei ,  Stefan M. Robert ,  Anna Harley-Trochimczyk ,  Thomas George O'Connell ,  Anderson Ionut Micu

IPC: A61B5/145

CPC classification number: A61B5/14546 ,  A61B5/14532

Abstract: Various examples are directed to systems and methods that may utilize an analyte sensor system comprising a sensor enclosure; an analyte sensor extending from the sensor enclosure; and sensor electronics positioned within the sensor enclosure. The sensor electronics may be configured to detect that a wireless signal has changed from a first state to a second state, where the wireless signal may be provided through the sensor enclosure. After detecting that the wireless signal has changed from the first state to the second state, the sensor electronics may monitor whether the wireless signal remains in the second state for at least a stability threshold time period. The sensor electronics may execute a responsive action in the sensor system based at least in part on whether the wireless signal remains in the second state for at least the stability threshold time period.

公开(公告)号：US20230186115A1

公开(公告)日：2023-06-15

申请号：US18066254

申请日：2022-12-14

Applicant: Dexcom, Inc.

Inventor： Afshan A. KLEINHANZL ,  Alexander Michael DIENER ,  Adam G. NOAR, JR. ,  Stacey Lynne FISCHER ,  Chad M. PATTERSON ,  Carly Rose OLSON ,  Michiko Araki KELLEY ,  Amit Premal JOSHIPURA ,  Spencer Troy FRANK ,  Qi AN ,  Abdulrahman JBAILY ,  Sophia PARK ,  Justin Yi-Kai LEE ,  Joost Herman VAN DER LINDEN ,  Mark DERDZINSKI

IPC: G06N5/022

CPC classification number: G06N5/022

Abstract: Systems, devices, and methods for data collection and development as well as providing user interaction policies are provided. In one embodiment, a method includes collecting contextual data for a first subset of a plurality of users. The method further includes generating a first set of contextual profiles for the first subset of the plurality of users based on the collected contextual data. Additionally, the method includes training one or more imputation models to develop the contextual data for the second subset of the plurality of users. The method also includes generating the contextual data for the second subset of the plurality of users using the one or more imputation models. Further, the method includes generating a second set of contextual profiles for the second subset of the plurality of users based on the generated contextual data for the second subset of the plurality of users.

公开(公告)号：US11677443B1

公开(公告)日：2023-06-13

申请号：US18163241

申请日：2023-02-01

Applicant: Dexcom, Inc.

Inventor： Thomas Miller ,  Mark Dervaes ,  Phong Lieu ,  Peter C. Simpson ,  Shawn Larvenz ,  Jacob S. Leach ,  Sebastian Bohm

IPC: H04B5/00 ,  H04W76/14 ,  A61B5/145 ,  A61B5/1486 ,  A61B5/1495 ,  G01N27/327 ,  H04W12/06 ,  H04W4/80 ,  H04W52/02 ,  H04B5/02

CPC classification number: H04B5/0031 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/14532 ,  G01N27/3271 ,  H04B5/0043 ,  H04W4/80 ,  H04W12/06 ,  H04W12/068 ,  H04W52/0229 ,  H04W76/14 ,  H04B5/02 ,  Y02D30/70

Abstract: Systems and methods for processing, transmitting and displaying data received from an analyte sensor, such as a glucose sensor, are disclosed. In an embodiment, a method for transmitting data between a first communication device associated with an analyte sensor and a second communication device configured to provide user access to sensor-related information comprises: activating a transceiver of a first communication device associated with an analyte sensor at a first time; and establishing a two-way communication channel with the second communication device; wherein the activating comprises waking the transceiver from a low power sleep mode using a forced wakeup from the second communication device.

公开(公告)号：US20230170090A1

公开(公告)日：2023-06-01

申请号：US18163255

申请日：2023-02-01

Applicant: Dexcom, Inc.

Inventor： Naresh C. BHAVARAJU ,  Arturo GARCIA ,  Phil MAYOU ,  Thomas A. PEYSER ,  Apurv Ullas KAMATH ,  Aarthi MAHALINGAM ,  Kevin SAYER ,  Thomas HALL ,  Michael Robert MENSINGER ,  Hari HAMPAPURAM ,  David PRICE ,  Jorge VALDES ,  Murrad KAZALBASH

IPC: G16H40/67 ,  A61M5/172 ,  A61M5/142 ,  G16H40/63 ,  G16H50/30 ,  G16H15/00 ,  G16H20/17 ,  G01N33/49 ,  G16H50/00

CPC classification number: G16H40/67 ,  A61M5/1723 ,  A61M5/142 ,  G16H40/63 ,  G16H50/30 ,  G16H15/00 ,  G16H20/17 ,  G01N33/49 ,  G16H50/00

Abstract: Methods and apparatus, including computer program products, are provided for processing analyte data. In some example implementations, a method may include generating glucose sensor data indicative of a host's glucose concentration using a glucose sensor; calculating a glycemic variability index (GVI) value based on the glucose sensor data; and providing output to a user responsive to the calculated glycemic variability index value. The GVI may be a ratio of a length of a line representative of the sensor data and an ideal length of the line. Related systems, methods, and articles of manufacture are also disclosed.

公开(公告)号：US11653859B2

公开(公告)日：2023-05-23

申请号：US16011570

申请日：2018-06-18

Applicant: DexCom, Inc.

Inventor： Joseph J. Baker ,  Justen Deering England ,  Warren Terry ,  Patrick John Castagna ,  Randall Scott Koplin ,  Andrew Joncich

IPC: A61B5/145 ,  A61B5/00 ,  A61B17/34

CPC classification number: A61B5/14503 ,  A61B5/0004 ,  A61B5/14532 ,  A61B5/6833 ,  A61B5/6849 ,  A61B5/742 ,  A61B17/3468 ,  A61B5/14546 ,  A61B5/688 ,  A61B5/6848 ,  A61B2560/0406 ,  A61B2560/063 ,  A61B2562/12 ,  A61B2562/242

Abstract: Applicators for applying an on-skin assembly to skin of a host and methods of their use and/or manufacture are provided. An applicator includes an insertion assembly configured to insert at least a portion of the on-skin assembly into the skin of the host, a housing configured to house the insertion assembly, the housing comprising an aperture through which the on-skin assembly can pass, an actuation member configured to, upon activation, cause the insertion assembly to insert at least the portion of the on-skin assembly into the skin of the host, and a sealing element configured to provide a sterile barrier and a vapor barrier between an internal environment of the housing and an external environment of the housing.

公开(公告)号：US20230140651A1

公开(公告)日：2023-05-04

申请号：US18049924

申请日：2022-10-26

Applicant: Dexcom. Inc.

Inventor： Arturo Garcia ,  Peter C. Simpson ,  Apurv U. Kamath ,  Naresh C. Bhavaraju ,  Stephen J. Vanslyke

IPC: A61B5/00 ,  A61B5/145 ,  A61B5/1495

Abstract: Systems and methods are provided to calibrate an analyte concentration sensor within a biological system, generally using only a signal from the analyte concentration sensor. For example, at a steady state, the analyte concentration value within the biological system is known, and the same may provide a source for calibration. Similar techniques may be employed with slow-moving averages. Variations are disclosed.

公开(公告)号：US20230140055A1

公开(公告)日：2023-05-04

申请号：US18051840

申请日：2022-11-01

Applicant: Dexcom, Inc.

Inventor： Simone FACCIOLI ,  Andrea FACCHINETTI ,  Simone DEL FAVERO ,  Francisco PRENDIN ,  Giovanni SPARACINO

IPC: A61B5/00 ,  A61B5/145

Abstract: Certain aspects of the present disclosure relate to methods and systems for providing decision support around glucose management for patients with diabetes. Time-varying inputs including blood glucose, meal intake information, and amount of infused insulin are processed using a machine learning model to obtain predicted glucose levels for a plurality of prediction horizons and uncertainties for the predictions. A confidence interval is generated for each prediction and the confidence intervals are compared to hypo- and hyperglycemic thresholds. If a confidence interval is entirely below or entirely above the hypo- and hyperglycemic thresholds, respectively, then a decision support output is provided.

公开(公告)号：US20230138407A1

公开(公告)日：2023-05-04

申请号：US18091658

申请日：2022-12-30

Applicant: DexCom, Inc.

Inventor： Jiong Zou ,  Robert J. Boock ,  Andrew Trinin Dennis ,  Ted Tang Lee ,  Jeff T. Suri ,  David Sze ,  Mark A. Tapsak ,  Huashi Zhang ,  Shanger Wang

IPC: G01N27/327 ,  C12N11/089 ,  C12N11/093 ,  C12N11/08 ,  C08L39/06 ,  C08L69/00 ,  C08L75/04 ,  C12Q1/00 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1486 ,  G01N33/66 ,  A61K31/045 ,  A61K31/137 ,  A61K31/46 ,  A61K31/465 ,  A61K31/485 ,  A61K31/515 ,  A61K31/56 ,  A61K33/00 ,  A61K36/185 ,  A61K38/28 ,  A61B5/1473

Abstract: Disclosed are devices for determining an analyte concentration (e.g., glucose). The devices comprise a sensor configured to generate a signal associated with a concentration of an analyte and a sensing membrane located over the sensor. The sensing membrane comprises an enzyme layer, wherein the enzyme layer comprises an enzyme and a polymer comprising polyurethane and/or polyurea segments and one or more zwitterionic repeating units. The enzyme layer protects the enzyme and prevents it from leaching from the sensing membrane into a host or deactivating.

公开(公告)号：US20230129853A1

公开(公告)日：2023-04-27

申请号：US18145220

申请日：2022-12-22

Applicant: Dexcom, Inc.

Inventor： Peter C. SIMPSON ,  Robert J. BOOCK ,  Apurv Ullas KAMATH, JR. ,  Matthew D. WIGHTLIN ,  Michael J. ESTES

IPC: A61B5/1473 ,  A61B5/1486 ,  B05C3/12 ,  B05C3/02 ,  B23K26/362 ,  A61B5/145 ,  B05C3/10

Abstract: Devices and methods are provided for continuous measurement of an analyte concentration. The device can include a sensor having a plurality of sensor elements, each having at least one characteristic that is different from other sensor(s) of the device. In some embodiments, the plurality of sensor elements are each tuned to measure a different range of analyte concentration, thereby providing the device with the capability of achieving a substantially consistent level of measurement accuracy across a physiologically relevant range. In other embodiments, the device includes a plurality of sensor elements each tuned to measure during different time periods after insertion or implantation, thereby providing the sensor with the capability to continuously and accurately measure analyte concentrations across a wide range of time periods. For example, a sensor system 180 is provided having a first working electrode 150 comprising a first sensor element 102 and a second working electrode 160 comprising a second sensor element 104, and a reference electrode 108 for providing a reference value for measuring the working electrode potential of the sensor elements 102, 104.