公开(公告)号：US07625926B2

公开(公告)日：2009-12-01

申请号：US10574098

申请日：2004-10-06

Applicant: Keuk Chan Bang ,  Mi Young Cha ,  Young Gil Ahn ,  Young Jin Ham ,  Maeng Sup Kim ,  Gwan Sun Lee

Inventor： Keuk Chan Bang ,  Mi Young Cha ,  Young Gil Ahn ,  Young Jin Ham ,  Maeng Sup Kim ,  Gwan Sun Lee

IPC: C07D401/14 ,  A61K31/4709

CPC classification number: C04B35/632 ,  C07D257/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12

Abstract: The bioavailability of an anticancer agent is enhanced when the anticancer agent is administered together with a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof.

Abstract translation: 当抗癌剂与包含式（I）化合物或其药学上可接受的盐的药物组合物一起施用时，抗癌剂的生物利用度得到增强。

公开(公告)号：US20090036683A1

公开(公告)日：2009-02-05

申请号：US12293959

申请日：2007-03-16

Applicant: Kwee Hyun Suh ,  Sang Min Yun ,  Eun Sook Kim ,  Gwan Sun Lee

Inventor： Kwee Hyun Suh ,  Sang Min Yun ,  Eun Sook Kim ,  Gwan Sun Lee

IPC: C07D495/04

CPC classification number: C07D495/04

Abstract: The present invention relates to a method for preparing clopidogrel 1,5-naphthalenedisulfonate or a hydrate thereof, which comprises reacting a clopidogrel-acid addition salt with disodium 1,5-naphthalenedisulfonate or its hydrate in water, or a mixture of water and an organic solvent. High quality clopidogrel 1,5-naphthalenedisulfonate can be prepared by the inventive method by way of using non-corrosive disodium 1,5-naphthalenedisulfonate.

Abstract translation: 本发明涉及一种氯吡格雷1,5-萘二磺酸盐或其水合物的制备方法，该方法包括使氯吡格雷酸加成盐与1,5-萘二磺酸二钠或其水合物在水中或水与有机物的混合物 溶剂。 通过本发明方法可以通过使用1,5-萘二磺酸非腐蚀性二钠制备高质量的氯萘吡格雷1,5-萘二磺酸盐。

公开(公告)号：US20080318950A1

公开(公告)日：2008-12-25

申请号：US12093108

申请日：2006-11-08

Applicant: Young-Gil Ahn ,  Jong Woo Kim ,  Keuk Chan Bang ,  Bum Woo Park ,  Se Young Kim ,  Kyungik Lee ,  Kyuhang Lee ,  Myoung-Sil Ko ,  Han Kyong Kim ,  Young Hoon Kim ,  Maeng Sup Kim ,  Gwan Sun Lee

Inventor： Young-Gil Ahn ,  Jong Woo Kim ,  Keuk Chan Bang ,  Bum Woo Park ,  Se Young Kim ,  Kyungik Lee ,  Kyuhang Lee ,  Myoung-Sil Ko ,  Han Kyong Kim ,  Young Hoon Kim ,  Maeng Sup Kim ,  Gwan Sun Lee

IPC: A61K31/5377 ,  C07D401/02 ,  A61K31/517 ,  C07D413/02 ,  A61P35/00

CPC classification number: C07D239/94

Abstract: The present invention relates to a novel quinazoline derivative and a pharmaceutically acceptable salt thereof as a multiplex inhibitor, a method for the preparation thereof, and a pharmaceutical composition and a therapeutic composition comprising same as an active ingredient. The inventive quinazoline derivative as a multiplex inhibitor can selectively and effectively inhibit diseases caused by the overactivity of a tyrosine kinase.

Abstract translation: 本发明涉及作为多重抑制剂的新型喹唑啉衍生物及其药学上可接受的盐，其制备方法，以及包含其作为活性成分的药物组合物和治疗组合物。 作为多重抑制剂的本发明喹唑啉衍生物可以选择性和有效地抑制由酪氨酸激酶的过度活性引起的疾病。

公开(公告)号：US20080064066A1

公开(公告)日：2008-03-13

申请号：US11975541

申请日：2007-10-19

Applicant: Se-Chang Kwon ,  Sung-Youb Jung ,  Sung-Min Bae ,  Gwan-Sun Lee

Inventor： Se-Chang Kwon ,  Sung-Youb Jung ,  Sung-Min Bae ,  Gwan-Sun Lee

IPC: C12P21/04 ,  C07K14/00 ,  C12N1/20 ,  C12N15/00 ,  C12N15/11

CPC classification number: C07K14/535 ,  C07K2319/034 ,  C07K2319/75 ,  C12N15/625 ,  C12N15/70

Abstract: A modified human granulocyte-colony stimulating factor (hG-CSF) is produced by culturing a microorganism transformed with an expression vector comprising a gene encoding a modified hG-CSF to produce and secrete the modified hG-CSF to periplasm, said modified hG-CSF being obtained by replacing at least one of the 1st, 2nd, 3rd and 17th amino acids of wild-type hG-CSF (SEQ ID NO: 2) with other amino acid

Abstract translation: 通过培养用包含编码修饰的hG-CSF的基因的表达载体转化的微生物来产生修饰的人粒细胞集落刺激因子（hG-CSF），以产生和分泌经修饰的hG-CSF至周质，所述修饰的hG-CSF 通过将野生型hG-CSF（SEQ ID NO：2）的第1，第2，第3和第17氨基酸中的至少一个替换为其他氨基酸而获得

公开(公告)号：US20080058509A1

公开(公告)日：2008-03-06

申请号：US11572404

申请日：2005-06-23

Applicant: Jaeheon Lee ,  Gha-Seung Park ,  Moonsub Lee ,  Cheol-Kyong Kim ,  Jae-Chul Lee ,  Young-Kil Chang ,  Gwan-Sun Lee

Inventor： Jaeheon Lee ,  Gha-Seung Park ,  Moonsub Lee ,  Cheol-Kyong Kim ,  Jae-Chul Lee ,  Young-Kil Chang ,  Gwan-Sun Lee

IPC: C07H19/00 ,  C07D317/14

CPC classification number: C07H3/08

Abstract: 3R-carboxylate enantiomer derivative of formula (III) can be prepared easily and selectively by the method of the present invention, and a highly pure D-erythro-2,2-difluoro-2-deoxy-1-oxoribose derivative can be prepared efficiently from the compound of formula (III) as an intermediate.

Abstract translation: 可以通过本发明的方法容易地和选择性地制备式（III）的3R-羧酸酯对映异构体衍生物，并且可以有效地制备高纯度的D-赤式-2,2-二氟-2-脱氧-1-氧代果糖衍生物 由作为中间体的式（III）化合物制备。

公开(公告)号：US07157576B2

公开(公告)日：2007-01-02

申请号：US10479291

申请日：2002-06-05

Applicant: Gwan-Sun Lee ,  Young-Kil Chang ,  Hong-Sun Kim ,  Chul-Hyun Park ,  Gha-Seung Park ,  Cheol-Kyung Kim

Inventor： Gwan-Sun Lee ,  Young-Kil Chang ,  Hong-Sun Kim ,  Chul-Hyun Park ,  Gha-Seung Park ,  Cheol-Kyung Kim

IPC: C07D501/22

CPC classification number: C07D501/00

Abstract: High purity cefdinir is prepared in a high yield by a process comprising the steps of: treating a crystalline salt of a cefdinir intermediate with a formic acid-sulfuric acid mixture or a formic acid-methanesulfonic acid mixture to obtain a crystalline salt of cefdinir and reacting the crystalline salt with a base in a solvent.

Abstract translation: 通过包括以下步骤的方法以高产率制备高纯度头孢地尼：用甲酸 - 硫酸混合物或甲酸 - 甲磺酸混合物处理头孢地尼中间体的结晶盐，得到头孢地尼的结晶盐，并使 与溶剂中的碱的结晶盐。

公开(公告)号：US06620930B1

公开(公告)日：2003-09-16

申请号：US10110162

申请日：2002-04-04

Applicant: Gwan-Sun Lee ,  Jae-Heon Lee ,  Young-Kil Chang ,  Chul-Hyun Park ,  Gha-Seung Park ,  Cheol-Kyung Kim

Inventor： Gwan-Sun Lee ,  Jae-Heon Lee ,  Young-Kil Chang ,  Chul-Hyun Park ,  Gha-Seung Park ,  Cheol-Kyung Kim

IPC: C07D5026

CPC classification number: C07D501/00

Abstract: 7-amino-3-methoxymethyl-3-cephem-4-carboxylic acid of formula (I) can be easily prepared by reacting 7-aminocephalosporanic acid of formula (II) with an azeotropic mixture of trimethyl borate and methanol in the presence of methanesulfonic acid:

Abstract translation: 式（I）的7-氨基-3-甲氧基甲基-3-头孢烯-4-羧酸可以通过使式（II）的7-氨基头孢烷酸与甲磺酸三甲酯和甲醇的共沸混合物在甲磺酸存在下容易地制备 酸：

公开(公告)号：US06605697B1

公开(公告)日：2003-08-12

申请号：US09786569

申请日：2001-03-07

Applicant: Se-Chang Kwon ,  Sung-Youb Jung ,  Hoon Shin ,  Jay-Do Choi ,  Ki-Doo Choi ,  Gwan-Sun Lee

Inventor： Se-Chang Kwon ,  Sung-Youb Jung ,  Hoon Shin ,  Jay-Do Choi ,  Ki-Doo Choi ,  Gwan-Sun Lee

IPC: C07K100

CPC classification number: C12N15/70 ,  C07K14/245 ,  C07K14/61 ,  C07K2319/02 ,  C07K2319/034 ,  C07K2319/75 ,  C12N15/625

Abstract: A heterologous protein is produced by: (i) culturing a microorganism transformed with an expression vector comprising a gene encoding a modified E. coli enterotoxin II signal peptide fused with the heterologous protein to produce and secrete the heterologous protein to periplasm, the modified E. coli enterotoxin II signal peptide being obtained by replacing at least one of the 2nd, 4th, 5th, 12th, 20th, and 22nd amino acids of E. coli enterotoxin II signal peptide of the following amino acid sequence (SEQ ID NO: 1) with another amino acid, with the proviso that at least one of the 2nd and 4th amino acid of the modified peptide is lysine; and (ii) recovering the heterologous protein from the periplasm.

Abstract translation: 通过以下方式产生异源蛋白质：（i）培养用包含编码与异源蛋白质融合的修饰的大肠杆菌肠毒素II信号肽的基因的表达载体转化的微生物，以产生和分泌异源蛋白质至周质，修饰的E. 通过将下述氨基酸序列（SEQ ID NO：1）的大肠杆菌肠毒素II信号肽的第2，第4，第5，第12，第20和第22氨基酸中的至少一个替换为大肠杆菌肠毒素II信号肽， 另一氨基酸，条件是修饰肽的第二和第四氨基酸中的至少一个是赖氨酸; 和（ii）从周质中回收异源蛋白质。

公开(公告)号：US09636420B2

公开(公告)日：2017-05-02

申请号：US13055406

申请日：2009-07-23

Applicant: Dae Hae Song ,  Jae Hee Shin ,  Mi Ji Lee ,  Sung Hee Hong ,  Se Chang Kwon ,  Gwan Sun Lee

Inventor： Dae Hae Song ,  Jae Hee Shin ,  Mi Ji Lee ,  Sung Hee Hong ,  Se Chang Kwon ,  Gwan Sun Lee

IPC: A61K47/48 ,  C07K14/62 ,  C07K14/505 ,  C07K14/52 ,  C07K14/56 ,  C07K14/61 ,  C07K14/475 ,  C07K19/00 ,  A61K38/28 ,  C07K14/59

CPC classification number: A61K47/48715 ,  A61K47/60 ,  A61K47/6811 ,  A61K47/6889 ,  C07K14/59 ,  C07K19/00 ,  C07K2319/31

Abstract: Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.

公开(公告)号：US08895281B2

公开(公告)日：2014-11-25

申请号：US13255199

申请日：2010-03-18

Applicant: Dae Hae Song ,  Jae Hee Shin ,  Jae Min Lee ,  Young Kyung Park ,  Se Chang Kwon ,  Gwan Sun Lee

Inventor： Dae Hae Song ,  Jae Hee Shin ,  Jae Min Lee ,  Young Kyung Park ,  Se Chang Kwon ,  Gwan Sun Lee

IPC: C12N9/00 ,  C07K7/04 ,  C07K14/00 ,  C07K1/107 ,  A61K47/48 ,  C07K14/575 ,  C07K14/605 ,  C07K14/62

CPC classification number: C07K1/1077 ,  A61K47/60 ,  C07K14/575 ,  C07K14/605 ,  C07K14/62

Abstract: The present invention provides a method for preparing a site-specific physiologically active polypeptide conjugate in a high yield by treating a physiologically active polypeptide with a non-peptidyl polymer in the presence of an alcohol at a specific pH, which can be desirably employed in the development of long acting formulations of various peptide drugs having high in-vivo activity and markedly prolonged in-blood half-life.

Abstract translation: 本发明提供了一种通过在特定pH下在醇的存在下用非肽基聚合物处理生理活性多肽而以高产率制备位点特异性生理活性多肽缀合物的方法，其可以理想地用于 开发具有高体内活性和明显延长的血液半衰期的各种肽药物的长效制剂。