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公开(公告)号：US10139317B2
公开(公告)日：2018-11-27
申请号：US14928694
申请日：2015-10-30
Applicant: South Dakota Board of Regents
Inventor： Brian Logue
IPC: G01N1/10 , B01D9/04 , G01N1/40 , G01N1/42 , G01N33/18 , B01D15/02 , B01D15/08 , B01D9/00 , G01N1/28 , G01N1/38 , B01F13/08
Abstract: Methods of analyzing analytes from a liquid medium are disclosed. A system and apparatus for the analysis of analytes from a liquid medium are further disclosed. In particular, methods and apparatus of analyzing analytes by freezing liquid medium and partitioning the analyte into a sorptive stirrer are disclosed. Further, the methods and apparatus of the present invention can be useful in concentrating and isolating target chemicals of high value.
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公开(公告)号：US20180064613A1
公开(公告)日：2018-03-08
申请号：US15707742
申请日：2017-09-18
Applicant: South Dakota Board of Regents
Inventor： Grigoriy Sereda , Joshua Brower
IPC: A61K6/00 , A61Q11/00 , A61K8/34 , A23G4/06 , A61C19/06 , A61C19/08 , A61K8/73 , A61K8/60 , A61K8/365 , A61K8/29 , A61K8/26 , A61K8/25 , A61K8/24 , A61K8/11 , A61K8/02
CPC classification number: A61K6/0047 , A23G4/06 , A23G4/064 , A61C5/62 , A61C19/063 , A61C19/08 , A61K6/0008 , A61K6/007 , A61K8/0241 , A61K8/11 , A61K8/24 , A61K8/25 , A61K8/26 , A61K8/29 , A61K8/347 , A61K8/365 , A61K8/604 , A61K8/733 , A61K8/735 , A61K8/736 , A61K2800/28 , A61K2800/412 , A61K2800/413 , A61K2800/612 , A61K2800/884 , A61K2800/92 , A61Q11/00
Abstract: The present invention relates to a method of remineralizing and desensitizing teeth utilizing the sequential steps of first applying to the teeth a first component that attaches to the teeth and secondly applying to the teeth treated with the first component a second component that attaches to the first component.
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公开(公告)号：US20170239361A1
公开(公告)日：2017-08-24
申请号：US15441191
申请日：2017-02-23
Applicant: South Dakota Board of Regents
Inventor： Hemachand Tummala , Pratik Muley
CPC classification number: A61K45/06 , A61K31/555 , A61K47/542 , A61K47/549 , A61K2300/00
Abstract: Compositions and methods for the use thereof for the treatment of cancer in a subject in need thereof comprising administering to the subject an effective amount of a composition comprising an anticancer composition comprising a antineoplastic compound and a conjugated targeting moiety with or without a chemical linker. In certain aspects the antineoplastic compound is a platin and the conjugated targeting moiety is an amino acid.
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74.发明申请SELECTIVE LIQUEFACTION OF LIGNIN AND BIOMASS IN A MIXTURE OF SUB- AND SUPERCRITICAL FLUIDS IN ABSENCE OR PRESENCE OF HETEROGENEOUS CATALYSTS 有权在异源催化剂存在或不存在的情况下，亚液和超临界流体混合物中的木质素和生物质的选择性液化公开(公告)号：US20170073291A1
公开(公告)日：2017-03-16
申请号：US15263141
申请日：2016-09-12
Applicant: South Dakota Board of Regents
Inventor： Alevtina Smirnova , Chris Lynde , Abu Md Numan-Al-Mobin , Rudresh Bommadihalli Rajappagowda
Abstract: Disclosed herein are methods for selective synthesis of specific phenolic products by means biomass or biomass products liquefaction, manipulation of the said selectivity in favor of one specific phenolic compound or a mixture of specific phenolic compounds, and the synthesis of the phenolic compounds from a liquid or biomass organic fraction produced in presence of a homogeneous catalyst in supercritical state or a mixture of said homogeneous and one or several heterogeneous catalysts mixed with water in sub-critical, near-critical, or supercritical condition.
Abstract translation: 本文公开了通过生物质或生物质产物液化选择合成特定酚类产物的方法，有利于一种特定酚类化合物或特定酚类化合物的混合物的所述选择性的操作以及来自液体的酚类化合物的合成或 在超临界状态的均相催化剂存在下生产的生物质有机部分或所述均相和一种或多种非均相催化剂与亚临界，近临界或超临界条件下的水混合的混合物。
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75.发明申请Sequential Material Deposition for Remineralization and Desensitization of Teeth 审中-公开连续材料沉积用于牙齿的再矿化和脱敏公开(公告)号：US20160374904A1
公开(公告)日：2016-12-29
申请号：US15189228
申请日：2016-06-22
Applicant: South Dakota Board of Regents
Inventor： Grigoriy Sereda
IPC: A61K6/00 , A61K8/58 , A61K8/19 , A61K8/73 , A61K8/24 , A61C15/04 , A61K8/34 , A61K8/365 , A61K8/29 , A61K8/26 , A61C15/02 , A61Q11/00 , A61K8/72
CPC classification number: A61K6/0047 , A23G4/06 , A23G4/064 , A61C5/62 , A61C19/063 , A61C19/08 , A61K6/0008 , A61K6/007 , A61K8/0241 , A61K8/11 , A61K8/24 , A61K8/25 , A61K8/26 , A61K8/29 , A61K8/347 , A61K8/365 , A61K8/604 , A61K8/733 , A61K8/735 , A61K8/736 , A61K2800/28 , A61K2800/412 , A61K2800/413 , A61K2800/612 , A61K2800/884 , A61K2800/92 , A61Q11/00
Abstract: The present invention relates to a method of remineralizing and desensitizing teeth utilizing the sequential steps of first applying to the teeth a first component that attaches to the teeth and secondly applying to the teeth treated with the first component a second component that attaches to the first component.
Abstract translation: 本发明涉及一种再矿化和脱敏牙齿的方法，其中使用顺序步骤，首先向牙齿施加附着到牙齿上的第一部件，其次施加到用第一部件处理的牙齿附着到第一部件上的第二部件 。
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Patent Agency Ranking
公开(公告)号：US20160303222A1
公开(公告)日：2016-10-20
申请号：US15131989
申请日：2016-04-18
Applicant: South Dakota Board of Regents
Inventor： Victor Huber , Ying Fang
IPC: A61K39/145
CPC classification number: A61K39/145 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/55 , A61K2039/552 , A61K2039/575 , C12N2760/16121 , C12N2760/16122 , C12N2760/16134 , C12N2760/16141
Abstract: Disclosed herein are compositions and methods useful for immunizing a subject against disease caused by influenza A. Disclosed methods comprise administering to the subject an immunoprotective dose of an immunogenic composition. In certain aspects, the immunogenic composition is a vaccine comprised of a recombinant chimeric hemagglutinin polypeptide. In certain aspects, the subject is a mammal. In further aspects, the mammal is a pig. In still further aspects, the mammal is a human.
Abstract translation: 本文公开了可用于免疫针对由流感A引起的疾病的受试者的组合物和方法。公开的方法包括向受试者施用免疫保护剂量的免疫原性组合物。 在某些方面，免疫原性组合物是由重组嵌合型血凝素多肽组成的疫苗。 在某些方面，受试者是哺乳动物。 在另外的方面，哺乳动物是猪。 在另外的方面，哺乳动物是人类。
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77.发明申请Glutathione Disulfide Compositions and Related Methods for the Treatment of Cancer 审中-公开谷胱甘肽二硫化物组合物和相关方法治疗癌症公开(公告)号：US20160129070A1
公开(公告)日：2016-05-12
申请号：US14875862
申请日：2015-10-06
Applicant: South Dakota Board of Regents
Inventor： Xiangming Guan , Chandradhar Dwivedi , Teresa Seefeldt , Satya Sadhu
CPC classification number: A61K38/063 , A61K9/0019 , A61K9/1272 , A61K45/06 , A61K2300/00
Abstract: Compositions and methods for the treatment of cancer in a subject in need thereof comprising administering to the subject an effective amount of a composition comprising a GSSG and a carrier thereof. In an aspect, the carrier is a liposome. In a further aspect, the liposome is a positively charged liposome.
Abstract translation: 用于治疗有需要的受试者的癌症的组合物和方法，其包括向所述受试者施用有效量的包含GSSG及其载体的组合物。 在一方面，载体是脂质体。 另一方面，脂质体是带正电荷的脂质体。
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78.发明申请公开(公告)号：US20150250195A1
公开(公告)日：2015-09-10
申请号：US14616952
申请日：2015-02-09
Applicant: South Dakota Board of Regents
Inventor： Hasmukh Patel , Lloyd Metzger , Gopinathan Meletharayil
CPC classification number: A23C9/1307 , A23C9/142 , A23C9/1512 , A23C2210/202 , A23C2240/20 , A23V2002/00 , A23V2250/11
Abstract: A method for improving yogurt texture in a yogurt manufacture process includes providing a volume of milk, injecting carbon dioxide (CO2) at a selected injection pressure into the provided volume of milk to establish a selected pH level in the provided volume of milk, storing the CO2-injected milk at a selected temperature for a selected time period, forming a retentate by applying a filtration process to the CO2-injected milk, mixing the retentate with a volume of non-treated milk to form a mixture of retentate and non-treated milk in a selected proportion and forming a yogurt product with the mixture of retentate and non-treated milk.
Abstract translation: 一种用于改善酸奶制造方法中的酸奶质地的方法包括提供一定体积的牛奶，以选定的注射压力将二氧化碳（CO 2）注入到所提供的体积的牛奶中，以在所提供的乳汁体积中建立选定的pH水平， 二氧化碳注射的牛奶在所选择的温度下选定的时间段，通过对二氧化碳注射的牛奶进行过滤过程形成渗余物，将渗余物与一定体积的未处理的牛奶混合以形成滞留物和未处理的牛奶的混合物 以选定比例的牛奶，并与渗余物和未处理的牛奶的混合物形成酸奶产品。
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79.发明申请Ascorbic Acid-Eluting Implantable Medical Devices, Systems, and Related Methods 审中-公开抗坏血酸洗脱植入式医疗器械，系统及相关方法公开(公告)号：US20150182675A1
公开(公告)日：2015-07-02
申请号：US14418221
申请日：2013-07-23
Applicant: South Dakota Board of Regents
Inventor： Gopinath Mani
CPC classification number: A61L31/16 , A61L29/085 , A61L29/10 , A61L29/16 , A61L31/022 , A61L31/086 , A61L31/10 , A61L2300/21 , A61L2300/412 , A61L2300/428 , A61L2300/606 , A61M25/1029 , A61M2025/1031 , A61M2025/105 , C08L67/04 , C08L5/02
Abstract: Implantable medical devices may elute drugs that promote the growth of endothelial cells while inhibiting the growth of smooth muscle cells. In some instances, implantable medical devices may elute L-ascorbic acid, or vitamin C. In some instances, an implantable medical device configured to elute L-ascorbic acid may be a stent, although a variety of other implantable medical devices are contemplated.
Abstract translation: 可植入医疗器械可以洗脱促进内皮细胞生长的药物，同时抑制平滑肌细胞的生长。 在一些情况下，可植入的医疗装置可以洗脱L-抗坏血酸或维生素C.在一些情况下，构造成洗脱L-抗坏血酸的可植入医疗装置可以是支架，尽管考虑了各种其它可植入的医疗装置。
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公开(公告)号：US20150064838A1
公开(公告)日：2015-03-05
申请号：US14477344
申请日：2014-09-04
Applicant: South Dakota Board of Regents
Inventor： Brian A. Logue , Mahdi Farrakh Baroughi , Venkataiah Mallam
IPC: H01G9/20 , C23C16/448 , B05D1/00
CPC classification number: H01G9/2059 , B05D1/185 , B05D1/60 , C23C14/12 , C23C16/4485 , H01G9/2031 , Y02E10/542
Abstract: Self-assembled monolayer hybrid materials having a modified carboxylic acid deposited from the gas-phase onto a metal oxide substrate, methods of using targeted α-carbon modified carboxylic acids to rapidly deposit activated organic molecules into a self-assembled monolayer on metal oxide substrates, and the self-assembled monolayer hybrid materials capable of being used in various industries, such as optoelectronics and separation science.
Abstract translation: 具有从气相沉积到金属氧化物基底上的改性羧酸的自组装单层混合材料，使用目标α-碳改性羧酸将激活的有机分子快速沉积到金属氧化物基底上的自组装单层中的方法， 以及能够用于各种行业的自组装单层混合材料，如光电子学和分离科学。
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