公开(公告)号：US08126538B2

公开(公告)日：2012-02-28

申请号：US11422423

申请日：2006-06-06

申请人： Allan C. Shuros ,  Randy Westlund ,  M. Jason Brooke

发明人： Allan C. Shuros ,  Randy Westlund ,  M. Jason Brooke

IPC分类号： A61B5/05

CPC分类号： A61N1/362 ,  A61B5/0031 ,  A61B5/0452 ,  A61B5/415 ,  A61B5/418 ,  A61M2202/0405 ,  A61N1/0504

摘要： Described herein are a method and apparatus for introducing instrumentation into the lymphatic system that can be used for physiological monitoring and/or delivery of therapy. Such instrumentation, for example, may include one or more sensors for measuring physiological variables and/or one or more instruments for delivering therapy that is adapted to be disposed within a lymphatic vessel.

摘要翻译： 本文描述了用于将仪器引入淋巴系统中的方法和装置，其可用于治疗的生理监测和/或递送。 例如，这种仪器可以包括用于测量生理变量的一个或多个传感器和/或用于递送适于布置在淋巴管内的治疗的一个或多个仪器。

公开(公告)号：US20110257523A1

公开(公告)日：2011-10-20

申请号：US13086116

申请日：2011-04-13

申请人： Roger Hastings ,  Allan C. Shuros ,  Frank Ingle ,  Mark Hollingsworth

发明人： Roger Hastings ,  Allan C. Shuros ,  Frank Ingle ,  Mark Hollingsworth

IPC分类号： A61B8/12 ,  A61B18/02 ,  A61N7/00

CPC分类号： A61N7/022 ,  A61B8/0891 ,  A61B8/12 ,  A61B8/4488 ,  A61B18/0206 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2090/3784 ,  A61N2007/003 ,  A61N2007/0095

摘要： Acoustic energy is delivered to innervated vascular that contributes to renal sympathetic nerve activity, such as innervated tissue of the renal artery and abdominal aorta. Focused acoustic energy is delivered via an intravascular device of sufficient power to ablate innervated renal or aortal tissue. Focused acoustic energy may be delivered via an intravascular or extracorporeal device to image and locate target innervated renal or aortal tissue. Intravascular, extravascular, or transvascular focused ultrasound devices provide for high precision denervation of innervated vascular to terminate renal sympathetic nerve activity.

摘要翻译： 声能传递给有助于肾交感神经活动的神经支配的血管，如肾动脉和腹主动脉的神经支配组织。 聚焦的声能通过具有足够功率的血管内装置递送以消融支配的肾脏或主动脉组织。 聚焦的声能可以通过血管内或体外装置递送到图像并定位目标神经支配的肾或主动脉组织。 血管内，血管外或经血管聚焦的超声装置提供神经支配血管的高精度去神经支配以终止肾交感神经活动。

公开(公告)号：US07894906B2

公开(公告)日：2011-02-22

申请号：US11422414

申请日：2006-06-06

申请人： Allan C. Shuros

发明人： Allan C. Shuros

IPC分类号： A61N1/34

CPC分类号： A61B5/415 ,  A61B5/076 ,  A61B5/418 ,  A61N1/36071 ,  A61N1/37211

摘要： A device and method are disclosed for treating chronic pain by delivering electrical stimulation to nervous tissue or smooth muscle fibers by means of electrodes disposed in the body's lymphatic system. An implanted pulse generator is connected to an electrode by a lead that may be intravenously introduced into the lymphatic system. The stimulation may be patient-controlled or be delivered in accordance with a programmed schedule.

摘要翻译： 公开了一种通过借助设置在身体的淋巴系统中的电极递送对神经组织或平滑肌纤维的电刺激来治疗慢性疼痛的装置和方法。 植入的脉冲发生器通过可以静脉内引入淋巴系统的引线连接到电极。 刺激可以是患者控制的或者按照编程的时间表进行递送。

公开(公告)号：US20100042170A1

公开(公告)日：2010-02-18

申请号：US12604233

申请日：2009-10-22

申请人： Allan C. Shuros ,  Randy Westlund ,  Anthony V. Caparso

发明人： Allan C. Shuros ,  Randy Westlund ,  Anthony V. Caparso

IPC分类号： A61N1/05

CPC分类号： A61N1/36114

摘要： An implantable neural stimulation system includes an implantable medical device having a neural stimulation circuit and at least one implantable lead configured to allow one or more stimulation electrodes to be placed in one or more lymphatic vessels of a patient, such as the patient's thoracic duct and/or vessels branching from the thoracic duct. Neural stimulation pulses are delivered from the implantable medical device to one or more target regions adjacent to the thoracic duct or the vessels branching from the thoracic duct through the one or more stimulation electrodes.

摘要翻译： 可植入神经刺激系统包括具有神经刺激电路的可植入医疗装置和至少一个可植入引线，其被配置为允许将一个或多个刺激电极放置在患者的一个或多个淋巴管中，例如患者的胸导管和/ 或从胸导管分支的血管。 神经刺激脉冲从可植入医疗装置传送到与胸导管相邻的一个或多个目标区域或通过一个或多个刺激电极从胸导管分支的血管。

公开(公告)号：US07643879B2

公开(公告)日：2010-01-05

申请号：US11466974

申请日：2006-08-24

申请人： Allan C. Shuros ,  Michael J. Kane

发明人： Allan C. Shuros ,  Michael J. Kane

IPC分类号： A61N1/00

CPC分类号： A61N1/3621 ,  A61F2/2403 ,  A61N1/36514 ,  A61N1/3962

摘要： Systems and methods using a heart valve and an implantable medical device, such as for event detection and optimization of cardiac output. The cardiac management system includes a heart valve, having a physiological sensor. The physiological sensor is adapted to measure at least one of an intrinsic electrical cardiac parameter, a hemodynamic parameter or the like. The system further includes an implantable electronics unit, such as a cardiac rhythm management unit, coupled to the physiological sensor of the heart valve to receive physiological information. The electronics unit is adapted to use the received physiological information to control delivery of an electrical output to the subject.

摘要翻译： 使用心脏瓣膜和可植入医疗装置的系统和方法，例如用于事件检测和心输出量的优化。 心脏管理系统包括具有生理传感器的心脏瓣膜。 生理传感器适于测量本征电心脏参数，血液动力学参数等中的至少一个。 该系统还包括可植入电子单元，例如心律管理单元，其耦合到心脏瓣膜的生理传感器以接收生理信息。 电子单元适于使用所接收的生理信息来控制向对象的电输出的传递。

公开(公告)号：US20090270960A1

公开(公告)日：2009-10-29

申请号：US12431607

申请日：2009-04-28

申请人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

发明人： Weiying Zhao ,  Stephen Ruble ,  Allan C. Shuros ,  Jason J. Hamann

IPC分类号： A61N1/00

CPC分类号： A61N1/0551 ,  A61N1/0553 ,  A61N1/0556 ,  A61N1/36071 ,  A61N1/36114

摘要： Various system embodiments comprise a lead having a distal end and a proximal end. The distal end includes a plurality of electrodes. The lead is configured to be fed into a dorsal epidural space of a human to a desired region of a spinal column and to be fed laterally to at least partially encircle a spinal cord in the desired region to place at least one stimulation electrode in position to stimulate a dorsal nerve root and at least another stimulation electrode in position to stimulate a ventral nerve root. The desired region may include cervical vertebrae, thoracic vertebrae, or lumbar vertebrae. Some embodiments stimulate the spinal cord in the T1-T5 region.

摘要翻译： 各种系统实施例包括具有远端和近端的引线。 远端包括多个电极。 引线被配置为被馈送到人的背部硬膜外空间到脊柱的期望区域，并且被横向馈送以至少部分地环绕所需区域中的脊髓，以将至少一个刺激电极置于适当位置 刺激背神经根和至少另一个刺激电极，以刺激腹侧神经根。 所需区域可包括颈椎，胸椎或腰椎。 一些实施方案刺激T1-T5区域中的脊髓。

公开(公告)号：US20090270941A1

公开(公告)日：2009-10-29

申请号：US12422770

申请日：2009-04-13

申请人： Eric A. Mokelke ,  Allan C. Shuros

发明人： Eric A. Mokelke ,  Allan C. Shuros

IPC分类号： A61N1/362 ,  A61M39/22 ,  A61M25/14

CPC分类号： A61N1/0565 ,  A61M25/104 ,  A61M39/0606 ,  A61M2039/062 ,  A61M2039/0633 ,  A61M2039/1022 ,  A61N1/056 ,  A61N2001/0585

摘要： Systems and methods for temporarily pacing a patient's heart are provided. One system includes a hemostasis valve with an adjustable electrical connection, the adjustable electrical connection having one or more adjustable contacts. The adjustable contacts have a first, radially expanded configuration and a second, radially constricted configuration. In the radially constricted configuration, the adjustable contacts are configured to pierce through a layer of an elongate medical device that is disposed in the hemostasis valve. The elongate medical device has a distal electrode and a conductor extending along a portion of the elongate medical device. The adjustable contacts pierce through a make contact with the conductor, providing an electrical pathway to the distal electrode. Also provided are vascular access systems including a hemostasis valve and a guide catheter, guide wire torquers with adjustable contacts and methods of temporarily pacing a patient's heart.

摘要翻译： 提供了临时起搏患者心脏的系统和方法。 一个系统包括具有可调节电连接的止血阀，该可调电气连接具有一个或多个可调触头。 可调接点具有第一径向扩张构型和第二径向收缩构造。 在径向收缩的构造中，可调节触点构造成穿过布置在止血阀中的细长医疗装置的层。 细长医疗装置具有远端电极和沿细长医疗装置的一部分延伸的导体。 可调触头穿过与导体的接触，提供到远端电极的电通路。 还提供了血管通路系统，包括止血阀和引导导管，具有可调触点的导丝扭矩和临时起搏患者心脏的方法。

公开(公告)号：US20090125076A1

公开(公告)日：2009-05-14

申请号：US12269558

申请日：2008-11-12

申请人： Allan C. Shuros ,  Craig Stolen ,  Timothy Meyer ,  Stephen Ruble

发明人： Allan C. Shuros ,  Craig Stolen ,  Timothy Meyer ,  Stephen Ruble

IPC分类号： A61N1/365

CPC分类号： A61N1/08 ,  A61N1/36071 ,  A61N1/36114

摘要： This document discusses, among other things, a system and method for calculating a neural stimulation energy at an external patient management (EPM) system using received information about a chemical characteristic indicative of a physiological state of a subject.

摘要翻译： 本文件尤其涉及使用接收到的关于指示受试者的生理状态的化学特征的信息来计算外部患者管理（EPM）系统的神经刺激能量的系统和方法。

公开(公告)号：US20080281367A1

公开(公告)日：2008-11-13

申请号：US11745016

申请日：2007-05-07

申请人： Yi Zhang ,  Allan C. Shuros ,  Dan Li

发明人： Yi Zhang ,  Allan C. Shuros ,  Dan Li

IPC分类号： A61N1/362

CPC分类号： A61N1/36521 ,  A61B5/02028 ,  A61B5/0464 ,  A61B5/0535 ,  A61B5/0538 ,  A61B5/7264

摘要： An implantable medical device detects a tachyarrhythmia of a heart. During the detected tachyarrhythmia, the device determines a local myocardial impedance. Using the local myocardial impedance, the device determines whether there is sufficient perfusion to the heart. The device can then either deliver a less aggressive device therapy in response to the detected tachyarrhythmia when there is sufficient perfusion to the heart, or deliver a more aggressive device therapy in response to the detected tachyarrhythmia when there is insufficient perfusion to the heart. The perfusion information can also be used to alter tachyarrhythmia detection or classification.

摘要翻译： 可植入医疗装置检测心脏的快速性心律失常。 在检测到的快速性心律失常期间，该装置确定局部心肌阻抗。 使用局部心肌阻抗，该装置确定心脏是否有足够的灌注。 然后，当心脏充分灌注时，该装置可以响应于检测到的快速性心律失常而递送较不激进的装置疗法，或者当心脏灌注不充分时响应于检测到的快速性心律失常而递送更积极的装置疗法。 灌注信息也可用于改变快速性心律失常检测或分类。

公开(公告)号：US20080234773A1

公开(公告)日：2008-09-25

申请号：US11690700

申请日：2007-03-23

申请人： Quan Ni ,  Christopher Hartemink ,  Andres Belalcazar ,  Allan C. Shuros ,  Loell Boyce Moon

发明人： Quan Ni ,  Christopher Hartemink ,  Andres Belalcazar ,  Allan C. Shuros ,  Loell Boyce Moon

IPC分类号： A61N1/05

CPC分类号： A61N1/36521 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/11 ,  A61B5/686 ,  A61B5/6869 ,  A61N1/3627 ,  A61N1/3684

摘要： An apparatus comprises a first impedance sensing circuit, a second sensing circuit, and an impedance-based cardiac dyssynchrony detector. The impedance sensing circuit senses an intracardiac local impedance signal that is indicative of a cardiac local wall motion of a first cardiac region from an implantable first bipolar pair of impedance sensing electrodes. The second sensing circuit is configured to produce a second sensor signal indicative of cardiovascular activity. The impedance-based cardiac dyssynchrony detector is configured for detecting cardiac dyssynchrony using a relationship between the first intracardiac local impedance signal and the second sensor signal. Other apparatuses and methods are disclosed.

摘要翻译： 一种装置包括第一阻抗感测电路，第二感测电路和基于阻抗的心脏不同步检测器。 阻抗感测电路感测指示来自可植入的第一双极对阻抗感测电极的第一心脏区域的心脏局部壁运动的心内局部阻抗信号。 第二感测电路被配置为产生指示心血管活动的第二传感器信号。 基于阻抗的心脏不同步检测器被配置为使用第一心内局部阻抗信号和第二传感器信号之间的关系来检测心脏不同步。 公开了其他装置和方法。