Abstract:
The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
Abstract:
An apparatus includes a recording media including a substrate, a plurality of tracks of magnetic material on the substrate, and a non-magnetic material between the tracks; a recording head having an air bearing surface positioned adjacent to the recording media, and including a magnetic pole, an optical transducer, and a near-field transducer, wherein the near-field transducer directs electromagnetic radiation onto tracks to heat portions of the tracks and a magnetic field from the magnetic pole is used to create magnetic transitions in the heated portions of the tracks; and a plasmonic material positioned adjacent to the magnetic material to increase coupling between the electromagnetic radiation and the magnetic material.
Abstract:
Data storage systems having barriers that may reduce erasure flux and increase write-ability are provided. Data storage systems include a writing element. The writing element has a write pole with a flare region. A magnetic flux barrier is located along the write pole flare region. The magnetic flux barrier is illustratively made from an in-plane magnetically anisotropic material that has an easy plane of magnetization. In another embodiment, a data storage system includes a writing element having an air bearing surface and a shield at the air bearing surface. The shield has a magnetic permeability of approximately zero. The shield illustratively includes alternating layers of positive and negative permeabilities. The shield optionally includes a plurality of shields that may include top, bottom, and side shields.
Abstract:
Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. Additionally, the invention provides methods of producing influenza viruses with enhanced ability to replicate in embryonated chicken eggs and/or cells (e.g., Vero and/or MDCK) and further provides influenza viruses with enhanced replication characteristics. A method of producing a cold adapted (ca) influenza virus that replicates efficiently at, e.g., 25° C. (and immunogenic compositions comprising the same) is also provided.
Abstract:
A re-enterable enclosure for a cable splice includes a first cover member and a second cover member configured for engagement with each other, and movable between an open position and a closed position. The first and second cover members form a cavity for enclosing the cable splice when the cover members are in the closed position. Internal walls in at least one of the first and second cover members are configured to define a sealant containment space that at least partially surrounds the cavity. At least one latch is configured to maintain the first and second cover members in the closed position, the at least one latch configured to exert a compression force along a line extending through the sealant containment space.
Abstract:
Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided.
Abstract:
A magnetic recording media with a multilayer structure and methods for forming the media are described. The magnetic recording media includes a substrate, an underlayer on top of the substrate and a magnetic layer over the underlayer. The underlayer includes a CrN film formed by sputter depositing chromium in the presence of nitrogen or nitrogen containing compounds.
Abstract:
A modular framework for data import/export in an application that allows modules/components to be independently developed for importing and exporting data related to specific entities, including the handling of dependencies between entities. The framework is metadata driven which allows new entities to be introduced in the application with new modules for importing/exporting data related to those entities, without updating modules for exporting existing entities. Each type of entity is defined with a schema that represents the logical entity such that the entity is agnostic as to how the entity data is stored in database tables. A master configuration file is created for the application that lists each entity that can be imported or exported by the application, and defines how the framework imports or exports the business entity. Additionally, dynamic batching is provided to divide large datasets into multiple batches for suitable consumption by consumers of the exported data.
Abstract:
The present invention provides recombinant respiratory syncytial viruses that have an attenuated phenotype and that comprise one or more mutations in the viral P, M2-1 and/or M2-2 proteins, as well as live attenuated vaccines comprising such viruses and nucleic acids encoding such viruses. Recombinant RSV P, M2-1 and M2-2 proteins are described. Methods of producing attenuated recombinant RSV, and methods of quantitating neutralizing antibodies that utilize recombinant viruses of family Paramyxoviridae, are also provided.
Abstract:
A system and method for measuring and controlling stator winding temperature in an AC motor while idling is disclosed. The system includes a circuit having an input connectable to an AC source and an output connectable to an input terminal of a multi-phase AC motor. The circuit further includes a plurality of switching devices to control current flow and terminal voltages in the multi-phase AC motor and a controller connected to the circuit. The controller is configured to activate the plurality of switching devices to create a DC signal in an output of the motor control device corresponding to an input to the multi-phase AC motor, determine or estimate a stator winding resistance of the multi-phase AC motor based on the DC signal, and estimate a stator temperature from the stator winding resistance. Temperature can then be controlled and regulated by DC injection into the stator windings.