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115 条记录 (耗时 0.064 秒)

    Bone morphogenetic protein (BMP)-binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and use of same
    72.
    发明申请
    Bone morphogenetic protein (BMP)-binding domains of proteins of the repulsive guidance molecule (RGM) protein family and functional fragments thereof, and use of same 审中-公开
    排斥指导分子（RGM）蛋白家族的蛋白质的骨形态发生蛋白（BMP）结合结构域及其功能片段及其使用

    公开(公告)号：US20100322948A1

    公开(公告)日：2010-12-23

    申请号：US12677054

    申请日：2008-09-08

    申请人： Bernhard Mueller ,  Gregor Schaffar ,  Axel Meyer ,  Martin Schmidt

    发明人： Bernhard Mueller ,  Gregor Schaffar ,  Axel Meyer ,  Martin Schmidt

    IPC分类号： A61K39/395 ,  C07K14/47 ,  C07K5/08 ,  C07K5/10 ,  C07K7/06 ,  C07K7/08 ,  C07K19/00 ,  C07K16/18 ,  A61K38/02 ,  A61P3/10 ,  A61P25/02 ,  A61P19/08 ,  A61P7/06 ,  A61P9/00 ,  A61P17/06 ,  A61P1/04 ,  A61P17/14

    CPC分类号： C07K14/705 ,  C07K16/22

    摘要： The present invention relates to the identification and use of bone morphogenetic protein (BMP)-binding domains of members of the repulsive guidance molecule (RGM) protein family, and polypeptide fragments and fusion proteins derived therefrom. The domains, i.e., peptide fragments and fusion proteins, according to the invention are suitable as agents for the active or passive immunization of individuals, or as diagnostic and therapeutic agents for use for diseases or medical conditions in whose origin or progression a member of the RGM family and a cellular receptor associated with this molecule, such as neogenin and/or BMP in particular, is involved. The invention further relates to monoclonal and polyclonal antibodies directed against the binding domains according to the invention, and against the polypeptides derived therefrom, and to methods for producing the polypeptides, fusion proteins, and antibodies according to the invention.

    摘要翻译： 本发明涉及排斥性指导分子（RGM）蛋白家族的成员的骨形态发生蛋白（BMP）结合结构域的鉴定和应用，以及从其衍生的多肽片段和融合蛋白质。 根据本发明的结构域，即肽片段和融合蛋白，适合作为个体的主动或被动免疫的试剂，或作为用于疾病或医学病症的诊断和治疗剂，其来源或进展是 涉及RGM家族和与该分子相关的细胞受体，例如特别是新生蛋白和/或BMP。 本发明还涉及针对根据本发明的结合结构域和针对本发明的多肽的单克隆抗体和多克隆抗体，以及根据本发明的用于产生多肽，融合蛋白和抗体的方法。

    Absorbent articles comprising super absorbent polymer having a substantially non-convalently bonded surface coating
    76.
    发明授权
    Absorbent articles comprising super absorbent polymer having a substantially non-convalently bonded surface coating 有权
    包含具有基本上非共价键合的表面涂层的高吸收性聚合物的吸收制品

    公开(公告)号：US07405341B2

    公开(公告)日：2008-07-29

    申请号：US10950011

    申请日：2004-09-24

    申请人： Holger Beruda ,  Yasue Nakagawa ,  Andrea Lieselotte Link ,  Axel Meyer

    发明人： Holger Beruda ,  Yasue Nakagawa ,  Andrea Lieselotte Link ,  Axel Meyer

    IPC分类号： A61F13/537

    CPC分类号： A61L15/60 ,  A61L15/24 ,  C08L39/02

    摘要： The present invention relates to absorbent articles comprising superabsorbent polymer particles. The superabsorbent polymer particles are coated with cationic polymers having 1 to 25 mol/kg, referring to the total weight of the cationic polymers, of cationic groups, which can be protonated. The cationic polymers are not substantially covalently bound to the superabsorbent polymer particles. Furthermore, the superabsorbent polymer particles are not substantially covalently surface cross-linked.

    摘要翻译： 本发明涉及包含超吸收聚合物颗粒的吸收制品。 超吸收性聚合物颗粒用阳离子聚合物的阳离子聚合物涂覆，阳离子聚合物可以是阳离子基团的总重量为1至25mol / kg，阳离子聚合物可被质子化。 阳离子聚合物基本上不与超吸收聚合物颗粒共价结合。 此外，超吸收性聚合物颗粒基本上不共表面交联。