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    Fossil resin flotation from coal by selective coagulation and depression of coal
    71.
    发明授权
    Fossil resin flotation from coal by selective coagulation and depression of coal 失效
    煤的化石树脂浮选通过选择性凝结和抑制煤

    公开(公告)号：US4904373A

    公开(公告)日：1990-02-27

    申请号：US333606

    申请日：1989-04-04

    申请人： Jan D. Miller ,  Qiang Yu ,  Ye Yi

    发明人： Jan D. Miller ,  Qiang Yu ,  Ye Yi

    IPC分类号： B03D1/02 ,  B03D1/04

    CPC分类号： B03D1/04 ,  B03D1/02

    摘要： disclosed is a process for separating resin from a mixture of resin-bearing coal particles by increasing the pH of a froth flotation process to a value of at least 12. Particles of reduced size resin-bearing coal are preferably mixed with water to from a slurry. The pH of the slurry is then adjusted with a chemical agent to about 12. The slurry is then subjected to froth flotation. The coal particles aggregate to one another allowing the remaining resin-rich particles to attach to the bubbles formed during the flotation process. A much improved separation efficiency for resin flotation from coal is observed.

    摘要翻译： 公开了一种通过将泡沫浮选工艺的pH提高到至少12的值从含树脂的煤颗粒的混合物中分离树脂的方法。减小尺寸的含树脂的煤的颗粒优选与水混合从浆料 。 然后将浆料的pH用化学试剂调节至约12.然后将浆料进行泡沫浮选。 煤颗粒彼此聚集，使剩余的富含树脂的颗粒附着到在浮选过程中形成的气泡。 观察到来自煤的树脂浮选的分离效率大大提高。

    METHODS AND COMPOSITIONS FOR TREATING CANCER
    72.
    发明申请
    METHODS AND COMPOSITIONS FOR TREATING CANCER 有权
    用于治疗癌症的方法和组合物

    公开(公告)号：US20130123328A1

    公开(公告)日：2013-05-16

    申请号：US13520472

    申请日：2011-01-10

    申请人： Qiang Yu ,  Jing Tan

    发明人： Qiang Yu ,  Jing Tan

    IPC分类号： C12Q1/68 ,  A61K31/436 ,  C12Q1/42 ,  A61K45/06 ,  G01N33/68 ,  A61K31/506 ,  A61K31/713

    CPC分类号： C12Q1/6886 ,  A61K31/436 ,  A61K31/506 ,  A61K31/713 ,  A61K45/06 ,  C12Q1/42 ,  G01N33/57407 ,  G01N33/6893

    摘要： We describe a method of determining whether a cancer cell is likely to be resistant to treatment by an mTOR inhibitor. The method may comprise detecting PPP2R2B (GenBank Accession Number: NM_18167) in or of the cell. It may, alter-natively, or in addition, comprise detecting PDK1 (GenBank Accession Number: NM_002613), in or of the cell. The method may comprise detecting methylation of the PPP2R2B promoter in or of the cell. It may comprise detecting the expression and/or activity of PPP2R2B in or of the cell. It may comprise detecting PDK1 mediated Myc phosphorylation activity. Methods of choosing a treatment for an individual suffering from or suspected to be suffering from a cancer, determining whether an individual suffering from or suspected to be suffering from a cancer will respond to treatment by an mTOR inhibitor, increasing the sensitivity of a cancer cell to treatment by an mTOR inhibitor, for treating or preventing cancer in an individual suffering or suspected to be suffering from cancer are also provided. We further provide for a combination of an inhibitor of PDK1 expression and/or activity and an mTOR inhibitor for use in a method of treatment or prevention of cancer.

    摘要翻译： 我们描述一种确定癌细胞是否可能对mTOR抑制剂治疗有抗性的方法。 该方法可以包括在细胞内或细胞中检测PPP2R2B（GenBank登录号：NM_18167）。 可以或者另外还包括检测细胞内或细胞中的PDK1（GenBank登录号：NM_002613）。 该方法可以包括检测细胞内或细胞中的PPP2R2B启动子的甲基化。 它可以包括检测细胞中或细胞中的PPP2R2B的表达和/或活性。 它可以包括检测PDK1介导的Myc磷酸化活性。 为患有或怀疑患有癌症的个体选择治疗方法，确定患有或怀疑患有癌症的个体是否会对mTOR抑制剂的治疗产生反应，从而增加癌细胞的敏感性 还提供了用于治疗或预防患有或怀疑患有癌症的个体的癌症的mTOR抑制剂的治疗。 我们进一步提供PDK1表达和/或活性的抑制剂和用于治疗或预防癌症的方法中的mTOR抑制剂的组合。

    Methods for cancer therapy and stem cell modulation
    74.
    发明授权
    Methods for cancer therapy and stem cell modulation 有权
    癌症治疗和干细胞调节方法

    公开(公告)号：US08211869B2

    公开(公告)日：2012-07-03

    申请号：US13245709

    申请日：2011-09-26

    申请人： Qiang Yu ,  Jing Tan ,  Xiao Jing Yang

    发明人： Qiang Yu ,  Jing Tan ,  Xiao Jing Yang

    IPC分类号： A01N43/04 ,  A61K31/70

    CPC分类号： A61K31/519 ,  A61K31/52

    摘要： The present invention relates to a method of modulating pluripotency and/or self-renewing characteristics of a stem/progenitor cell. The method comprises administering to the respective cell a compound of the general formula (I) In the general formula A is C or N. R1, R4 and R5 are, independently selected, H or aliphatic, cycloaliphatic, aromatic, arylaliphatic, or arylcycloaliphatic hydrocarbyl groups, that comprise 0-3 heteroatoms being N, O, S, or Si. R4 and R5 may optionally be linked so as to define an aliphatic hydrocarbyl bridge. R2 is H or a halogen. R3 is H, or an aliphatic or arylaliphatic hydrocarbyl group comprising 1-8 main chain carbon atoms and 0-3 heteroatoms being N, O, S, Si, or a halogen.

    摘要翻译： 本发明涉及一种调节干细胞/祖细胞的多能性和/或自我更新特性的方法。 该方法包括向各细胞施用通式（I）的化合物。在通式A中是C或N.R 1，R 4和R 5独立地选自H或脂族，脂环族，芳族，芳基脂族或芳基环脂族烃基 基团，其包含0-3个杂原子是N，O，S或Si。 R 4和R 5可以任选连接以限定脂族烃基桥。 R2是H或卤素。 R3是H或包含1-8个主链碳原子和0-3个杂原子的脂族或芳基脂族烃基是N，O，S，Si或卤素。

    SET ACCELERATOR FOR GYPSUM HYDRATION
    75.
    发明申请
    SET ACCELERATOR FOR GYPSUM HYDRATION 有权
    用于GYPSUM HYDRATION的加速器

    公开(公告)号：US20120160133A1

    公开(公告)日：2012-06-28

    申请号：US12976190

    申请日：2010-12-22

    申请人： Srinivas Veeramasuneni ,  Qiang Yu

    发明人： Srinivas Veeramasuneni ,  Qiang Yu

    IPC分类号： C04B11/00

    CPC分类号： C04B28/145 ,  C04B2103/12 ,  C04B22/16

    摘要： In a first embodiment of the invention, aged brushite is combined with calcium sulfate hemihydrate and water to make a gypsum slurry. Aged brushite slurry behaves similarly to calcium sulfate dihydrate to act as a seed crystal and rapidly initiate crystallization. The brushite slurry does not require the addition of a coating to maintain its activity over time compared to calcium sulfate dihydrate set accelerators. A gypsum-based product made using brushite slurry as the set accelerator is a second embodiment. The product has the brushite molecules integrated as part of the calcium sulfate dihydrate matrix and is distributed throughout the matrix.

    摘要翻译： 在本发明的第一个实施方案中，将老化的白泥与半水合硫酸钙和水混合以制备石膏浆料。 老化的水泥浆浆体的作用类似于硫酸钙二水合物作为晶种，并迅速引发结晶。 与硫酸钙二水合物凝固加速器相比，该悬浮液不需要添加涂层以保持其随时间的活性。 作为第二实施方式的使用石灰浆作为凝固加速剂的石膏制品是第二实施方式。 该产品具有整合作为硫酸钙二水合物基质的一部分的分散在整个基质中的挥发分子。

    EFFICIENT WET STARCH PREPARATION SYSTEM FOR GYPSUM BOARD PRODUCTION
    76.
    发明申请
    EFFICIENT WET STARCH PREPARATION SYSTEM FOR GYPSUM BOARD PRODUCTION 有权
    有效的湿纸浆生产制作系统

    公开(公告)号：US20100061180A1

    公开(公告)日：2010-03-11

    申请号：US12205615

    申请日：2008-09-05

    申请人： Qiang Yu ,  Ron Schenck ,  Salvatore Digennaro ,  Stephen Folson ,  Kevin Henry ,  Tim Guined

    发明人： Qiang Yu ,  Ron Schenck ,  Salvatore Digennaro ,  Stephen Folson ,  Kevin Henry ,  Tim Guined

    IPC分类号： B01F15/04 ,  B01F15/02

    CPC分类号： C04B28/145 ,  B01F3/1271 ,  B01F5/0413 ,  B28B19/0092 ,  B28C7/0418 ,  C04B2111/0062 ,  C04B14/42 ,  C04B22/16 ,  C04B24/22 ,  C04B24/38 ,  C04B40/0028

    摘要： The present invention provides a wet starch preparation system for gypsum wallboard comprising a loss-in-weight starch feeder, a venturi mixer, a vacuum pick-up unit for supplying the dry starch from the feeder at an adjustable rate to the venturi mixer, a first water pump for supplying water at an adjustable rate to the venturi mixer to form a starch pre-dispersion of from about 2% to about 10% by weight starch and a second water pump for supplying gauging water to the starch pre-dispersion, the system equipped with appropriate system controls. The present system provides more efficient use of starch such that the amount of pregelatinized starch is at least about 10% less than a system in which the starch is not pre-dispersed in water prior to the board mixer. The system can be used to make gypsum-containing products including gypsum wallboard having increased board strength and reduced board weight.

    摘要翻译： 本发明提供了一种用于石膏墙板的湿淀粉制备系统，其包括重量损失的淀粉进料器，文氏管混合器，用于以可调节速率从该文丘里搅拌器将来自进料器的干淀粉供给到真空吸盘单元， 第一水泵，其以可调节的速率向文氏管混合器供水以形成约2％至约10％重量的淀粉的淀粉预分散体和用于向淀粉预分散体供应测量水的第二水泵， 系统配备了适当的系统控制。 本发明的系统提供了更有效地使用淀粉，使得预胶化淀粉的量比在板混合器之前未预分散在水中的系统少至少约10％。 该系统可用于制造含石膏墙板的石膏墙板，其具有增加的板强度和减小的板重量。

    SENSITIZING A CELL TO CANCER TREATMENT BY MODULATING THE ACTIVITY OF A NUCLEIC ACID ENCODING RPS27L PROTEIN
    77.
    发明申请
    SENSITIZING A CELL TO CANCER TREATMENT BY MODULATING THE ACTIVITY OF A NUCLEIC ACID ENCODING RPS27L PROTEIN 审中-公开
    通过调节核酸编码RPS27L蛋白的活性来感染癌症治疗细胞

    公开(公告)号：US20090137517A1

    公开(公告)日：2009-05-28

    申请号：US12281423

    申请日：2007-03-01

    申请人： Qiang Yu

    发明人： Qiang Yu

    IPC分类号： A61K31/7105 ,  C12N5/06 ,  C12N15/00

    CPC分类号： C12N15/113 ,  C12N2310/14 ,  C12N2310/53

    摘要： The present invention refers to a method of sensitizing a cell to cancer treatment comprising modulating the activity of a nucleic acid which encodes the RPS27L protein by use of an oligonucleotide which is a RNAi agent or an antisense nucleotide molecule. The oligonucleotides of the present invention can be used in combination with at least one cytostatic drug for, e.g., chemotherapy. The present invention further refers to an expression vector comprising an oligonucleotide used in the method of the present invention as well as to a pharmaceutical comprising the oligonucleotides together with at least one chemotherapeutic agent used in the method of the present invention.

    摘要翻译： 本发明涉及使细胞对癌症治疗敏感的方法，包括通过使用作为RNAi试剂或反义核苷酸分子的寡核苷酸调节编码RPS27L蛋白质的核酸的活性。 本发明的寡核苷酸可与至少一种用于例如化学疗法的细胞抑制药组合使用。 本发明还涉及包含本发明方法中使用的寡核苷酸的表达载体以及包含寡核苷酸与本发明方法中使用的至少一种化学治疗剂的药物。

    COMPOSITE LIGHT WEIGHT GYPSUM WALLBOARD
    79.
    发明申请
    COMPOSITE LIGHT WEIGHT GYPSUM WALLBOARD 有权
    复合轻重量GYPSUM墙板

    公开(公告)号：US20070059513A1

    公开(公告)日：2007-03-15

    申请号：US11537395

    申请日：2006-09-29

    申请人： Qiang Yu ,  Weixin Song

    发明人： Qiang Yu ,  Weixin Song

    IPC分类号： B32B3/26

    CPC分类号： B32B13/04 ,  B32B13/02 ,  B32B13/08 ,  B32B13/14 ,  B32B29/00 ,  B32B2250/40 ,  B32B2307/306 ,  B32B2307/536 ,  B32B2307/546 ,  B32B2307/5825 ,  B32B2419/04 ,  B32B2607/00 ,  C04B28/145 ,  C04B2111/0062 ,  Y02W30/97 ,  Y10T428/24496 ,  Y10T428/249953 ,  C04B14/42 ,  C04B18/241 ,  C04B22/16 ,  C04B24/226 ,  C04B24/383 ,  C04B38/106 ,  C04B2103/65

    摘要： The invention generally provides a light weight composite gypsum board including a foamed low density set gypsum core, a top non-foamed (or reduced-foamed) bonding high density layer and a bottom non-foamed (or reduced-foamed) bonding high density layer, a top cover sheet bonded to the foamed low density set gypsum core by the top non-foamed (or reduced-foamed) bonding high density layer, and a bottom cover sheet bonded to the foamed low density set gypsum core by the bottom non-foamed (or reduced-foamed) bonding high density layer. The foamed low density set gypsum core and the non-foamed (or reduced-foamed) bonding high density layers are made from a gypsum slurry including stucco, pregelatinized starch present in an amount of about 0.5-10% by weight based on the weight of stucco, preferably a naphthalenesulfonate disperant present in an amount of about 0.1-3.0% by weight based on the weight of stucco, and preferably sodium trimetaphosphate present in an amount of about 0.12-0.4% by weight based on the weight of stucco. Other slurry additives can include accelerators, binders, paper fiber, glass fiber, and other known ingredients. The foamed low density set gypsum core is prepared having a density of less than about 30 pcf using soap foam in the gypsum-containing slurry. The combination of components provide a composite gypsum board having light weight and high strength. A method of making the composite gypsum board is also provided.

    摘要翻译： 本发明通常提供了一种重量轻的复合石膏板，其包括泡沫低密度组合石膏芯，顶部非发泡（或还原发泡）键合高密度层和底部非发泡（或还原发泡）键合高密度层 ，通过顶部非发泡（或还原发泡）接合高密度层与顶层发泡低密度石膏芯结合的顶盖片，以及通过底部非密封层结合到泡沫低密度凝固石膏芯上的底盖片， 发泡（或还原发泡）键合高密度层。 泡沫低密度凝固石膏芯和非发泡（或还原发泡）结合的高密度层由石膏浆料制成，所述石膏浆料包含灰泥，预胶化淀粉，其量为约0.5-10重量％，基于 灰泥，优选以基于灰泥重量计约0.1-3.0重量％的量存在的萘磺酸盐阴离子，优选以灰泥重量计约0.12-0.4重量％的量存在的三偏磷酸钠。 其它浆料添加剂可以包括促进剂，粘合剂，纸纤维，玻璃纤维和其它已知成分。 使用含石膏浆料中的肥皂泡沫，制备密度低于约30PCF的泡沫低密度凝固石膏芯。 组分的组合提供了重量轻且强度高的复合石膏板。 还提供了制备复合石膏板的方法。