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公开(公告)号:US5696165A
公开(公告)日:1997-12-09
申请号:US557565
申请日:1995-11-14
IPC分类号: A61K9/20 , A61K31/19 , A61K31/192 , A61P25/04 , A61P29/00 , C07B57/00 , C07C51/41 , C07C57/30
CPC分类号: A61K31/192 , A61K31/19 , C07C57/30 , Y10S514/886 , Y10S514/937 , Y10S514/944 , Y10S514/969
摘要: The use of S(-)sodium 2-(4-isobutylphenyl)propionate (the sodium salt of S(+)-ibuprofen) in pharmaceutical compositions for the treatment of inflammation, pain and pyrexia is described. Preferred compositions comprise S(-)sodium 2-(4-isobutylphenyl)propionate dihydrate. Processes to prepare S(-)sodium 2-(4-isobutyl-phenyl)propionate and its use in a process to prepare S(+) 2-(4-isobutylphenyl)propionic acid of high enantiomeric purity are also described.
摘要翻译: 描述了用于治疗炎症,疼痛和发热的药物组合物中使用S-( - )2-(4-异丁基苯基)丙酸钠(S(+) - 布洛芬的钠盐)。 优选的组合物包含S-( - )2-(4-异丁基苯基)丙酸钠二水合物。 还描述了制备S-( - )2-(4-异丁基 - 苯基)丙酸钠的方法及其在制备高对映体纯度的S(+)2-(4-异丁基苯基)丙酸的方法中的用途。
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公开(公告)号:US5636055A
公开(公告)日:1997-06-03
申请号:US686478
申请日:1996-07-26
申请人: John Portman , Alan Smith , Christopher Masters
发明人: John Portman , Alan Smith , Christopher Masters
CPC分类号: E04B9/0428 , G03B21/58 , E04B2009/0492
摘要: A screen assembly that includes a screen material which is bonded to a thin metal substrate. The substrate is typically a solid 1/16 inch thick sheet of aluminum that is both light weight and strong. The bonded screen/substrate subassembly is mounted to an flip panel frame which is pivotally connected to an outer frame. To increase the rigidity of the substrate, the edges of the screen subassembly are located within a channel of the flip panel frame and held in place by a flexible foam cord that is pressed between the subassembly and the frame. The outer frame is pivotally connected to a stationary frame that is mounted to a structure, such as the wall of an aircraft passenger compartment. To display images on the screen, the outer frame is rotated away from the wall and the flip panel frame is flipped around to expose the screen to the passenger compartment.
摘要翻译: 一种屏幕组件,其包括结合到薄金属基板的屏幕材料。 基材通常是固体+ E,fra 1/16 + EE英寸厚的铝板,重量轻且坚固。 粘合的屏幕/基板子组件安装到枢转地连接到外框的翻转框框架。 为了增加基板的刚度,屏幕子组件的边缘位于翻盖框架的通道内,并通过按压在子组件和框架之间的柔性泡沫绳线保持就位。 外框架枢转地连接到固定框架,该固定框架安装到诸如飞机乘客舱的壁的结构上。 为了在屏幕上显示图像,外框离开墙壁旋转,翻转框架被翻转,将屏幕暴露于乘客舱。
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公开(公告)号:US4782979A
公开(公告)日:1988-11-08
申请号:US043891
申请日:1987-04-16
申请人: Alan Smith , George K. Butler
发明人: Alan Smith , George K. Butler
CPC分类号: D01H9/18 , B65H67/067 , B65H2701/31
摘要: A device for dispensing conical objects to form a stream of generally horizontal side-by-side conical objects with alternate conical objects having one orientation and intervening conical objects having the reversed orientation. The stacks having a first orientation have release cams driven from a common cam shaft while the intervening stacks have release cams driven from a common cam shaft, the timing of the two cam shafts being such that the conical objects are released successively starting from stack and ending at stack.
摘要翻译: 一种用于分配锥形物体以形成大致水平的并列锥形物体的流的装置,其具有具有一个取向的交替圆锥体物体和具有相反取向的中间锥形物体。 具有第一方向的堆叠具有从公共凸轮轴驱动的释放凸轮,而中间堆叠具有从共同的凸轮轴驱动的释放凸轮,两个凸轮轴的正时使得圆锥形物体从堆叠开始并且结束 在堆栈
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公开(公告)号:US4611463A
公开(公告)日:1986-09-16
申请号:US743441
申请日:1985-06-11
申请人: Alan Smith , Stephen W. Yates
发明人: Alan Smith , Stephen W. Yates
CPC分类号: D01H13/005
摘要: An open-end spinning machine incorporating a doffer robot also includes separate tracks for the doffer robot and a piecer-cleaner robot. The robots are able to patrol continuously along one side of the machine and back along the other side of the machine, with sufficient separation for the doffer robot to pass the piecer-cleaner robot, and vice versa and for the two robots to pass end casings of the machine.
摘要翻译: 结合道夫机器人的开放式纺纱机还包括用于道夫机器人的独立轨道和一个接头清洁机器人。 机器人能够沿着机器的一侧连续巡视并沿着机器的另一侧返回,具有足够的间隔,用于道夫机器人通过接头清洁机器人,反之亦然,并且两个机器人通过端部外壳 的机器。
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公开(公告)号:US4225451A
公开(公告)日:1980-09-30
申请号:US857602
申请日:1977-12-05
申请人: Joseph E. McCrudden , Alan Smith
发明人: Joseph E. McCrudden , Alan Smith
IPC分类号: C11D7/54 , C07C67/00 , C07C407/00 , C07C409/00 , C07C409/30 , C07C409/40 , C11D3/39 , C11D7/56 , C11D17/00 , D06L3/02 , B05D7/00 , C11D3/395
CPC分类号: C11D17/0039 , C07C409/30 , C11D3/3945 , Y10T428/2991
摘要: The present invention provides aromatic peroxyacids containing at least two peroxyacid groups and a total of at least three peroxyacid or carboxy acid groups, which can be incorporated in detergent or bleaching compositions.The aromatic peroxyacids can be desensitized by intimate contact with a diluent e.g. magnesium sulphate or lauric acid, and coated to reduce destructive interaction with other components of the detergent or bleaching composition. Preferred aromatic peroxyacids include triperoxy trimellitic acid, triperoxy trimesic acid and tetraperoxy pyomellitic acid.The aromatic peroxyacids are especialy suitable for washing white fabrics or cleaning hard surfaces, particularly at a temperature of from 30.degree. to 60.degree. C.
摘要翻译: 本发明提供了含有至少两个过氧酸基团和总共至少三个过氧酸或羧酸基团的芳族过氧酸,其可以掺入洗涤剂或漂白组合物中。 芳族过氧酸可以通过与稀释剂紧密接触而脱敏。 硫酸镁或月桂酸,并涂覆以减少与洗涤剂或漂白组合物的其它组分的破坏性相互作用。 优选的芳族过氧酸包括三过氧偏苯三酸,三过氧均苯三甲酸和四枯烯β-薄荷黑酸。 芳族过氧酸特别适合于洗涤白色织物或清洁硬表面,特别是在30至60℃的温度下。
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公开(公告)号:US11319223B2
公开(公告)日:2022-05-03
申请号:US15502119
申请日:2014-08-08
IPC分类号: C02F1/52 , C02F11/14 , C02F11/147
摘要: An apparatus for preparing and dispensing a flocculant solution to dewatering an aqueous process stream includes a mixing pump, a maturing tank, and a feeding unit. The mixing pump mixes the flocculant solution and builds up a pressure onto the flocculant solution. The maturing pressure tank is fluidly connected with the mixing pump, so that the pressurized diluted flocculant solution is led from the mixing pump into the maturing pressure tank and matured therein under pressure that is above atmosphere pressure.
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公开(公告)号:US20190117947A1
公开(公告)日:2019-04-25
申请号:US15632329
申请日:2017-06-24
申请人: Frank Tagliaferri , Alan Smith , David Enscore , Gaurav Tolia , Mirek Baudys
发明人: Frank Tagliaferri , Alan Smith , David Enscore , Gaurav Tolia , Mirek Baudys
IPC分类号: A61M37/00 , A61K47/38 , A61K47/18 , A61K47/12 , A61P5/50 , A61K31/4468 , A61K9/70 , A61P23/02 , A61K31/485
摘要: Disclosed are a patch, system, and method for delivery of a permeant composition into a subject via at least one formed pathway through a biological membrane of the subject. The patch comprises a matrix, at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the permeant can dissolve in biological moisture received from the subject, and at least one permeability enhancer disposed within the matrix. Also disclosed are systems and methods for delivery of a permeant composition into a subject via at least one formed pathway through a skin layer of the subject.
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公开(公告)号:US08946208B2
公开(公告)日:2015-02-03
申请号:US12201226
申请日:2008-08-29
申请人: Jonathan Castile , Alan Smith , Yu-Hui Cheng , Peter James Watts
发明人: Jonathan Castile , Alan Smith , Yu-Hui Cheng , Peter James Watts
IPC分类号: A01N43/62 , A61K31/55 , C07D243/12 , A61K9/00 , A61K9/08 , A61K31/5517 , A61K47/10 , A61K47/14 , A61K47/22
CPC分类号: A61K9/0043 , A61K9/08 , A61K31/55 , A61K31/5517 , A61K47/10 , A61K47/14 , A61K47/22
摘要: A composition for intranasal delivery of a drug comprising: includes: (i) the drug; and (ii) a non-aqueous vehicle containing (a) propylene glycol and at least one additional solvent selected from N-methylpyrrolidone, propylene carbonate, dimethyl sulfoxide and at least one propylene glycol fatty acid ester; (b) from about 40 to 100% by volume of N-methylpyrrolidone; or (c) from about 40 to 100% by volume of dimethyl sulfoxide (DMSO).
摘要翻译: 一种用于鼻内递送药物的组合物,包括:(i)药物; 和(ii)含有(a)丙二醇和至少一种另外的选自N-甲基吡咯烷酮,碳酸亚丙酯,二甲基亚砜和至少一种丙二醇脂肪酸酯的溶剂的非水性载体; (b)约40-100%(体积)的N-甲基吡咯烷酮; 或(c)约40〜100体积%的二甲基亚砜(DMSO)。
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公开(公告)号:US08733392B2
公开(公告)日:2014-05-27
申请号:US12064853
申请日:2006-09-12
申请人: Alan Smith , Nigel Charles Wood
发明人: Alan Smith , Nigel Charles Wood
IPC分类号: F16K31/365 , B05B12/08 , B05B15/12
CPC分类号: G05D16/185 , B05B12/088 , B05B14/40 , Y10T137/7793 , Y10T137/7825 , Y10T137/7826
摘要: A paint circulating system back pressure regulator comprises a flow passage for paint, at least part of which is disposed between a fixed structure and a moveable surface which is moveable to vary the width of the flow passage so as to regulate a pressure of paint upstream of the regulator. The regulator is also provided with a chamber having an opening for communicating with a supply of a pressurized fluid for controlling operation of the regulator.
摘要翻译: 涂料循环系统背压调节器包括用于涂料的流动通道,其至少一部分设置在固定结构和可移动表面之间,该可移动表面可移动以改变流动通道的宽度,以便调节流动通道的上游压力 监管者。 调节器还设置有具有用于与用于控制调节器的操作的加压流体供应源连通的开口的室。
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公开(公告)号:US08216604B2
公开(公告)日:2012-07-10
申请号:US12047388
申请日:2008-03-13
IPC分类号: A61F13/00 , A61K31/445 , A61K31/35 , A01N43/40 , A01N43/16
CPC分类号: A61K31/4468 , A61K9/0043 , A61K47/26 , A61K47/36 , A61M11/00 , A61M15/08
摘要: A composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal includes an aqueous solution of fentanyl or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive selected from (i) a pectin and (ii) a poloxamer and chitosan or a salt or derivative thereof; provided that when the composition comprises a pectin it is substantially free of divalent metal ions; and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax) that is from 10 to 80% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. A method for treating or managing pain by intranasally administering the composition is also disclosed.
摘要翻译: 用于向动物鼻内递送芬太尼或其药学上可接受的盐的组合物包括芬太尼或其药学上可接受的盐的水溶液和选自以下的药学上可接受的添加剂:(i)果胶和(ii)泊洛沙姆和壳聚糖或 其盐或衍生物; 条件是当组合物包含果胶时,其基本上不含二价金属离子; 并且与以相同剂量鼻内施用的芬太尼的简单水溶液相比,提供了芬太尼(C max)的峰值血浆浓度,其为使用芬太尼简单的水溶液在10%至80% 芬太尼剂量相同。 还公开了通过鼻内施用组合物治疗或治疗疼痛的方法。
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