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    Diagnosis of rheumatoid arthritis in vivo using a novel spectroscopic approach
    72.
    发明授权
    Diagnosis of rheumatoid arthritis in vivo using a novel spectroscopic approach 失效
    使用新的光谱方法在体内诊断类风湿关节炎

    公开(公告)号：US06424859B2

    公开(公告)日：2002-07-23

    申请号：US09334661

    申请日：1999-06-17

    申请人： Michael Jackson ,  Michael G. Sowa ,  James R. Mansfield ,  Hans H. Eysel ,  Henry H. Mantsch ,  Hani El-Gabalawy ,  Jan M. Canvin

    发明人： Michael Jackson ,  Michael G. Sowa ,  James R. Mansfield ,  Hans H. Eysel ,  Henry H. Mantsch ,  Hani El-Gabalawy ,  Jan M. Canvin

    IPC分类号： A61B600

    CPC分类号： G01N21/49 ,  A61B5/0059 ,  A61B5/4528 ,  A61B5/7267 ,  G01N21/359

    摘要： A novel near infrared spectroscopic technique was used to characterize the joints in arthritis with comparison against normal joints. A beam of near infrared light was passed to joints through a fibre optic cable. Scattered light was collected by the same fibre bundle and a spectrum of the joint computed. Multivariate pattern recognition techniques identified regions of the spectrum which allowed discrimination between healthy and affected joints. Linear discriminant analysis resulted in correct classification of 74% of the joints. The high degree of similarity between mean spectra representing the early, late and control groups along with the significant between—subject variability in the data make diagnosis based on visual assessment of the spectra impossible. Linear discriminant analysis was therefore applied to spectra to determine if spectra could be classified by statistical methods as arising from early or late RA. Application of LDA resulted in correct classification of 74% of the joints. Interestingly, the spectral regions in which diagnostic differences were found by the multivariate analysis contain absorption bands related to tissue oxygenation status (oxy and deoxyhaemoglobin) and oxygen utilisation (cytochrome aa3), suggesting that ischaemic changes within the joint are being detected.

    摘要翻译： 与正常关节相比，使用新型近红外光谱技术来表征关节炎关节。 一束近红外光通过光缆传递到接头。 散射光被相同的纤维束收集，并计算出关节的光谱。 多变量模式识别技术确定了允许区分健康和受影响关节的频谱区域。 线性判别分析导致74％关节的正确分类。 表示早期，晚期和对照组的平均光谱之间的高度相似性以及数据中显着的受试者间变异性，基于对光谱的视觉评估不可能进行诊断。 因此，将线性判别分析应用于光谱，以确定是否可以通过统计学方法将光谱分类为早期或晚期RA引起的。 LDA的应用导致74％的关节正确分类。 有趣的是，通过多变量分析发现诊断差异的光谱区域包含与组织氧合状态（氧和脱氧血红蛋白）和氧利用（细胞色素aa3）相关的吸收带，表明正在检测到关节内的缺血性变化。

    Method of determining groove angle to give optimum tread wear
    74.
    发明授权
    Method of determining groove angle to give optimum tread wear 有权
    确定槽角度以获得最佳胎面磨损的方法

    公开(公告)号：US06200401B1

    公开(公告)日：2001-03-13

    申请号：US09164459

    申请日：1998-10-01

    申请人： David Robert Watkins ,  Michael Jackson

    发明人： David Robert Watkins ,  Michael Jackson

    IPC分类号： B29D3000

    CPC分类号： B60C11/03 ,  B60C11/0302 ,  B60C11/0306 ,  B60C2200/10 ,  Y10S152/903 ,  Y10S152/904

    摘要： A tire for a two-wheeled vehicle comprising a ground contacting tread having at least one tread groove formed therein and extending axially from the tread center to the tread edge, wherein in a first region of the tire tread, which is the central tread region and is the region of contact between the tire and the ground when the motorcycle is in the condition of moving in a straight line, the alignment of the tread groove is substantially circumferential, and in a second region of the tire tread, which is at the axial edge of the tread and is the region of contact when the motorcycle is in the condition of turning under maximum cornering, the alignment of the tread grooves is substantially transverse, and in a third region, which is the tread region between the first central region and the second axial region and which is the ground contacting region when the motorcycle is turning at less than the maximum cornering condition, the groove alignment changes progressively axially outwardly from substantially circumferential to substantially transverse so that in the first, second and third axial regions of the tire tread the tread grooves are substantially aligned with the resultant forces acting on the tire tread surface in the contact region between the tread and with the ground.

    摘要翻译： 一种用于两轮车辆的轮胎，其包括具有形成在其中并且从胎面中心轴向延伸到胎面边缘的至少一个胎面槽的地面接触胎面，其中在作为中心胎面区域的轮胎胎面的第一区域中， 是当摩托车处于直线移动的状态下轮胎和地面之间的接触区域，胎面槽的对准基本上是周向的，并且在轮胎胎面的位于轴向的第二区域中 胎面的边缘是当摩托车处于最大转弯时转动的状态下的接触区域，胎面花纹槽的对准基本上是横向的，在第三区域中，胎面区域在第一中心区域和第 第二轴向区域，并且当摩托车在小于最大转弯条件下转动时是地面接触区域，槽对准沿轴向向外变化 从基本上圆周到基本横向，使得在轮胎胎面的第一，第二和第三轴向区域中，胎面花纹沟基本上对准作用在胎面和地面之间的接触区域中的轮胎胎面表面上的合力。

    Method of manufacturing tire including grooves
    75.
    发明授权
    Method of manufacturing tire including grooves 失效
    制造包括槽的轮胎的方法

    公开(公告)号：US06190478B1

    公开(公告)日：2001-02-20

    申请号：US09164773

    申请日：1998-10-01

    申请人： David Robert Watkins ,  Michael Jackson ,  Paul Stephens

    发明人： David Robert Watkins ,  Michael Jackson ,  Paul Stephens

    IPC分类号： B29D3000

    CPC分类号： B60C11/0304 ,  B60C19/001 ,  B60C2011/0374 ,  Y10S152/903 ,  Y10S152/904

    摘要： A tire for a vehicle having at least one wheel at each corner, the tire comprising a ground contacting tread extending axially between first and second edge regions and having tread grooves formed therein, wherein in the first axial edge region of the tread the tread grooves are aligned substantially in the tire circumferential direction and in the second axial edge region of the tread the grooves are aligned substantially in the tire axial direction and in a third axial region of the tread axially between the first and second edge regions the alignment of the grooves changes progressively from circumferential to axial.

    摘要翻译： 一种用于在每个角落具有至少一个车轮的车辆轮胎，所述轮胎包括在第一和第二边缘区域之间轴向延伸并具有形成在其中的胎面花纹的接地胎面，其中在所述胎面的所述第一轴向边缘区域中， 基本上在轮胎周向上对准，并且在胎面的第二轴向边缘区域中，凹槽基本上在轮胎轴向方向上对准，并且在胎面的第三轴向区域中轴向地在第一和第二边缘区域之间，凹槽的对准改变 逐渐从圆周到轴向。

    Massline loudspeaker enclosure
    78.
    发明授权
    Massline loudspeaker enclosure 失效
    大众音箱扬声器

    公开(公告)号：US5749433A

    公开(公告)日：1998-05-12

    申请号：US600497

    申请日：1996-02-13

    申请人： Michael Jackson

    发明人： Michael Jackson

    IPC分类号： H04R1/28 ,  H05K5/00

    CPC分类号： H04R1/2834

    摘要： A loudspeaker system comprises a housing consisting of three interconnected sealed enclosures. The primary sealed enclosure has an aperture in it in which a loudspeaker is mounted in a sealed relationship. This enclosure is interconnected with an intermediate sealed enclosure located between it and a third or output enclosure. The intermediate sealed enclosure has an aperture communicating between it and the interior of the primary sealed enclosure. A first passive plate is movably mounted in this aperture in sealed relationship. A second passive plate is movably mounted in an aperture between the second enclosure and the output enclosure in sealed relationship to form a sealed airspace between the first and second passive plates. The output enclosure has a port in it for communication with the air surrounding the enclosures. The system provides low frequency bandwidth and reduced distortion in a composite system, which has a significantly reduced volume compared with conventional speaker enclosures providing comparable low frequency response.

    摘要翻译： 扬声器系统包括由三个互连的密封外壳组成的壳体。 主密封外壳中具有一个孔，其中扬声器以密封的关系安装。 该外壳与位于其与第三或输出外壳之间的中间密封外壳相互连接。 中间密封外壳具有在其与主密封外壳内部连通的孔。 第一被动板以密封的关系可移动地安装在该孔中。 第二被动板以密封的关系可移动地安装在第二外壳和输出外壳之间的孔中，以在第一和第二被动板之间形成密封的空间。 输出外壳有一个端口，用于与机箱周围的空气进行通讯。 该系统在复合系统中提供低频带宽和减少的失真，与提供可比较的低频响应的传统扬声器外壳相比，其体积显着减小。

    Motorcycle radial tire with supplementary breaker ply
    79.
    发明授权
    Motorcycle radial tire with supplementary breaker ply 失效
    摩托车子午线轮胎配有辅助断路器层

    公开(公告)号：US5529102A

    公开(公告)日：1996-06-25

    申请号：US382151

    申请日：1995-02-01

    申请人： David R. Watkins ,  Nigel G. Nock ,  Michael Jackson

    发明人： David R. Watkins ,  Nigel G. Nock ,  Michael Jackson

    IPC分类号： B60C3/04 ,  B60C9/06 ,  B60C9/20 ,  B60C3/00 ,  B60C9/08 ,  B60C9/18

    CPC分类号： B60C9/20 ,  B60C3/04 ,  B60C9/06 ,  B60C9/2009 ,  B60C2200/10 ,  Y10T152/10765 ,  Y10T152/10792

    摘要： A motorcycle radial tire comprises a tread reinforced between its edges by a breaker assembly and having in its normally inflated fitted condition a camber value C/L of between 0.5 and 0.7, a reinforcing carcass of radially disposed cords extending radially inside the breaker assembly and between two bead regions and wrapped in each bead region around an annular bead core from the axial inside to the outside to form carcass ply turn-ups, and tire sidewalls between the tread edges and bead regions, the tire characterized in that the breaker assembly comprises two breaker plies each reinforced with aromatic polyamide cords oppositely inclined with respect to the circumferential direction of the tire and a supplementary ply disposed radially adjacent to the breaker plies and reinforced with nylon reinforcements laid parallel to each other and disposed at an angle in the range of 75.degree.-90.degree. to the circumferential direction of the tire.

    摘要翻译： 摩托车子午线轮胎包括通过断路器组件在其边缘之间增强的胎面，并且在其通常的充气配合状态下具有0.5至0.7之间的外倾角值C / L，径向设置的帘线的径向设置的帘线径向延伸在破碎机组件内部以及 两个胎圈区域，并且围绕环形胎圈芯从轴向内部包裹到每个胎圈区域到外部，以形成胎体帘布层，以及胎面边缘和胎圈区域之间的轮胎侧壁，其特征在于，所述破碎机组件包括两个 每个用相对于轮胎圆周方向相对倾斜的芳族聚酰胺帘线增强的断路器帘布层和邻近断路器层布置的辅助帘布层，并且以与彼此平行布置并以75度的角度设置的尼龙增强件加强 相对于轮胎的圆周方向为-90°。

    Method of making mechanical pulp
    80.
    发明授权
    Method of making mechanical pulp 失效
    制造机械纸浆的方法

    公开(公告)号：US4789429A

    公开(公告)日：1988-12-06

    申请号：US78180

    申请日：1987-05-28

    申请人： Michael Jackson ,  Knut O. Danielsson ,  Bo G. S. Falk

    发明人： Michael Jackson ,  Knut O. Danielsson ,  Bo G. S. Falk

    IPC分类号： D21B1/16 ,  D21C3/22 ,  D21D1/30

    CPC分类号： D21B1/16

    摘要： A method for producing mechanical pulps which are useful for producing coated light weight paper, magazine paper and the like, is disclosed, which includes preheating lignocellulose-containing material in the presence of impregnation chemicals, refining the preheated lignocellulose-containing material utiilizing a pair of counter-rotating refining discs under pressure, bleaching the thus produced partially refined lignocellulose-containing material, and refining the bleached material in a second refining step utilizing a pair of refining discs, one of which is stationary and the other which is rotating under pressure.

    摘要翻译： PCT No.PCT / SE86 / 00454 Sec。 371日期：1987年5月28日 102（e）日期1987年5月28日PCT提交1986年10月7日PCT公布。 出版物WO87 / 0302200 日本1987年5月21日公开了一种生产机械纸浆的方法，其用于生产涂布的轻质纸，杂志纸等，其包括在浸渍化学品存在下预热含木素纤维素的材料，将预热的木质纤维素 - 在压力下使一对反向旋转精炼圆盘的材料漂白，漂白由此制得的部分精制的含木素纤维素的材料，并在第二精炼步骤中利用一对精炼圆盘精炼漂白材料，其中一个精炼圆盘是静止的，另一个是固定的 它在压力下旋转。