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157 条记录 (耗时 0.053 秒)

    System, network, mobile terminal, computer program product and method for cross-paging a mobile terminal via a data burst message
    71.
    发明授权
    System, network, mobile terminal, computer program product and method for cross-paging a mobile terminal via a data burst message 失效
    系统，网络，移动终端，通过数据突发消息对移动终端进行跨寻呼的计算机程序产品和方法

    公开(公告)号：US07668136B2

    公开(公告)日：2010-02-23

    申请号：US11353542

    申请日：2006-02-14

    申请人： Lei Yu

    发明人： Lei Yu

    IPC分类号： H04W4/00

    CPC分类号： H04W68/12 ,  H04W52/0216 ,  H04W68/025 ,  H04W88/06 ,  Y02D70/1224 ,  Y02D70/1242

    摘要： Systems and methods are provided to permit a network, such as a data only network, with which a mobile terminal is not currently communicating to notify the mobile terminal that the network desires to establish communication with the mobile terminal, even in instances in which the mobile terminal is actively communicating via another network, such as a voice and data network and has stopped monitoring for paging messages. The mobile terminal can then end communications with the network with which it has been previously communicating and commence communications with the other network that has transmitted the paging message. For example, a mobile terminal may terminate voice communications via a voice and data network in order to receive a Multimedia Message Service message via a data only network upon receiving notification that the data only network desires to establish a communications session with the mobile terminal.

    摘要翻译： 提供系统和方法，以允许移动终端当前不进行通信的网络（例如仅数据网络）来通知移动终端网络期望与移动终端建立通信，即使在移动终端 终端正在通过诸如语音和数据网络的另一网络进行主动通信，并且已经停止对寻呼消息的监视。 移动终端然后可以终止与之前通信的网络的通信，并开始与已发送寻呼消息的另一个网络的通信。 例如，移动终端可以通过语音和数据网络终止语音通信，以便在接收到仅数据网络期望与移动终端建立通信会话的通知时经由仅数据网络接收多媒体消息服务消息。

    Multi-valent guanidinium compounds for enhancing molecular translocation across cellular membranes and epithelial tissues
    76.
    发明申请
    Multi-valent guanidinium compounds for enhancing molecular translocation across cellular membranes and epithelial tissues 失效
    用于增强细胞膜和上皮组织分子易位的多价胍化合物

    公开(公告)号：US20070078078A1

    公开(公告)日：2007-04-05

    申请号：US11525512

    申请日：2006-09-21

    申请人： Zheng Hou ,  Jian Liu ,  Lei Yu

    发明人： Zheng Hou ,  Jian Liu ,  Lei Yu

    IPC分类号： A61K38/16 ,  C07K7/64 ,  A61K38/12

    CPC分类号： C07K7/02 ,  A61K47/55 ,  A61K47/64 ,  C07K7/64

    摘要： Disclosed herein are guanidinium containing compounds consisting of a core moiety with a plurality of side chains containing guanidinium groups. Such compounds have enhanced translocation across cellular membranes and epithelial tissues. The compounds may also have a therapeutic or other biologically active moiety attached so that these moieties may be effectively transported into a cell by the guanidinium containing compound.

    摘要翻译： 本文公开了含有胍基的化合物，其由具有多个含有胍基的侧链的核心部分组成。 这些化合物通过细胞膜和上皮组织增强易位。 化合物还可以具有连接的治疗或其他生物活性部分，使得这些部分可以通过含胍化合物有效地转运到细胞中。

    Culture device and method for eukaryotic cell transfection
    78.
    发明授权
    Culture device and method for eukaryotic cell transfection 失效
    用于真核细胞转染的培养装置和方法

    公开(公告)号：US07125709B2

    公开(公告)日：2006-10-24

    申请号：US10775341

    申请日：2004-02-10

    申请人： Yasunobu Tanaka ,  Lei Yu ,  Shouping Ji

    发明人： Yasunobu Tanaka ,  Lei Yu ,  Shouping Ji

    IPC分类号： C12M1/00 ,  C12M1/16

    CPC分类号： C12N5/0068 ,  C12N2510/00 ,  C12N2533/18 ,  C12N2533/54

    摘要： A cell culture device for transfecting a eukaryotic cell is disclosed. The cell culture/transfection device may be a multiwell plate or slide which has been coated with a metal salt such as CaCl2. Methods of using the cell culture device to transfect mammalian cells and/or to monitor cell transfection are described. Kits are also described which include the cell transfection device, eukaryotic cells to be transformed and nucleic acid for transformation.

    摘要翻译： 公开了用于转染真核细胞的细胞培养装置。 细胞培养/转染装置可以是已经涂覆有金属盐如CaCl 2 2的多孔板或载玻片。 描述了使用细胞培养装置转染哺乳动物细胞和/或监测细胞转染的方法。 还描述了包括细胞转染装置，待转化的真核细胞和用于转化的核酸的试剂盒。

    Biodegradable polyacetals
    79.
    发明授权
    Biodegradable polyacetals 失效
    可生物降解聚缩醛

    公开(公告)号：US06878374B2

    公开(公告)日：2005-04-12

    申请号：US10375705

    申请日：2003-02-25

    申请人： Lei Yu ,  Sang Van ,  Shouping Ji ,  Kenji Matsumoto

    发明人： Lei Yu ,  Sang Van ,  Shouping Ji ,  Kenji Matsumoto

    IPC分类号： A61K47/48 ,  C08G65/00 ,  C08G73/02 ,  A61K39/44 ,  C08F283/00

    CPC分类号： C08G73/0213 ,  A61K47/59 ,  C08G65/002

    摘要： A polymer comprising recurring units represented by formula (I): wherein X is selected from the group consisting of C(O)OR1, C(O)SR1, C(O)NR1R2, and VZ, where R1 and R2 are each individually selected from the group consisting of hydrogen, C1 to C10 alkyl, and C6 to C10 aryl, where V is a labile linker group, and where Z is selected from the group consisting of poly(ethyleneimine), poly(propyleneimine), poly(lysine), PAMAM dendrimer, octaamine dendrimer, and hexadecaamine dendrimer; and wherein Y is selected from the group consisting of —(CH2)2—, —(CH2)2—O—(CH2)2—, —(CH2)2—O—(CH2)2—, and —(CH2)3—NHC(O)—(CH2)6—C(O)NH—(CH2)3— is useful in nucleic acid delivery applications. Polyacetals of the formula (I) are preferably made by reacting appropriate diols and divinyl ethers. In preferred embodiments, complexes formed between polyacetals of the formula (I) and polynucleotides are useful as transfection reagents.

    摘要翻译： 一种包含由式（I）表示的重复单元的聚合物：其中X选自C（O）OR 1，C（O）SR 1，C（O）NR 1 R 2 >和VZ，其中R 1和R 2各自独立地选自氢，C 1至C 10烷基和C 6至C 10芳基，其中V是不稳定的连接基团，并且其中Z被选择 由聚（乙烯亚胺），聚（丙烯亚胺），聚（赖氨酸），PAMAM树枝状聚合物，八胺树枝状聚合物和十六胺树枝状聚合物组成的组中; 其中Y选自 - （CH 2）2 - ， - （CH 2）2 -O-（CH 2）2 - ， - （CH 2）2 -O-（CH 2）2 - 和 - （CH 2） 3-NHC（O） - （CH 2）6 -C（O）NH-（CH 2）3 - 可用于核酸递送应用。 式（I）的聚缩醛优选通过使适当的二醇和二乙烯基醚反应来制备。 在优选的实施方案中，在式（I）的聚缩醛和多核苷酸之间形成的络合物可用作转染试剂。

    Alleles of the human mu opioid receptor, diagnostic methods using said alleles, and methods of treatment based thereon
    80.
    发明授权
    Alleles of the human mu opioid receptor, diagnostic methods using said alleles, and methods of treatment based thereon 失效
    人类μ阿片样物质受体的等位基因，使用所述等位基因的诊断方法和基于其的治疗方法

    公开(公告)号：US06337207B1

    公开(公告)日：2002-01-08

    申请号：US09113426

    申请日：1998-07-10

    申请人： Mary Jeanne Kreek ,  Karl Steven LaForge ,  Lei Yu ,  Jay A. Tischfield

    发明人： Mary Jeanne Kreek ,  Karl Steven LaForge ,  Lei Yu ,  Jay A. Tischfield

    IPC分类号： C12N1563

    CPC分类号： C12N15/73 ,  C07K14/72 ,  C07K16/28 ,  C12N15/75 ,  C12Q1/6827

    摘要： Provided herein are variant alleles of a gene encoding a mu opioid receptor, along with cloning vectors for replicating such variant alleles, expressing vectors for expressing the variant alleles to produce variant mu opioid receptors, and antibodies to such variant receptors. Also disclosed are binding characteristics of such variant receptors regarding binding to opioid ligands, and the using of such binding characteristics to diagnose a subjects susceptibility to pain, susceptibility to an addictive disease, selecting an appropriate pain reliever along with a therapeutically effective amount of the reliever to administer to a subject suffering from pain. In addition, diagnostic methods for diagnosing a disease or disorder such as infertility, constipation, diarrhea, decreased immune response relative to a standard, and decreased ability to withstand stress relative to a standard, along with commercial kits for diagnosing such diseases or disorders.

    摘要翻译： 本文提供了编码μ阿片受体的基因的变异等位基因，以及用于复制这种变异等位基因的克隆载体，表达用于表达变体等位基因以产生变体μ阿片样物质受体的载体，以及针对这种变体受体的抗体。 还公开了这样的变体受体关于结合阿片样物质配体的结合特征，以及使用这种结合特征来诊断受试者对疼痛的敏感性，对成瘾性疾病的易感性，选择适当的止痛药以及治疗有效量的缓解剂 给予痛苦的受试者。 此外，用于诊断疾病或病症的诊断方法，例如不育症，便秘，腹泻，相对于标准物的免疫应答降低，以及相对于标准物承受应力的能力降低，以及用于诊断这些疾病或病症的商业试剂盒。