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公开(公告)号：US5552418A
公开(公告)日：1996-09-03
申请号：US447886
申请日：1995-05-23
申请人： Patrick Depreux , Hamid Ait Mansour , Daniel Lesieur , Fran.cedilla.ois Lefoulon , Pierre Renard , G erard Adam , Philippe Delagrange
发明人： Patrick Depreux , Hamid Ait Mansour , Daniel Lesieur , Fran.cedilla.ois Lefoulon , Pierre Renard , G erard Adam , Philippe Delagrange
IPC分类号： A61K31/165 , A61K31/17 , A61K31/18 , A61K31/215 , A61K31/22 , A61P1/00 , A61P3/04 , A61P9/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07C231/12 , C07C233/18 , C07C233/25 , C07C233/31 , C07C233/60 , C07C233/61 , C07C273/18 , C07C275/24 , C07C275/26 , C07C327/42 , C07C327/46 , A61K31/44 , C07D213/16 , C07D213/26 , C07D213/63
CPC分类号： C07C233/31 , C07C233/18 , C07C233/60 , C07C233/61 , C07C275/24 , C07C275/26 , C07C327/42 , C07C327/46 , C07C2101/02 , C07C2101/04 , C07C2101/08 , C07C2101/14 , C07C2101/16
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which R, R.sub.1, R.sub.2 and R.sub.3 are as defined in the specification,and a medicinal product containing said compound for treating a disorder of the melatoninergic system.
摘要翻译： 本发明涉及一种选自式（I）的化合物：其中R，R 1，R 2和R 3如本说明书中所定义的其中R 1，R 2和R 3如本文所定义的含有所述化合物的药物， 褪黑激素系统。
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公开(公告)号：US5459138A
公开(公告)日：1995-10-17
申请号：US217192
申请日：1994-03-24
申请人： Bernard Pirotte , Pascal de Tullio , Bernard Masereel , Jacques Delarge , Jean Lepagnol , Pierre Renard
发明人： Bernard Pirotte , Pascal de Tullio , Bernard Masereel , Jacques Delarge , Jean Lepagnol , Pierre Renard
IPC分类号： A61K31/54 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D513/04
CPC分类号： C07D513/04
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which A, R.sub.1, R.sub.2 and R.sub.4 are as defined in the description,and medicinal products containing the same which is useful for treating a pathology related to dysfunctioning of glutamatergic neurotransmission.
摘要翻译： 本发明涉及一种选自式（I）的化合物：其中A，R 1，R 2和R 4如说明书中所定义，其中含有该化合物的医药产品可用于治疗病理学 与谷氨酸能神经传递功能障碍有关。
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公开(公告)号：US5449690A
公开(公告)日：1995-09-12
申请号：US359605
申请日：1994-12-20
申请人： Daniel Lesieur , Said Yous , Patrick DePreux , Gerard Adam , Pierre Renard , Bruno Pfeiffer , Beatrice Guardiola-Lemaitre
发明人： Daniel Lesieur , Said Yous , Patrick DePreux , Gerard Adam , Pierre Renard , Bruno Pfeiffer , Beatrice Guardiola-Lemaitre
IPC分类号： A61K31/17 , A61K8/42 , A61K8/46 , A61P1/00 , A61P17/00 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P35/00 , A61Q7/00 , A61Q17/00 , A61Q19/00 , C07C273/02 , C07C275/24 , C07C335/12 , C07C335/14
CPC分类号： C07C335/12 , A61K8/42 , A61K8/46 , A61Q19/00 , C07C275/24 , A61Q17/00 , A61Q7/00 , C07C2101/02 , C07C2101/14 , Y10S514/923
摘要： A compound selected from those of formula (I): ##STR1## in which the meanings of R, R.sub.1, R.sub.2 and X are as defined in the specification, and medicinal products containing the same which are useful in treating or in preventing a disorder of the melatoninergic system.
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公开(公告)号：US5420150A
公开(公告)日：1995-05-30
申请号：US174187
申请日：1993-12-27
IPC分类号： A61K31/40 , A61K31/445 , A61P9/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D491/10 , C07D491/107 , C07D519/00
CPC分类号： C07D491/10
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, A and m are as defined in the description.Medicinal product which is useful for treating depression and anxiety.
摘要翻译： 本发明涉及一种选自式（I）的化合物：其中R 1，R 2，R 3，A和m如说明书中所定义。 用于治疗抑郁和焦虑的药用产品。
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公开(公告)号：US5389683A
公开(公告)日：1995-02-14
申请号：US930285
申请日：1992-08-14
申请人： Daniel Lesieur , Said Yous , Patrick Depreux , Gerard Adam , Pierre Renard , Bruno Pfeiffer , Beatrice Guardiola-Lemaitre
发明人： Daniel Lesieur , Said Yous , Patrick Depreux , Gerard Adam , Pierre Renard , Bruno Pfeiffer , Beatrice Guardiola-Lemaitre
IPC分类号： A61K31/17 , A61K8/42 , A61K8/46 , A61P1/00 , A61P17/00 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , A61P35/00 , A61Q7/00 , A61Q17/00 , A61Q19/00 , C07C273/02 , C07C275/24 , C07C335/12 , C07C335/14 , C07C275/06
CPC分类号： C07C335/12 , A61K8/42 , A61K8/46 , A61Q19/00 , C07C275/24 , A61Q17/00 , A61Q7/00 , C07C2101/02 , C07C2101/14 , Y10S514/923
摘要： A compound selected from those of formula (I): ##STR1## in which the meanings of R, R.sub.1, R.sub.2 and X are as defined in the specification, andmedicinal products containing the same which are in treating or in preventing a disorder of the melatoninergic system.
摘要翻译： 选自式（I）的化合物：其中R，R 1，R 2和X的含义如说明书中所定义的其中的化合物和含有该化合物的药物，其用于治疗或预防 褪黑激素系统紊乱。
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公开(公告)号：US5376661A
公开(公告)日：1994-12-27
申请号：US36329
申请日：1993-03-24
IPC分类号： A61K31/40 , A61K31/445 , A61P9/00 , A61P25/04 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D491/10 , C07D491/107 , C07D519/00 , C07D471/20 , A61K31/44
CPC分类号： C07D491/10
摘要： The invention relates to a compound selected from those of formula (I): ##STR1## in which R.sub.1, R.sub.2, R.sub.3, A and m are as defined in the description.Medicinal product which is useful for treating depression and anxiety.
摘要翻译： 本发明涉及一种选自式（I）的化合物：其中R 1，R 2，R 3，A和m如说明书中所定义。 用于治疗抑郁和焦虑的药用产品。
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公开(公告)号：US5242923A
公开(公告)日：1993-09-07
申请号：US839819
申请日：1992-02-21
申请人： Gerald Guillaumet , Christine Flouzat , Michelle Devissaguet , Pierre Renard , Daniel H. Caignard , Gerard Adam
发明人： Gerald Guillaumet , Christine Flouzat , Michelle Devissaguet , Pierre Renard , Daniel H. Caignard , Gerard Adam
IPC分类号： C07D213/74 , C07D498/04
CPC分类号： C07D213/74
摘要： The invention relates to the compounds of general formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, R.sub.4, A, Z and m are as defined in the description, their isomers, epimers and diastereoisomers,their addition salts with a pharmaceutically acceptable acid and, when R1 and R.sub.2 each represent a hydrogen atom, their addition salts with a pharmaceutically acceptable base.
摘要翻译： 本发明涉及通式（I）的化合物：其中：R1，R2，R3，R4，A，Z和m如说明书中所定义，它们的异构体，差向异构体和非对映异构体，其加成盐与 药学上可接受的酸，并且当R 1和R 2各自表示氢原子时，它们与药学上可接受的碱的加成盐。
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公开(公告)号：US5190960A
公开(公告)日：1993-03-02
申请号：US791261
申请日：1991-11-12
申请人： Gerald Guillaumet , Christine Flouzat , Daniel H. Caignard , Pierre Renard , Michelle Devissaguet , Beatrice Guardiola
发明人： Gerald Guillaumet , Christine Flouzat , Daniel H. Caignard , Pierre Renard , Michelle Devissaguet , Beatrice Guardiola
IPC分类号： C07D213/74 , C07D498/04
CPC分类号： C07D213/74
摘要： Compounds of general formula (I): ##STR1## in which: R.sub.1 and R.sub.2 each represent a hydrogen atom or, with the nitrogen and oxygen which bear them, form an --O--CO--N link,W represents a halogen atom or a lower alkyl or alkoxy group optionally substituted with one or more halogen atoms, such as trifluoromethyl, and m being between 0 and 3,A is a linear or branched alkyl radical comprising from 1 to 6 carbon atoms,R.sub.3 and R.sub.4 are defined in the description.
摘要翻译： 通式（I）的化合物：其中：R 1和R 2各自表示氢原子，或者与含有它们的氮和氧形成-O-CO-N键，W表示卤素 原子或任选被一个或多个卤素原子取代的低级烷基或烷氧基，例如三氟甲基，m在0和3之间，A是包含1至6个碳原子的直链或支链烷基，R3和R4被定义 在说明中。
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公开(公告)号：US5155116A
公开(公告)日：1992-10-13
申请号：US711297
申请日：1991-06-06
申请人： Gerald Guillaumet , Christine Flouzat , Daniel H. Caignard , Pierre Renard , Michelle Devissaguet , Beatrice Guardiola
发明人： Gerald Guillaumet , Christine Flouzat , Daniel H. Caignard , Pierre Renard , Michelle Devissaguet , Beatrice Guardiola
IPC分类号： A61K31/44 , A61P9/00 , A61P25/04 , A61P25/28 , C07D213/74 , C07D498/04
CPC分类号： C07D213/74
摘要： Compounds of general formula (I): ##STR1## in which: R.sub.1 and R.sub.2 each represent a hydrogen atom or, with the nitrogen and oxygen which bear them, form an --O--CO--N link,W represents a halogen atom or a lower alkyl or alkoxy group optionally substituted with one or more halogen atoms, such as trifluoromethyl, and m being between 0 and 3,A is a linear or branched alkyl radical comprising from 1 to 6 carbon atoms,R.sub.3 and R.sub.4 are defined in the description have medicinal properties.
摘要翻译： 通式（I）的化合物：其中：R 1和R 2各自表示氢原子，或者与含有它们的氮和氧形成-O-CO-N键，W表示卤素 原子或任选被一个或多个卤素原子取代的低级烷基或烷氧基，例如三氟甲基，m在0和3之间，A是包含1至6个碳原子的直链或支链烷基，R3和R4被定义 在说明书中具有药用性质。
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公开(公告)号：US5130311A
公开(公告)日：1992-07-14
申请号：US792423
申请日：1991-11-15
申请人： Gerald Guillaumet , Christine Flouzat , Michelle Devissaguet , Pierre Renard , Daniel H. Caignard , Gerard Adam
发明人： Gerald Guillaumet , Christine Flouzat , Michelle Devissaguet , Pierre Renard , Daniel H. Caignard , Gerard Adam
IPC分类号： A61K31/44 , A61P25/04 , C07D213/72 , C07D213/74 , C07D498/04
CPC分类号： C07D213/74
摘要： The invention relates to the analgesic compounds of general formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, R.sub.4, A, Z and m are as defined in the description, their isomers, epimers and diastereoisomers, their addition salts with a pharmaceutically acceptable acid and, when R.sub.1 and R.sub.2 each represent a hydrogen atom, their addition salts with a pharmaceutically acceptable base.
摘要翻译： 本发明涉及通式（I）的止痛化合物：其中：R1，R2，R3，R4，A，Z和m如说明书中所定义，它们的异构体，差向异构体和非对映异构体，其加成盐 具有药学上可接受的酸，并且当R 1和R 2各自表示氢原子时，它们与药学上可接受的碱的加成盐。
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