公开(公告)号：US20090300415A1

公开(公告)日：2009-12-03

申请号：US12083894

申请日：2006-03-15

申请人： Yi Zhang ,  Jian Zhou ,  Zhenxin Xi ,  Hongping Tian

发明人： Yi Zhang ,  Jian Zhou ,  Zhenxin Xi ,  Hongping Tian

IPC分类号： G06F21/00 ,  G06F11/07

CPC分类号： G06F21/577 ,  G06F11/2284

摘要： The present invention proposes a computer system and a method capable of performing integrity detection, comprising: a running mode unit which comprises an integrity detection boot variable to determine whether or not to initiate an integrity detection boot mode by judging said running mode unit; an EFI integrity detection unit (5), which is used for performing an integrity detection on EFI image codes in the integrity detection boot mode, and comprises an integrity metric value for being compared with an EFI integrity calculated value generated after the EFI integrity detection unit performs the integrity detection on the EFI image codes, to determine the integrity of the EFI image codes; an operating system integrity detection unit (6); and an integrity management unit. The present invention is based on the EFI BIOS to perform the integrity detection on the operating system during the pre-boot stage, having better reliability and security.

摘要翻译： 本发明提出一种能够执行完整性检测的计算机系统和方法，包括：运行模式单元，其包括完整性检测引导变量，以通过判断所述运行模式单元来确定是否启动完整性检测引导模式; EFI完整性检测单元（5），其用于对完整性检测引导模式中的EFI图像代码执行完整性检测，并且包括与EFI完整性检测单元之后生成的EFI完整性计算值进行比较的完整性度量值 对EFI图像代码执行完整性检测，以确定EFI图像代码的完整性; 操作系统完整性检测单元（6）; 和诚信管理单位。 本发明基于EFI BIOS，以在预引导阶段对操作系统执行完整性检测，具有更好的可靠性和安全性。

公开(公告)号：US20090287106A1

公开(公告)日：2009-11-19

申请号：US12510962

申请日：2009-07-28

申请人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Z. Siejko

发明人： Yi Zhang ,  Richard Fogoros ,  Carlos Haro ,  Yousufali Dalal ,  Marina Brockway ,  Krzysztof Z. Siejko

IPC分类号： A61B5/02

CPC分类号： A61N1/3627 ,  A61B5/0031 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0456 ,  A61B7/04 ,  A61N1/36578 ,  A61N1/395

摘要： A system comprising an implantable medical device (IMD) includes an implantable heart sound sensor to produce an electrical signal representative of at least one heart sound. The heart sound is associated with mechanical activity of a patient's heart. Additionally, the IMD includes a heart sound sensor interface circuit coupled to the heart sound sensor to produce a heart sound signal, and a signal analyzer circuit coupled to the heart sound sensor interface circuit. The signal analyzer circuit measures a baseline heart sound signal, and deems that an ischemic event has occurred using, among other things, a measured subsequent change in the heart sound signal from the established baseline heart sound signal.

摘要翻译： 包括可植入医疗装置（IMD）的系统包括可植入心音传感器，以产生代表至少一个心音的电信号。 心脏声音与患者心脏的机械活动有关。 另外，IMD包括耦合到心脏声音传感器以产生心脏声音信号的心脏声音传感器接口电路，以及耦合到心脏声音传感器接口电路的信号分析器电路。 信号分析器电路测量基线心音信号，并且认为已经发生了缺血事件，其中使用来自已建立的基线心音信号的心音信号的测量后续变化。

公开(公告)号：US20090234211A1

公开(公告)日：2009-09-17

申请号：US12402224

申请日：2009-03-11

申请人： Dan Li ,  Haresh G. Sachanandani ,  Michael John Kane ,  Yi Zhang

发明人： Dan Li ,  Haresh G. Sachanandani ,  Michael John Kane ,  Yi Zhang

IPC分类号： A61B5/1468 ,  A61B5/04

CPC分类号： A61B5/0402 ,  A61B5/0468 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1459 ,  A61N1/3627 ,  A61N1/36585

摘要： Embodiments of the invention are related to devices and methods for myocardial ischemia detection, amongst other things. In an embodiment, the invention includes an implantable medical device including control circuitry, an electrical field sensor in communication with the control circuitry, the electrical field sensor configured to generate a signal corresponding to cardiac electrical fields. The implantable medical device can also include a chemical sensor in communication with the control circuitry, the chemical sensor configured to generate a signal corresponding to the concentration of a physiological analyte that affects cardiac electrical field waveform morphology. The control circuitry can be configured to monitor for the presence of myocardial ischemia by evaluating both the signal generated by the electrical field sensor and the signal generated by the chemical sensor. Other embodiments are also included herein.

摘要翻译： 本发明的实施方案涉及用于心肌缺血检测的装置和方法等。 在一个实施例中，本发明包括可植入医疗装置，其包括控制电路，与控制电路通信的电场传感器，电场传感器被配置为产生对应于心​​脏电场的信号。 可植入医疗装置还可以包括与控制电路通信的化学传感器，化学传感器被配置为产生对应于影响心电场波形形态的生理分析物的浓度的信号。 控制电路可以被配置为通过评估由电场传感器产生的信号和由化学传感器产生的信号来监测是否存在心肌缺血。 本文还包括其它实施例。

公开(公告)号：US20090228060A1

公开(公告)日：2009-09-10

申请号：US12469012

申请日：2009-05-20

申请人： Imad Libbus ,  Paul A. Haefner ,  Aaron R. McCabe ,  Yi Zhang

发明人： Imad Libbus ,  Paul A. Haefner ,  Aaron R. McCabe ,  Yi Zhang

IPC分类号： A61N1/365

CPC分类号： A61N1/36135 ,  A61N1/36114 ,  A61N1/365 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36571

摘要： A neural stimulator senses a reference signal indicative of cardiac cycles each including a predetermined type timing reference event using a sensor external to the heart and blood vessels. The delivery of the neural stimulation pulses are synchronized to that timing reference event. Examples of the timing reference event include a predetermined cardiac event such as a P-wave or an R-wave detected from a subcutaneous ECG signal, a predetermined type heart sound detected from an acoustic signal, and a peak detected from a hemodynamic signal related to blood flow or pressure.

摘要翻译： 神经刺激器感测指示心脏周期的参考信号，每个参考信号包括使用心脏和血管外部的传感器的预定类型的定时参考事件。 神经刺激脉冲的输送与该定时参考事件同步。 定时参考事件的示例包括预定的心脏事件，例如从皮下ECG信号检测到的P波或R波，从声信号检测到的预定类型心音，以及从与 血流或压力。

公开(公告)号：US20090203124A1

公开(公告)日：2009-08-13

申请号：US12016690

申请日：2008-01-18

申请人： Yi Zhang ,  Pascal Chaux ,  Thierry Boon-Falleur ,  Pierre van der Bruggen

发明人： Yi Zhang ,  Pascal Chaux ,  Thierry Boon-Falleur ,  Pierre van der Bruggen

IPC分类号： C12N5/00 ,  C07H21/04 ,  C12N15/63

CPC分类号： C07K14/4748 ,  A61K38/00

摘要： The invention describes HLA class II binding peptides encoded by the MAGE tumor associated genes, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of MAGE genes.

摘要翻译： 本发明描述了由MAGE肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以MAGE基因表达为特征的病症的方法和产品。

公开(公告)号：US20090203057A1

公开(公告)日：2009-08-13

申请号：US12091205

申请日：2006-10-27

申请人： Yi Zhang ,  Yuichi Tsukada ,  Kenichi Yamane ,  Robert John Klose

发明人： Yi Zhang ,  Yuichi Tsukada ,  Kenichi Yamane ,  Robert John Klose

IPC分类号： C12Q1/34

CPC分类号： C12Q1/26 ,  G01N33/5008 ,  G01N33/6875 ,  G01N2333/90245 ,  G01N2500/00 ,  G01N2500/04

摘要： Post-translational modification, including protein methylation, plays an important role in regulating protein function. The present invention provides a novel assay for evaluating demethylase activity and the discovery of a family of protein demethylases comprising a novel demethylase motif.

摘要翻译： 翻译后修饰，包括蛋白质甲基化，在调节蛋白质功能中起重要作用。 本发明提供了用于评估脱甲基酶活性和发现包含新型脱甲基酶基序的蛋白质脱甲基酶家族的新型测定法。

公开(公告)号：US20090198301A1

公开(公告)日：2009-08-06

申请号：US12409348

申请日：2009-03-23

申请人： Yi Zhang ,  Jiang Ding ,  Aaron R. McCabe ,  Scott A. Meyer

发明人： Yi Zhang ,  Jiang Ding ,  Aaron R. McCabe ,  Scott A. Meyer

IPC分类号： A61N1/37

CPC分类号： A61N1/3712 ,  A61N1/365

摘要： Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed for automatic capture verification using cardiac activation sequence information. Devices and methods sense composite cardiac signals using implantable electrodes. A source separation is performed using the composite signals. One or more signal vectors are produced that are associated with all or a portion of one or more cardiac activation sequences based on the source separation. A cardiac response to the pacing pulses is classified using characteristics associated with cardiac signal vectors and the signals associated with the vectors. Further embodiments may involve classifying the cardiac response as capture or non-capture, fusion or intrinsic cardiac activity. The characteristics may include an angle or an angle change of the cardiac signal vectors, such as a predetermined range of angles of the one or more cardiac signal vectors.

摘要翻译： 提供一种或多种监测，诊断，除颤和起搏的心脏监测和/或刺激方法和系统。 心脏信号分离被用于使用心脏激活序列信息的自动捕获验证。 装置和方法使用可植入电极感测复合心脏信号。 使用复合信号进行源分离。 产生与基于源分离的一个或多个心脏激活序列的全部或一部分相关联的一个或多个信号载体。 使用与心脏信号矢量相关联的特征和与矢量相关联的信号来分类对起搏脉冲的心脏反应。 进一步的实施方案可以包括将心脏反应分类为捕获或非捕获，融合或内在心脏活动。 特征可以包括心脏信号矢量的角度或角度变化，例如一个或多个心脏信号矢量的预定角度范围。

公开(公告)号：US07563589B2

公开(公告)日：2009-07-21

申请号：US11140659

申请日：2005-05-27

申请人： Yi Zhang ,  Ru Cao

发明人： Yi Zhang ,  Ru Cao

IPC分类号： C12Q1/48 ,  C12N9/10

CPC分类号： C12N9/1007 ,  C07K14/82 ,  C07K2319/20 ,  C12N2799/026 ,  C12Y201/01043 ,  G01N2333/91011

摘要： The present invention provides a reconstituted complex including EED, EZH2 and SUZ12 wherein the reconstituted complex has histone methyltransferase (HMTase) activity for lysine 27 of histone H3 (H3-K27). The reconstituted complex may further include RbAp48, AEBP2 or both. Also disclosed are methods of producing the reconstituted complex, methods of identifying compounds that inhibit the HTMase activity of the reconstituted complex and methods of identifying candidate compounds for treating cancer. Reagents and kits including the reconstituted complex are further provided.

摘要翻译： 本发明提供了包含EED，EZH2和SUZ12的复原复合物，其中重构的复合物对组蛋白H3（H3-K27）的赖氨酸27具有组蛋白甲基转移酶（HMTase）活性。 重构的复合物还可以包括RbAp48，AEBP2或两者。 还公开了生产重建复合物的方法，鉴定抑制重构复合物的HTMase活性的化合物的方法和鉴定用于治疗癌症的候选化合物的方法。 还提供了试剂和试剂盒，包括重构的复合物。

公开(公告)号：US07542800B2

公开(公告)日：2009-06-02

申请号：US11099141

申请日：2005-04-05

申请人： Imad Libbus ,  Paul A. Haefner ,  Aaron McCabe ,  Yi Zhang

发明人： Imad Libbus ,  Paul A. Haefner ,  Aaron McCabe ,  Yi Zhang

IPC分类号： A61N1/36

CPC分类号： A61N1/36135 ,  A61N1/36114 ,  A61N1/365 ,  A61N1/36542 ,  A61N1/36564 ,  A61N1/36571

摘要： A neural stimulator senses a reference signal indicative of cardiac cycles each including a predetermined type timing reference event using a sensor external to the heart and blood vessels. The delivery of the neural stimulation pulses are synchronized to that timing reference event. Examples of the timing reference event include a predetermined cardiac event such as a P-wave or an R-wave detected from a subcutaneous ECG signal, a predetermined type heart sound detected from an acoustic signal, and a peak detected from a hemodynamic signal related to blood flow or pressure.

摘要翻译： 神经刺激器感测指示心脏周期的参考信号，每个参考信号包括使用心脏和血管外部的传感器的预定类型的定时参考事件。 神经刺激脉冲的输送与该定时参考事件同步。 定时参考事件的示例包括预定的心脏事件，例如从皮下ECG信号检测到的P波或R波，从声信号检测到的预定类型心音，以及从与 血流或压力。

公开(公告)号：US07525950B1

公开(公告)日：2009-04-28

申请号：US10283512

申请日：2002-10-30

申请人： Yi Zhang

发明人： Yi Zhang

IPC分类号： H04L12/66

CPC分类号： H04L65/80 ,  H04L65/102 ,  H04M15/00 ,  H04M15/56 ,  H04M15/77 ,  H04M15/772 ,  H04M15/773 ,  H04M15/774 ,  H04M17/00 ,  H04M2203/2066 ,  H04M2215/202 ,  H04M2215/7254 ,  H04M2215/7263 ,  H04M2215/7268 ,  H04M2215/7272

摘要： A calling card system includes a public switched telephone network (PSTN) and a service selection gateway. The PSTN may receive calls from communication devices that may be either voice communication or data communication. The calls may be forwarded to the service selection gateway based on a calling card access number that is included in the call. Calls that are voice communication may be transferred to the PSTN or to a public network by the service selection gateway. The service selection gateway may provide voice communication transferred to the public network in a voice based network protocol such as VoIP that is transmittable over the public network. Calls that are data communication may be selectively transmitted over the public network in a data network protocol with the service selection gateway.

摘要翻译： 呼叫卡系统包括公共交换电话网（PSTN）和服务选择网关。 PSTN可以从可能是语音通信或数据通信的通信设备接收呼叫。 呼叫可以基于呼叫中包括的呼叫卡访问号码被转发到服务选择网关。 作为语音通信的呼叫可以由服务选择网关传送到PSTN或公共网络。 服务选择网关可以在可以通过公共网络传输的基于语音的网络协议（例如VoIP）中提供传送到公共网络的语音通信。 作为数据通信的呼叫可以通过与服务选择网关的数据网络协议中的公共网络选择性地发送。