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    Drug eluting medical devices having porous layers
    73.
    发明申请
    Drug eluting medical devices having porous layers 有权
    具有多孔层的药物洗脱医学装置

    公开(公告)号：US20090029077A1

    公开(公告)日：2009-01-29

    申请号：US11881749

    申请日：2007-07-27

    申请人： Liliana Atanasoska ,  Robert W. Warner ,  Michael S. Arney ,  Jan Weber

    发明人： Liliana Atanasoska ,  Robert W. Warner ,  Michael S. Arney ,  Jan Weber

    IPC分类号： B32B1/08 ,  B05D3/00 ,  B32B3/26

    CPC分类号： A61L31/16 ,  A61L31/022 ,  A61L31/082 ,  A61L31/10 ,  A61L31/146 ,  A61L31/148 ,  A61L2300/608 ,  Y10T428/13 ,  Y10T428/249994

    摘要： In accordance with an aspect of the invention, implantable or insertable medical devices are provided that comprise (a) a substrate and (b) a porous layer comprising close packed spherical pores disposed over the substrate. The porous layer may also comprise a therapeutic agent. In another aspect, the present invention provides methods of forming implantable or insertable medical devices. These methods comprise forming a predecessor structure that comprises (i) a substrate over which is disposed (ii) an assembly of microspheres. This assembly of microspheres is then used as a template for the formation of a porous layer, which may be subsequently loaded with a therapeutic agent.

    摘要翻译： 根据本发明的一个方面，提供了可植入或可插入的医疗装置，其包括（a）基底和（b）包含设置在基底上的紧密堆积的球形孔的多孔层。 多孔层还可以包含治疗剂。 在另一方面，本发明提供了形成可植入或可插入的医疗装置的方法。 这些方法包括形成前身结构，其包括（i）在其上设置（ii）微球组件的基底。 然后将该微球体组合物用作形成多孔层的模板，随后可以加入治疗剂。

    Medical devices having nanoporous coatings for controlled therapeutic agent delivery
    75.
    发明申请
    Medical devices having nanoporous coatings for controlled therapeutic agent delivery 有权
    具有用于受控治疗剂递送的纳米多孔涂层的医疗装置

    公开(公告)号：US20080188836A1

    公开(公告)日：2008-08-07

    申请号：US11701768

    申请日：2007-02-02

    申请人： Jan Weber ,  Liliana Atanasoska

    发明人： Jan Weber ,  Liliana Atanasoska

    IPC分类号： A61K9/22

    CPC分类号： A61L31/16 ,  A61L29/085 ,  A61L29/10 ,  A61L29/146 ,  A61L29/16 ,  A61L31/082 ,  A61L31/10 ,  A61L31/146 ,  A61L2300/608 ,  A61L2400/12 ,  A61L2420/08 ,  A61N1/375

    摘要： According to an aspect of the invention, medical devices are provided which include a substrate, at least one porous reservoir containing at least one therapeutic agent disposed over the substrate, at least one nanoporous layer disposed over the at least one porous reservoir, and at least one plugged aperture, which may be located within the substrate, within the nanoporous layer, or both. According to another aspect of the invention, a method of forming a medical device is provided which includes (a) forming a porous reservoir over a substrate, (b) forming a nanoporous layer over the porous reservoir, (c) forming an aperture within the substrate or the nanoporous layer, (d) filling the porous reservoir with therapeutic agent through the aperture, and (d) plugging the aperture.

    摘要翻译： 根据本发明的一个方面，提供了医疗装置，其包括基底，至少一个多孔储存器，其包含设置在基底上的至少一种治疗剂，至少一个纳米多孔层，设置在所述至少一个多孔容器上， 可以位于衬底内的一个堵塞的孔，在纳米多孔层内，或两者。 根据本发明的另一方面，提供了一种形成医疗装置的方法，其包括（a）在衬底上形成多孔容器，（b）在所述多孔容器上形成纳米多孔层，（c）在所述多孔容器内形成孔， 底物或纳米多孔层，（d）通过孔填充具有治疗剂的多孔容器，和（d）堵塞孔。