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105 条记录 (耗时 0.044 秒)

    Superabsorbent, freeze dried hydrogels for medical applications
    74.
    发明授权
    Superabsorbent, freeze dried hydrogels for medical applications 有权
    超吸收剂，用于医疗应用的冷冻干燥水凝胶

    公开(公告)号：US08795709B2

    公开(公告)日：2014-08-05

    申请号：US11465791

    申请日：2006-08-18

    申请人： Amarpreet S. Sawhney ,  Steven L. Bennett ,  Suresh S. Pai ,  Scott R. Sershen ,  Fred H. Co

    发明人： Amarpreet S. Sawhney ,  Steven L. Bennett ,  Suresh S. Pai ,  Scott R. Sershen ,  Fred H. Co

    IPC分类号： A61F2/00

    CPC分类号： A61L24/0031 ,  A61B2017/0065 ,  A61L24/046 ,  A61L24/10 ,  C08L71/02

    摘要： Methods are provided for making freeze dried hydrogel and structures therefrom that may be introduced into a patient's body for medical applications. Precursor components are combined to initiate crosslinking. The combined precursor components are placed in a chilled tray, and allowed to crosslink to a desired level of complete crosslinking before and/or after being placed onto the tray. The partially crosslinked hydrogel is frozen and freeze dried. After freeze drying, the hydrogel is conditioned to substantially complete crosslinking, and formed into one or more structures, e.g., plugs, hemostatic, or other medical devices. For example, the hydrogel may be cut, machined, rolled, folded, compressed, and/or cored into that may be loaded into delivery devices that may be introduced into a body to implant or otherwise deliver the structures into the body, e.g., to seal a puncture or other passage through tissue.

    摘要翻译： 提供了用于制备冻干的水凝胶和其结构的方法，其可以被引入患者体内用于医疗应用。 组合前体组分以引发交联。 将组合的前体组分置于冷藏的托盘中，并在放置在托盘上之前和/或之后使其交联至所需水平的完全交联。 将部分交联的水凝胶冷冻并冷冻干燥。 冷冻干燥后，将水凝胶调节至基本上完全交联，并形成一种或多种结构，例如塞子，止血剂或其他医疗装置。 例如，水凝胶可以被切割，机加工，滚压，折叠，压缩和/或加工成可以被加载到可被引入到体内的输送装置中以将结构植入或以其他方式将结构输送到体内，例如 密封穿刺或穿过组织的其他通道。

    Biocompatible polymers and hydrogels and methods of use
    75.
    发明授权
    Biocompatible polymers and hydrogels and methods of use 有权
    生物相容性聚合物和水凝胶及其使用方法

    公开(公告)号：US08535705B2

    公开(公告)日：2013-09-17

    申请号：US11985588

    申请日：2007-11-16

    申请人： Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Peter G. Edelman

    发明人： Chandrashekhar P. Pathak ,  Amarpreet S. Sawhney ,  Peter G. Edelman

    IPC分类号： A61F2/00

    CPC分类号： A61K9/0024 ,  A61K31/74 ,  A61K47/34 ,  A61K47/46 ,  A61L27/18 ,  A61L27/50 ,  A61L27/52 ,  A61L27/58 ,  A61L31/06 ,  A61L31/145 ,  A61L31/148 ,  C08G63/08 ,  C08G63/912

    摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable or not are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants.

    摘要翻译： 公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子基团和亲核基团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解或不生物降解的方法与控制降解速率的方法一样。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。

    Surgical delivery system for medical sealant
    76.
    发明授权
    Surgical delivery system for medical sealant 有权
    医用密封胶手术输送系统

    公开(公告)号：US07862538B2

    公开(公告)日：2011-01-04

    申请号：US12012606

    申请日：2008-02-04

    申请人： Amarpreet S. Sawhney ,  William H. Ransone, II ,  Mukesh Singhal

    发明人： Amarpreet S. Sawhney ,  William H. Ransone, II ,  Mukesh Singhal

    IPC分类号： A61M37/00

    CPC分类号： A61B17/0057 ,  A61B2017/00495 ,  A61B2017/0065

    摘要： Described herein are systems for packaging dual or multiple-component adhesive systems that provide enhanced convenience and efficacy. In one aspect, the components of such a system may be divided into containers that allow for foolproof mixing schemes to avoid mixing the wrong components while also providing a sterile surface for mixing materials, with the sterile surface having optimal physical properties for mixing the materials, especially in small amounts. Certain embodiments include a surgical delivery system for a medical sealant including a packaging system with a detachable a sterile surface for mixing the sealant as needed for application.

    摘要翻译： 本文描述的是用于包装双组分或多组分粘合剂体系的系统，其提供增强的便利性和有效性。 在一个方面，这种系统的组件可以被分成容器，其允许防混合方案以避免混合错误的组分，同时还提供用于混合材料的无菌表面，无菌表面具有用于混合材料的最佳物理性质， 特别是少量。 某些实施方案包括用于医用密封剂的手术递送系统，其包括具有可拆卸无菌表面的包装系统，用于根据需要混合密封剂。

    Biocompatible hydrogels made with small molecule precursors
    78.
    发明申请
    Biocompatible hydrogels made with small molecule precursors 有权
    用小分子前体制备的生物相容性水凝胶

    公开(公告)号：US20080260802A1

    公开(公告)日：2008-10-23

    申请号：US12156085

    申请日：2008-05-29

    申请人： Amarpreet S. Sawhney ,  Steven Bennett ,  Peter G. Edelman

    发明人： Amarpreet S. Sawhney ,  Steven Bennett ,  Peter G. Edelman

    IPC分类号： A61L27/58 ,  A61L27/52

    CPC分类号： A61K47/42 ,  A61K9/0014 ,  A61K9/0019 ,  A61L27/52 ,  A61L27/58 ,  A61L31/145 ,  A61L31/148 ,  C07K14/75 ,  C08L89/00 ,  C08L2666/02

    摘要： Biocompatible crosslinked polymers, and methods for their preparation and use, are disclosed in which the biocompatible crosslinked polymers are formed from water soluble precursors having electrophilic and nucleophilic functional groups capable of reacting and crosslinking in situ. Methods for making the resulting biocompatible crosslinked polymers biodegradable, or not, are provided, as are methods for controlling the rate of degradation. The crosslinking reactions may be carried out in situ on organs or tissues or outside the body. Applications for such biocompatible crosslinked polymers and their precursors include controlled delivery of drugs, prevention of post-operative adhesions, coating of medical devices such as vascular grafts, wound dressings and surgical sealants. Visualization agents may be included with the crosslinked polymers. Embodiments that include hydrogels having isolated hydrolytically degradable esters are set forth. Embodiments including the use of low molecular weight amines to make degradable hydrogels are also set forth.

    摘要翻译： 公开了生物相容的交联聚合物及其制备和使用的方法，其中生物相容的交联聚合物由具有能够原位反应和交联的亲电子和亲核官能团的水溶性前体形成。 制备生物相容的交联聚合物可生物降解的方法也可以提供，以及用于控制降解速率的方法。 交联反应可以在器官或组织上或身体外的原位进行。 用于这种生物相容性交联聚合物及其前体的应用包括药物的受控递送，术后粘连的预防，医疗装置如血管移植物，伤口敷料和手术密封剂的涂覆。 可交联剂可以与交联聚合物一起包含。 阐述包括具有分离的水解可降解酯的水凝胶的实施方案。 还阐述了包括使用低分子量胺来制备可降解水凝胶的实施方案。