公开(公告)号：US20080269716A1

公开(公告)日：2008-10-30

申请号：US11739982

申请日：2007-04-25

申请人： Eric H. Bonde ,  Martin T. Gerber

发明人： Eric H. Bonde ,  Martin T. Gerber

IPC分类号： A61M31/00

CPC分类号： A61N1/0526 ,  A61B17/06109 ,  A61B17/3468 ,  A61B2017/00946 ,  A61B2017/06052 ,  A61N1/0551 ,  A61N1/36071

摘要： The disclosure is directed to a method for implanting a medical device proximate to a target tissue site within an occipital region of a patient, such as proximate to an occipital nerve or a trigeminal nerve. The method comprises introducing an implant tool into a patient to define an insertion path to the target tissue site. The implant tool includes a shape memory cannula and a malleable needle at least partially disposed within an inner lumen of the cannula. The shape of the needle may be changed to accommodate different anatomical structures/features of the patient. Upon withdrawal of the needle from the cannula, the cannula may change shape, thereby changing the shape of the insertion path.

摘要翻译： 本公开涉及一种用于将医疗设备植入接近患者枕骨区域内的目标组织部位（例如靠近枕骨神经或三叉神经）的方法。 该方法包括将植入物工具引入患者以限定到目标组织部位的插入路径。 植入物工具包括形状记忆套管和至少部分地设置在套管的内腔内的有韧性的针。 可以改变针的形状以适应患者的不同解剖结构/特征。 当针从套管中取出时，套管可以改变形状，从而改变插入路径的形状。

公开(公告)号：US20080262380A1

公开(公告)日：2008-10-23

申请号：US12023073

申请日：2008-01-31

申请人： Martin T. Gerber ,  John C. Rondoni

发明人： Martin T. Gerber ,  John C. Rondoni

IPC分类号： A61B5/01

CPC分类号： A61B5/01 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/076 ,  A61B5/145 ,  A61B5/14539 ,  A61B5/6846 ,  A61M5/14276 ,  A61M5/16836 ,  A61M2205/18 ,  A61M2205/3368 ,  A61M2205/3523 ,  A61M2205/3561 ,  A61N1/08 ,  A61N1/36521 ,  A61N1/37258 ,  A61N1/3756

摘要： A method includes obtaining a baseline value for an indicator of infection in proximity to an implantable medical device and monitoring the indicator of infection in proximity to the device. The method further includes determining whether the monitored indicator is indicative of infection in proximity to the device. The determination as to whether the monitored indicator is indicative of infection includes comparing a value associated with the monitored indicator to the baseline value.

摘要翻译： 一种方法包括获得接近可植入医疗装置的感染指标的基线值，并监测靠近装置的感染指标。 该方法还包括确定所监视的指示符是否指示在设备附近的感染。 关于监测的指示符是否指示感染的确定包括将与监测的指示符相关联的值与基线值进行比较。

公开(公告)号：US20080262332A1

公开(公告)日：2008-10-23

申请号：US11737173

申请日：2007-04-19

申请人： Martin T. Gerber ,  John C. Rondoni

发明人： Martin T. Gerber ,  John C. Rondoni

IPC分类号： A61B5/145 ,  A61B5/01 ,  A61B5/053

CPC分类号： A61B5/01 ,  A61B5/0031 ,  A61B5/053 ,  A61B5/076 ,  A61B5/145 ,  A61B5/14539 ,  A61B5/6846 ,  A61M5/14276 ,  A61M5/16836 ,  A61M2205/18 ,  A61M2205/3368 ,  A61M2205/3523 ,  A61M2205/3561 ,  A61N1/08 ,  A61N1/36521 ,  A61N1/37258 ,  A61N1/3756

摘要： A method includes monitoring an indicator of infection in proximity to an implanted active therapy delivering medical device and providing information regarding the monitored indicator to the implanted medical device. The method further includes determining whether the information regarding the monitored indicator is indicative of infection in proximity to the implanted medical device.

摘要翻译： 一种方法包括在输送医疗装置的植入式主动疗法附近监测感染指示器，并将关于所监视的指示器的信息提供给植入的医疗装置。 该方法还包括确定关于所监视的指示符的信息是否指示在植入的医疗装置附近的感染。

公开(公告)号：US20080262323A1

公开(公告)日：2008-10-23

申请号：US11737181

申请日：2007-04-19

申请人： Martin T. Gerber ,  John C. Rondoni

发明人： Martin T. Gerber ,  John C. Rondoni

IPC分类号： A61B5/00

CPC分类号： A61B5/0031 ,  A61B5/01 ,  A61B5/024 ,  A61B5/0452 ,  A61B5/0488 ,  A61B5/053 ,  A61B5/0538 ,  A61B5/0816 ,  A61B5/11 ,  A61B5/14539 ,  A61B5/14546 ,  A61B5/1473

摘要： Methods for monitoring an infection in proximity to an implantable medical device include monitoring a first indicator of infection in proximity to a medical device implanted in a patient; monitoring a second patient parameter; and determining whether the combination of the first indicator and the second parameter are indicative of infection in proximity to the implanted device. If a determination is made that the combination of the first indicator and the second parameter are indicative of infection, an alert may be issued.

摘要翻译： 用于监测在植入式医疗装置附近的感染的方法包括监测植入患者体内的医疗装置附近的第一感染指示器; 监测第二个患者参数; 以及确定所述第一指示符和所述第二参数的组合是否指示所述植入装置附近的感染。 如果确定第一指示符和第二参数的组合指示感染，则可以发出警报。

公开(公告)号：US07437194B2

公开(公告)日：2008-10-14

申请号：US10698881

申请日：2003-10-31

申请人： Thomas R. Skwarek ,  Martin T. Gerber

发明人： Thomas R. Skwarek ,  Martin T. Gerber

IPC分类号： A61N1/00

CPC分类号： A61N1/36007

摘要： The invention is directed to techniques for providing electrical stimulation to the prostate gland of a patient. In particular, various techniques are described for providing such stimulation in order to treat sexual dysfunction, benign prostatic hyperplasia (BPH), or other disorders. In some embodiments, the stimulation may be provided to the prostate gland to cause erection or ejaculation in order to treat various sexual dysfunctions. In other embodiments, the stimulation may comprise a training sequence of pulses selected to train and modify the cellular structure of the prostate gland in order to treat BPH or similar prostate disorders.

摘要翻译： 本发明涉及向患者的前列腺提供电刺激的技术。 特别地，描述了用于提供这种刺激以治疗性功能障碍，良性前列腺增生（BPH）或其他病症的各种技术。 在一些实施方案中，刺激可以提供给前列腺以引起勃起或射精，以便治疗各种性功能障碍。 在其他实施方案中，刺激可以包括选择用于训练和修饰前列腺的细胞结构的脉冲的训练序列，以便治疗BPH或类似的前列腺障碍。

公开(公告)号：US07415308B2

公开(公告)日：2008-08-19

申请号：US11117062

申请日：2005-04-28

申请人： Martin T. Gerber ,  John C Rondoni

发明人： Martin T. Gerber ,  John C Rondoni

IPC分类号： A61N1/00

CPC分类号： A61N1/36007 ,  A61N1/08

摘要： In general, the disclosure is directed to an implantable neurostimulator and system capable of providing adaptive neurostimulation therapy to alleviate incontinence. The neurostimulator operates according to a set of stimulation parameters stored in memory. During operation, information is obtained from the patient, the implanted neurostimulator, one or more implanted sensors, or some combination thereof. A processor analyzes the information to automatically generate proposed adjustments to the stimulation parameters applied by the neurostimulator. The adjustments provide an adaptive neurostimulation therapy that supports or enhances therapeutic efficacy based on the information.

摘要翻译： 一般来说，本发明涉及能够提供自适应神经刺激疗法以减轻失禁的可植入神经刺激器和系统。 神经刺激器根据存储在存储器中的一组刺激参数进行操作。 在操作期间，从患者，植入的神经刺激器，一个或多个植入的传感器或其某些组合获得信息。 处理器分析信息以自动生成由神经刺激器施加的刺激参数的建议调整。 该调整提供了基于该信息支持或增强治疗功效的适应性神经刺激疗法。

公开(公告)号：US20080132979A1

公开(公告)日：2008-06-05

申请号：US11606772

申请日：2006-11-30

申请人： Martin T. Gerber

发明人： Martin T. Gerber

IPC分类号： A61N1/05

CPC分类号： A61N1/0526 ,  A61N1/0504

摘要： A method for implanting one or more implantable medical leads of an electrical stimulation system proximate to an occipital region of a patient comprises utilizing a needle to define an insertion path through tissue of the patient to a target tissue site. The insertion path may be dilated to a size large enough to receive an implantable medical lead. An electrical test signal may be delivered to the patient via the needle, a guide wire or a dilator assembly during the implantation procedure in order to assess the efficacy of stimulation prior to implantation of the lead and/or to establish the location of the needle, guide wire and/or dilator assembly within the patient.

摘要翻译： 用于将邻近患者枕骨区域的电刺激系统的一个或多个可植入医疗引线植入的方法包括利用针来限定通过患者组织到目标组织部位的插入路径。 插入路径可以扩大到足够大以接收可植入医疗引线的尺寸。 在植入过程期间，电测试信号可以经由针，导丝或扩张器组件递送给患者，以便在植入引导之前评估刺激的功效和/或建立针的位置， 导丝和/或扩张器组件在患者体内。

公开(公告)号：US20080125844A1

公开(公告)日：2008-05-29

申请号：US12023817

申请日：2008-01-31

申请人： John Matthew Swoyer ,  Keith Carlton ,  Martin T. Gerber ,  George J. Mamo ,  Michele Spinelli ,  Steven David Hartle

发明人： John Matthew Swoyer ,  Keith Carlton ,  Martin T. Gerber ,  George J. Mamo ,  Michele Spinelli ,  Steven David Hartle

IPC分类号： A61N1/05

CPC分类号： A61N1/0558 ,  A61N1/0551

摘要： An implantable medical electrical lead particularly for stimulation of the sacral nerves comprises a lead body extending between a distal end and a proximal end, and the distal end having at least one electrode of an electrode array extending longitudinally from the distal end toward the proximal end. The lead body at its proximal end may be coupled to a pulse generator, additional intermediate wiring, or other stimulation device. A fixation mechanism is formed on or integrally with the lead body proximal to the electrode array that is adapted to be implanted in and engage subcutaneous tissue, particularly muscle tissue, to inhibit axial movement of the lead body and dislodgement of the stimulation electrodes. The fixation mechanism comprises a M tine elements arrayed in a tine element array along a segment of the lead proximal to the stimulation electrode array. Each tine element comprises at least N flexible, pliant, tines, each tine having a tine width and thickness and extending through a tine length from an attached tine end to a free tine end. The attached tine end is attached to the lead body from a tine attachment site and supports the tine extending outwardly of the lead body and proximally toward the lead proximal end. The M×N tines are adapted to be folded inward against the lead body when fitted into and constrained by the lumen of an introducer such that the tine free ends of more distal tines of more distal tine elements are urged toward or alongside the attached tine ends of the adjacent more proximal tines of more proximal tine elements, and the folded tines do not overlap one another.

摘要翻译： 特别是用于刺激骶神经的可植入医用电气引线包括在远端和近端之间延伸的引线体，并且远端具有从远端向近端纵向延伸的电极阵列的至少一个电极。 其近端的引线体可以耦合到脉冲发生器，附加的中间布线或其它刺激装置。 在与电极阵列接近的引线体上形成一体的固定机构，该固定机构适于被植入并接合皮下组织，特别是肌肉组织，以抑制引线体的轴向移动和刺激电极的移动。 固定机构包括沿着靠近刺激电极阵列的引线的段排列在齿元件阵列中的M元件。 每个齿元件包括至少N个柔性，柔韧的尖齿，每个齿具有齿的宽度和厚度并且延伸穿过齿长从附接的齿端延伸到游离齿端。 附着的尖端从齿附着位置附接到引线本体，并且支撑从引线主体向外延伸并向近端朝向引线近端的齿。 MxN齿适合于当插入导引器的内腔并被约束的引导体时向内折叠，使得更远端的尖齿元件的更远远的尖齿的齿自由端朝着或与其相连的齿端被推向 相邻的更接近的尖齿元件的近端齿，并且折叠的齿不相互重叠。

公开(公告)号：US20080103573A1

公开(公告)日：2008-05-01

申请号：US11591282

申请日：2006-10-31

申请人： Martin T. Gerber

发明人： Martin T. Gerber

IPC分类号： A61N1/05

CPC分类号： A61N1/0558 ,  A61N1/0529 ,  A61N1/0534 ,  A61N1/0536

摘要： An implantable medical elongated member, such as a lead or catheter, includes an integrated fixation mechanism that expands upon implantation of the elongated member to fix the elongated member relative to a target tissue site, such as tissue within the epidural region proximate the spine or the sacral foramen or subcutaneous tissue proximate to an occipital or other peripheral nerve. The fixation mechanism may include a plurality of wire-like elements, which may be configured in a substantial helical shape. The wire-like elements may be formed from an elastic or super-elastic material, and expand radially outward when a restraint mechanism is removed following implantation of the elongated member.

摘要翻译： 可植入医疗细长构件，例如引线或导管，包括整体固定机构，其在植入细长构件时膨胀，以相对于目标组织部位固定细长构件，例如靠近脊柱的硬膜外区域内的组织或 骶骨孔或靠近枕骨或其他周围神经的皮下组织。 固定机构可以包括多个线状元件，其可被构造成大致螺旋形状。 线状元件可以由弹性材料或超弹性材料形成，并且在植入细长构件之后移除约束机构时径向向外膨胀。

公开(公告)号：US20080103572A1

公开(公告)日：2008-05-01

申请号：US11591171

申请日：2006-10-31

申请人： Martin T. Gerber

发明人： Martin T. Gerber

IPC分类号： A61N1/05

CPC分类号： A61N1/0529 ,  A61N1/0534 ,  A61N1/0536 ,  A61N1/0558 ,  A61N1/057 ,  A61N1/3605

摘要： The disclosure is directed to securing electrodes of a medical lead adjacent to a target tissue site. The medical lead may include one or more threaded fixation structures disposed circumferentially about the outer surface of the lead body, or elongated member, that resembles a “screw” or “auger.” During implantation, a clinician may rotate the entire lead to “screw” the lead into the tissue of the patient until electrodes of the lead reside adjacent to a target tissue. In this manner, the threaded fixation structure secures the lead within the patient to resist lead migration and improper therapy and provide a fine adjustment for depth of placement. The threaded fixation structure may be disposed on a portion of the lead proximal to or distal to the electrodes of the lead or over the portion of the lead that includes the electrodes.

摘要翻译： 本公开涉及固定与目标组织部位相邻的医疗引线的电极。 医疗引线可以包括一个或多个螺纹固定结构，其围绕引线本体或细长构件的外表面周向设置，类似于“螺钉”或“螺旋钻”。 在植入期间，临床医生可以旋转整个引线以将引线“螺丝”到患者的组织中，直到引线的电极邻近靶组织。 以这种方式，螺纹固定结构固定患者内的引线以抵抗引线移动和不正确的治疗，并且为深度放置提供微调。 螺纹固定结构可以设置在引线的靠近或远离引线的电极的一部分上，或者设置在引线的包括电极的部分上。