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公开(公告)号：US20250003003A1
公开(公告)日：2025-01-02
申请号：US18885063
申请日：2024-09-13
Applicant: Natera, Inc.
Inventor： MATTHEW RABINOWITZ , Matthew Micah HILL , Bernhard ZIMMERMANN , Johan BANER , George GEMELOS , Milena BANJEVIC , Allison RYAN , Styrmir SIGURJONSSON , Zachary DEMKO
IPC: C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874
Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20240401142A1
公开(公告)日：2024-12-05
申请号：US18812696
申请日：2024-08-22
Applicant: Natera, Inc.
Inventor： MATTHEW RABINOWITZ , Matthew Micah HILL , Bernhard ZIMMERMANN , Johan BANER , George GEMELOS , Milena BANJEVIC , Allison RYAN , Styrmir SIGURJONSSON , Zachary DEMKO
IPC: C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874
Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20240352513A1
公开(公告)日：2024-10-24
申请号：US18753991
申请日：2024-06-25
Applicant: Natera, Inc.
Inventor： Joshua BABIARZ , Tudor Pompiliu CONSTANTIN , Lane A. EUBANK , George GEMELOS , Matthew Micah HILL , Huseyin Eser KIRKIZLAR , Matthew RABINOWITZ , Onur SAKARYA , Styrmir SIGURJONSSON , Bernhard ZIMMERMANN
IPC: C12Q1/686 , C12Q1/68 , C12Q1/6811 , C12Q1/6848 , C12Q1/6874 , C12Q1/6883
CPC classification number: C12Q1/686 , C12Q1/68 , C12Q1/6811 , C12Q1/6848 , C12Q1/6874 , C12Q1/6883 , C12Q2600/156
Abstract: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号：US20240331799A1
公开(公告)日：2024-10-03
申请号：US18585708
申请日：2024-02-23
Applicant: Natera, Inc.
Inventor： MATTHEW RABINOWITZ , George GEMELOS , Milena BANJEVIC , Allison RYAN , Zachary DEMKO , Matthew Hill , Bernhard ZIMMERMANN , Johan BANER
IPC: G16B20/00 , C12Q1/6806 , C12Q1/6827 , C12Q1/686 , C12Q1/6862 , C12Q1/6869 , C12Q1/6874 , C12Q1/6883 , G16B20/10 , G16B20/20 , G16B20/40 , G16B40/00
CPC classification number: G16B20/00 , C12Q1/6806 , C12Q1/6827 , C12Q1/686 , C12Q1/6862 , C12Q1/6869 , C12Q1/6874 , C12Q1/6883 , G16B20/10 , G16B20/20 , G16B20/40 , C12Q2525/179 , C12Q2527/113 , C12Q2527/143 , C12Q2537/143 , C12Q2537/149 , C12Q2537/159 , C12Q2545/114 , C12Q2600/156 , C12Q2600/16 , G16B40/00
Abstract: The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.
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公开(公告)号：US20240309464A1
公开(公告)日：2024-09-19
申请号：US18678577
申请日：2024-05-30
Applicant: Natera, Inc.
Inventor： Joshua BABIARZ , Tudor Pompiliu CONSTATIN , Lane A. EUBANK , George GEMELOS , Matthew Micah HILL , Huseyin Eser KIRKIZLAR , Matthew RABIBOWITZ , Onur SAKARYA , Styrmir SIGURJONSSON , Bernhard ZIMMERMANN
IPC: C12Q1/6886 , C12Q1/6869 , G06N7/01 , G06N20/00 , G16B15/00 , G16B20/00 , G16B20/10 , G16B20/20 , G16B25/00 , G16B25/20 , G16B40/00 , G16B40/20 , G16H10/40 , G16H50/20 , G16Z99/00
CPC classification number: C12Q1/6886 , C12Q1/6869 , G06N7/01 , G06N20/00 , G16B15/00 , G16B20/00 , G16B20/10 , G16B20/20 , G16B25/00 , G16B40/00 , G16B40/20 , G16H10/40 , G16H50/20 , G16Z99/00 , C12Q2539/10 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , C12Q2600/172 , G16B25/20
Abstract: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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Patent Agency Ranking
公开(公告)号：US20240309456A1
公开(公告)日：2024-09-19
申请号：US18678417
申请日：2024-05-30
Applicant: Natera, Inc.
Inventor： MATTHEW RABINOWITZ , Matthew Micah HILL , Bernhard A. ZIMMERMANN , Johan BANER , George GEMELOS , Milena BANJEVIC , Allison RYAN , Styrmir SIGURJONSSON , Zachary DEMKO
IPC: C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874
CPC classification number: C12Q1/6883 , C12Q1/6809 , C12Q1/6811 , C12Q1/6844 , C12Q1/6848 , C12Q1/6851 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2600/156
Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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公开(公告)号：US20230054494A1
公开(公告)日：2023-02-23
申请号：US17945334
申请日：2022-09-15
Applicant: Natera, Inc.
Inventor： Matthew RABINOWITZ , George GEMELOS , Milena BANJEVIC , Allison RYAN , Zachary DEMKO , Matthew HILL , Bernhard ZIMMERMANN , Johan BANER
IPC: G16B20/00 , C12Q1/6827 , C12Q1/6862 , C12Q1/686 , G16B20/10 , G16B20/20 , G16B20/40 , C12Q1/6883 , C12Q1/6869 , C12Q1/6806 , C12Q1/6874
Abstract: The present disclosure provides methods for determining the ploidy status of a chromosome in a gestating fetus from genotypic data measured from a mixed sample of DNA comprising DNA from both the mother of the fetus and from the fetus, and optionally from genotypic data from the mother and father. The ploidy state is determined by using a joint distribution model to create a plurality of expected allele distributions for different possible fetal ploidy states given the parental genotypic data, and comparing the expected allelic distributions to the pattern of measured allelic distributions measured in the mixed sample, and choosing the ploidy state whose expected allelic distribution pattern most closely matches the observed allelic distribution pattern. The mixed sample of DNA may be preferentially enriched at a plurality of polymorphic loci in a way that minimizes the allelic bias, for example using massively multiplexed targeted PCR.
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公开(公告)号：US20220282335A1
公开(公告)日：2022-09-08
申请号：US17738354
申请日：2022-05-06
Applicant: Natera, Inc.
Inventor： Joshua BABIARZ , Tudor Pompiliu CONSTANTIN , Lane A. EUBANK , George GEMELOS , Matthew Micah HILL , Huseyin Eser KIRKIZLAR , Matthew RABINOWITZ , Onur SAKARYA , Styrmir SIGURJONSSON , Bernhard ZIMMERMANN
IPC: C12Q1/6886 , G06N7/00 , G16Z99/00 , G16H50/20 , G16B25/00 , G16B20/20 , G16H10/40 , G16B40/20 , G06N20/00 , G16B20/10 , G16B15/00 , G16B40/00 , G16B20/00 , C12Q1/6869
Abstract: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号：US20220154290A1
公开(公告)日：2022-05-19
申请号：US17568854
申请日：2022-01-05
Applicant: Natera, Inc.
Inventor： Joshua BABIARZ , Tudor Pompiliu CONSTANTIN , Lane A. EUBANK , George GEMELOS , Matthew Micah HILL , Huseyin Eser KIRKIZLAR , Matthew RABINOWITZ , Onur SAKARYA , Styrmir SIGURJONSSON , Bernhard ZIMMERMANN
IPC: C12Q1/6886 , G06N7/00 , G06N20/00 , G16B15/00 , G16B20/00 , G16B20/10 , G16B20/20 , G16B25/00 , G16B40/00 , G16B40/20 , G16H10/40 , G16H50/20 , G16Z99/00 , C12Q1/6869
Abstract: The invention provides methods, systems, and computer readable medium for detecting ploidy of chromosome segments or entire chromosomes, for detecting single nucleotide variants and for detecting both ploidy of chromosome segments and single nucleotide variants. In some aspects, the invention provides methods, systems, and computer readable medium for detecting cancer or a chromosomal abnormality in a gestating fetus.
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公开(公告)号：US20220098667A1
公开(公告)日：2022-03-31
申请号：US17545881
申请日：2021-12-08
Applicant: Natera, Inc.
Inventor： Matthew RABINOWITZ , Matthew Micah HILL , Bernhard ZIMMERMANN , Johan BANER , George GEMELOS , Milena BANJEVIC , Allison RYAN , Styrmir SIGURJONSSON , Zachary DEMKO
IPC: C12Q1/6883 , C12Q1/6811 , C12Q1/6848 , C12Q1/6809 , C12Q1/6851 , C12Q1/6844 , C12Q1/6869 , C12Q1/6855 , C12Q1/6874
Abstract: The invention provides methods for simultaneously amplifying multiple nucleic acid regions of interest in one reaction volume as well as methods for selecting a library of primers for use in such amplification methods. The invention also provides library of primers with desirable characteristics, such as minimal formation of amplified primer dimers or other non-target amplicons.
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