-
公开(公告)号：US20060211050A1
公开(公告)日：2006-09-21
申请号：US11442747
申请日：2006-05-30
IPC分类号： G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705
CPC分类号： C12N9/18 , A61K38/00 , C12Y301/01001
摘要： The invention provides isolated nucleic acid molecules, designated COE-2 nucleic acid molecules, which encode novel carboxylesterase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing COE-2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a COE-2 gene has been introduced or disrupted. The invention still further provides isolated COE-2 proteins, fusion proteins, antigenic peptides and anti-COE-2 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
-
公开(公告)号：US20060121518A1
公开(公告)日：2006-06-08
申请号：US11325013
申请日：2006-01-04
CPC分类号： C12N9/1029 , A61K38/00 , C12Y203/01015
摘要： The invention provides isolated nucleic acid molecules, designated ACTR-1 nucleic acid molecules, which encode novel acyltransferase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ACTR-1 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ACTR-1 gene has been introduced or disrupted. The invention still further provides isolated ACTR-1 proteins, fusion proteins, antigenic peptides and anti-ACTR-1 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新的酰基转移酶家族成员的分离的核酸分子，命名为ACTR-1核酸分子。 本发明还提供了反义核酸分子，含有ACTR-1核酸分子的重组表达载体，其中引入了表达载体的宿主细胞和其中引入或破坏了ACTR-1基因的非人类转基因动物。 本发明还进一步提供了分离的ACTR-1蛋白，融合蛋白，抗原肽和抗ACTR-1抗体。 还提供了利用本发明组合物的诊断方法。
-
73.发明申请公开(公告)号：US20060040306A1
公开(公告)日：2006-02-23
申请号：US11206587
申请日：2005-08-18
CPC分类号： C12N9/6489 , C07K14/705 , C07K2319/00 , C12N9/78 , C12Y304/24057 , C12Y305/04004
摘要： The invention provides isolated nucleic acids molecules, designated 38650, 28472, 5495, 65507, 81588 or 14354 nucleic acid molecules, which encode novel adenosine deaminase, glycoprotease, or seven transmembrane receptor family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 38650, 28472, 5495, 65507, 81588 or 14354 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 38650, 28472, 5495, 65507, 81588 or 14354 gene has been introduced or disrupted. The invention still further provides isolated 38650, 28472, 5495, 65507, 81588 or 14354 proteins, fusion proteins, antigenic peptides and anti-38650, 28472, 5495, 65507, 81588 or 14354 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为38650,28472,5495,65507,81588或14354核酸分子，其编码新的腺苷脱氨酶，糖蛋白酶或七个跨膜受体家族成员。 本发明还提供反义核酸分子，含有38650,28472,5495,65507,81588或14354核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中38650,28472， 5495,65507,81588或14354基因被引入或破坏。 本发明还进一步提供分离的38650,28472,5495,65507,81588或14354蛋白，融合蛋白，抗原肽和抗-38650,28472,5495,65507,81588或14354抗体。 还提供了利用本发明组合物的诊断方法。
-
74.发明申请Novel 27875, 22025, 27420, 17906, 16319, 55092 and 10218 molecules and uses therefor 审中-公开小分子27875,22025,27420,17906,16319,55092和10218分子及其用途公开(公告)号：US20060009632A1
公开(公告)日：2006-01-12
申请号：US11226701
申请日：2005-09-14
申请人： Rosana Kapeller-Libermann , David White , Keith Robison , Kyle MacBeth , Joseph Carroll , William Cook , Rachel Meyers , Miyoung Chun , Mark Williamson
发明人： Rosana Kapeller-Libermann , David White , Keith Robison , Kyle MacBeth , Joseph Carroll , William Cook , Rachel Meyers , Miyoung Chun , Mark Williamson
IPC分类号： C07H21/04
CPC分类号： G01N33/5008 , A61K38/00 , C12N9/1007 , C12N9/16 , C12N9/6489 , C12Q1/37 , C12Q1/6883 , C12Q2600/158 , C12Y301/04017 , G01N33/5011 , G01N33/502 , G01N33/56983 , G01N33/56994 , G01N33/57426 , G01N33/5761 , G01N33/5767 , G01N33/68 , G01N2333/916 , G01N2333/96486 , G01N2500/04
摘要： The invention provides isolated nucleic acids molecules, designated 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 27875, 22025, 27420, 16319, 55092 and 10218 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 27875, 22025, 27420, 16319, 55092 and 10218 gene has been introduced or disrupted. The invention still further provides isolated 27875, 22025, 27420, 17906, 16319, 55092 or 10218 proteins, fusion proteins, antigenic peptides and anti-27875, 22025, 27420, 17906, 16319, 55092 or 10218 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为27875,22025,27420,16319,55092和10218核酸分子。 本发明还提供反义核酸分子，含有27875,22025,27420,16319,55092和10218核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及非人类转基因动物，其中27875,22025， 27420,16319,55092和10218基因已被引入或破坏。 本发明还进一步提供了分离的27875,22025,27420,17906,16319,55092或10218蛋白，融合蛋白，抗原肽和抗27875,22025,27420,17906,16319,55092或10218抗体。 还提供了利用本发明组合物的诊断和治疗方法。
-
公开(公告)号：US20060003413A1
公开(公告)日：2006-01-05
申请号：US11151601
申请日：2005-06-13
申请人： Rachel Meyers , Peter Olandt , Rosana Kapeller-Libermann , Rory Curtis , Mark Williamson , Nadine Weich
发明人： Rachel Meyers , Peter Olandt , Rosana Kapeller-Libermann , Rory Curtis , Mark Williamson , Nadine Weich
CPC分类号： C12N9/1205 , A61K38/00 , C07K16/40 , C12N9/12 , C12N9/16 , C12N9/48 , C12N9/6424 , C12N9/6427 , C12N9/6472 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156
摘要： The invention provides isolated nucleic acids molecules, designated 53070, 15985, 26583, 21953, m32404, 14089, and 23436 nucleic acid molecules, which encode novel human protein kinase family members, serine/threonine protein kinase family members, serine/threonine phosphatase family members, prolyl oligopeptidase family members, trypsin family members, trypsin serine protease family members, and ubiquitin protease family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 53070, 15985, 26583, 21953, m32404, 14089, or 23436 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 53070, 15985, 26583, 21953, m32404, 14089, or 23436 gene has been introduced or disrupted. The invention still further provides isolated 53070, 15985, 26583, 21953, m32404, 14089, or 23436 proteins, fusion proteins, antigenic peptides and anti-53070, 15985, 26583, 21953, m32404, 14089, or 23436 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
-
76.发明申请69583 and 85924 Novel human protein kinase family members and uses therefor 审中-公开69583和85924新型人类蛋白激酶家族成员及其用途公开(公告)号：US20050064544A1
公开(公告)日：2005-03-24
申请号：US10490592
申请日：2002-10-24
IPC分类号： G01N33/50 , C07K14/47 , C07K16/40 , C07K16/46 , C12N5/10 , C12N9/12 , C12N15/09 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/48 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , C07H21/04
CPC分类号： C12N9/1205
摘要： The invention provides isolated nucleic acids molecules, designated 69583 and 85924 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 69583 or 85924 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 69583 or 85924 gene has been introduced or disrupted. The invention still further provides isolated 69583 or 85924 proteins, fusion proteins, antigenic peptides and anti-69583 or -85924 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供编码新的蛋白激酶家族成员的分离的核酸分子，命名为69583和85924核酸分子。 本发明还提供了反义核酸分子，含有69583或85924个核酸分子的重组表达载体，已经引入表达载体的宿主细胞，以及引入或破坏69583或85924基因的非人转基因动物。 本发明还进一步提供分离的69583或85924蛋白，融合蛋白，抗原肽和抗-69583或-85924抗体。 还提供了利用本发明组合物的诊断和治疗方法。
-
公开(公告)号：US06797502B2
公开(公告)日：2004-09-28
申请号：US09963908
申请日：2001-09-26
IPC分类号： C12N920
CPC分类号： C12Q1/44 , A01K2217/05 , A61K31/7088 , A61K38/00 , A61K48/00 , C12N9/20
摘要： The present invention relates to a newly identified human lipase belonging to the family of mammalian lipases. The invention also relates to polynucleotides encoding the lipase. The invention further relates to methods using the lipase polypeptides and polynucleotides as a target for diagnosis and treatment in lipase-mediated or -related disorders. The invention further relates to drug-screening methods using the lipase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the lipase polypeptides and polynucleotides. The invention further relates to procedures for producing the lipase polypeptides and polynucleotides.
摘要翻译： 本发明涉及属于哺乳动物脂肪酶家族的新鉴定的人类脂肪酶。 本发明还涉及编码脂肪酶的多核苷酸。 本发明还涉及使用脂肪酶多肽和多核苷酸作为在脂肪酶介导或相关疾病中进行诊断和治疗的靶标的方法。 本发明还涉及使用脂肪酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于脂肪酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及产生脂肪酶多肽和多核苷酸的方法。
-
78.发明授权2504, 15977, and 14760, novel protein kinase family members and uses therefor 失效2504,15977和14760，新型蛋白激酶家族成员及其用途公开(公告)号：US06730491B2
公开(公告)日：2004-05-04
申请号：US09797039
申请日：2001-02-28
IPC分类号： C12Q148
CPC分类号： C12N9/1205 , A61K38/00 , A61K2039/505 , C07K16/40
摘要： The invention provides isolated nucleic acids molecules, designated 2504, 15977, or 14760 nucleic acid molecules, which encode novel protein kinase family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 2504, 15977, or 14760 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 2504, 15977, or 14760 gene has been introduced or disrupted. The invention still further provides isolated 2504, 15977, or 14760 proteins, fusion proteins, antigenic peptides and anti-2504, 15977, or 14760 antibodies. Diagnostic methods utilizing compositions of the invention are also provided.
摘要翻译： 本发明提供分离的核酸分子，命名为2504,15977或14760核酸分子，其编码新的蛋白激酶家族成员。 本发明还提供了反义核酸分子，含有2504,15977或14760个核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及其中已经存在2504,15977或14760基因的非人转基因动物 引入或中断 本发明还进一步提供分离的2504,15977或14760蛋白，融合蛋白，抗原肽和抗2504,15977或14760抗体。 还提供了利用本发明组合物的诊断方法。
-
79.发明授权公开(公告)号：US06673564B2
公开(公告)日：2004-01-06
申请号：US09420190
申请日：1999-10-18
IPC分类号： C12Q144
摘要： The present invention relates to methods for using a human cyclic nucleotide phosphodiesterase belonging to the superfamily of mammalian phosphodiesterases. The invention also relates to methods for using polynucleotides encoding the phosphodiesterase. The invention relates to methods using the phosphodiesterase polypeptides and polynucleotides as a target for diagnosis and treatment in phosphodiesterase-mediated or -related disorders. The invention further relates to drug-screening methods using the phosphodiesterase polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the phosphodiesterase polypeptides and polynucleotides. The invention further relates to agonists and antagonists identifiefd by drug screening methods with the phosphodiesterase polypeptides and polynucleotides as a target.
摘要翻译： 本发明涉及使用属于哺乳动物磷酸二酯酶超家族的人环状核苷酸磷酸二酯酶的方法。 本发明还涉及使用编码磷酸二酯酶的多核苷酸的方法。 本发明涉及使用磷酸二酯酶多肽和多核苷酸作为磷酸二酯酶介导的或相关疾病中的诊断和治疗的靶标的方法。 本发明还涉及使用磷酸二酯酶多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。 本发明还包括基于磷酸二酯酶多肽和多核苷酸的激动剂和拮抗剂。 本发明还涉及用磷酸二酯酶多肽和多核苷酸作为靶标的药物筛选方法鉴定的激动剂和拮抗剂。
-
80.发明授权公开(公告)号：US06630335B1
公开(公告)日：2003-10-07
申请号：US09781882
申请日：2001-02-12
IPC分类号： C12N912
CPC分类号： C12N9/1205
摘要： The invention relates to a novel kinase nucleic acid sequence and protein. Also provided are vectors, host cells, and recombinant methods for making and using the novel molecules.
摘要翻译： 本发明涉及一种新的激酶核酸序列和蛋白质。 还提供了用于制备和使用新分子的载体，宿主细胞和重组方法。
-
-
-
-
-
-
-
-
-
搜索结果
100 条记录 (耗时 0.109 秒)
