公开(公告)号：US20100093015A1

公开(公告)日：2010-04-15

申请号：US12462350

申请日：2009-08-03

申请人： Janice L. Panza ,  John Maier ,  Jason Neiss

发明人： Janice L. Panza ,  John Maier ,  Jason Neiss

IPC分类号： C12Q1/02 ,  C12M1/34

CPC分类号： G01J3/44 ,  G01J3/10 ,  G01J3/36 ,  G01N15/1475 ,  G01N21/6458 ,  G01N21/65 ,  G01N2015/1006 ,  G01N2015/1488 ,  G02B21/0096

摘要： A system and method to distinguish normal cells from cells having undergone a biochemical change. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference spectral data sets for normal cells and a second plurality of reference spectral data sets for cells having undergone a biochemical change. A sample is irradiated to generate a target spectral data set based on photons absorbed, reflected, emitted, or scattered by the sample. The target spectral data set is transformed into a pre-determined vector space. A distribution of transformed data is analyzed in the pre-determined vector space. Based on the analysis, the sample is classified as containing normal cells, cells having undergone a biochemical change, and combinations thereof. The method includes treating the sample with a pharmaceutical agent prior to irradiating the sample and using the classification to assess the efficiency of the pharmaceutical agent.

摘要翻译： 将正常细胞与经历生物化学变化的细胞区分开的系统和方法。 选择预定向量空间，其中矢量空间数学地描述正常小区的第一多个参考频谱数据集，以及已经历生化变化的小区的第二多个参考频谱数据集。 照射样品以基于样品吸收，反射，发射或散射的光子产生目标光谱数据集。 将目标光谱数据集转换为预定向量空间。 在预定向量空间中分析变换数据的分布。 基于该分析，将样品分类为含有正常细胞，经历生物化学变化的细胞及其组合。 该方法包括在照射样品之前用药剂处理样品并使用分类来评估药剂的效率。

公开(公告)号：US20080273199A1

公开(公告)日：2008-11-06

申请号：US12070010

申请日：2008-02-14

申请人： John Maier ,  Jeffrey Cohen ,  Janice L. Panza ,  Amy J. Drauch

发明人： John Maier ,  Jeffrey Cohen ,  Janice L. Panza ,  Amy J. Drauch

IPC分类号： G01J3/44

CPC分类号： G01N21/65 ,  G01J3/02 ,  G01J3/0291 ,  G01J3/0294 ,  G01J3/2823 ,  G01J3/44 ,  G01J2003/2826 ,  G01N2021/656 ,  G01N2201/1293 ,  G01N2201/1296

摘要： A system and method to predict the progression of disease of a test sample. A group of known biological samples is provided. Each known biological sample has an associated known outcome including a non-diseased sample or a diseased sample. A Raman data set is obtained for each known biological sample. Each Raman data set is analyzed to identify a diseased or non-diseased reference Raman data set depending on whether respective biological sample is the non-diseased sample or the diseased sample. A first database is generated where the first database contains reference Raman data sets for all diseased samples. A second database is generated where the second database contains reference Raman data sets for all non-diseased samples. A test Raman data set of a test biological sample is received, where the test biological sample has an unknown disease status. A diagnostic is provided as to whether the test sample is a non-diseased sample or a diseased sample. The diagnostic is obtained by comparing the test Raman data set against the reference Raman data sets in the first and the second databases using a chemometric technique. A prediction of the progression of disease may be then provided.

摘要翻译： 一种预测测试样本疾病进展的系统和方法。 提供了一组已知的生物样品。 每个已知的生物样品具有相关的已知结果，包括非患病样品或患病样品。 获得每个已知生物样品的拉曼数据集。 分析每个拉曼数据集，以根据相应的生物样品是非患病样品还是患病样品来鉴定患病或非患病参考拉曼数据集。 生成第一个数据库，其中第一个数据库包含所有患病样本的参考拉曼数据集。 生成第二数据库，其中第二数据库包含所有非患病样本的参考拉曼数据集。 接受测试生物样品的测试拉曼数据集，其中测试生物样品具有未知的疾病状态。 提供了关于测试样品是否是非患病样品或患病样品的诊断。 通过使用化学计量技术将测试拉曼数据集与第一和第二数据库中的参考拉曼数据集进行比较来获得诊断。 可以提供疾病进展的预测。

公开(公告)号：US20080093539A1

公开(公告)日：2008-04-24

申请号：US11907613

申请日：2007-10-15

申请人： David Tuschel ,  John Maier

发明人： David Tuschel ,  John Maier

IPC分类号： G01N21/27 ,  G01N21/31

CPC分类号： G01N21/6428 ,  G01J3/10 ,  G01J3/2823 ,  G01J3/4406 ,  G01N21/31 ,  G01N21/65 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6423

摘要： In one embodiment, the disclosure relates to a method for determining illumination parameters for a stained sample, the method may include providing a stained sample and obtaining an absorption band of the sample; obtaining an emission band of the sample and determining the illumination parameters for the sample as a function of the absorption band and the emission band of the sample.

摘要翻译： 在一个实施方案中，本公开涉及一种用于确定染色样品的照明参数的方法，所述方法可包括提供染色样品并获得样品的吸收带; 获得样品的发射带，并根据样品的吸收带和发射带确定样品的照射参数。

公开(公告)号：US20070224979A1

公开(公告)日：2007-09-27

申请号：US11385110

申请日：2006-03-21

申请人： Shawn O'Neal ,  John Maier

发明人： Shawn O'Neal ,  John Maier

IPC分类号： G06F15/16 ,  H04M3/42

CPC分类号： G06Q30/02

摘要： A method and apparatus for providing opt-in data communications to a user of a wireless device such as a mobile telephone is provided. The user can call a telephone number associated with an interactive voice response unit, towards opting in to receipt of digital messaging, such as advertising or marketing material. In response, information captured during the telephone call can be used to prepare, format and transmit digital messaging to the user.

摘要翻译： 提供了一种用于向诸如移动电话之类的无线设备的用户提供选择加入数据通信的方法和装置。 用户可以呼叫与交互式语音响应单元相关联的电话号码，以选择接收诸如广告或营销材料的数字消息。 作为响应，在电话呼叫期间捕获的信息可用于准备，格式化和传送数字消息给用户。

公开(公告)号：US20070153268A1

公开(公告)日：2007-07-05

申请号：US11650378

申请日：2007-01-05

申请人： Janice Panza ,  John Maier ,  Jason Neiss

发明人： Janice Panza ,  John Maier ,  Jason Neiss

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01J3/44 ,  G01J3/28 ,  G01J3/36 ,  G01N15/1475 ,  G01N21/65 ,  G01N2015/1006 ,  G01N2015/1488 ,  G01N2021/656

摘要： A system and method to distinguish normal cells from apoptotic cells. A pre-determined vector space is selected where the vector space mathematically describes a first plurality of reference Raman data sets for normal cells and a second plurality of reference Raman data sets for apoptotic cells. A sample is irradiated with substantially monochromatic light generating a target Raman data set based on scattered photons. The target Raman data set is transformed into a vector space defined by the pre-determined vector space. A distribution of transformed data is analyzed in the pre-determined vector space. Based on the analysis, the sample is classified as containing normal cells, apoptotic cells, and a combination of normal and apoptotic cells. The sample includes the step of treating the sample with a pharmaceutical agent prior to irradiating the sample. Based on the classification, the therapeutic efficiency of the pharmaceutical agent is assessed.

摘要翻译： 将正常细胞与凋亡细胞区分开的系统和方法。 选择预定矢量空间，其中矢量空间在数学上描述用于正常细胞的第一多个参考拉曼数据集和用于凋亡细胞的第二多个参考拉曼数据集。 用基本上单色的光照射样品，产生基于散射光子的目标拉曼数据集。 目标拉曼数据集被转换成由预定向量空间定义的向量空间。 在预定向量空间中分析变换数据的分布。 基于分析，样品被分类为含有正常细胞，凋亡细胞，以及正常细胞和凋亡细胞的组合。 样品包括在照射样品之前用药剂处理样品的步骤。 根据分类，评估药剂的治疗效果。

公开(公告)号：US20070133984A1

公开(公告)日：2007-06-14

申请号：US11585535

申请日：2006-10-24

申请人： John Maier ,  Patrick Treado ,  Matthew Nelson ,  Lindy McClelland ,  Shona Stewart

发明人： John Maier ,  Patrick Treado ,  Matthew Nelson ,  Lindy McClelland ,  Shona Stewart

IPC分类号： H04B10/08 ,  H04B17/00

CPC分类号： G01N21/65 ,  G01J3/28 ,  G01J3/2823 ,  G01J3/44 ,  G01N21/274 ,  G01N2021/656

摘要： A system and method to automatically obtain spectra for samples. The method involves a two phase process including a photobleaching phase and a spectral acquisition phase. In the photobleaching phase, a series of spectral data sets of a sample are collected. A relative difference is determined between the background of subsequent spectral data sets is determined and compared to a predetermined threshold value. If threshold difference is less than the relative difference between the background of subsequent spectral data sets, the steps of collecting a series of spectra data sets is automatically repeated. In the spectrum acquisition phase, a series of Raman data sets of the sample are collected until a target SNR is obtained.

摘要翻译： 自动获取样品光谱的系统和方法。 该方法涉及包括光漂白相和光谱采集阶段的两相过程。 在漂白漂白阶段，收集样品的一系列光谱数据集。 在确定后续光谱数据集的背景并将其与预定阈值进行比较之间确定相对差。 如果阈值差小于随后的光谱数据集的背景之间的相对差，则自动重复收集一系列光谱数据集的步骤。 在频谱采集阶段，收集样本的一系列拉曼数据集，直到获得目标SNR。

公开(公告)号：US20060276713A1

公开(公告)日：2006-12-07

申请号：US11267913

申请日：2005-11-03

申请人： John Maier

发明人： John Maier

IPC分类号： A61B5/00

CPC分类号： G06F19/10 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/1459 ,  A61B5/415 ,  A61B5/418 ,  A61B5/4519

摘要： The invention relates to methods and devices for assessing one or more components of a selected tissue in an animal. The present invention permits non-invasive assessment of tissue components in a body structure containing multiple tissue types by assessing multiple regions of the animal's body for an optical characteristic of the tissue of interest and separately assessing one or more optical (e.g., Raman or NIR) characteristics of the tissue component for one or more regions that exhibit the optical characteristic of the tissue of interest.

公开(公告)号：US20060268266A1

公开(公告)日：2006-11-30

申请号：US11366660

申请日：2006-03-03

申请人： Charles Gardner ,  John Maier ,  Matthew Nelson ,  Robert Schweitzer ,  Patrick Treado ,  G. Vanni ,  Julianne Wolfe ,  Joseph Demuth ,  Jason Neiss ,  Chenhui Wang

发明人： Charles Gardner ,  John Maier ,  Matthew Nelson ,  Robert Schweitzer ,  Patrick Treado ,  G. Vanni ,  Julianne Wolfe ,  Joseph Demuth ,  Jason Neiss ,  Chenhui Wang

IPC分类号： G01J3/44 ,  G01N21/65

CPC分类号： G01N21/65 ,  G01N21/6456 ,  G01N2021/6421 ,  G01N2201/0221

摘要： The disclosure relates to methods and apparatus for assessing occurrence of one or more hazardous agents in a sample by performing multipoint spectral analysis of the sample using a portable or hand-held device. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.

公开(公告)号：US07045757B1

公开(公告)日：2006-05-16

申请号：US11097161

申请日：2005-04-04

申请人： David Tuschel ,  John Maier ,  Joseph Demuth

发明人： David Tuschel ,  John Maier ,  Joseph Demuth

IPC分类号： H01L27/00

CPC分类号： G01N21/6428 ,  G01J3/02 ,  G01J3/027 ,  G01J3/10 ,  G01N21/65 ,  G01N2021/6417 ,  G01N2021/6471 ,  G01N2201/067

摘要： In one embodiment, the disclosure relates to a method for determining illumination parameters for a stained sample, the method may include providing a stained sample and obtaining an absorption band of the sample; obtaining an emission band of the sample and determining the illumination parameters for the sample as a function of the absorption band and the emission band of the sample.

摘要翻译： 在一个实施方案中，本公开涉及一种用于确定染色样品的照明参数的方法，所述方法可包括提供染色样品并获得样品的吸收带; 获得样品的发射带，并根据样品的吸收带和发射带确定样品的照射参数。

公开(公告)号：US20060001881A1

公开(公告)日：2006-01-05

申请号：US10879630

申请日：2004-06-30

申请人： John Maier ,  Jason Neiss ,  Shona Stewart

发明人： John Maier ,  Jason Neiss ,  Shona Stewart

IPC分类号： G01J3/51

CPC分类号： G01J3/28 ,  G01J3/0227 ,  G01J3/027 ,  G01J3/0286 ,  G01J3/44

摘要： In one embodiment the disclosure relates to a method and a system for determining the corrected wavelength of a photon scattered by a sample. The method includes the steps of determining a wavelength of a photon scattered from a sample exposed to illuminating photons and passed through a tunable filter and correcting the determined wavelength of the photon as a function of the temperature of the tunable filter and as a function of the bandpass set point of the tunable filter. The step of correcting the determined wavelength can further include determining an offset and adding the offset to the determined wavelength of the photon.

摘要翻译： 在一个实施例中，本公开涉及一种用于确定由样本散射的光子的校正波长的方法和系统。 该方法包括以下步骤：确定从暴露于照射光子的样品散射的光子的波长，并且通过可调谐滤光器并校正所确定的光子波长作为可调滤光器的温度的函数，并且作为 可调谐滤波器的带通设定点。 校正所确定的波长的步骤还可以包括确定偏移并将偏移量加到所确定的光子的波长上。