公开(公告)号：US20050080529A1

公开(公告)日：2005-04-14

申请号：US10846876

申请日：2004-05-17

申请人： Kohji Hashimoto ,  Katsuya Nakamoto ,  Yuki Iwagami ,  Akihiro Ishii

发明人： Kohji Hashimoto ,  Katsuya Nakamoto ,  Yuki Iwagami ,  Akihiro Ishii

IPC分类号： F02D45/00 ,  G05B19/05 ,  G06F11/00 ,  G06F11/267 ,  G06F13/00 ,  G06F13/40 ,  H04B7/212

CPC分类号： G06F11/0757 ,  G06F11/221

摘要： A first control circuit section (master station) and a second control circuit section (substation) communicate with each other via series-parallel converters. The master station includes regular transmission device and transmission-permitting signal generation device; and the sub station includes regular report device, confirmation reply device relative to a transmission data from the master station, and an unprocessed data table. The unprocessed data table prevents jam-up in upstream communication from the sub station to the master station, enabling to carry out timely regular transmission and regular reporting. Transmission from the sub station to the master station is performed based on a transmission-permitting control signal that the master station generates. Consequently, it is possible to execute communication error processing and diminish communication control burden on the master station while properly performing the regular transmission and regular report between the master station and sub station.

摘要翻译： 第一控制电路部分（主站）和第二控制电路部分（变电站）通过串并联转换器彼此通信。 主站包括常规传输设备和传输许可信号发生设备; 并且子站包括相对于来自主站的传输数据的常规报告设备，确认回复设备和未处理的数据表。 未处理的数据表防止从子站到主站的上行通信中的卡住，能够及时定期传输和定期报告。 基于主站产生的发送允许控制信号，执行从子站到主站的传输。 因此，在主站和子站之间正常执行正常传输和定期报告的同时，可以执行通信错误处理并减少主站的通信控制负担。

公开(公告)号：US06245678B1

公开(公告)日：2001-06-12

申请号：US09226111

申请日：1999-01-07

申请人： Hiroaki Yamamoto ,  Akihiro Ishii

发明人： Hiroaki Yamamoto ,  Akihiro Ishii

IPC分类号： H01L21302

CPC分类号： H01L21/02021 ,  H01L21/6708

摘要： A Bernoulli type chucking device 2 supports the rear surface 12 of a semiconductor wafer 1. The etchant 30 turns around and reaches the portion beneath the beveled portion 13 of the semiconductor wafers 1. However, the etchant is restrained on the beveled portion by a gas flow coming from the openings 22A of the gas-expelling passages 22 in the centrifugal direction. The gas belows off the etchant, which has turned around and is going to reach the rear surface. Thus, the beveled portion 13 is mirror-finished when etching of the semiconductor wafer front surface 11 is carried out, and mirror-finishing of part of the rear surface 12 can be avoided. Furthermore, mirror-finishing can be performed without being influenced by the shape of the beveled portions of semiconductor wafers. Compared with conventional method, this invention can perform mirror-finishing more efficiently.

摘要翻译： 伯努利型夹持装置2支撑半导体晶片1的后表面12.蚀刻剂30绕转并到达半导体晶片1的斜面部分13下方的部分。然而，蚀刻剂通过气体被限制在斜面部分上 气体排出通道22的离心方向的开口22A流动。 气体已经脱离了已经转向并将要到达后表面的蚀刻剂。 因此，当进行半导体晶片前表面11的蚀刻时，斜面部分13被镜面化，并且可以避免后表面12的一部分的镜面抛光。 此外，可以在不受半导体晶片的斜面部的形状的影响的情况下进行镜面精加工。 与传统方法相比，本发明可以更有效地进行镜面抛光。

公开(公告)号：US06234873B1

公开(公告)日：2001-05-22

申请号：US09179934

申请日：1998-10-28

申请人： Hiroaki Yamamoto ,  Akihiro Ishii ,  Kouichi Imura

发明人： Hiroaki Yamamoto ,  Akihiro Ishii ,  Kouichi Imura

IPC分类号： H01L21304

CPC分类号： H01L21/02008 ,  H01L21/02019

摘要： A method for manufacturing semiconductor wafers is provided. According to this invention, wafers are obtained by slicing a single-crystal semiconductor ingot. The sliced wafers are beveled at their peripheral rims. The beveled wafers are flattened by a lapping process. The front and the rear surfaces of the flattened wafers are spin-etched with an acid etchant liquid. The glossiness of the rear surfaces of the spin-etched wafers is controlled to a value of 130-300 %. The front surfaces of the wafers whose rear surfaces have been spin-etched are polished, thereby obtaining mirror-polished surfaces. The front surfaces may also be spin-etched prior to polishing.

摘要翻译： 提供了制造半导体晶片的方法。 根据本发明，通过切割单晶半导体晶锭获得晶片。 切片晶片在其外围边缘处是斜切的。 斜面晶片通过研磨工艺变平。 用酸蚀剂液体旋转刻蚀扁平晶片的前表面和后表面。 旋转蚀刻晶片的后表面的光泽度被控制在130-300％的值。 对后表面进行了旋转刻蚀的晶片的前表面进行研磨，得到镜面研磨面。 在抛光之前，还可以旋转刻蚀前表面。

公开(公告)号：US08835669B2

公开(公告)日：2014-09-16

申请号：US13125452

申请日：2009-10-15

申请人： Akihiro Ishii ,  Manabu Yasumoto

发明人： Akihiro Ishii ,  Manabu Yasumoto

IPC分类号： C07C315/02 ,  C07D207/16 ,  C07B53/00 ,  C07C303/24

CPC分类号： C07D207/16 ,  C07B53/00 ,  C07C303/24 ,  C07C305/26

摘要： Fluorosulfuric acid esters can be produced by reacting alcohols with sulfuryl fluoride (SO2F2) in the presence of a base and water. As a substrate thereof, optically active secondary alcohols are preferable, and optically active α-hydroxyesters and optically active 4-hydroxyprolines are particularly preferable. By performing the reaction in a two-phase system in the presence of a reaction solvent immiscible with water, a desired reaction proceeds particularly well. The present invention is a production method solving all the problems involved in conventional techniques while being industrially practicable.

摘要翻译： 氟代硫酸酯可以通过在碱和水的存在下使醇与硫酰氟（SO 2 F 2）反应来制备。 作为其基材，优选光学活性仲醇，特别优选光学活性的α-羟基酯和光学活性的4-羟基脯氨酸。 通过在与水不混溶的反应溶剂的存在下在两相体系中进行反应，期望的反应进行得特别好。 本发明是在工业上可行的情况下解决常规技术中涉及的所有问题的生产方法。

公开(公告)号：US08809557B2

公开(公告)日：2014-08-19

申请号：US13201171

申请日：2010-02-22

申请人： Koichi Mikami ,  Kohsuke Aikawa ,  Junpei Aida ,  Akihiro Ishii ,  Misugi Kato ,  Takashi Masuda

发明人： Koichi Mikami ,  Kohsuke Aikawa ,  Junpei Aida ,  Akihiro Ishii ,  Misugi Kato ,  Takashi Masuda

IPC分类号： C07D305/04

CPC分类号： C07D305/04 ,  B01J31/223 ,  B01J31/2409 ,  B01J2231/32 ,  B01J2531/0266 ,  B01J2531/46 ,  B01J2531/824 ,  C07B53/00 ,  C07D305/08

摘要： Disclosed is a method of producing an optically active fluorinated oxetane, which can be an important pharmaceutical or agricultural intermediate, by reaction of a fluorinated α-keto ester with an acyl alkenyl ether in the presence of a transition metal complex with an optically active ligand. This method utilizes a catalytic asymmetric synthesis process and does not require a stoichiometric amount of chiral source. It is thus possible to dramatically reduce the amount of use of the asymmetric catalyst especially when the reaction is performed at a high concentration of substrate (with the use of a small amount of reaction solvent) or in the absence of a reaction solvent (under neat conditions). Further, the target optically active fluorinated oxetane can be obtained with high yield and with very high optical purity. The product contains almost no difficult-to-separate impurity and shows high chemical purity.

摘要翻译： 公开了通过氟化α-酮酯与酰基烯基醚在过渡金属配合物与光学活性配体的存在下反应，制备可以是重要的药用或农业中间体的光学活性氟化氧杂环丁烷的方法。 该方法利用催化不对称合成方法，不需要化学计量的手性源。 因此，可以显着地减少不对称催化剂的使用量，特别是当在高浓度的底物（使用少量的反应溶剂）下进行反应时，或者在没有反应溶剂的情况下 条件）。 此外，可以高产率和非常高的光学纯度获得目标光学活性氟化氧杂环丁烷。 该产品几乎没有难以分离的杂质，显示出高的化学纯度。

公开(公告)号：US08748653B2

公开(公告)日：2014-06-10

申请号：US12673956

申请日：2008-08-05

申请人： Akihiro Ishii ,  Hideyuki Tsuruta ,  Yuzuru Morino ,  Mikihiro Takahashi

发明人： Akihiro Ishii ,  Hideyuki Tsuruta ,  Yuzuru Morino ,  Mikihiro Takahashi

IPC分类号： C07C69/63

CPC分类号： C07B53/00 ,  C07B57/00 ,  C07C67/307 ,  C07C67/54 ,  C07C69/63

摘要： Disclosed is a purification method of reducing and removing fluoride ions contained in an optically active α-fluorocarboxylic acid ester represented by formula [1] [in the formula, R1 represents a C1-6 alkyl group, R2 represents a C1-4 alkyl group, and * represents an asymmetric carbon], the purification method of the optically active α-fluorocarboxylic acid ester being characterized by that a distillation is conducted in the presence of an organic base. By this method, it is possible to greatly reduce the concentration of fluoride ion traces contained in the optically active α-fluorocarboxylic acid ester by a relatively easy operation. Of the organic base, a tertiary amine is preferable, and above all tri-n-butylamine is particularly preferable.

摘要翻译： 公开了通式[1]表示的光学活性α-氟代羧酸酯中所含的氟离子的还原和除去净化方法[式中，R1表示C1-6烷基，R2表示C1-4烷基， 和*表示不对称碳]，光学活性α-氟代羧酸酯的纯化方法的特征在于在有机碱的存在下进行蒸馏。 通过该方法，可以通过相对容易的操作大大降低光学活性α-氟代羧酸酯中含有的氟离子痕迹的浓度。 在有机碱中，优选叔胺，特别优选三正丁胺。

公开(公告)号：US08669382B2

公开(公告)日：2014-03-11

申请号：US13697691

申请日：2011-04-25

申请人： Akihiro Ishii ,  Hirokatsu Nagura ,  Hideyuki Tsuruta

发明人： Akihiro Ishii ,  Hirokatsu Nagura ,  Hideyuki Tsuruta

IPC分类号： C07D317/10

CPC分类号： C07D317/30 ,  Y02P20/55

摘要： In the presence invention, a (2R)-2-fluoro-2-C-methyl-D-ribono-γ-lactone precursor is produced in the form of a ring-opened fluorinated compound by reaction of a 1,2-diol with sulfuryl fluoride (SO2F2) in the presence of an organic base and, optionally, a fluoride ion source. The production method of the present invention secures less number of process steps as compared to the conventional production method (shortening of three steps: cyclic sulfurous esterification, oxidation and ring-opening fluorination to one step) and satisfies the requirements for industrial production (high yield and high reproductivity). The thus-obtained (2R)-2-fluoro-2-C-methyl-D-ribono-γ-lactone precursor is useful as an important intermediate for the synthesis of 2′-deoxy-2′-fluoro-2′-C-methylcytidine with antivirus activity.

摘要翻译： 在本发明的存在下，通过1,2-二醇与式（Ⅱ）的反应制备开环氟化合物形式的（2R）-2-氟-2-C-甲基-D-内罗糖-γ-内酯前体 硫酰氟（SO 2 F 2）在有机碱和任选的氟离子源存在下进行。 本发明的制造方法与现有的制造方法（缩短三个步骤：环状亚硫酸酯化，氧化和开环氟化至一步）相比确保了较少的工艺步骤，并且满足了工业生产的要求（高产率 和高繁殖力）。 由此获得的（2R）-2-氟-2-C-甲基-D-内罗糖-γ-内酯前体可用作合成2'-脱氧-2'-氟-2'-碳 甲基胞苷具有抗病毒活性。

公开(公告)号：US08658840B2

公开(公告)日：2014-02-25

申请号：US13990114

申请日：2012-01-27

申请人： Akihiro Ishii ,  Takashi Ootsuka ,  Takehisa Ishimaru ,  Mari Imamura

发明人： Akihiro Ishii ,  Takashi Ootsuka ,  Takehisa Ishimaru ,  Mari Imamura

IPC分类号： C07C31/38 ,  C07F15/00

CPC分类号： C07C29/149 ,  B01J31/189 ,  B01J2231/643 ,  B01J2531/0258 ,  B01J2531/821 ,  C07D213/30 ,  C07C31/38 ,  C07C31/42 ,  C07C33/46 ,  C07C33/423

摘要： A production method of a β-fluoroalcohol includes performing a reaction of an α-fluoroester with hydrogen gas (H2) in the presence of a specific ruthenium complex (i.e. a ruthenium complex of the general formula [2], preferably a ruthenium complex of the general formula [4]). This production method can employ a suitable hydrogen pressure of 1 MPa or less by the use of such a specific ruthenium complex and does not require a high-pressure gas production facility when put in industrial practice. In addition, this production method can remarkably reduce the amount of catalyst used therein (to e.g. a substrate/catalyst ratio of 20,000) in comparison to the substrate/catalyst ratio conventional reduction of α-fluoroalcohol. It is possible by these reduction in hydrogen pressure and catalyst amount to largely reduce the production cost of the β-fluoroalcohol.

摘要翻译： β-氟代醇的制备方法包括在特定的钌络合物（即通式[2]的钌络合物）存在下进行α-氟代酯与氢气（H 2）的反应，优选的是钌络合物 通式[4]）。 该制造方法可以通过使用这种特定的钌络合物来采用1MPa以下的合适的氢压，并且在投入工业实践中不需要高压气体生产设备。 此外，与通常的α-氟代醇还原反应的底物/催化剂比例相比，该制造方法可以显着地减少其中使用的催化剂的用量（例如基质/催化剂比为20,000）。 通过这些氢气压力和催化剂量的降低可以大大降低β-氟代醇的生产成本。

公开(公告)号：US08653295B2

公开(公告)日：2014-02-18

申请号：US13060565

申请日：2009-09-24

申请人： Akihiro Ishii ,  Manabu Yasumoto ,  Takako Yamazaki ,  Kaori Mogi ,  Kazunori Mori ,  Takashi Masuda

发明人： Akihiro Ishii ,  Manabu Yasumoto ,  Takako Yamazaki ,  Kaori Mogi ,  Kazunori Mori ,  Takashi Masuda

IPC分类号： C07C69/76

CPC分类号： C07C67/317 ,  C07C67/327 ,  C07C69/65

摘要： An α-trifluoromethyl-α,β-unsaturated ester can be produced by reacting an α-trifluoromethyl-α-hydroxy ester with sulfuryl fluoride (SO2F2) in the presence of an organic base. It is preferable that the raw substrate has a hydrogen atom as one β-position substituent group and either an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, an aromatic ring group or a substituted aromatic ring group as the other β-position substituent group. It is more preferable that an ester moiety of the raw substrate is an alkyl ester. This raw substrate is readily available. Further, the desired reaction can proceed favorably with the use of this raw substrate. It is also preferable to use either 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) or 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as the organic base. The desired reaction can proceed more favorably with the use of this organic base.

摘要翻译： α-三氟甲基-α，β-不饱和酯可以通过在有机碱存在下使α-三氟甲基-α-羟基酯与硫酰氟（SO 2 F 2）反应来制备。 原料优选为具有作为一个β位取代基的氢原子，烷基，取代烷基，链烯基，取代烯基，芳香环基或取代芳环基作为 其他β位取代基。 原料的酯部更优选为烷基酯。 该原料基材容易获得。 此外，期望的反应可以有利地利用该原始基底进行。 还优选使用1,5-二氮杂双环[4.3.0]壬-5-烯（DBN）或1,8-二氮杂双环[5.4.0]十一碳-7-烯（DBU）作为有机碱。 使用该有机碱可以更有利地进行所需的反应。

公开(公告)号：US08524913B2

公开(公告)日：2013-09-03

申请号：US13002595

申请日：2009-08-27

申请人： Akihiro Ishii ,  Manabu Yasumoto ,  Takako Yamazaki ,  Kaori Mogi ,  Takashi Masuda

发明人： Akihiro Ishii ,  Manabu Yasumoto ,  Takako Yamazaki ,  Kaori Mogi ,  Takashi Masuda

IPC分类号： C07D261/04 ,  C07C229/20

CPC分类号： C07D261/04 ,  C07B53/00 ,  C07C229/20

摘要： α-Trifluoromethyl-β-substituted-β-amino acids can be produced by allowing α-trifluoromethyl-β-substituted-α,β-unsaturated esters to react with hydroxylamine to convert α-trifluoromethyl-β-substituted-α,β-unsaturated esters into dehydrogenated closed-ring body of α-trifluoromethyl-β-substituted-β-amino acid, and by hydrogenolyzing the dehydrogenated closed-ring body. According to this production process, novel α-trifluoromethyl-β-substituted-β-amino acids which are free amino acids whose functional groups are not protected can be produced, in which β-position substituent is not limited to aromatic ring group or substituted aromatic ring group while the relative stereochemistry of α-position and β-position can be also controlled.

摘要翻译： α-三氟甲基-β-取代的β-取代的β-氨基酸可以通过使α-三氟甲基-β-取代的α，β-不饱和酯与羟胺反应以转化α-三氟甲基-β-取代的α，β-不饱和的 酯转化成α-三氟甲基-β-取代的β-氨基酸的脱氢闭环体，并通过氢化脱氢闭环体。 根据该制造方法，可以制备作为官能团未被保护的游离氨基酸的新型α-三氟甲基-β-取代的β-氨基酸，其中β位取代基不限于芳环或取代芳族 环组，而α位和β位的相对立体化学也可以被控制。