摘要:
Method of treating a tumor in a mammal comprises administering to said mammal an effective anti-tumor amount of proteases originating from microorganisms.Method of treating a tumor in a mammal comprises administering to said mammal an effective anti-tumor amount of a protease originating from a microorganism which protease is chemically modified by one of the following procedures:(a) coupling with a saccharide,(b) introduction of a hydrophobic polymeric group,(c) alteration of electric charge of the protein surface,(d) conjugation with a low molecular weight anti-tumor agent of molecular weight less than 2,000,(e) formation of dimer or oligomer by cross-linking of protease molecules,(f) conjugation with a synthetic polycation,(g) conjugation with a synthetic polyanion, and(h) combination of the above-mentioned procedures.Microorganism protease is chemically modified by one of the following procedures:(a) coupling with a saccharide,(b) introduction of a hydrophobic polymeric group,(c) alteration of electric charge of the protein surface,(d) conjugation with a low molecular weight anti-tumor agent of molecular weight less than 2,000,(e) formation of dimer or oligomer by cross-linking of protease molecules,(f) conjugation with a synthetic polycation,(g) conjugation with a synthetic polyanion, and(h) combination of the above-mentioned procedures.
摘要:
A process for producing a conjugated diene polymer, which comprises polymerizing (a) a conjugated diene, (b) two or more conjugated dienes or (c) at least one conjugated diene with a monovinyl aromatic compound, at a temperature of from about 30 to about 100.degree. C in an inert hydrocarbon solvent in the presence of a catalyst composition comprising (i) an alkenyl sodium containing 3 to 8 carbon atoms in the alkenyl moiety and (ii) a sodium alkoxide of a dimethylalkyl carbinol containing 1 to 5 carbon atoms in the alkyl moiety.
摘要:
Internal combustion engine system includes an electric supercharger which supercharges sucked air; a throttle valve which adjusts the flow amount of intake air of supercharged air into a cylinder; an EGR path in which a part of exhaust gas exhausted from the exhaust manifold side is recirculated to the intake manifold side; an EGR valve which adjusts the amount of exhaust gas passing through the EGR path; and an internal combustion engine control unit which controls the throttle valve, the EGR valve, and the electric supercharger. This enables to satisfy both performance of the supercharger and fuel consumption of the internal combustion engine without complicating the structure of EGR.
摘要:
Disclosed is an ink composition for clear layer formation having excellent adhesion properties on substrates, recording layers, and clear layers, as well as excellent overcoat characteristics and refinishing properties. Further disclosed are a coating method for the ink composition, and a printed article formed using the ink composition. The ink composition for clear layer formation is used for forming at least one clear layer on a substrate, or on a printed article on which a printed coating film is formed on a substrate as a recording layer. The ink composition for clear layer formation is characterised in that: the surface free energy of the substrate is 30-45 (mJ/m2); the surface free energy of the recording layer is 40-50 (mJ/m2); the contact angle of the ink composition to the substrate is 30-65 degrees, the contact angle of the ink composition to the recording layer is 40-55 degrees, and the contact angle of the ink composition to the clear layer is 45-60 degrees.
摘要:
The motor control device includes: a vehicle control device (1) for generating a first torque command value Tref according to state quantities of the vehicle acquired from various sensors (7); a vehicle-resonance-compensation calculation unit (23) for extracting a frequency component generating a vehicle resonance from torque ripple components detected from an electrical angle ω of a motor for traveling (3) by a vehicle resonance component extraction filter (24), and generating a second torque command value Tcmp as a resonance compensation value for carrying out feedback control for the extracted frequency component; and an adder (20) for generating a torque command value Tref_cmp by subtracting the second torque command value Tcmp from the first torque command value Tref, and the motor (3) is controlled according to the torque command value. With this, it is possible to restrain the resonance of the vehicle caused by the torque ripple of the motor (3).
摘要:
Internal combustion engine system includes an electric supercharger which supercharges sucked air; a throttle valve which adjusts the flow amount of intake air of supercharged air into a cylinder; an EGR path in which a part of exhaust gas exhausted from the exhaust manifold side is recirculated to the intake manifold side; an EGR valve which adjusts the amount of exhaust gas passing through the EGR path; and an internal combustion engine control unit which controls the throttle valve, the EGR valve, and the electric supercharger. This enables to satisfy both performance of the supercharger and fuel consumption of the internal combustion engine without complicating the structure of EGR.
摘要:
A housing case that houses a fuel cell is provided with mounts for fixing two ends of a lower surface of an end plate that retains stacked unit cells of the fuel cell, and a mount for fixing a central portion of a lower surface of another end plate. Using these three mounts, the fuel cell is fixed to the housing case.
摘要:
The present invention provides a lactam compound, a sugar transport enhancement agent containing this compound as an active ingredient, an agent for the prevention and/or treatment of diabetes mellitus, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macrovascular disease, glucose tolerance anomaly, obesity and the like. In addition, the present invention also provides a preparation method for the novel lactam compound, and a preparation intermediate thereof.
摘要:
The present invention provides an antifouling coating composition, which can form an antifouling coating film capable of giving excellent slime resistance and has a property such that the recrystallization of an antifouling agent in a paint is depressed. The antifouling coating composition of the present invention is obtainable by blending a coating film forming resin (A) with as an antifouling agent, an inorganic copper antifouling agent (B) such as copper suboxide, etc and N,N′-dimethyl-N′-tolyl(N-fluorodichloromethylthio)sulfamide (C). The antifouling agent (B) is contained in an amount of preferably 60 to 1000 parts by weight based on 100 parts by weight of the coating film forming resin (A), and the antifouling agent (C) is contained in an amount of preferably 1.4 to 80 parts by weight based on 100 parts by weight of the coating film forming resin (A) and also the antifouling agent (C) is contained in an amount of preferably 0.1 to 100 parts by weight based on 100 parts by weight of the antifouling agent (B).
摘要:
When information on a device such as a server, storage, and an FC switch constituting a SNA system is input, these devices are displayed and arranged properly on a screen (S1, S2). When information on a physical path is input by a designer by using this display screen, a virtual SAN system in which the devices are connected by a fiber channel is displayed on the screen (S3). Furthermore, when information on an access path is input by the designer by using the construction image, the access path is additionally displayed on the construction image of the virtual SAN system (S5). Since the construction image of the virtual SAN system is displayed on the screen, the designer can easily create a design drawing while visually checking the SAN system. This can reduce the work load and time required for construction of the SAN system.