Near infrared chemical imaging microscope

    公开(公告)号:US20060164640A1

    公开(公告)日:2006-07-27

    申请号:US11366762

    申请日:2006-03-02

    IPC分类号: G01J3/28

    摘要: A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

    Near infrared chemical imaging microscope

    公开(公告)号:US20060091311A1

    公开(公告)日:2006-05-04

    申请号:US11257222

    申请日:2005-10-24

    IPC分类号: G01J5/02

    摘要: A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

    Raman spectral analysis of pathogens
    74.
    发明申请
    Raman spectral analysis of pathogens 有权
    拉曼光谱分析病原体

    公开(公告)号:US20060055923A1

    公开(公告)日:2006-03-16

    申请号:US11206007

    申请日:2005-08-17

    IPC分类号: G01J3/44 G01N21/65

    摘要: Raman scattering of radiation applied to a water sample is used to assess occurrence of a pathogen in the sample. The method is useful for detecting pathogens that are difficult to detect using other methods, such as protozoa. Examples of organisms that can be detected in water samples using these methods include protozoa of the genus Cryptosporidium and the genus Giardia. The methods described herein have important applications, such as for detection of Cryptosporidium organisms in municipal water systems.

    摘要翻译: 使用施加到水样品的辐射的拉曼散射来评估样品中病原体的发生。 该方法可用于检测使用其他方法(如原生动物)难以检测的病原体。 使用这些方法可以在水样中检测的生物体的实例包括隐孢子虫属和贾第虫属的原生动物。 本文描述的方法具有重要的应用,例如用于在市政水系统中检测隐孢子虫生物体。

    Near infrared chemical imaging microscope

    公开(公告)号:US20060033026A1

    公开(公告)日:2006-02-16

    申请号:US11256889

    申请日:2005-10-24

    IPC分类号: G01N21/35

    摘要: A chemical imaging system is provided which uses a near infrared radiation microscope. The system includes an illumination source which illuminates an area of a sample using light in the near infrared radiation wavelength and light in the visible wavelength. A multitude of spatially resolved spectra of transmitted, reflected, emitted or scattered near infrared wavelength radiation light from the illuminated area of the sample is collected and a collimated beam is produced therefrom. A near infrared imaging spectrometer is provided for selecting a near infrared radiation image of the collimated beam. The filtered images are collected by a detector for further processing. The visible wavelength light from the illuminated area of the sample is simultaneously detected providing for the simultaneous visible and near infrared chemical imaging analysis of the sample. Two efficient means for performing three dimensional near infrared chemical imaging microscopy are provided.

    Method and apparatus for compact birefringent interference imaging spectrometer
    77.
    发明申请
    Method and apparatus for compact birefringent interference imaging spectrometer 有权
    紧凑型双折射干涉成像光谱仪的方法和装置

    公开(公告)号:US20060007437A1

    公开(公告)日:2006-01-12

    申请号:US11216175

    申请日:2005-09-01

    IPC分类号: G01J3/44 G01N21/65

    摘要: The disclosure relates to a method and apparatus for a compact birefringent interference imaging spectrometer. More specifically, the disclosure relates to a portable system for obtaining a spectrum of a sample. The portable system may include a first photon emission source for illuminating the sample with a first plurality of photons to thereby produce photons scattered by the sample; an optical lens for collecting the scattered photons; a filter for receiving the collected scattered photons and providing therefrom filtered photons; a first photon detector for receiving the filtered photons and obtaining therefrom a spectrum of the sample; and a rejection filter for blocking the photons from said first photon emission source from entering said first photon detector. The disclosure additionally relates to methods of using such portable systems.

    摘要翻译: 本发明涉及紧凑型双折射干涉成像光谱仪的方法和装置。 更具体地,本公开涉及一种用于获得样品的光谱的便携式系统。 便携式系统可以包括用于用第一多个光子照射样品从而产生被样品散射的光子的第一光子发射源; 用于收集散射光子的光学透镜; 用于接收所收集的散射光子并从其提供过滤的光子的滤光器; 第一光子检测器,用于接收经滤光的光子并从中获得样品的光谱; 以及用于阻挡来自所述第一光子发射源的光子进入所述第一光子检测器的滤波器。 本公开另外涉及使用这种便携式系统的方法。

    System and method for spectroscopy and imaging
    79.
    发明申请
    System and method for spectroscopy and imaging 审中-公开
    用于光谱和成像的系统和方法

    公开(公告)号:US20060001868A1

    公开(公告)日:2006-01-05

    申请号:US10879633

    申请日:2004-06-30

    IPC分类号: G01J3/44 G01N21/65

    CPC分类号: G01J3/44 G01J3/0297 G01N21/65

    摘要: The disclosure relates to a substrate material for the improved detection, resolution and imaging of biological material for spectroscopic characterization by Raman of optical imaging spectroscopy. The substrate provides a uniform, optically flat, highly reflective surface which can be made hydrophobic to prevent spreading of the sample and facilitating its optical evaluation. Moreover, the substrate can be coated with a material that does not emit Raman scattered photons when exposed to said illuminating photons. The principles disclosed herein allow a low spectroscopic background particularly suitable for examining small samples or samples having low concentrations of the suspected component.

    摘要翻译: 本公开涉及用于通过光学成像光谱法的拉曼进行光谱表征的生物材料的改进的检测,分辨和成像的基底材料。 衬底提供均匀的光学平坦的高反射表面,其可以被制成疏水性以防止样品的扩散并且便于其光学评估。 此外,当暴露于所述照射光子时,衬底可以涂覆有不发射拉曼散射光子的材料。 本文公开的原理允许低光谱背景特别适合于检查具有低浓度可疑成分的小样品或样品。