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71.发明授权Therapy prediction and optimization for renal failure blood therapy, especially home hemodialysis 有权肾衰竭血液治疗的治疗预测和优化，特别是家庭血液透析公开(公告)号：US08845570B2
公开(公告)日：2014-09-30
申请号：US13088064
申请日：2011-04-15
Applicant: Alp Akonur , John Kenneth Leypoldt , Ying-Cheng Lo , Baris Ugar Agar
Inventor： Alp Akonur , John Kenneth Leypoldt , Ying-Cheng Lo , Baris Ugar Agar
CPC classification number: A61M1/1603 , A61M1/16 , A61M1/1611 , A61M1/1613 , A61M1/1619 , A61M1/3609 , A61M2202/0498 , A61M2205/15 , A61M2205/3584 , A61M2205/50 , A61M2205/502 , A61M2205/52 , A61M2230/20 , G06F19/3481
Abstract: A method of predicting serum phosphorus concentrations in a patient during hemodialysis includes measuring serum phosphorus concentrations of the patient over a hemodialysis treatment session time and an ultrafiltration rate calculated by a difference between pre- and post-dialytic body weight of the patient during an initial hemodialysis treatment session divided by a total treatment time of the treatment session and estimating a phosphorous mobilization clearance and a pre-dialysis distribution volume of phosphorus for the patient. Serum phosphorus concentrations of the patient can then be predicted at any time during any hemodialysis treatment session with the estimated phosphorous mobilization clearance and pre-dialysis distribution volume of phosphorus of the patient.
Abstract translation: 在血液透析期间预测患者血清磷浓度的方法包括测量血液透析治疗会话时间的患者的血清磷浓度，以及通过初始血液透析期间患者的透析前和透析后体重之间的差异计算的超滤率 治疗时间除以治疗会话的总治疗时间，并估计患者的磷的移动清除率和磷酸盐的透析前分布体积。 然后可以在任何血液透析治疗期间的任何时间预测患者的血清磷浓度，其中估计磷移动清除率和患者的磷的透析前分布体积。
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公开(公告)号：US08377012B2
公开(公告)日：2013-02-19
申请号：US12696889
申请日：2010-01-29
Applicant: Paul R. Chapman , Brian J. Connell , Ying-Cheng Lo
Inventor： Paul R. Chapman , Brian J. Connell , Ying-Cheng Lo
IPC: A61M5/00
CPC classification number: A61M1/285 , A61M39/12 , A61M39/28 , A61M39/286
Abstract: Transfer sets are disclosed in the present patent. The transfer set provides a connection between a source of peritoneal dialysis fluid and a patient for whom peritoneal dialysis has been prescribed. The transfer sets disclosed herein are smaller and provide a more compact and convenient device by which a dialysis patient controls the flow of dialysis fluid to and from the peritoneum of the patient. The devices are more compact and convenient because they include more convenient mechanisms for starting and stopping flow of the dialysis fluid. It is also easy to determine whether the mechanism is in a closed or open configuration by simply looking at the mechanism.
Abstract translation: 转让集合在本专利中公开。 转移组提供腹膜透析液源和已经规定了腹膜透析的患者之间的连接。 本文公开的转移组较小，并且提供更紧凑和方便的装置，通过该装置透析患者控制透过液流入和离开患者腹膜的流动。 这些装置更紧凑和便利，因为它们包括更方便的起始和停止透析液流动的机构。 通过简单地查看机制，也很容易确定机制是否处于关闭或打开配置。
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公开(公告)号：US20120071815A1
公开(公告)日：2012-03-22
申请号：US13195376
申请日：2011-08-01
Applicant: Robert W. Childers , Ying-Cheng Lo , Peter Hopping
Inventor： Robert W. Childers , Ying-Cheng Lo , Peter Hopping
IPC: A61M1/28
Abstract: The present system and method in one embodiment limit a maximum instantaneous peritoneal volume to a comfortable level, while allowing the dialysis machine to advance to fill a prescribed volume whenever the drain ends after a minimum drain percentage has been attained. If a low drain condition occurs, the nominal fill volume is lowered and a therapy cycle is added, so that a prescribed total amount of fresh therapy fluid is used during therapy, maximizing therapeutic benefit. An allowable residual volume at the end of an incomplete drain is increased, thereby lowering the probability of a subsequent low drain condition.
Abstract translation: 在一个实施例中，本系统和方法将最大瞬时腹膜容积限制到舒适水平，同时每当排水终点达到最小排水百分比后，允许透析机前进以填充规定的体积。 如果发生低排泄状况，则标称填充体积降低并加入治疗周期，使得在治疗期间使用规定的总量的新鲜治疗液，使治疗效果最大化。 在不完全排水结束时允许的剩余体积增加，从而降低随后的低排放条件的可能性。
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公开(公告)号：US20110303598A1
公开(公告)日：2011-12-15
申请号：US13213692
申请日：2011-08-19
Applicant: Ying-Cheng Lo , Robert W. Childers , Thomas D. Kelly , Justin Rohde
Inventor： Ying-Cheng Lo , Robert W. Childers , Thomas D. Kelly , Justin Rohde
IPC: B01D61/28
CPC classification number: A61M1/1639 , A61M1/16 , A61M1/1603 , A61M1/1605 , A61M1/1635 , A61M1/166 , A61M1/28 , A61M1/284 , A61M1/34 , A61M1/3627 , A61M2205/127 , A61M2205/3331 , A61M2205/3368 , A61M2205/502 , Y10T29/49826
Abstract: A hemodialysis system includes: (i) a dialyzer; (ii) a dialysate source; a dialysate pump; (iii) a dialysate cassette operatively connected to the dialysate pump such that the dialysate pump can pump dialysate through the dialysate cassette when the dialysate cassette is in fluid communication with the dialysate source, the dialysate cassette in fluid communication with the dialyzer; (iv) a blood pump; and (v) a blood cassette separate from the dialysate cassette, the blood cassette operatively connected to the blood pump such that the blood pump can pump blood through the blood cassette, the blood cassette including a housing, the housing including a from-patient tube connector, a to-patient tube connector, a saline/priming tube connector, a to-dialyzer tube connector, a from-dialyzer tube connector, and an internal air separation chamber.
Abstract translation: 血液透析系统包括：（i）透析器; （ii）透析液源; 透析泵; （iii）透析液盒，其可操作地连接到透析泵，使得透析液泵可以在透析液盒与透析液体流体连通时泵透透析液，透析液与透析器流体连通; （iv）血泵; 和（v）与透析液体盒分开的血盒，血盒与血液泵可操作地连接，使得血液泵能够通过血液盒吸入血液，血液盒包括壳体，该壳体包括从患者管 连接器，对讲管连接器，生理盐水/灌注管连接器，透析器管连接器，透析器管连接器和内部空气分离室。
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公开(公告)号：US20110297599A1
公开(公告)日：2011-12-08
申请号：US13213676
申请日：2011-08-19
Applicant: Ying-Cheng Lo , Robert W. Childers , Thomas D. Kelly , Justin Rohde
Inventor： Ying-Cheng Lo , Robert W. Childers , Thomas D. Kelly , Justin Rohde
CPC classification number: A61M1/1639 , A61M1/16 , A61M1/1603 , A61M1/1605 , A61M1/1635 , A61M1/166 , A61M1/28 , A61M1/284 , A61M1/34 , A61M1/3627 , A61M2205/127 , A61M2205/3331 , A61M2205/3368 , A61M2205/502 , Y10T29/49826
Abstract: A hemodialysis system for operation with a blood source and a dialysate source, the system including: (i) a first machine portion including a blood pump; (ii) a blood cassette operatively connected to the blood pump such that the blood pump can pump blood through the blood cassette when the blood cassette is in fluid communication with the blood source; (iii) a dialyzer fluidly connected to the blood cassette; (iv) a second machine portion separate from the first machine portion, the second machine portion including a dialysate pump; and (v) a dialysate cassette separate from the blood cassette, the dialysate cassette operatively connected to the dialysate pump such that the dialysate pump can pump dialysate through the dialysate cassette when the dialysate cassette is in fluid communication with the dialysate source, the dialysate cassette being fluidly connected to the dialyzer.
Abstract translation: 一种用于与血液源和透析液源一起操作的血液透析系统，该系统包括：（i）包括血液泵的第一机器部分; （ii）可操作地连接到所述血液泵的血盒，使得当所述血盒与所述血液源流体连通时，所述血泵可以将血液泵送通过所述血盒; （iii）流体地连接到血液盒的透析器; （iv）与第一机器部分分开的第二机器部分，第二机器部分包括透析泵; 和（v）与血液盒分离的透析液盒，所述透析液盒可操作地连接到透析泵，使得当透析液盒与透析液流体连通时透析液泵可以透析透析液，透析液盒 流体连接到透析器。
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Patent Agency Ranking
76.发明申请公开(公告)号：US20110297598A1
公开(公告)日：2011-12-08
申请号：US13213812
申请日：2011-08-19
Applicant: Ying-Cheng Lo , Robert W. Childers , Thomas D. Kelly , Justin Rohde
Inventor： Ying-Cheng Lo , Robert W. Childers , Thomas D. Kelly , Justin Rohde
CPC classification number: A61M1/1639 , A61M1/16 , A61M1/1603 , A61M1/1605 , A61M1/1635 , A61M1/166 , A61M1/28 , A61M1/284 , A61M1/34 , A61M1/3627 , A61M2205/127 , A61M2205/3331 , A61M2205/3368 , A61M2205/502 , Y10T29/49826
Abstract: A hemodialysis system includes (i) a dialyzer; (ii) a blood pump; (iii) a blood cassette operatively connected to the dialyzer and the blood pump; (iv) a dialysate heater; (v) first and second peristaltic dialysate pumps; and (vi) a dialysate cassette separate from the blood cassette, the dialysate cassette including an organizer configured to support a drain tube, a to-dialyzer tube and a from-dialyzer tube, the cassette further including a first pumping tube, a second pumping tube and an inline fluid heating pathway, the cassette when mounted for operation orienting (a) the first pumping tube for operation with the first peristaltic dialysate pump, (b) the second pumping tube for operation with the second peristaltic dialysate pump and (c) the fluid heating pathway for operation with the dialysate heater.
Abstract translation: 血液透析系统包括（i）透析器; （ii）血液泵; （iii）可操作地连接到透析器和血液泵的血盒; （iv）透析液加热器; （v）第一和第二蠕动透析液泵; 和（vi）与血液盒分离的透析盒，所述透析液盒包括构造成支撑排液管，透析器管和透析器管的组织器，所述盒还包括第一泵管，第二抽吸 管和管线流体加热通道，当安装用于操作时的盒子定向（a）用于与第一蠕动透析泵一起操作的第一泵管，（b）用于与第二蠕动透析泵一起操作的第二泵管，以及（c） 用于与透析液加热器一起操作的流体加热路径。
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公开(公告)号：US08038639B2
公开(公告)日：2011-10-18
申请号：US11530842
申请日：2006-09-11
Applicant: Ying-Cheng Lo , Robert W. Childers , Thomas D Kelly , Justin Rohde
Inventor： Ying-Cheng Lo , Robert W. Childers , Thomas D Kelly , Justin Rohde
CPC classification number: A61M1/1639 , A61M1/16 , A61M1/1603 , A61M1/1605 , A61M1/1635 , A61M1/166 , A61M1/28 , A61M1/284 , A61M1/34 , A61M1/3627 , A61M2205/127 , A61M2205/3331 , A61M2205/3368 , A61M2205/502 , Y10T29/49826
Abstract: A kidney failure therapy system includes: (a) a dilaysate supply; (b) at least one valve actuator; (c) at least one pump actuator; and (d) a disposable unit including first and second flexible sheets sealed together for form: (i) at least one flow path configured to be placed in fluid communication with the dilaysate supply; and operable with the at least one valve actuator; and (ii) at least one pumping portion configured to operate with the at least one pump actuator.
Abstract translation: 肾衰竭治疗系统包括：（a）稀释供应; （b）至少一个阀致动器; （c）至少一个泵致动器; 和（d）包括密封在一起的第一和第二柔性片的一次性单元，用于形成：（i）至少一个流路，被配置为与所述稀释物供应流体连通; 并且可与所述至少一个阀致动器一起操作; 和（ii）配置成与所述至少一个泵致动器一起操作的至少一个泵送部分。
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公开(公告)号：US20090124963A1
公开(公告)日：2009-05-14
申请号：US11938083
申请日：2007-11-09
Applicant: Michael E. Hogard , Donald D. Busby , Robert W. Childers , Yuanpang S. Ding , Katherine M. Holian , Mark E. Jablonski , Thomas D. Kelly , Ying-Cheng Lo , Shincy J. Maliekkal , Rodolfo G. Roger , Donald A. Smith , Atif M. Yardimci
Inventor： Michael E. Hogard , Donald D. Busby , Robert W. Childers , Yuanpang S. Ding , Katherine M. Holian , Mark E. Jablonski , Thomas D. Kelly , Ying-Cheng Lo , Shincy J. Maliekkal , Rodolfo G. Roger , Donald A. Smith , Atif M. Yardimci
IPC: A61M1/28
CPC classification number: A61M1/14 , A61M1/16 , A61M1/1605 , A61M1/1613 , A61M1/1635 , A61M1/166 , A61M1/1696 , A61M1/28 , A61M1/284 , A61M1/288 , A61M1/341 , A61M1/3413 , A61M1/3417 , A61M1/342 , A61M1/3427 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3444 , A61M1/3458 , A61M1/3465 , A61M1/3468 , A61M2205/12 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2205/3393
Abstract: A system and method for balancing flows of renal replacement fluid is disclosed. The method uses pressure controls and pressure sensing devices to more precisely meter and balance the flow of fresh dialysate and spent dialysate. The balancing system may use one or two balancing devices, such as a balance tube, a tortuous path, or a balance chamber.
Abstract translation: 公开了一种用于平衡肾替代液体流动的系统和方法。 该方法使用压力控制和压力感测装置来更精确地计量和平衡新鲜透析液和用过的透析液的流动。 平衡系统可以使用一个或两个平衡装置，例如平衡管，曲折路径或平衡室。
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公开(公告)号：US20090087654A1
公开(公告)日：2009-04-02
申请号：US12244594
申请日：2008-10-02
Applicant: Michael Tung-Kiung Ling , Moh-Ching Oliver Chang , Thomas John Myers , Ying-Cheng Lo
Inventor： Michael Tung-Kiung Ling , Moh-Ching Oliver Chang , Thomas John Myers , Ying-Cheng Lo
IPC: B32B5/00
CPC classification number: B32B27/32 , B32B7/00 , B32B7/06 , B32B27/08 , B32B27/325 , B32B2250/24 , B32B2250/42 , B32B2274/00 , B32B2307/306 , B32B2307/31 , B32B2439/70 , B32B2439/80 , Y10T428/269 , Y10T428/31743 , Y10T428/31909
Abstract: Films containing microlayer structures are provided. In a general embodiment, the present disclosure provides an autoclavable film containing a first microlayer of a heat resistant polymer and a second microlayer of a flexible polymer attached to the first microlayer. Each of the first microlayer and the second microlayer has a thickness ranging between about 0.01 microns and about 10 microns.
Abstract translation: 提供了含有微层结构的薄膜。 在一般实施例中，本公开提供了一种耐高压灭菌膜，其包含耐热聚合物的第一微层和附着到第一微层的柔性聚合物的第二微层。 第一微层和第二微层中的每一个具有约0.01微米至约10微米的厚度。
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公开(公告)号：US07217356B2
公开(公告)日：2007-05-15
申请号：US11198804
申请日：2005-08-05
Applicant: William H. Cork , James J. Ulmes , Richard L. West , Ying-Cheng Lo , Mark C. Weber , Kyungyoon Min
Inventor： William H. Cork , James J. Ulmes , Richard L. West , Ying-Cheng Lo , Mark C. Weber , Kyungyoon Min
IPC: B01D61/32
CPC classification number: A61B5/14546 , A61B5/14557 , A61B5/417 , A61B50/13 , A61B2562/028 , A61M1/0209 , A61M1/3609 , A61M1/367 , A61M1/3696 , A61M1/38 , A61M2205/12 , A61M2205/33 , A61M2205/52 , A61M2230/20 , B01D61/22 , G01N33/491 , G01N33/5005 , G01N33/5094 , G01N35/08 , G01N2035/00237 , Y10T436/117497
Abstract: A biological suspension processing system is disclosed that may include a suspension treatment device for treating one or more components of a biological suspension, a first fluid flow path for introducing a suspension into the treatment device and a second fluid flow path for withdrawing a constituent of the suspension from the device. At least one microelectromechanical (MEM) sensor communicates with one of the fluid flow paths for sensing a selected characteristic of the fluid therewith. The MEM sensor may be located elsewhere, such as on a container or bag and communicate with the interior for sensing a characteristic of the fluid contained therein. A wide variety of characteristics may be sensed, such as flow rate, pH, cell type, cell antigenicity, DNA, viral or bacterial presence, cholesterol, hematocrit, cell concentration, cell count, partial pressure, pathogen presence, or viscosity.
Abstract translation: 公开了一种生物悬浮处理系统，其可以包括用于处理生物悬浮液的一种或多种组分的悬浮处理装置，用于将悬浮液引入处理装置的第一流体流动路径和用于取出生物悬浮液的成分的第二流体流动路径 从设备暂停。 至少一个微机电（MEM）传感器与流体流动路径中的一个通信，用于感测流体的选定特性。 MEM传感器可以位于别处，例如在容器或袋上，并与内部连通，以便感测其中所含流体的特性。 可以检测各种各样的特征，例如流速，pH，细胞类型，细胞抗原性，DNA，病毒或细菌存在，胆固醇，血细胞比容，细胞浓度，细胞计数，分压，病原体存在或粘度。
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