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公开(公告)号：US11535618B2
公开(公告)日：2022-12-27
申请号：US17282521
申请日：2019-10-04
Applicant: FORMA Therapeutics, Inc.
Inventor： Alex J. Buckmelter , Justin Andrew Caravella , Hongbin Li , Matthew W. Martin , Steven Mischke , David James Richard , Angela V. West
IPC: C07D471/18 , C07D403/12 , C07D471/08 , C07D487/08 , C07D487/18 , C07D491/107
Abstract: The disclosure relates to USP30 Inhibitor Compounds I, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising same, and medical uses involving same. (I)
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公开(公告)号：US20220169647A1
公开(公告)日：2022-06-02
申请号：US17669135
申请日：2022-02-10
Applicant: FORMA Therapeutics, Inc.
Inventor： Shawn E.R. Schiller , Torsten Herbertz , Hongbin Li , Bradford Graves , Steven Mischke , Angela V. West , Jennifer R. Downing , Anna Ericsson
IPC: C07D471/04 , A61P35/00 , C07D519/00
Abstract: The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.
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公开(公告)号：US11311527B2
公开(公告)日：2022-04-26
申请号：US16893147
申请日：2020-06-04
Applicant: FORMA Therapeutics, Inc.
Inventor： Patrick F. Kelly , Susan Ashwell , Blythe Thomson , Alan Collis , Jeff Davis , Duncan Walker , Wei Lu
IPC: A61K31/4709 , A61P35/00
Abstract: Patients diagnosed with a cancer harboring an IDH-1 mutation can be treated by the administration of a therapeutically effective amount of a pharmaceutical composition comprising Compound 1, a selective inhibitor of 2-HG production from mIDH-1 enzymes including the R132 mutations R132C, R132H, R132L, R132G, and R132S.
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公开(公告)号：US20210308108A1
公开(公告)日：2021-10-07
申请号：US17351389
申请日：2021-06-18
Applicant: FORMA Therapeutics, Inc.
Inventor： Anna Ericsson , Neal Green , Gary Gustafson , David R. Lancia, JR. , Gary Marshall , Lorna Mitchell , David Richard , Zhongguo Wang
IPC: A61K31/436 , A61P7/06 , A61K9/00 , C07D487/04
Abstract: This disclosure provides compounds and compositions for activating pyruvate kinase R (PKR) and related methods of manufacturing and using these compounds and compositions.
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公开(公告)号：US20210214323A1
公开(公告)日：2021-07-15
申请号：US17187061
申请日：2021-02-26
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , David R. Lancia, JR. , Hongbin LI , James Loch , Wei Lu , Matthew W. Martin , David S. Millan , Shawn E.R. Schiller , Mark J. Tebbe
IPC: C07D295/192 , A61K45/06 , C07D215/14 , C07D231/56 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D257/04 , C07D487/04 , C07D263/57 , C07D491/048 , C07D271/12 , C07D495/04 , C07D209/18 , C07D277/62 , C07D277/66 , C07D513/04 , C07D213/56 , C07D305/08 , A61K31/4965 , A61P35/00 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/5025 , A61K31/506 , C07D209/08 , C07D213/65 , C07D213/69 , C07D217/16 , C07D231/12 , C07D235/08 , C07D401/04 , C07D403/04 , C07D417/04
Abstract: The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
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Patent Agency Ranking
公开(公告)号：US10550098B2
公开(公告)日：2020-02-04
申请号：US16290240
申请日：2019-03-01
Applicant: FORMA Therapeutics, Inc.
Inventor： Jian Lin , Anna Ericsson , Ann-Marie Campbell , Gary Gustafson , Zhongguo Wang , R. Bruce Diebold , Susan Ashwell , David R. Lancia, Jr. , Justin Andrew Caravella , Wei Lu
IPC: C07D401/12 , C07D401/14 , C07D471/04 , A61P35/00 , A61K31/47
Abstract: The invention relates to inhibitors of mutant isocitrate dehydrogenase (mt-IDH) proteins with neomorphic activity useful in the treatment of cell-proliferation disorders and cancers, having the Formula: where A, U, W1, W2, W3, R1-R6, and R9 are described herein.
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公开(公告)号：US20200017458A1
公开(公告)日：2020-01-16
申请号：US16566119
申请日：2019-09-10
Applicant: FORMA Therapeutics, Inc.
Inventor： Kenneth W. Bair , David R. Lancia, JR. , Hongbin LI , James Loch , Wei Lu , Matthew W. Martin , David S. Millan , Shawn E.R. Schiller , Mark J. Tebbe
IPC: C07D295/192 , C07D417/04 , C07D403/04 , C07D401/04 , C07D235/08 , C07D231/12 , C07D217/16 , C07D213/69 , C07D213/65 , C07D209/08 , A61K31/506 , A61K31/5025 , A61K31/4985 , A61K31/497 , A61K31/496 , A61K31/495 , A61K31/4965 , C07D305/08 , C07D213/56 , C07D513/04 , C07D277/66 , C07D277/62 , C07D209/18 , C07D495/04 , C07D271/12 , C07D491/048 , C07D263/57 , C07D487/04 , C07D257/04 , C07D471/04 , C07D417/12 , C07D413/12 , C07D405/12 , C07D231/56 , C07D215/14 , A61K45/06
Abstract: The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:
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公开(公告)号：US10532047B2
公开(公告)日：2020-01-14
申请号：US16414716
申请日：2019-05-16
Applicant: FORMA Therapeutics, Inc.
Inventor： George P. Luke
IPC: C07D471/04 , A61K31/4709 , A61K47/12 , A61K47/38 , A61K9/00
Abstract: The present disclosure reports solid forms of ((S)-5-((1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)amino)-1-methyl-6-oxo-1,6-dihydropyridine-2-carbonitrile.
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公开(公告)号：US10508098B2
公开(公告)日：2019-12-17
申请号：US16179099
申请日：2018-11-02
Applicant: FORMA Therapeutics, Inc.
Inventor： Stephanos Ioannidis , Adam Charles Talbot , Bruce Follows , Alexandre Joseph Buckmelter , Minghua Wang , Ann-Marie Campbell , David R. Lancia, Jr.
IPC: C07D401/06 , C07D487/04 , C07D471/04 , C07D239/88
Abstract: The present disclosure relates to inhibitors of USP7 inhibitors useful in the treatment of cancers, neurodegenerative diseases, immunological disorders, inflammatory disorders, cardiovascular diseases, ischemic diseases, viral infections and diseases, and bacterial infections and diseases, having the Formula: where R1, R2, R3, R4, R4′, X1, Y1, Y2, Y3, Y4, n, and m are described herein.
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公开(公告)号：US10508088B2
公开(公告)日：2019-12-17
申请号：US16202207
申请日：2018-11-28
Applicant: FORMA Therapeutics, Inc.
Inventor： Jennifer Lee , Nicholas Barczak , Jaime A. Escobedo , Chiara Conti , Bingsong Han , David R. Lancia, Jr. , Cuixian Liu , Matthew W. Martin , Pui Yee Ng , Aleksandra Rudnitskaya , Jennifer R. Thomason , Xiaozhang Zheng
IPC: C07D263/58 , A61P35/00 , A61K31/403 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/4192 , A61K31/422 , A61K31/423 , A61K31/4245 , A61K31/427 , A61K31/428 , A61K31/435 , A61K31/437 , A61K31/438 , A61K31/4439 , A61K31/4709 , A61K31/4985 , A61K31/506 , A61K31/52 , A61K31/5377 , A61K31/5383 , A61K45/06 , C07C53/06 , C07D209/40 , C07D209/54 , C07D221/20 , C07D235/30 , C07D277/82 , C07D401/04 , C07D401/06 , C07D401/14 , C07D403/04 , C07D403/06 , C07D405/04 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D473/00 , C07D487/04 , C07D491/056 , C07D491/107 , C07D498/04
Abstract: The present invention provides methods and uses of inhibitors of histone deacetylase 11 (HDAC11) in the treatment of diseases and/or disorders, such as, for example, cell proliferative diseases.
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