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    Mixture of HMOs
    71.
    发明授权
    Mixture of HMOs 有权

    公开(公告)号：US11432578B2

    公开(公告)日：2022-09-06

    申请号：US16062598

    申请日：2016-12-15

    Applicant: GLYCOM A/S

    Inventor： Bruce McConnell ,  Louise Kristine Vignæs

    IPC: A23L33/00 ,  A61K31/702 ,  A23L33/135 ,  A61P31/12 ,  A61P31/04 ,  A23L33/12 ,  A23L33/19 ,  A23L33/195

    Abstract: A synthetic mixture of human milk oligosaccharides (HMOs) consisting essentially of lacto-N-neotetraose (LNnT), lacto-N-tetraose (LNT), 2′-fucosyllactose (2′FL), 3′-O-sialyllactose (3′-SL), 6′-O-sialyllactose (6′-SL) either difucosyllactose (DFL) or 3-fucosyllactose (3-FL), preferably DFL, and optionally lactose. Said synthetic composition is useful for: treating or preventing viral and/or bacterial infection in a non-infant human; modulating the microbiota of a non-infant human; and/or improving the cognitive function of a non-infant human and as a pharmaceutical or nutritional composition.

    MIXTURE OF HMOS FOR TREATING AUTOIMMUNE DISEASES
    77.
    发明申请
    MIXTURE OF HMOS FOR TREATING AUTOIMMUNE DISEASES 有权

    公开(公告)号：US20210213038A1

    公开(公告)日：2021-07-15

    申请号：US17059942

    申请日：2019-05-31

    Applicant: Glycom A/S

    Inventor： Louise Kristine Vigsnæs ,  Bruce McConnell ,  Kristine Rothaus Christensen

    IPC: A61K31/702

    Abstract: The invention relates to a method, compounds and compositions for the secondary prevention, treatment or dietary management of symptomatic and asymptomatic non-intestinal autoimmune diseases in a non-infant human including Sjogren's syndrome and type 1 diabetes. Said method, compounds and compositions for the secondary prevention, treatment or dietary management include human milk oligosaccharide (HMO), preferably mixtures of human milk oligosaccharides selected from the group of 2′-FL, LNnT, LNT, DFL, and 6′-SL.

    NUCLEIC ACID CONSTRUCT FOR IN VITRO AND IN VIVO GENE EXPRESSION
    79.
    发明申请
    NUCLEIC ACID CONSTRUCT FOR IN VITRO AND IN VIVO GENE EXPRESSION 有权

    公开(公告)号：US20210102216A1

    公开(公告)日：2021-04-08

    申请号：US16956092

    申请日：2018-12-19

    Applicant: GLYCOM A/S

    Inventor： Margit PEDERSEN ,  Manos PAPADAKIS

    IPC: C12N15/70

    Abstract: The present invention relates to the field of recombining production of biological molecules in host cells. The invention provides nucleic acid constructs that allow to modify expression of a desired gene using both in vitro and in vivo gene expression systems. The constructs can advantageously be used to produce a variety of biological molecules recombinantly in industrial scales, e.g. human milk oligosaccharides (HMO).

    Mixtures of HMOs
    80.
    发明授权
    Mixtures of HMOs 有权

    公开(公告)号：US10946032B2

    公开(公告)日：2021-03-16

    申请号：US16435949

    申请日：2019-06-10

    Applicant: Glycom A/S

    Inventor： Elise Champion ,  Bruce McConnell ,  Gyula Dekany

    IPC: A61K31/702 ,  C07H5/06 ,  C12P19/26 ,  A61K31/715 ,  C12P19/18 ,  A61K31/7016

    Abstract: The invention relates to a mixture of human milk oligosaccharides that consists essentially of: a) a component A which is 3-FL or DFL, a component B which is LNT, LNnT, LNFP-I or 2′-FL, a component C, which is LNFP-II when component B is LNT, or LNFP-III when component B is LNnT, or LNDFH-I when component B is LNFP-I, or DFL when component B is 2′-FL, and a component D, which is lactose when component A is 3-FL, or 2′-FL when component A is DFL, with the proviso that if component B is 2′-FL, then component A is 3-FL; or consists essentially of: b) 3-FL, a component E which is LNT, LNnT or LNFP-I, and a component F, which is LNFP-II when component E is LNT, or LNFP-III when component E is LNnT, or LNDFH-I when component E is LNFP-I, and to processes for producing them and their uses.

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