公开(公告)号：US20060128630A1

公开(公告)日：2006-06-15

申请号：US11280954

申请日：2005-11-16

申请人： Joseph Harding ,  John Wright

发明人： Joseph Harding ,  John Wright

IPC分类号： A61K38/08

CPC分类号： A61K38/06 ,  A61K38/05 ,  A61K38/07 ,  A61K38/08

摘要： AT4 receptor agonists are potent activators of angiogenesis and can be used to treat diseases that are characterized by vascular insufficiency. AT4 receptor antagonists, which are potent inhibitors of angiogenesis, and can be used as anti-angiogenic agents for the treatment of cancer, diabetic retinopathy, rheumatoid arthritis, psoriasis, atherosclerotic plaque formation, and any disease process that is characterized by excessive, undesired or inappropriate angiogenesis or proliferation of endothelial cells.

公开(公告)号：US20060066434A1

公开(公告)日：2006-03-30

申请号：US10535315

申请日：2003-11-18

申请人： Robert Richards ,  David Bahr ,  Cecilia Richards

发明人： Robert Richards ,  David Bahr ,  Cecilia Richards

IPC分类号： H01H61/00

CPC分类号： H01L23/34 ,  B82Y30/00 ,  F25B2400/15 ,  F28F13/00 ,  F28F2013/008 ,  H01L2924/0002 ,  H01L2924/00

摘要： The present disclosure concerns embodiments of a thermal switch used to control the transfer of heat from a heat source to a heat sink. According to one aspect, the thermal switch can be activated, or turned “on”, so as to establish a path of low thermal resistance between the heat source and the heat sink to facilitate the transfer of heat therebetween. The thermal switch can also be de-activated, or turned “off”, so as to establish a path of high thermal resistance between the heat source and the heat sink to minimize or totally prevent the transfer of heat between the heat source and heat sink. In certain embodiments, the thermal switch includes at least drop of a thermally conductive liquid that thermally couples the heat source to the heat sink whenever the switch is activated.

摘要翻译： 本公开涉及用于控制从热源到散热器的热传递的热开关的实施例。 根据一个方面，热开关可以被激活或变为“接通”，以便在热源和散热器之间建立低热阻的路径，以便于它们之间的热传递。 热开关也可以被去激活或关闭，以便在热源和散热器之间建立高热阻的路径，以最小化或完全防止热源和散热器之间的热传递 。 在某些实施例中，热开关包括至少一滴导热液体，每当该开关被激活时，其将热源热耦合到散热器。

公开(公告)号：US06857224B1

公开(公告)日：2005-02-22

申请号：US09830529

申请日：1999-10-26

申请人： Rudolf Kammereck ,  Lawrence E. Schrader

发明人： Rudolf Kammereck ,  Lawrence E. Schrader

IPC分类号： A01N3/00 ,  A01N61/00 ,  A23B7/157 ,  A23B7/16 ,  A01B79/00 ,  A01G1/00 ,  A01H3/00

CPC分类号： A01N61/00 ,  A01N3/00 ,  A23B7/157 ,  A23B7/16 ,  Y10S47/06 ,  Y10S47/11

摘要： Sunburn and insect damage to fruit and vegetable crops is significantly reduced by treatment of both fruit and foliage with a preventative amount of thixotropic smectic clay material, chemically altered to render its surface lipophilic, which is combined with a wax emulsion comprising a matrix of complex hydrocarbons, an emulsifying agent and water. In the practice of this invention the sunburn and insect protective composition is further diluted in an aqueous solution that is sprayable by commercial applicators.

摘要翻译： 通过用预防量的触变性近晶粘土材料处理水果和植物作物，对水果和蔬菜作物的灼伤和昆虫损害显着降低，化学改变以使其表面亲油，其与包含复杂烃基质的蜡乳液 ，乳化剂和水。 在本发明的实践中，晒伤和昆虫防护组合物进一步在可由商业施用器喷雾的水溶液中稀释。

公开(公告)号：US06854337B1

公开(公告)日：2005-02-15

申请号：US10635978

申请日：2003-08-07

申请人： Julie M. Tarara ,  John C. Ferguson ,  Francis J. Pierce ,  Marvin J. Pitts ,  Gary M. Hyde ,  Robert L. Wample ,  Andre L. Baritelle

发明人： Julie M. Tarara ,  John C. Ferguson ,  Francis J. Pierce ,  Marvin J. Pitts ,  Gary M. Hyde ,  Robert L. Wample ,  Andre L. Baritelle

IPC分类号： A01G1/00 ,  A01G17/06 ,  G01G19/14 ,  G01N3/08

CPC分类号： G01G19/14 ,  A01G2/00 ,  A01G17/06 ,  A01G2017/065

摘要： The present disclosure concerns apparatus and methods useful in estimating crop yields of plants that are supported on a trellis. According to one aspect, a method for measuring the mass of trellised plant structures includes measuring the tension of a support wire of the trellis structure on which the plant structures are supported, such as with a load cell placed in-line with the support wire. The tension of the support wire is converted into the mass of new plant growth supported on the support wire, using, for example, an empirically derived algorithm specific to the trellis structure.

摘要翻译： 本公开涉及用于估计支撑在格子上的植物的作物产量的装置和方法。 根据一个方面，一种用于测量格栅植物结构的质量的方法包括测量支撑植物结构的网状结构的支撑线的张力，例如与放置在支撑线上的负载单元一起放置。 使用例如特定于网格结构的经验导出的算法将支撑线的张力转换成支撑在支撑线上的新植物生长的质量。

公开(公告)号：US20030175861A1

公开(公告)日：2003-09-18

申请号：US10025145

申请日：2001-12-19

申请人： Washington State University Research Foundation

发明人： C.L. Steele ,  Joerg Bohlmann ,  Rodney B. Croteau ,  Michael A. Phillips

IPC分类号： A01H007/00 ,  C07H021/04 ,  C12N009/00 ,  C12N009/10 ,  C12P021/02 ,  C12N005/04

CPC分类号： C11B1/00 ,  A23D9/00 ,  C12N9/88 ,  C12N15/8242 ,  C12N15/8243

摘要： cDNAs encoding gymnosperm monoterpene synthases have been isolated and sequenced, and the corresponding amino acid sequences have been determined. Modified host cells are provided that have been transformed, transfected, infected and/or injected with a recombinant cloning vehicle and/or DNA sequence encoding a monoterpene synthase of the invention. Thus, systems and methods are provided for the recombinant expression of recombinant monoterpene synthases that may be used to facilitate their production, isolation and purification in significant amounts.

摘要翻译： 已经分离并测序了编码裸子植物单萜合酶的cDNA，并确定了相应的氨基酸序列。 提供已经用编码本发明的单萜合酶的重组克隆载体和/或DNA序列转化，转染，感染和/或注射的修饰的宿主细胞。 因此，提供用于重组表达重组单萜合酶的系统和方法，其可用于促进其显着量的产生，分离和纯化。

公开(公告)号：US20030166176A1

公开(公告)日：2003-09-04

申请号：US10356153

申请日：2003-01-29

申请人： Washington State University Research Foundation

发明人： Rodney B. Croteau ,  Anne Schoendorf ,  Stefan Jennewein

IPC分类号： C12P017/02 ,  C07H021/04 ,  C12N009/02 ,  C12P021/02 ,  C12N005/04 ,  C07D35/14

CPC分类号： C12P17/02 ,  A01K2217/05 ,  C12N9/0077

摘要： Oxygenase enzymes and the use of such enzymes to produce paclitaxel (Taxolnull) related taxoids, as well as intermediates in the Taxolnull biosynthetic pathway are disclosed. Also disclosed are nucleic acid sequences encoding the oxygenase enzymes. Particular oxygenase enzymes include the disclosed taxoid-14-beta hydroxylases.

摘要翻译： 公开了加氧酶和使用这些酶来生产紫杉醇（Taxol））相关的紫杉烷类，以及生物合成途径中的中间体。 还公开了编码加氧酶的核酸序列。 特别的加氧酶包括所公开的紫杉烷-14-β羟化酶。

公开(公告)号：US20020177147A1

公开(公告)日：2002-11-28

申请号：US10044671

申请日：2002-01-10

申请人： Washington State University Research Foundation

发明人： Katrina L. Mealey ,  Steven A. Bentjen

IPC分类号： C12Q001/68

CPC分类号： C12N15/8509 ,  A01K2217/05 ,  A01K2227/00 ,  A01K2267/02 ,  A01K2267/03 ,  A61K49/0008 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156 ,  C12Q2600/158 ,  G01N33/6893

摘要： This invention provides the identification of a truncation polymorphism of the mdr1 gene that is linked to ivermectin sensitivity in subjects, such as collies. Also provided are methods for detecting drug transport sensitivity in a subject, and animal models and in vitro cell systems using cells from animals having an mdr1 truncation.

摘要翻译： 本发明提供了与受试者（例如，乳制品）中的伊维菌素敏感性相关的mdr1基因的截短多态性的鉴定。 还提供了用于检测受试者中药物转运敏感性的方法，以及使用具有mdr1截短的动物的细胞的动物模型和体外细胞系统。

公开(公告)号：US6156546A

公开(公告)日：2000-12-05

申请号：US80025

申请日：1998-05-15

申请人： Michael E. Konkel ,  Steven G. Garvis

发明人： Michael E. Konkel ,  Steven G. Garvis

IPC分类号： C07K14/205 ,  C12Q1/68 ,  C12P19/34 ,  C07H21/04

CPC分类号： C07K14/205 ,  C12Q1/689

摘要： A novel gene encoding a 37 kDa outer membrane protein from Campylobacter coli M275 has been cloned and sequenced. This protein has been named CadF and is expressed in a large number of clinical isolates of Campylobacter species. The invention also provides assays for detecting the presence of pathogenic Campylobacter species based on the antibody-based detection of CadF, or the polymerase chain reaction (PCR)-based amplification of a segment of the C. coli cadF gene.

摘要翻译： 已经克隆并测序了来自弯曲杆菌M275的编码37kDa外膜蛋白的新基因。 该蛋白质被命名为CadF，并在大量临床分离的弯曲杆菌属物种中表达。 本发明还提供了基于基于抗体的CadF检测或基于聚合酶链反应（PCR）的大肠杆菌cadF基因片段的扩增来检测病原性弯曲杆菌物种的存在的测定法。

公开(公告)号：US6083731A

公开(公告)日：2000-07-04

申请号：US881784

申请日：1997-06-24

申请人： Rodney Bruce Croteau ,  Shari Lee Lupien ,  Frank Karp

发明人： Rodney Bruce Croteau ,  Shari Lee Lupien ,  Frank Karp

IPC分类号： C12N1/21 ,  C12N9/02 ,  C12N15/53

CPC分类号： C12N9/0071 ,  C12N2799/026

摘要： cDNA encoding (-)-limonene-6-hydroxylase from spearmint and (-)-limonene-3-hydroxylase from peppermint have been isolated and sequenced, and the corresponding amino acid sequences have been determined. Accordingly, isolated DNA sequences are provided which code for the expression of (-)-limonene-6-hydroxylase from spearmint (SEQ ID No:1, from Mentha spicata) and (-)-limonene-3-hydroxylase from peppermint (SEQ ID No:8, from Mentha piperita). In other aspects, replicable recombinant cloning vehicles are provided which code for limonene hydroxylase or for a base sequence sufficiently complementary to at least a portion of the limonene hydroxylase DNA or RNA to enable hybridization therewith (e.g., antisense limonene hydroxylase RNA or fragments of complementary limonene hydroxylase DNA which are useful as polymerase chain reaction primers or as probes for limonene hydroxylase or related genes). In yet other aspects, modified host cells are provided that have been transformed, transfected, infected and/or injected with a recombinant cloning vehicle and/or DNA sequence encoding limonene hydroxylase. Thus, systems and methods are provided for the recombinant expression of limonene hydroxylase that may be used to facilitate the production, isolation and purification of significant quantities of recombinant limonene hydroxylase (or of the primary enzyme products, trans-carveol or trans-isopiperitenol, respectively) for subsequent use, to obtain expression or enhanced expression of limonene hydroxylase in plants to attain enhanced production of trans-carveol or trans-isopiperitenol as a predator or pathogen defense mechanism, or may be otherwise employed for the regulation or expression of limonene hydroxylase or the production of trans-carveol or trans-isopiperitenol.

摘要翻译： 从薄荷和（ - ） - 柠檬烯-3-羟化酶从薄荷中编码（ - ） - 柠檬烯-6-羟化酶的cDNA已被分离并测序，并确定了相应的氨基酸序列。 因此，提供了分离的DNA序列，其编码来自薄荷的（ - ） - 柠檬烯-6-羟化酶的表达（SEQ ID No：1，来自Mentha spicata）和（ - ） - 来自薄荷的（ - ） - 柠檬烯-3-羟化酶 否：8，来自Mentha piperita）。 在其他方面，提供可复制的重组克隆载体，其编码柠檬烯羟化酶或与至少一部分柠檬烯羟化酶DNA或RNA充分互补的碱基序列，以使其能够进行杂交（例如，反义柠檬烯羟化酶RNA或互补柠檬烯的片段 可用作聚合酶链反应引物或作为柠檬烯羟化酶或相关基因的探针的羟化酶DNA）。 在另一方面，提供已经用编码柠檬烯羟化酶的重组克隆载体和/或DNA序列转化，转染，感染和/或注射的修饰的宿主细胞。 因此，提供了用于重组表达柠檬烯羟化酶的系统和方法，其可用于促进显着量的重组柠檬烯羟化酶（或主要酶产物，反式肉豆蔻酸或反式异戊烯醇的生产，分离和纯化） ），以获得植物中柠檬烯羟化酶的表达或增强的表达，以获得增强的生产反糠醛或反式异戊烯醇作为捕食者或病原体防御机制，或者可以另外用于调节或表达柠檬烯羟化酶或 生产反式槟榔醇或反式异戊烯醇。

公开(公告)号：USPP11385P

公开(公告)日：2000-05-16

申请号：US66066

申请日：1998-04-24

申请人： Thomas K. Toyama

发明人： Thomas K. Toyama

摘要： A new and distinct variety of self-infertile sweet cherry tree which bears very large mahogany red colored fruits that are 10-14 grams in weight. Its fruits, which are well suited for the high quality early season premium market, ripen six to nine days ahead of the commercially grown `Bing` variety, to which in many ways the new variety is comparable.