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    Catheter with cryogenic and electrical heating ablation
    71.
    发明申请
    Catheter with cryogenic and electrical heating ablation 有权
    导管用低温和电加热消融

    公开(公告)号：US20060004351A1

    公开(公告)日：2006-01-05

    申请号：US11219061

    申请日：2005-09-02

    申请人： Steven Arless ,  Fredric Milder ,  Marwan Abboud ,  Dan Wittenberger ,  Sean Carroll

    发明人： Steven Arless ,  Fredric Milder ,  Marwan Abboud ,  Dan Wittenberger ,  Sean Carroll

    IPC分类号： A61B18/02 ,  A61B18/18 ,  A61B18/14 ,  A61B5/04

    CPC分类号： A61B18/02 ,  A61B18/1492 ,  A61B18/18 ,  A61B2017/00243 ,  A61B2018/0212 ,  A61B2018/0268

    摘要： A catheter includes a cryoablation tip with an electrically-driven ablation assembly for heating tissue. The cryoablation tip may be implemented with a cooling chamber through which a controllably injected coolant circulates to lower the tip temperature, and having an RF electrode at its distal end. The RF electrode may be operated to warm cryogenically-cooled tissue, or the coolant may be controlled to conductively cool the tissue in coordination with an RF treatment regimen, allowing greater versatility of operation and enhancing the lesion size, speed or placement of multi-lesion treatment or single lesion re-treatment cycles. In one embodiment a microwave energy source operates at a frequency to extend beyond the thermal conduction depth, or to penetrate the cryogenic ice ball and be absorbed in tissue beyond an ice boundary, thus extending the depth and/or width of a single treatment locus. In another embodiment, the cooling and the application of RF energy are both controlled to position the ablation region away from the surface contacted by the electrode, for example to leave surface tissue unharmed while ablating at depth or to provide an ablation band of greater uniformity with increasing depth. The driver or RF energy source may supply microwave energy at a frequency effective to penetrate the ice ball which develops on a cryocatheter, and different frequencies may be selected for preferential absorption in a layer of defined thickness at depth in the nearby tissue. The catheter may operate between 70 and minus 70 degrees Celsius for different tissue applications, such as angioplasty, cardiac ablation and tissue remodeling, and may preset the temperature of the tip or adjacent tissue, and otherwise overlay or delay the two different profiles to tailor the shape or position where ablation occurs or to speed up a treatment cycle.

    摘要翻译： 导管包括具有用于加热组织的电驱动消融组件的冷冻消融尖端。 冷冻消融尖端可以用冷却室来实现，通过该冷却室可控制地注入的冷却剂循环以降低尖端温度，并且在其远端具有RF电极。 RF电极可以被操作以加热低温冷却的组织，或者可以控制冷却剂以与RF治疗方案协调地导电地冷却组织，从而允许操作的更大的通用性和增强病变大小，速度或放置多病变 治疗或单次病变再治疗周期。 在一个实施例中，微波能量源的频率以超出热传导深度的频率运行，或者穿透低温冰球并被吸收在超过冰界的组织中，从而延长单个处理轨迹的深度和/或宽度。 在另一个实施例中，RF能量的冷却和应用都被控制以将消融区域远离与电极接触的表面，例如在深度消融时留下表面组织而不受伤害，或者提供具有更大均匀性的消融带， 增加深度。 驱动器或RF能源可以以有效穿透在低温导管上形成的冰球的频率提供微波能量，并且可以选择不同的频率用于在附近组织的深度处的限定厚度的层中的优先吸收。 对于不同的组织应用（例如血管成形术，心脏消融和组织重建），导管可以在70摄氏度和零下70度之间运行，并且可以预设尖端或相邻组织的温度，否则叠加或延迟两个不同的轮廓以定制 消融发生的形状或位置或加速治疗周期。

    Endovascular cryotreatment catheter
    74.
    发明申请
    Endovascular cryotreatment catheter 有权
    血管内冷冻治疗导管

    公开(公告)号：US20020045893A1

    公开(公告)日：2002-04-18

    申请号：US09945319

    申请日：2001-08-31

    发明人： Miriam Lane ,  Leonilda Capuano ,  David Holtan ,  Jean-Pierre Lalonde ,  Claudia Luckge ,  Jean-Luc Pageard ,  Marwan Abboud ,  Johnny Al Asmar ,  Abderrahim Benrabah ,  Ken Chen ,  John W. Lehmann ,  Philippe Marchand ,  Robert Martin ,  Fredric L. Milder ,  Daniel Nahon

    IPC分类号： A61B018/02

    CPC分类号： A61B18/02 ,  A61B2017/22001 ,  A61B2017/22051 ,  A61B2017/22054 ,  A61B2017/22069 ,  A61B2018/0022 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268

    摘要： An elongated catheter device with a distal balloon assembly is adapted for endovascular insertion. Coolant injected through the device may, in different embodiments, directly cool tissue contacting the balloon, or may cool a separate internal chamber. In the first case, the coolant also inflates the balloon, and spent coolant is returned to the handle via a return passage extending through the body of the catheter. Plural balloons may be provided, wherein a secondary outer balloon surrounds a primary inner balloon, the primary balloon being filled with coolant and acting as the cooling chamber, the secondary balloon being coupled to a vacuum return lumen to serve as a robust leak containment device and thermal insulator around the cooling chamber. Various configurations, such as surface modification of the balloon interface, or placement of particles, coatings, or expandable meshes or coils in the balloon interface, may be employed to achieve this function.

    摘要翻译： 具有远端球囊组件的细长导管装置适于血管内插入。 在不同的实施例中，通过装置注入的冷却剂可以直接冷却接触气囊的组织，或者可以冷却单独的内部腔室。 在第一种情况下，冷却剂还使气囊膨胀，并且废弃的冷却剂经由延伸穿过导管主体的返回通道返回到手柄。 可以提供多个气球，其中次级外球囊围绕主内球囊，主气球填充有冷却剂并用作冷却室，次级球囊联接到真空返回腔以用作鲁棒的泄漏容纳装置， 冷却室周围的绝热体。 可以采用各种构造，例如球囊界面的表面改性，或者在气球界面中放置颗粒，涂层或可膨胀的网孔或线圈，以实现该功能。

    Catheter for plaque stabilisation
    75.
    发明授权
    Catheter for plaque stabilisation 有权

    公开(公告)号：US11974796B2

    公开(公告)日：2024-05-07

    申请号：US15028790

    申请日：2014-10-01

    申请人： Cryotherapeutics GmbH

    发明人： Domenic Santoinanni ,  Stewart Maddison Fox ,  Daniel Nahon ,  Peter Kyone Park

    IPC分类号： A61B18/02 ,  A61B18/00

    CPC分类号： A61B18/02 ,  A61B2018/00023 ,  A61B2018/00041 ,  A61B2018/00166 ,  A61B2018/00214 ,  A61B2018/0022 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/0212 ,  A61B2018/0262 ,  A61B2018/0268

    摘要： Disclosed herein is a catheter for plaque stabilisation by cryotherapy, the catheter comprising: a first tube with a first end for receiving a flow of a coolant and a second end for supplying the flow of the coolant to a cooling element; a second tube, with a first end and a second end, wherein the second end of the second tube is configured to receive a flow of the coolant from the cooling element such that the second tube provides a flow path of the coolant from the second end of the second tube to the first end of the second tube; an inflatable flexible heat transfer element on the outer surface of the catheter; and a conduit for supplying an inflation fluid for inflating the flexible heat transfer element, wherein, when the flexible heat transfer element is inflated by the inflation fluid, the cooling element is configured to be within the balloon and in thermal conductivity with the inflation fluid; wherein the cooling element comprises an elongate tubular wall defining an elongate cooling chamber therein, the cooling chamber has a first end that is in fluid communication with the second end of the second tube and the cooling chamber has a second end that is closed.

    Cryoablation method and system
    78.
    发明授权
    Cryoablation method and system 有权

    公开(公告)号：US11653968B2

    公开(公告)日：2023-05-23

    申请号：US17110365

    申请日：2020-12-03

    申请人： Medtronic CryoCath LP

    发明人： Rachid Mahrouche ,  Dan Wittenberger

    IPC分类号： A61B18/02 ,  A61B18/00

    CPC分类号： A61B18/02 ,  A61B2018/00011 ,  A61B2018/00017 ,  A61B2018/0022 ,  A61B2018/00023 ,  A61B2018/00041 ,  A61B2018/00577 ,  A61B2018/0212 ,  A61B2018/0268

    摘要： A system and method for providing greater control over the temperature of a thermal treatment element of a medical device, enabling an operator to extend a thawing period of a cryoablation procedure. The system may include a fluid flow path that bypasses a subcooler, giving the operator selective control over the temperature of refrigerant delivered to the treatment element and, therefore, treatment element temperature. Additionally or alternatively, the system may include a fluid delivery conduit that is in communication with a liquid refrigerant and a gaseous refrigerant. Adjustment of the ratio of liquid to gaseous refrigerant also offers control over the treatment element temperature. Additionally or alternatively, the system may include one or more valves and/or heating elements in the fluid delivery and recovery conduits to control the treatment element temperature.