-
公开(公告)号：US20180215836A1
公开(公告)日：2018-08-02
申请号：US15883569
申请日：2018-01-30
Applicant: Kaneka Corporation
Inventor： Masakatsu Nishihachijyo , Fuminori Konoike , Yoshiyuki Nakano , Masayuki Takano , Keita Yamashita
CPC classification number: C07K17/02 , B01D15/3809 , B01J20/286 , B01J20/3204 , B01J20/321 , B01J20/3274 , C07K1/22 , C07K14/31 , C07K16/065 , C07K16/42 , C07K2317/52 , C07K2317/92 , C12N15/09
Abstract: A protein includes two or more amino acid sequences, wherein each amino acid sequence is derived from a sequence selected from the group consisting of SEQ ID NOs: 1 to 5. The amino acid sequence closest to the N-terminus includes more Lys residues than the other amino acid sequence(s), and in the amino acid sequence closest to the N-terminus, a total number of Lys in positions 1 to 38 is equal to or greater than a total number of Lys in position 39 and subsequent positions.
-
公开(公告)号：US20180118852A1
公开(公告)日：2018-05-03
申请号：US15700404
申请日：2017-09-11
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Dipali Deshpande , Gang Chen , Darya Burakov , James Fandl , Thomas Aldrich , Vishal Kamat
CPC classification number: C07K16/4258 , C07K16/22 , C07K16/2863 , C07K16/42 , C07K2317/31 , C07K2317/526 , C07K2317/64 , C07K2317/92
Abstract: Recombinant cell surface capture proteins and detection molecules that are useful for isolating and detecting cells that produce a secreted heterodimeric protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain are provided. Recombinant cell surface capture proteins and detection molecules that isolate and detect bispecific antibodies are also provided. The invention also provides recombinant antigen-binding proteins that are capable of recognizing and binding to proteins of interest that contain a CH3 domain and/or a modified CH3 domain, such as a CH3 domain with or without amino acid substitutions at H95 and Y96 (IMGT).
-
公开(公告)号：US20180088110A1
公开(公告)日：2018-03-29
申请号：US15558416
申请日：2016-08-03
Applicant: SEKISUI MEDICAL CO., LTD.
Inventor： Yasushi OCHIAI , Kimiyoshi NISHITANI
IPC: G01N33/543 , G01N33/569 , C07K16/42
CPC classification number: G01N33/54393 , C07K16/42 , C07K16/4283 , G01N33/531 , G01N33/543 , G01N33/56983 , G01N2333/08
Abstract: A problem is to provide a method of inhibiting nonspecific reaction unique to feces in a detection method using immunochromatography developing a fecal sample in an insoluble membrane so as to detect an analyte in the sample, and an immunochromatographic test strip used therefor. The present invention provides a method of performing an immunochromatographic reaction in the presence of an anti-IgA antibody so as to detect an analyte in a fecal sample without being affected by nonspecific reaction, and an immunochromatographic test strip used therefor.
-
公开(公告)号：US20170369527A1
公开(公告)日：2017-12-28
申请号：US15616781
申请日：2017-06-07
Applicant: BAC IP B.V.
CPC classification number: C07K1/22 , A61K39/44 , C07K16/42 , C07K2317/22 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/565 , C07K2317/569 , C07K2317/92
Abstract: The invention relates to a method of immunoaffinity purification which comprises the use of a binding agent which binds to an epitope that it is present at least twice on the target molecule. In another embodiment the method uses at least two different binding agents, each binding to different epitopes on the target molecule.
-
公开(公告)号：US20170326260A1
公开(公告)日：2017-11-16
申请号：US15660215
申请日：2017-07-26
Applicant: CytomX Therapeutics, Inc.
Inventor： Luc Roland Desnoyers , Tony W. Liang , Annie Yang Weaver
CPC classification number: A61K51/1078 , A61K2039/505 , C07K16/00 , C07K16/2863 , C07K16/2896 , C07K16/42 , C07K16/4291 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2319/00 , C07K2319/50 , G01N33/6854
Abstract: The invention relates generally to antibodies and antigen-binding fragments thereof that bind activatable antibodies and/or conjugated activatable antibodies and methods of making and using these antibodies that bind activatable antibodies and/or conjugated activatable antibodies.
-
Patent Agency Ranking
公开(公告)号：US09758592B2
公开(公告)日：2017-09-12
申请号：US14079686
申请日：2013-11-14
Applicant: Regeneron Pharmaceuticals, Inc.
Inventor： Dipali Deshpande , Gang Chen , Darya Burakov , James Fandl , Thomas Aldrich , Vishal Kamat
CPC classification number: C07K16/4258 , C07K16/22 , C07K16/2863 , C07K16/42 , C07K2317/31 , C07K2317/526 , C07K2317/64 , C07K2317/92
Abstract: Recombinant cell surface capture proteins and detection molecules that are useful for isolating and detecting cells that produce a secreted heterodimeric protein of interest (POI) that has an immunoglobulin CH3 domain and/or substituted CH3 domain are provided. Recombinant cell surface capture proteins and detection molecules that isolate and detect bispecific antibodies are also provided. The invention also provides recombinant antigen-binding proteins that are capable of recognizing and binding to proteins of interest that contain a CH3 domain and/or a modified CH3 domain, such as a CH3 domain with or without amino acid substitutions at H95 and Y96 (IMGT).
-
公开(公告)号：US20170101463A1
公开(公告)日：2017-04-13
申请号：US15332954
申请日：2016-10-24
Applicant: ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AND ON BEHALF OF
Inventor： Michael Sierks , Yong Shen
IPC: C07K16/18
CPC classification number: C07K16/18 , A61K2039/505 , C07K16/283 , C07K16/40 , C07K16/42 , C07K2317/31 , C07K2317/622 , C07K2317/626 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C07K2319/02 , C07K2319/21 , C07K2319/41
Abstract: The present invention relates to therapeutic agents comprising bispecific recombinant antibody fragments to selectively clear a protein associated with a neurological disease and methods of use of these therapeutic agents to treat neurological diseases.
-
公开(公告)号：US20160368990A1
公开(公告)日：2016-12-22
申请号：US15187209
申请日：2016-06-20
Applicant: Daiichi Sankyo Company, Limited
Inventor： Shu Takahashi , Tatsuji Matsuoka , Kenji Murakami , Takeshi Takizawa , Kenji Hirotani , Atsushi Urano , Keisuke Fukuchi , Mitsuhiro Yazawa
IPC: C07K16/28 , A61K39/395 , A61K45/06 , C07K16/30
CPC classification number: C07K16/2827 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/30 , C07K16/42 , C07K2317/24 , C07K2317/40 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/92
Abstract: The present invention relates to an antibody having a therapeutic effect on a tumor. That is, the invention relates to an antibody which binds to B7-H3 to exhibit an antitumor activity. An object of the invention is to provide a pharmaceutical having a therapeutic effect on a tumor. By obtaining an anti-B7-H3 antibody which binds to B7-H3 to exhibit an antitumor activity, a pharmaceutical composition for treating a tumor comprising the antibody and the like are obtained.
Abstract translation: 本发明涉及对肿瘤具有治疗作用的抗体。 也就是说，本发明涉及与B7-H3结合以显示抗肿瘤活性的抗体。 本发明的目的是提供对肿瘤具有治疗作用的药物。 通过获得与B7-H3结合以显示抗肿瘤活性的抗B7-H3抗体，获得用于治疗包含抗体等的肿瘤的药物组合物。
-
公开(公告)号：US20160115244A1
公开(公告)日：2016-04-28
申请号：US14922098
申请日：2015-10-23
Applicant: SINGH MOLECULAR MEDICINE, LLC
Inventor： Sunanda Singh
CPC classification number: C07K16/241 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K16/3015 , C07K16/303 , C07K16/3069 , C07K16/32 , C07K16/40 , C07K16/42 , C07K16/4241 , C07K2317/569 , C07K2317/73 , C07K2317/76 , C07K2317/92 , G01N33/574 , G01N33/6854 , G01N33/686 , G01N33/6872 , G01N33/94
Abstract: This invention provides compositions and methods to treat a condition or disease without the use of exogenous targeting sequences or chemical compositions. The present invention relates to single-domain antibodies (sdAbs), proteins and polypeptides comprising the sdAbs that are directed against intracellular components that cause a condition or disease. The invention also includes nucleic acids encoding the sdAbs, proteins and polypeptides, and compositions comprising the sdAbs. The invention includes the use of the compositions, sdAbs, and nucleic acids encoding the sdAbs for prophylactic, therapeutic or diagnostic purposes.
Abstract translation: 本发明提供了在不使用外源性靶向序列或化学组成的情况下治疗病症或疾病的组合物和方法。 本发明涉及单结构域抗体（sdAb），蛋白质和多肽，其包含针对导致病症或疾病的细胞内成分的sdAb。 本发明还包括编码sdAb，蛋白质和多肽的核酸，以及包含sdAb的组合物。 本发明包括使用组合物，sdAb和编码sdAb的核酸用于预防，治疗或诊断目的。
-
公开(公告)号：US09321836B2
公开(公告)日：2016-04-26
申请号：US14068010
申请日：2014-02-18
Applicant: JANSSEN BIOTECH, INC.
Inventor： George Heavner , David M. Knight , Jill Giles-Komar , Bernard Scallon , David Shealy
IPC: A61K39/395 , A61K38/18 , A61K38/19 , A61K38/27 , A61K45/06 , C07K16/24 , G01N33/53 , C07K16/42 , G01N33/566 , A61K39/00
CPC classification number: C07K16/241 , A61K9/19 , A61K38/1816 , A61K38/19 , A61K38/27 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/42 , C07K16/4241 , C07K2317/14 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , G01N33/566 , Y02A50/386 , Y02A50/412 , Y10S514/825 , Y10S514/826
Abstract: The present invention relates to anti-TNF antibodies comprising all of the heavy chain variable CDR regions of SEQ ID NOS: 1, 2 and 3 and/or all of the light chain variable CDR regions of SEQ ID NOS:4, 5 and 6, specific for at least one human tumor necrosis factor alpha (TNF) protein or fragment thereof, as well as nucleic acids encoding such anti-TNF antibodies, complementary nucleic acids, vectors, host cells, production methods and therapeutic methods.
Abstract translation: 本发明涉及包含SEQ ID NO：1,2和3的所有重链可变CDR区和/或SEQ ID NO：4,5和6的所有轻链可变CDR区的抗TNF抗体， 特异于至少一种人肿瘤坏死因子α（TNF）蛋白或其片段，以及编码这种抗TNF抗体的核酸，互补核酸，载体，宿主细胞，生产方法和治疗方法。
-
-
-
-
-
-
-
-
-
Search Results
326
records
(took 0.036 seconds)
