公开(公告)号：US20180042240A1

公开(公告)日：2018-02-15

申请号：US15685509

申请日：2017-08-24

申请人： MATOKE HOLDINGS LIMITED

发明人： Thomas PATTON ,  James BRENNAN ,  John Reginald BARRETT ,  Ian STAPLES

IPC分类号： A01N63/00 ,  A01N63/02 ,  A61L15/38 ,  A61L15/46 ,  A61L15/40 ,  A01N65/20 ,  A01N59/00 ,  A23L29/00 ,  A23L21/25 ,  A23L33/10 ,  A01N65/00 ,  A61K38/44 ,  A61K35/644

CPC分类号： A01N63/00 ,  A01N59/00 ,  A01N63/02 ,  A01N65/00 ,  A23L21/25 ,  A23L29/06 ,  A23L33/10 ,  A61K35/644 ,  A61K38/443 ,  A61L15/38 ,  A61L15/40 ,  A61L15/46 ,  A61L2300/254 ,  A61L2300/404 ,  C12Y101/03004 ,  A01N65/20 ,  A61K2300/00

摘要： Storage-stable compositions for generating antimicrobial activity are described. The compositions comprise an enzyme that is able to convert a substrate to release hydrogen peroxide, and an unrefined natural substance, such as a honey, that includes a substrate for the enzyme. In certain embodiments, the enzyme is a purified enzyme. In other embodiments, the substrate lacks catalase activity, and the enzyme is additional to any enzyme activity able to convert the substrate to release hydrogen peroxide that may be present in the unrefined natural substance. The storage-stable compositions do not include sufficient free water to allow the enzyme to convert the substrate. Use of the compositions to treat microbial infections and wounds is described, as well as methods for their production.

公开(公告)号：US20180036560A1

公开(公告)日：2018-02-08

申请号：US15784322

申请日：2017-10-16

申请人： John D. Blizzard ,  Robert L. McKellar

发明人： John D. Blizzard ,  Robert L. McKellar

IPC分类号： A61Q19/00 ,  A01N65/00 ,  A01N65/44 ,  A61K31/606 ,  A01N25/04 ,  A61K31/045 ,  A61K8/895 ,  A61K31/165 ,  A61K31/60 ,  A61Q9/04 ,  A61Q5/02

CPC分类号： A61Q19/00 ,  A01N25/04 ,  A01N65/00 ,  A01N65/44 ,  A61K8/895 ,  A61K31/045 ,  A61K31/165 ,  A61K31/60 ,  A61K31/606 ,  A61K2800/10 ,  A61Q5/02 ,  A61Q9/04 ,  Y02A50/34

摘要： A siloxane polymer base that is useful as an excipient for many variable materials that can be compounded into it. Also disclosed are a method for the preparation of such bases, and another method regarding the preparation of the base and actives.

公开(公告)号：US20180020678A1

公开(公告)日：2018-01-25

申请号：US15476523

申请日：2017-03-31

申请人： Michael E. Scharf ,  Brittany F. Peterson

发明人： Michael E. Scharf ,  Brittany F. Peterson

IPC分类号： A01N65/00 ,  A01N43/16 ,  A61K38/47 ,  A01N43/50 ,  A01N57/16

CPC分类号： C12Y302/01 ,  A01N51/00 ,  A61K38/47 ,  A01N63/00 ,  A01N63/04

摘要： Methods and compositions for controlling termite populations by leveraging newly discovered mechanisms for symbiont- and host mediated anti-fungal defenses in the termite hind-gut. Such methods may include administering a composition to a termite, the composition formulated to promote protist dysbiosis in the gut of the termite, or silencing specific host or symbiont genes by RNA interference, and exposing the termite to a pathogen, where the composition increases the susceptibility of the termite to the pathogen. Compositions are also provided for the treatment of fungal infections, the composition comprising a medically effective amount of recombinant glycosyl hydrolase family 7 cellulase, as well as methods for utilizing the same.

公开(公告)号：US09867858B2

公开(公告)日：2018-01-16

申请号：US15017380

申请日：2016-02-05

申请人： CRESTOVO HOLDINGS LLC

发明人： Thomas Julius Borody

IPC分类号： A61K39/08 ,  A61K39/00 ,  A61K39/38 ,  A61K39/116 ,  A61K39/09 ,  A01N63/00 ,  A01N65/00 ,  A61K35/742 ,  A61K35/74 ,  A61K38/48 ,  A61K35/741 ,  A61K35/744 ,  A61K35/747 ,  A61K36/062 ,  A61K45/06 ,  A61K38/14 ,  A61K31/341 ,  A61K31/41 ,  A61K31/495 ,  A61K31/7034 ,  A23L2/52 ,  A61K35/745 ,  A61K35/38 ,  A61K35/24 ,  A61K9/00 ,  A23C9/123 ,  A61K9/48 ,  A23C9/13 ,  A23L33/135 ,  A23C9/127 ,  A61K9/19 ,  A61K35/37 ,  A61K31/545 ,  A61K35/76 ,  A61K31/43 ,  A61K38/00 ,  A61K31/7048 ,  A61K9/50 ,  A61K39/39 ,  A61K51/12 ,  A61K35/00

CPC分类号： A61K35/742 ,  A23C9/123 ,  A23C9/127 ,  A23C9/13 ,  A23L2/52 ,  A23L33/135 ,  A23V2002/00 ,  A61K9/0031 ,  A61K9/0053 ,  A61K9/19 ,  A61K9/48 ,  A61K9/4891 ,  A61K9/50 ,  A61K9/5005 ,  A61K9/5078 ,  A61K31/341 ,  A61K31/41 ,  A61K31/43 ,  A61K31/495 ,  A61K31/545 ,  A61K31/7034 ,  A61K31/7048 ,  A61K35/24 ,  A61K35/37 ,  A61K35/38 ,  A61K35/74 ,  A61K35/741 ,  A61K35/744 ,  A61K35/745 ,  A61K35/747 ,  A61K35/76 ,  A61K36/062 ,  A61K38/00 ,  A61K38/14 ,  A61K38/4893 ,  A61K39/00 ,  A61K39/39 ,  A61K45/06 ,  A61K51/1217 ,  A61K2035/115 ,  C12N2795/00032 ,  Y02A50/401 ,  Y02A50/469 ,  Y02A50/473 ,  A61K2300/00

摘要： The present invention relates to pharmaceutical compositions suitable for the treatment of chronic diseases associated with the presence of abnormal or an abnormal distribution of microflora in the gastrointestinal tract of a mammalian host, which compositions comprise viable non-pathogenic or attenuated pathogenic Clostridia. The compositions further comprise one or more additional viable non-pathogenic or attenuated pathogenic microorganisms selected from the group consisting of Bacteroides, Eubacteria, Fusobacteria, Propionibacteria, Lactobacilli, anaerobic cocci, Ruminococcus, E. coli, Gemmiger, Desulfomonas, Peptostreptococcus, and fungi. The present invention also provides pharmaceutical compositions suitable for the treatment of the same chronic diseases comprising viable non-pathogenic or attenuated pathogenic Escherichia coli, at least one strain of viable non-pathogenic or attenuated pathogenic Bacteroides and at least one strain of viable non-pathogenic or attenuated pathogenic microorganism.

公开(公告)号：US20180000086A1

公开(公告)日：2018-01-04

申请号：US15708662

申请日：2017-09-19

申请人： MPT Mustard Products & Technologies Inc.

发明人： Mark Andrew Hetherington ,  James Robinson

IPC分类号： A01N47/46 ,  A01N51/00 ,  A01N47/40 ,  A01N43/76 ,  A01N43/38 ,  A01N43/20 ,  A01N43/16 ,  A01N37/36 ,  A01N37/34 ,  A01N65/00 ,  A01N25/04

CPC分类号： A01N47/46 ,  A01N25/02 ,  A01N25/04 ,  A01N37/34 ,  A01N37/36 ,  A01N43/16 ,  A01N43/20 ,  A01N43/38 ,  A01N43/76 ,  A01N47/40 ,  A01N51/00 ,  A01N65/00 ,  A01N65/08

摘要： Provided are liquid compositions comprising inactive biopesticide precursors comprising a glucosinolate concentrate, a plant material comprising a myrosinase enzyme complex, and a water soluble polyol. Further provided are methods of making and using such compositions.

公开(公告)号：US20170367351A1

公开(公告)日：2017-12-28

申请号：US15536705

申请日：2015-12-16

申请人： Heliae Development, LLC

发明人： Sandip Shinde ,  Stephen Ventre ,  Nicholas Donowitiz ,  Michael Clint Rohlfsen ,  Laura Carney

IPC分类号： A01N65/00 ,  C12N1/12 ,  A01N63/00

CPC分类号： A01N65/00 ,  A01N63/00 ,  A01N65/03 ,  C12N1/12 ,  A01N25/04 ,  A01N25/22

摘要： Methods preparing a liquid mixotrophic Chlorella based composition comprising pasteurization and stabilization of a low concentration of mixotrophic Chlorella whole cells that have not been subjected to a drying process are disclosed. The liquid composition can be used to enhance the emergence and growth of plants in low concentration and low frequency soil and foliar applications.

公开(公告)号：US20170347666A1

公开(公告)日：2017-12-07

申请号：US15637082

申请日：2017-06-29

申请人： MPT Mustard Products & Technologies Inc.

发明人： James Robinson

IPC分类号： A01N65/08 ,  A01N65/00

CPC分类号： A01N65/08 ,  A01N65/00 ,  A01N47/46 ,  A01N2300/00

摘要： A composition for controlling pests comprising a mixture of plant material obtainable from a mustard plant of the species Sinapis alba and plant material obtainable from a mustard plant of the species Brassica juncea is described.

公开(公告)号：US09820846B2

公开(公告)日：2017-11-21

申请号：US14686262

申请日：2015-04-14

申请人： National Tsing Hua University

发明人： Fan-Gang Tseng ,  Shueh-Yao Chu ,  Chiao-Wen Chu

IPC分类号： A01N63/00 ,  A01N65/00 ,  C12N5/00 ,  A61F2/06 ,  B05D1/18

CPC分类号： A61F2/062 ,  B05D1/18 ,  B05D2254/02 ,  B29D1/00

摘要： The present invention provides a reparation method of a tubular vascular graft, (a) immersing a tubular scaffold in a first light sensitivity gelatin solution, and irradiate the tubular scaffold by a first time period, to let surface of the tubular scaffold form a base layer; (b) immersing the tubular scaffold of the step (a) in a chitin gelatin solution, when the surface of the base layer form a film, then immersing the tubular scaffold into a sodium hydroxide solution to generate a middle layer of the surface of the base layer; (c) immersing the tubular scaffold of the step (b) in a second light sensitivity gelatin solution, wherein the second light sensitivity gelatin solution comprises a cell, the tubular scaffold is irradiated by a second time period to form a surface layer of the middle layer; (d) until the cell forms a tubular structure of the surface layer by the cell in the tubular scaffold of the step (c), heating the tubular scaffold by a temperature to solve the base layer into a solution, pulling out the tubular scaffold to get an artificial blood vessels.

公开(公告)号：US09816105B2

公开(公告)日：2017-11-14

申请号：US14525482

申请日：2014-10-28

申请人： PIONEER HI BRED INTERNATIONAL INC ,  E I DU PONT DE NEMOURS AND COMPANY

发明人： Karen E. Broglie ,  David Charles Cerf ,  Rafael Herrmann ,  Albert L. Lu ,  Brian McGonigle ,  James Kevin Presnail

IPC分类号： C12N15/82 ,  A01H5/00 ,  A01N57/16 ,  A01N65/00 ,  C12N15/113 ,  A01N65/44

CPC分类号： C12N15/8286 ,  A01N57/16 ,  A01N65/00 ,  A01N65/44 ,  C12N15/113 ,  C12N15/8218 ,  C12N2310/14 ,  C12N2310/531 ,  Y02A40/162

摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.

公开(公告)号：US09814747B2

公开(公告)日：2017-11-14

申请号：US14805324

申请日：2015-07-21

申请人： Henry Lowe ,  Ngeh J. Toyang ,  Joseph Bryant

发明人： Henry Lowe ,  Ngeh J. Toyang ,  Joseph Bryant

IPC分类号： A01N65/00 ,  A61K36/185 ,  A61K31/704

CPC分类号： A61K36/185 ,  A61K31/704

摘要： A therapeutic phenolic extract derived from plant biomass, and more specifically the indigenous Jamaican plant guaiacum officinale L. (Zygophyllaceae), for use in regressing or controlling HIV-1 replication in infected patients, and to help prevent sexual transmission of HIV-1, as well as the method for inhibiting HIV-1 by administering a pharmaceutically-acceptable amount of the crude extract to prevent HIV-viral replication without causing excessive damage to normal cells.