公开(公告)号：US12131498B2

公开(公告)日：2024-10-29

申请号：US17730377

申请日：2022-04-27

Applicant: The Broad Institute, Inc. ,  Massachusetts Institute of Technology ,  Yeda Research and Development Co. LTD. of Weizmann Institute of Science ,  National University of Ireland Maynooth

Inventor： Mehrtash Babadi ,  Luca D'Alessio ,  Muriel Medard ,  Ken Duffy ,  Yonina Eldar ,  Litian Liu

IPC: G06T7/73 ,  G01N21/64 ,  G06V10/98 ,  G06V20/00 ,  G06V20/69

CPC classification number: G06T7/73 ,  G01N21/6458 ,  G06V10/98 ,  G06V20/698 ,  G06V20/95 ,  G01N2021/6441 ,  G06T2207/10056 ,  G06T2207/10064 ,  G06T2207/30242

Abstract: A way to design a codebook for estimating the type of a molecule at a particular location in a fluorescence microscopy image makes use of one or both of (1) knowledge of the non-uniform prior distribution of molecule types (i.e., some types are known a priori to occur more frequently than others) and/or knowledge of co-occurrence of molecule types at close locations (e.g., in a same cell); and (2) knowledge of a model of the (e.g., random) process that yields the intensities that are expected at a location when a molecule with a particular subset of markers (i.e., a molecule of a type that has been assigned a codeword that defines that subset) is present at that location. The codebook design may provide experimental efficiency by reducing the number of images that need to be acquired and/or improve classification or detection accuracy by making the codewords for different molecule types more distinctive.

公开(公告)号：US20240300821A1

公开(公告)日：2024-09-12

申请号：US18668340

申请日：2024-05-20

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Igor LUBOMIRSKY ,  Maxim VARENIK

IPC: C01F17/235 ,  C01G25/00

CPC classification number: C01F17/235 ,  C01G25/006 ,  C01P2002/52 ,  C01P2004/03 ,  C01P2006/40

Abstract: This invention provides doped ceria-based materials exhibiting electrostriction properties and methods of preparation thereof.

公开(公告)号：US20240249384A1

公开(公告)日：2024-07-25

申请号：US18561314

申请日：2022-05-18

Applicant: Yeda Research And Development Co. Ltd

Inventor： Yonina ELDAR ,  Or BAR-SHIRA

IPC: G06T3/4053 ,  A61B8/08 ,  A61B8/13 ,  G06T3/4046

CPC classification number: G06T3/4053 ,  A61B8/13 ,  A61B8/481 ,  A61B8/5207 ,  A61B8/5276 ,  G06T3/4046

Abstract: An ultrasound scanning system includes an ultrasound scanner, a trained spare recovery neural network and a super resolution image generator. The ultrasound scanner views a patient after intravenous injection of microbubbles and then generates a sequence of ultrasound images. The sequence of ultrasound images is formed of a sequence of B-mode ultrasound images and a sequence of contrast enhanced ultrasound images corresponding to the B-mode ultrasound images. The trained sparse recovery neural network is trained on synthesized images of point sources and generates, for at least one image of the sequence of contrast-enhanced ultrasound images, a super-resolved image of locations of the microbubbles in that image. The super resolution image generator receives an output of the trained sparse recovery neural network and generates therefrom a super-resolved image of a microvasculature through which the microbubbles flowed.

公开(公告)号：US20240229221A1

公开(公告)日：2024-07-11

申请号：US18559576

申请日：2022-05-12

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Igor LUBOMIRSKY ,  David EHRE ,  Asaf COHEN

IPC: C23C14/06 ,  C23C14/00 ,  C23C14/02 ,  H10N30/06 ,  H10N30/076 ,  H10N30/079 ,  H10N30/20

CPC classification number: C23C14/0617 ,  C23C14/0036 ,  C23C14/021 ,  C23C14/025 ,  H10N30/06 ,  H10N30/076 ,  H10N30/079 ,  H10N30/2042

Abstract: This invention provides a process for the preparation of aluminum scandium nitride films. This invention further provides Caluminum scandium nitride films and layers, and devices and systems comprising aluminum scandium nitride films.

公开(公告)号：US12020120B2

公开(公告)日：2024-06-25

申请号：US18378617

申请日：2023-10-10

Applicant: QUANTUM SOURCE LABS LTD. ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Gil Semo ,  Ziv Aqua ,  Oded Melamed ,  Dan Charash ,  Serge Rosenblum ,  Barak Dayan

IPC: G06N10/40

CPC classification number: G06N10/40

Abstract: A quantum computing system includes a first resonator couplable to a first alkali atom, a second resonator couplable to a second alkali atom, and lasers for trapping, cooling, and manipulating the first alkali atom and the second alkali atom. Detectors detect a presence of the trapped first alkali atom and the trapped second alkali atom, and a processor is configured to receive at least one input signal from at least one of the detectors, the input signal indicating a presence of the trapped first alkali atom and the trapped second alkali atom, and, based on the received input, control at least some of the lasers to manipulate at least one of the trapped first alkali atom and the trapped second alkali atom to thereby generate photonic qubits using the trapped first alkali atom or generate entanglement between photonic qubits transmitted to the trapped second alkali atom.

公开(公告)号：US12016876B2

公开(公告)日：2024-06-25

申请号：US17734199

申请日：2022-05-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Alon Chen ,  Eran Hornstein ,  Orna Issler ,  Sharon Haramati ,  Naama Volk

IPC: C12N15/11 ,  A61K31/7105 ,  A61K31/713 ,  A61K48/00 ,  C12N15/113 ,  C12Q1/6883

CPC classification number: A61K31/7105 ,  A61K31/713 ,  A61K48/0058 ,  C12N15/113 ,  C12Q1/6883 ,  C12N2310/141 ,  C12Q2600/178

Abstract: microRNAs and compositions comprising same for the treatment and diagnosis of serotonin-, adrenalin-, noradrenalin-, glutamate-, and corticotropin-releasing hormone-associated medical conditions are provided.

公开(公告)号：US20240204171A1

公开(公告)日：2024-06-20

申请号：US18444698

申请日：2024-02-18

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Boris RYBTCHINSKI ,  Aayan MAITY ,  Haim WEISSMAN ,  Michal LESKES

IPC: H01M4/36 ,  H01M4/02 ,  H01M4/04 ,  H01M4/505 ,  H01M4/525 ,  H01M4/583 ,  H01M4/66 ,  H01M10/0525

CPC classification number: H01M4/364 ,  H01M4/0435 ,  H01M4/505 ,  H01M4/525 ,  H01M4/583 ,  H01M4/661 ,  H01M10/0525 ,  H01M2004/027 ,  H01M2004/028

Abstract: Provided herein noncovalent hybrids comprising carbon nanotubes (CNTs) and aromatic compounds, composites based on them, process of preparation and uses thereof, e.g. as electrodes and in lithium-ion cells; wherein the hybrids possess superior mechanical and electrical properties.

公开(公告)号：US20240140988A1

公开(公告)日：2024-05-02

申请号：US17637098

申请日：2020-04-16

Applicant: Ariel Scientific Innovations Ltd. ,  Yeda Research and Development Co. Ltd.

Inventor： Guy PATCHORNIK ,  Mordechai SHEVES ,  Irishi N. N. NAMBOOTHIRI ,  Gunasekaran DHANDAPANI

IPC: C07K1/32 ,  C07K1/34

CPC classification number: C07K1/32 ,  C07K1/34 ,  C07K2317/14

Abstract: A method of isolating an antibody is disclosed. The method comprises contacting a hydrophobic chelator, a non-ionic detergent and metal ions so as to generate an aggregate comprising the hydrophobic chelator, the detergent and the metal ions; and contacting the aggregate with a medium comprising the antibody under conditions that allow partitioning of the antibody into the aggregate. Kits for isolating the antibody are also disclosed.

公开(公告)号：US20240133870A1

公开(公告)日：2024-04-25

申请号：US18530406

申请日：2023-12-06

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ravid STRAUSSMAN ,  Oded SANDLER

IPC: G01N33/50

CPC classification number: G01N33/5011 ,  G01N33/5088

Abstract: Combined treatment for cancer is provided. Accordingly, there is provided a method of selecting or determining therapeutic efficacy of a combination of agents for the treatment of cancer in a subject in need thereof, the method comprising: (i) culturing a cancerous tissue of the subject in an ex-vivo organ culture (EVOC) in the presence of a combination of an anti-cancer agent and an additional agent, said additional agent is inhibiting expression and/or activity of a target conferring innate resistance to said anti-cancer agent or increasing expression and/or activity of a target conferring innate sensitivity to said anti-cancer agent; and (ii) determining an anti-cancer effect of the combination on the tissue, wherein responsiveness of the tissue to the combination indicates the combination is efficacious for the treatment of the cancer in the subject. Also provided are methods of treating cancer with a combination of agent wherein cancerous tissue obtained from the subject demonstrates responsiveness to the combination of agents in an ex-vivo organ culture (EVOC).

公开(公告)号：US20240124881A1

公开(公告)日：2024-04-18

申请号：US18334909

申请日：2023-06-14

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Igor ULITSKY ,  Caroline Jane ROSS

IPC: C12N15/113 ,  A61P25/00 ,  G16B30/10

CPC classification number: C12N15/1137 ,  A61P25/00 ,  G16B30/10 ,  C12N2310/11 ,  C12N2310/321

Abstract: A method of increasing an amount of Chromodomain Helicase DNA Binding Protein 2 (CHD2) in a neuronal cell is provided. The method comprising introducing into the cell a nucleic acid agent that down-regulates activity or expression of human Chaserr, wherein the nucleic acid agent is directed at the last exon of human Chaserr, thereby increasing the amount of CHD2 in the neuronal cell.