公开(公告)号：US20230309411A1

公开(公告)日：2023-09-28

申请号：US18042212

申请日：2021-08-19

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Binghai YAN ,  Jiewen XIAO

IPC: H10N50/20 ,  H10B61/00 ,  H10N50/80 ,  H10N50/85

CPC classification number: H10N50/20 ,  H10B61/00 ,  H10N50/80 ,  H10N50/85

Abstract: Devices for sensing and manipulating magnetic fields based on spin current interactions independent of the Spin Hall Effect (SHE) in heavy metal. Spin current is generated in ordinary metals by conversion of out-of-plane orbital current arising from the Orbital Hall Effect (OHE). The conversion from orbital current to spin current takes place in a thin layer of heavy metal (several atomic layers thick), thereby substantially reducing heavy metal requirements by replacing heavy metal with ordinary metal. Device applications include magnetoresistive sensors for detecting and measuring magnetic fields, and magnetic tunnel junction data storage units.

公开(公告)号：US20230273211A1

公开(公告)日：2023-08-31

申请号：US18128260

申请日：2023-03-30

Applicant: Yeda Research and Development Co. Ltd. ,  Tel HaShomer Medical Research Infrastructure and Services Ltd.

Inventor： Sima LEV ,  Yaron VINIK ,  Francisco Gabriel ORTEGA ,  Mordechai GUTMAN MD

IPC: G01N33/574 ,  G01N1/34

CPC classification number: G01N33/57415 ,  G01N1/34 ,  G01N33/57488 ,  G01N2333/912 ,  G01N2333/4703 ,  G01N2333/78 ,  G01N2800/56 ,  G01N2800/52

Abstract: A method of diagnosing breast cancer is disclosed. The method comprises lysing extracellular vesicles of a subject to generate a composition comprising components of extracellular vesicles; measuring the amount of MEK1 in the composition; and diagnosing the subject with breast cancer when a level of said MEK1 in said composition is above a predetermined threshold. Kits for breast cancer diagnosis are also disclosed.

公开(公告)号：US11731116B2

公开(公告)日：2023-08-22

申请号：US16076697

申请日：2017-02-08

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  Arkadi Nerush

Inventor： David Milstein ,  Alex Nerush ,  Matthias Vogt ,  Arup Mukherjee ,  Noel Angel Espinosa-Jalapa ,  Subrata Chakraborty

IPC: B01J31/00 ,  B01J31/18 ,  B01J31/24 ,  C07C249/02 ,  C07B43/06 ,  C07B43/08

CPC classification number: B01J31/181 ,  B01J31/2428 ,  C07C249/02 ,  B01J2231/348 ,  B01J2531/72 ,  C07B43/06 ,  C07B43/08

Abstract: The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C—C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di-lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a hydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.

公开(公告)号：US20230230775A1

公开(公告)日：2023-07-20

申请号：US18000826

申请日：2021-06-09

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Milko E. VAN DER BOOM ,  Michal LAHAV ,  Neta ELOOL DOV ,  Ofir EISENBERG ,  Yadid ALGAVI ,  Naveen MALIK ,  Yohonatan HAMO ,  Julia NAREVICIUS

IPC: H01G11/24 ,  H01G11/04 ,  H01G11/46 ,  H01G11/54 ,  H01G11/48 ,  H01G11/36

CPC classification number: H01G11/24 ,  H01G11/04 ,  H01G11/46 ,  H01G11/54 ,  H01G11/48 ,  H01G11/36 ,  H02J2207/50 ,  C08G61/126

Abstract: A hybrid supercapacitor where the charging state is indicated by color is demonstrated. The device comprises a molecular network that functions as both the battery-type electrode and the charge indicator. Related batteries, electrodes and devices, their processes of preparation and methods of use are provided as well. Further included in this invention are data-storage devices and catalysts based on multilayers comprising metal-ion organic complexes. This invention further provides methods of preparation of the multilayers, of the data-storage devices, of the catalyst devices and methods of use thereof.

公开(公告)号：US20230223147A1

公开(公告)日：2023-07-13

申请号：US18123435

申请日：2023-03-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran SEGAL ,  Eran ELINAV

IPC: G16H20/60 ,  G16H50/70 ,  G16H10/60

CPC classification number: G16H20/60 ,  G16H50/70 ,  G16H10/60

Abstract: Method of predicting a response of a subject to food is disclosed. The method comprises: selecting a food to which a response of the subject is unknown; accessing a first database having data describing the subject but not a response of the subject to the selected food; accessing a second database having data pertaining to responses of other subjects to foods, the responses of the other subjects including responses of at least one other subject to the selected food or a food similar to said selected food; and analyzing the databases based on the selected food to estimate the response of the subject to the selected food.

公开(公告)号：US20230203594A1

公开(公告)日：2023-06-29

申请号：US17958516

申请日：2022-10-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ravid STRAUSSMAN ,  Noam SHENTAL ,  Ilana LIVYATAN ,  Deborah GITTA ROSENBERG NEJMAN ,  Garold FUKS

IPC: C12Q1/6886 ,  C12Q1/689

CPC classification number: C12Q1/6886 ,  C12Q1/689 ,  C12Q1/6869

Abstract: A method of treating cancer in a subject is disclosed. The method comprises:

(a) analyzing for the abundance of at least one bacteria in the tumor microbiome of the subject; and
(b) administering to the subject a therapeutically effective amount of an immunotherapy treatment on the basis of the abundance of said at least one bacteria.

公开(公告)号：US20230165521A1

公开(公告)日：2023-06-01

申请号：US17919267

申请日：2021-04-14

Applicant: Yeda Research and Development Co. Ltd. ,  Mor Research Applications Ltd.

Inventor： Noam SOBEL ,  Anat ARZI ,  Liron ROZENKRANTZ ,  Lior GORODISKY ,  Yael HOLTZMAN ,  Yaron SACHER ,  Danit ROZENKRANTZ

IPC: A61B5/00 ,  A61B5/08 ,  A61B5/091

CPC classification number: A61B5/4842 ,  A61B5/091 ,  A61B5/0816 ,  A61B5/4011

Abstract: A method of assessing a subject including: measuring a plurality of respirations of the subject; determining one or more respiration parameter from the plurality of respirations; and determining, using the one or more respiration parameter, one or more of: a state of consciousness of the subject; and a prognosis of the subject.

公开(公告)号：US11639929B2

公开(公告)日：2023-05-02

申请号：US16783524

申请日：2020-02-06

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David Margulies ,  Leila Motiei ,  Naama Lahav

IPC: C07D249/04 ,  G01N33/533 ,  G01N33/68 ,  G01N33/58

Abstract: This invention is directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins. This invention further provides a system comprising recombinant cells decorated with various labels and/or synthetic agents, wherein said labels and/or synthetic agents can be reversibly modified or removed from the cells. Also disclosed herein are methods for decorating and/or modifying the cells and methods for using thereof.

公开(公告)号：US20230125981A1

公开(公告)日：2023-04-27

申请号：US17906243

申请日：2021-03-18

Applicant: Mor Research Applications Ltd. ,  Yeda Research and Development Co. Ltd.

Inventor： Yaniv SHILO ,  Brian BERKOWITZ

IPC: A61M27/00 ,  A61F2/04

Abstract: Embodiments pertain to ureteral stents for treatment of partial or full ureteral occlusion by bridging one or more ureteral occlusions, where each stent includes a tubular portion, a first spout portion and a second spout portion. The stent may have one or more tapered edges by having the smallest diameter of the first and/or the second spout portion smaller than the largest diameter of the tubular portion, and/or be of an overall length allowing the ureteral stent to be completely located within a patient's ureter once deployed therein.

公开(公告)号：US11633358B2

公开(公告)日：2023-04-25

申请号：US17190537

申请日：2021-03-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Jacob Klein ,  Ronit Goldberg ,  Jasmine Seror ,  Weifeng Lin ,  Reut Mashiach

IPC: A61K9/127 ,  A61K9/00 ,  A61K47/32 ,  A61K47/10 ,  A61K47/36 ,  A61K9/08 ,  A61K31/728 ,  A61K31/77 ,  A61K31/79 ,  B65D35/00 ,  B65D75/36

Abstract: A method of reducing a friction coefficient of a surface is disclosed herein, comprising attaching a water-soluble polymer to the surface, and contacting the water-soluble polymer with liposomes, thereby coating the surface with an amphiphilic lipid. Further disclosed herein are solutions comprising a water-soluble polymer attachable to the surface, liposomes, and an aqueous carrier, for reducing a friction coefficient of a surface, and methods utilizing same. Articles of manufacture comprising a substrate coated by a water-soluble polymer which is coated by an amphiphilic lipid are also described, as are uses and methods for treating a synovial joint disorder associated with increased articular friction.